Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PTPRH | 5794 | Protein tyrosine phosphatase, receptor type, H | 19 | SAP1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 9070877 | 1997 | Cell line : - Source : Pathology Department of Kobe University Hospital. Sample Type : CRC tumor and normal tissue No. of Sample : 48 CRC patientsand 17 adenoma Stage : - | Immunohistochemistry, In situ hybridization | Up-regulation | - | The frequent overexpression of SAP-1 in human colorectal cancers suggests that this protein, alone or in combination with CEA, may serve as a useful marker for the diagnosis and follow-up after surgery of the patients with this condition. SAP-1 is frequently overexpressed in human colorectal cancers and that such overexpression may occur relatively late in the adenoma-arcinoma sequence. |
| 22930170 | 2012 | Cell line : KM 12C, KM 12SM, HT 29 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Microarray analysis,Real time RT-PCR and FACS analysis | Up-regulation | - | Gene differentially expressed and analysed bye by Microarray. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like, Fibronectin type III domain containing |
| Description | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009] | Chromosome | 19 |
| Location | 19q13.4 |
| Start | 55181247 |
| End | 55209506 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 28260 |
| OMIM ID | 602510 |
| HGNC ID | HGNC:9672 |
| Unigene ID | Hs.179770 |
| Ensembl ID | ENSG00000080031 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001161440.2 |
|---|---|
| Exon | join(1..124,2308..2341,2552..2818,7185..7451,9005..9271, 10595..10864,12091..12390,12719..12985,17766..17844, 17959..18006,21339..21429,21904..21994,22967..23043, 23148..23282,23523..23645,23845..24005,27356..27491, 27604..28260) | mRNA Sequence | Download Select all |
| Length | 3401 |
CDS Information
| Location | join(74..124,2308..2341,2552..2818,7185..7451,9005..9271, 10595..10864,12091..12390,12719..12985,17766..17844, 17959..18006,21339..21429,21904..21994,22967..23043, 23148..23282,23523..23645,23845..24005,27356..27491, 27604..27753) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS54321.1 |
Protein Information
| Protein ID | |
|---|---|
| Protein Name | Protein tyrosine phosphatase, receptor type, H |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 0 |
| Uniprot ID | |
| Ensembl Protein ID |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
| EC | 3.1.3.48 |
|---|---|
| Name | protein-tyrosine-phosphatase phosphotyrosine phosphatase phosphoprotein phosphatase (phosphotyrosine) phosphotyrosine histone phosphatase protein phosphotyrosine phosphatase tyrosylprotein phosphatase phosphotyrosine protein phosphatase phosphotyrosylprotein phosphatase tyrosine O-phosphate phosphatase PPT-phosphatase PTPase [phosphotyrosine]protein phosphatase PTP-phosphatase |
| Class | Hydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases |
| Sysname | protein-tyrosine-phosphate phosphohydrolase |
| Substrate | protein tyrosine phosphate [CPD:C01167]; H2O |
| Product | protein tyrosine [CPD:C00585]; phosphate |
| Reaction (IUBMB) |  |
PPi Information
No STRING Network could be found.
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3932 | LCK | 1080 | NP_005347.3 | in vitro;in vivo | 12837766 |
| 5594 | MAPK1 | 1496 | NP_002736.3 | in vivo | 11278335 |
| 5747 | PTK2 | 2859 | NP_005598.3 | in vivo | 11278335 |
| 5829 | PXN | 3937 | BAA18998.1 | in vitro;in vivo | 11278335 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
No matching records could be found.
Ontology Information
| HPRD ID | 3105 |
|---|---|
| Molecular Class | Receptor tyrosine phosphatase |
| Molecular Function | Protein binding (GO:0005515) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.