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General Information
- Evidence
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19686745 | 2010 | Cell line : - Source : Tangdu Hospital, the University of the Fourth Military Medical University. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | real time RT-PCR, Western blotting, Bisulfite sequencing and methylation specific PCR | Methylation | - | QKI is significantly down-regulated and even absent in some colon cancers. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014 | Chromosome | 6 |
| Location | 6q26 |
| Start | 163835675 |
| End | 163999628 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 163954 |
| OMIM ID | 609590 |
| HGNC ID | HGNC:21100 |
| Unigene ID | Hs.510324 |
| Ensembl ID | ENSG00000112531 |
| PharmGKB ID | PA134912180 |
Protein Information
| Protein ID | NP_001288014.1 |
|---|---|
| Protein Name | QKI, KH domain containing, RNA binding |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 341 |
| Uniprot ID | Q12769 |
| Ensembl Protein ID | ENSP00000367721 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3276 | PRMT1 | 4257 | NP_001527.3 | in vitro;in vivo | 12529443 |
| 9491 | PSMF1 | 17919 | NP_848693.2 | yeast 2-hybrid | 16713569 |
| 10083 | USH1C | 9241 | NP_710142.1 | yeast 2-hybrid | 16713569 |
| 10169 | SERF2 | 5447 | NP_005761.2 | yeast 2-hybrid | 16713569 |
| 10432 | RBM14 | 11485 | NP_006319.1 | yeast 2-hybrid | 16713569 |
| 11030 | RBPMS | 11870 | NP_001008712.1 | yeast 2-hybrid | 16713569 |
| 11067 | C10orf10 | 12558 | NP_008952.1 | yeast 2-hybrid | 16713569 |
| 23543 | RBM9 | 15231 | NP_001076047.1 | yeast 2-hybrid | 16713569 |
| 51444 | RNF138 | 11508 | NP_057355.2 | yeast 2-hybrid | 16713569 |
| 54715 | - | 16091 | NP_665898.1 | yeast 2-hybrid | 16713569 |
| 55145 | THAP1 | 15496 | NP_060575.1 | yeast 2-hybrid | 16713569 |
| 57060 | PCBP4 | 16343 | NP_065151.1 | yeast 2-hybrid | 16713569 |
| 58155 | PTBP2 | 12233 | NP_067013.1 | yeast 2-hybrid | 16713569 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd02395 | 83-205 | SF1_like-KH |
| cl00098 | 83-205 | KH-I superfamily |
| smart00322 | 81-128 | KH |
| cd00105 | 84-128 | KH-I |
| pfam07777 | 232-309 | MFMR |
| cl06693 | 232-309 | MFMR superfamily |
| pfam13014 | 98-123 | KH_3 |
| pfam00013 | 97-127 | KH_1 |
| COG5176 | 83-206 | MSL5 |
| PHA03247 | 211-314 | PHA03247 |
| PRK14951 | 210-281 | PRK14951 |
| PRK14950 | 195-313 | PRK14950 |
| PRK14951 | 212-282 | PRK14951 |
| PRK07764 | 181-299 | PRK07764 |
Ontology Information
| HPRD ID | 5903 |
|---|---|
| Molecular Class | RNA binding protein |
| Molecular Function | Ubiquitin-specific protease activity (GO:0004843) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.