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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PTPRR 5801 protein tyrosine phosphatase, receptor type, R  12PTPBR7, PTP-SL, EC-PTP, PCPTP1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23096495   2013Cell line : -

Source : -

Sample Type : -

No. of Sample : 132 CRC patients

Stage : -

Methyl specific PCR and Illumina 27K microarray Hypermethylation-PTPR family has an important role in the etiology of CRC.

The analysis of promoter methylation using an Illumina 27K microarray revealed four protein tyrosine phosphatases PTPRM, PTPRT, PTPRR and PTPRZ1 as being hypermethylated with p-value 0.2 and P = 0.05.


Gene Details



Chromosome 12 - NC_000012.12 (70638073..70920804, complement)

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Gene Type protein coding
Gene Family Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like
Description The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12.  
Chromosome 12
Location 12q15
Start 70638073  
End 70920804  
Strand -  
Gene Sequence

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Length 282732  
OMIM ID 602853   
HGNC ID HGNC:9680   
Unigene ID Hs.506076   
Ensembl ID ENSG00000153233   
PharmGKB ID -   

mRNA Information


mRNA ID NM_002849.3
Exon join(1..472,27828..28126,156027..156140,159179..159334, 166504..166614,174719..174987,219482..219668, 222456..222540,236022..236101,236541..236678, 258200..258310,259708..259865,263988..264101, 281528..282732)  
mRNA Sequence

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Length 2860  



CDS Information


   
Location join(415..472,27828..28126,156027..156140,159179..159334, 166504..166614,174719..174987,219482..219668, 222456..222540,236022..236101,236541..236678, 258200..258310,259708..259865,263988..264101, 281528..281621)
CDS Sequence

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CCDS ID CCDS8998.1



Protein Information


      
Protein IDNP_001193944.1
Protein Nameprotein tyrosine phosphatase, receptor type, R
Molecular Wt. (Da)61284
Protein Sequence

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Length 545  
Uniprot IDP14061
Ensembl Protein ID ENSP00000466799  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation94
SPhosphorylation339
TPhosphorylation116
TPhosphorylation361
TPhosphorylation116
TPhosphorylation361
YPhosphorylation370;-
YPhosphorylation125;-

Enzyme Information


   
EC3.1.3.48
Nameprotein-tyrosine-phosphatase
phosphotyrosine phosphatase
phosphoprotein phosphatase (phosphotyrosine)
phosphotyrosine histone phosphatase
protein phosphotyrosine phosphatase
tyrosylprotein phosphatase
phosphotyrosine protein phosphatase
phosphotyrosylprotein phosphatase
tyrosine O-phosphate phosphatase
PPT-phosphatase
PTPase
[phosphotyrosine]protein phosphatase
PTP-phosphatase
ClassHydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases
Sysnameprotein-tyrosine-phosphate phosphohydrolase  
Substrateprotein tyrosine phosphate [CPD:C01167]; H2O  
Productprotein tyrosine [CPD:C00585]; phosphate  
Reaction (IUBMB)



PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
5594MAPK11496NP_002736.3in vitro;in vivo;yeast 2-hybrid98   571   901   041   951   000   000   000   
5595MAPK33479NP_002737.2in vitro;in vivo98   571   901   041   951   000   000   000   
5598MAPK73952NP_620603.2in vitro;in vivo12042304   


Pathway Information


      
Pathway Name Pathway ID
MAPK signaling pathway hsa04010


Structure Information


PDB ID2A8B
Resolution2.3
MethodX-RAY DIFFRACTION
Chains A  
Molecule Receptor-type tyrosine-protein phosphatase R  
Model View



Domain Information




ID Location Description
cd00047417-644  PTPc
cl21483417-644  PTPc superfamily
smart00404544-644  PTPc_motif
smart00012544-644  PTPc_DSPc
pfam00782574-650  DSPc
smart00195574-648  DSPc
pfam14566553-595  PTPlike_phytase
smart00194392-644  PTPc
pfam00102415-644  Y_phosphatase
PHA02746394-644  PHA02746
COG5599413-644  COG5599
PHA02742417-652  PHA02742
PHA02738419-647  PHA02738
PHA02747413-641  PHA02747
PHA02740430-649  PHA02740
COG2453503-654  CDC14


Ontology Information


   
HPRD ID7205
Molecular ClassReceptor tyrosine phosphatase
Molecular FunctionHeat shock protein activity (GO:0003773)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO