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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RAB27B 5874 RAB27B, member RAS oncogene family  18- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25580113   2014Cell line : -

Source : Affiliated Hospital of Nantong University

Sample Type : Tissue from patients with adenoma, carcinoma and ulcerative colitis

No. of Sample : 113 formalin-fixed, paraffin-embedded CRC tissues and matched tumor-adjacent normal tissues

Stage : TNM Stage I-IV

qPCR, immunohistochemistryUp-regulation-Higher expression of Rab27b was observed in CRC tissues and Rab27b may be identified as a useful predictor of metastasis and prognosis for CRC.


Gene Details



NC_000018.9 (52385097..52562747)

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Gene Type protein coding
Gene Family RAB, member RAS oncogene
Description Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997 [PubMed 9066979]).[supplied by OMIM, Nov 2010]  
Chromosome 18
Location 18q21.2
Start 52385097  
End 52562747  
Strand +  
Gene Sequence

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Length 177651  
OMIM ID 603869   
HGNC ID HGNC:9767   
Unigene ID Hs.25318   
Ensembl ID ENSG00000041353   
PharmGKB ID PA34118   

mRNA Information


mRNA ID ?NM_004163.4
Exon join(1..70,202..276,159702..159873,161504..161589, 166468..166571,170130..170253,171359..177651)  
mRNA Sequence

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Length 6924  



CDS Information


   
Location165..821
CDS Sequence

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CCDS ID CCDS11958.1



Protein Information


      
Protein IDNP_004154.2
Protein NameRAB27B, member RAS oncogene family
Molecular Wt. (Da)23336
Protein Sequence

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Length 218  
Uniprot IDP55884
Ensembl Protein ID ENSP00000354125  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
94121SYTL46735NP_542775.2in vitro;in vivo11956164   


Pathway Information


      
Pathway Name Pathway ID
Pancreatic secretion hsa04972


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd041276-185  Rab27A
cl214556-185  P-loop_NTPase superfamily
smart0017510-184  RAB
cd0015410-179  Rab
cd018677-184  Rab8_Rab10_Rab13_like
cd018687-181  Rab11_like
cd018698-184  Rab1_Ypt1
cd018659-181  Rab3
cd041105-218  Rab35
cd041118-218  Rab39
cd0186310-181  Rab18
cd0412310-182  Rab21
cd0186211-187  Rab7
cd0186011-177  Rab5_related
cd0411311-173  Rab4
cd0411211-173  Rab26
cd0411711-183  Rab15
cd0186111-171  Rab6
cd041145-177  Rab30
cd041228-173  Rab14
cd018647-177  Rab19
cd018666-173  Rab2
cd0087611-181  Ras
cd0410711-218  Rab32_Rab38
cd0411910-178  RJL
cd0412015-213  Rab12
smart0001011-184  small_GTPase
smart0017311-184  RAS
cd0411511-178  Rab33B_Rab33A
cd041169-175  Rab9
cd0015710-176  Rho
cd0087710-183  Ran
cd0088215-179  Ras_like_GTPase
cd0414411-217  Ras2
cd0410610-179  Rab23_like
cd0413811-181  H_N_K_Ras_like
smart0017412-178  RHO
cd041327-186  Rho4_like
cd0410111-177  RabL4
cd041215-184  Rab40
cd0417611-179  Rap2
cd0414511-181  M_R_Ras_like
cd0413711-217  RheB
cd0413310-174  Rop_like
cd0411810-177  Rab24
cd0410910-193  Rab28
cd0410811-170  Rab36_Rab34
cd0413010-176  Wrch_1
cd0413911-177  RalA_RalB
cd0412810-172  Spg1
cd0417711-182  RSR1
cd0413611-181  Rap_like
cd0412610-216  Rab20
cd0417511-183  Rap1
cd0412410-183  RabL2
cd0991410-179  RocCOR
cd0412911-175  Rho2
cd0187510-189  RhoG
cd0414111-184  Rit_Rin_Ric
cd0187110-171  Rac1_like
cd0187011-176  RhoA_like
cd0414611-183  RERG_RasL11_like
cd041407-180  ARHI_like
cd0414811-175  RGK
cd0414311-180  Rhes_like
cd0414711-178  Ras_dva
cd0087811-180  Arf_Arl
pfam0847711-136  Miro
cd0187410-166  Cdc42
cd0413510-179  Tc10
cd0417211-169  Rnd3_RhoE_Rho8
COG222910-178  Srp102
cd0413110-169  Rnd
cd0413411-173  Rho3
cd0415215-184  Arl4_Arl7
smart0017710-177  ARF
cd0410210-184  RabL3
cd0416013-179  Arfrp1
PLN0002310-137  PLN00023
cd018739-171  RhoBTB
cd0417311-169  Rnd2_Rho7
cd0415921-145  Arl10_like
PLN0022310-184  PLN00223
cd0417411-178  Rnd1_Rho6
cd01898127-181  Obg
cd0414210-164  RRP22
pfam0002510-181  Arf
cd0087911-182  Sar1
cd0414910-149  Arf6
cd0415611-177  ARLTS1
cd0415410-179  Arl2
cd0415311-139  Arl5_Arl8
PTZ0013310-185  PTZ00133
cd0416496-181  trmE
cd0415010-157  Arf1_5_like
cd0415712-179  Arl6
cd0415111-179  Arl1
cd0410310-172  Centaurin_gamma
cd0410513-137  SR_beta
cd01849108-185  YlqF_related_GTPase
cd01854126-172  YjeQ_EngC
cd01897125-180  NOG
cd0416212-152  Arl9_Arfrp2_like
cd0415811-145  ARD1
pfam00009128-181  GTP_EFTU
cd0088167-184  GTP_translation_factor
COG0378127-183  HypB
cd04171124-180  SelB
cd1138568-153  RagC_like
pfam0007111-183  Ras
PLN031103-178  PLN03110
PLN031086-189  PLN03108
PLN031184-186  PLN03118
COG11006-187  Gem1
PTZ0013210-172  PTZ00132
PLN0307110-172  PLN03071
PTZ0009932-171  PTZ00099
smart0017615-172  RAN
TIGR0023110-178  small_GTP
PTZ0036911-187  PTZ00369
PRK12299129-193  obgE
TIGR02729128-185  Obg_CgtA
PRK12298129-199  obgE
pfam0467011-164  Gtr1_RagA
PRK12297124-181  obgE
COG0536124-181  Obg
PRK12296124-168  obgE
PRK0529196-192  trmE
smart0017811-185  SAR
TIGR01393115-181  lepA
COG0486124-183  MnmE
PRK00098123-204  PRK00098
COG0481115-181  LepA
COG1161122-204  RbgA


Ontology Information


   
HPRD ID4884
Molecular ClassGTPase
Molecular FunctionTranslation regulator activity (GO:0045182)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO