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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PTPRR | 5801 | protein tyrosine phosphatase, receptor type, R  | 12 | PTPBR7, PTP-SL, EC-PTP, PCPTP1  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23096495    | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : 132 CRC patients Stage : - | Methyl specific PCR and Illumina 27K microarray | Hypermethylation | - | PTPR family has an important role in the etiology of CRC. The analysis of promoter methylation using an Illumina 27K microarray revealed four protein tyrosine phosphatases PTPRM, PTPRT, PTPRR and PTPRZ1 as being hypermethylated with p-value 0.2 and P = 0.05. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like |
| Description | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12.   | Chromosome | 12 |
| Location | 12q15 |
| Start | 70638073   |
| End | 70920804   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 282732   |
| OMIM ID | 602853    |
| HGNC ID | HGNC:9680    |
| Unigene ID | Hs.506076    |
| Ensembl ID | ENSG00000153233    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_002849.3 |
|---|---|
| Exon | join(1..472,27828..28126,156027..156140,159179..159334, 166504..166614,174719..174987,219482..219668, 222456..222540,236022..236101,236541..236678, 258200..258310,259708..259865,263988..264101, 281528..282732)   | mRNA Sequence |    Download   Select all |
| Length | 2860   |
CDS Information
| Location | join(415..472,27828..28126,156027..156140,159179..159334, 166504..166614,174719..174987,219482..219668, 222456..222540,236022..236101,236541..236678, 258200..258310,259708..259865,263988..264101, 281528..281621) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS8998.1 |    
Protein Information
| Protein ID | NP_001193944.1 |
|---|---|
| Protein Name | protein tyrosine phosphatase, receptor type, R |
| Molecular Wt. (Da) | 61284 |
| Protein Sequence |    Download   Select all |
| Length | 545   |
| Uniprot ID | P14061 |    
| Ensembl Protein ID | ENSP00000466799   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 94 |
| S | Phosphorylation | 339 |
| T | Phosphorylation | 116 |
| T | Phosphorylation | 361 |
| T | Phosphorylation | 116 |
| T | Phosphorylation | 361 |
| Y | Phosphorylation | 370;- |
| Y | Phosphorylation | 125;- |
Enzyme Information
| EC | 3.1.3.48 |    
|---|---|
| Name | protein-tyrosine-phosphatase phosphotyrosine phosphatase phosphoprotein phosphatase (phosphotyrosine) phosphotyrosine histone phosphatase protein phosphotyrosine phosphatase tyrosylprotein phosphatase phosphotyrosine protein phosphatase phosphotyrosylprotein phosphatase tyrosine O-phosphate phosphatase PPT-phosphatase PTPase [phosphotyrosine]protein phosphatase PTP-phosphatase |
| Class | Hydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases |
| Sysname | protein-tyrosine-phosphate phosphohydrolase   |
| Substrate | protein tyrosine phosphate [CPD:C01167]; H2O   |
| Product | protein tyrosine [CPD:C00585]; phosphate   |
| Reaction (IUBMB) | ![]() |
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5594 |    MAPK1 |    1496 |    NP_002736.3 |    in vitro;in vivo;yeast 2-hybrid |    98   571   901   041   951   000   000   000    |
| 5595 |    MAPK3 |    3479 |    NP_002737.2 |    in vitro;in vivo |    98   571   901   041   951   000   000   000    |
| 5598 |    MAPK7 |    3952 |    NP_620603.2 |    in vitro;in vivo |    12042304    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MAPK signaling pathway |    hsa04010 |    
Structure Information
| PDB ID | 2A8B |
|---|---|
| Resolution | 2.3 |
| Method | X-RAY DIFFRACTION |
| Chains | A   |
| Molecule | Receptor-type tyrosine-protein phosphatase R   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00047 | 417-644  | PTPc |
| cl21483 | 417-644  | PTPc superfamily |
| smart00404 | 544-644  | PTPc_motif |
| smart00012 | 544-644  | PTPc_DSPc |
| pfam00782 | 574-650  | DSPc |
| smart00195 | 574-648  | DSPc |
| pfam14566 | 553-595  | PTPlike_phytase |
| smart00194 | 392-644  | PTPc |
| pfam00102 | 415-644  | Y_phosphatase |
| PHA02746 | 394-644  | PHA02746 |
| COG5599 | 413-644  | COG5599 |
| PHA02742 | 417-652  | PHA02742 |
| PHA02738 | 419-647  | PHA02738 |
| PHA02747 | 413-641  | PHA02747 |
| PHA02740 | 430-649  | PHA02740 |
| COG2453 | 503-654  | CDC14 |
Ontology Information
| HPRD ID | 7205 |    
|---|---|
| Molecular Class | Receptor tyrosine phosphatase |
| Molecular Function | Heat shock protein activity (GO:0003773) |
| Biological Process | Protein metabolism (GO:0019538)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    

