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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PTPRG 5793 protein tyrosine phosphatase, receptor type, G  3RPTPG 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21150880   2011Cell line : -

Source : Leiden University Medical Center (Leiden, The Netherlands) or at the Rijnland Hospital (Leiderdorp, The Netherlands).

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : -

Chromatinimmunoprecipitation,CpG island microarrays,Differential methylation hybridisation,Bisulphite sequence analysis ,MS-MLPA assay,Real-time RT-PCRMethylation-PTPRG intron 1 methylation in both sporadic and hereditary colon cancers support biomarker potential for early detection of colon cancer.


Gene Details



NC_000003.11 (61547243..62280573)

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Gene Type protein coding
Gene Family Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like, "Fibronectin type III domain containing"
Description The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]  
Chromosome 3
Location 3p21-p14
Start 61547243  
End 62280573  
Strand +  
Gene Sequence

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Length 733331  
OMIM ID 176886   
HGNC ID HGNC:9671   
Unigene ID Hs.595541   
Ensembl ID ENSG00000144724   
PharmGKB ID PA34016   

mRNA Information


mRNA ID ?NM_002841.3
Exon join(1..804,187310..187414,428057..428236,441781..441929, 516595..516690,571034..571100,595499..595656, 606403..606595,629901..630085,633494..633602, 639937..639986,641605..642382,657283..657415, 669657..669743,682239..682330,693556..693647, 701230..701326,705842..705924,706117..706251, 707467..707601,709815..709987,711378..711513, 712130..712276,714305..714398,715404..715480, 715983..716111,719995..720141,721159..721301, 730853..730988,731593..733330)  
mRNA Sequence

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Length 6648  



CDS Information


   
Location720..5057
CDS Sequence

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CCDS ID CCDS2895.1



Protein Information


      
Protein IDNP_002832.3
Protein Nameprotein tyrosine phosphatase, receptor type, G
Molecular Wt. (Da)0
Protein Sequence

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Length 1445  
Uniprot IDO95185
Ensembl Protein ID ENSP00000406022  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation1435
SPhosphorylation1182

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0312267-319  alpha_CARP_receptor_like
cl0001267-319  alpha_CA superfamily
cd00047876-1118  PTPc
cl21483876-1118  PTPc superfamily
cd000471177-1408  PTPc
cl214831177-1408  PTPc superfamily
cd00063348-438  FN3
cl21522348-438  FN3 superfamily
smart0105760-316  Carb_anhydrase
cd0032680-317  alpha_CA
cd0311780-319  alpha_CA_IV_XV_like
cd0312367-320  alpha_CA_VI_IX_XII_XIV
cd0312667-320  alpha_CA_XII_XIV
pfam0019478-320  Carb_anhydrase
cd0315067-320  alpha_CA_IX
cd0312467-317  alpha_CA_prokaryotic_like
cd0312567-320  alpha_CA_VI
smart000121018-1118  PTPc_DSPc
smart004041018-1118  PTPc_motif
cd0311958-320  alpha_CA_I_II_III_XIII
cd0312180-317  alpha_CARP_X_XI_like
cd0314980-320  alpha_CA_VII
COG333860-320  Cah
cd0311880-320  alpha_CA_V
cd0312080-317  alpha_CARP_VIII
smart000121310-1409  PTPc_DSPc
smart004041310-1409  PTPc_motif
smart00060348-426  FN3
pfam00041348-426  fn3
pfam11179545-735  DUF2967
cl12728545-735  DUF2967 superfamily
PLN02202249-317  PLN02202
pfam03247567-623  Prothymosin
cl03959567-623  Prothymosin superfamily
pfam07423564-657  DUF1510
cl22487564-657  DUF1510 superfamily
smart001951054-1096  DSPc
pfam145661025-1077  PTPlike_phytase
pfam07423540-624  DUF1510
smart00194847-1118  PTPc
smart001941150-1408  PTPc
PLN0217917-272  PLN02179
pfam00102874-1118  Y_phosphatase
pfam001021175-1409  Y_phosphatase
COG5599872-1118  COG5599
PHA02738851-1116  PHA02738
PHA02747853-1113  PHA02747
PHA02746865-1121  PHA02746
PHA02742873-1118  PHA02742
COG55991175-1410  COG5599
PHA027471146-1416  PHA02747
PHA027461175-1407  PHA02746
PHA027381168-1407  PHA02738
PHA027421150-1414  PHA02742
PHA02740869-1116  PHA02740
PHA027401206-1414  PHA02740
COG24531025-1128  CDC14
pfam03344545-702  Daxx
pfam10243542-724  MIP-T3
PHA03169544-702  PHA03169
PHA03169560-643  PHA03169
PHA03307527-734  PHA03307
PHA03169569-710  PHA03169


Ontology Information


   
HPRD ID4767
Molecular ClassReceptor tyrosine phosphatase
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessDevelopment (GO:0007275)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO