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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RACGAP1 29127 Rac GTPase activating protein 1  12MgcRacGAP 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25568185   2015Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : Surgical specimens from 193 CRC patients (Cohort 1)and formalin-fixed paraffin-embedded samples from 298 CRC patients (Cohort 2)

Stage : -

 real-time PCR, immunohistochemistryUp-regulation-RacGAP1 a potential biomarker for identifying patients with lymph node metastasis and poor prognosis in CRC.


Gene Details



NC_000012.11 (50382945..50425586, complement)

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Gene Type protein coding
Gene Family -
Description This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12. [provided by RefSeq, Feb 2016]  
Chromosome 12
Location 12q13
Start 50382945  
End 50425586  
Strand -  
Gene Sequence

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Length 42642  
OMIM ID 604980   
HGNC ID HGNC:9804   
Unigene ID Hs.505469   
Ensembl ID -   
PharmGKB ID PA34165   

mRNA Information


mRNA ID ?NM_001126103.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS8795.1



Protein Information


      
Protein IDNP_001119575.1
Protein NameRac GTPase activating protein 1
Molecular Wt. (Da)0
Protein Sequence

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Length 632  
Uniprot IDQ9NQA5
Ensembl Protein ID ENSP00000406572  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation387
SPhosphorylation410
SPhosphorylation170
SPhosphorylation164
SPhosphorylation214
TPhosphorylation580
TPhosphorylation588
SPhosphorylation590
SPhosphorylation628
TPhosphorylation161
SPhosphorylation203
TPhosphorylation342
TPhosphorylation145
TPhosphorylation186
SPhosphorylation144
SPhosphorylation185
SPhosphorylation187
SPhosphorylation149
SPhosphorylation154
SPhosphorylation157
SPhosphorylation206
SPhosphorylation257
SPhosphorylation573
SPhosphorylation591
TPhosphorylation579
SPhosphorylation595
SPhosphorylation600
TPhosphorylation601
TPhosphorylation606
SPhosphorylation592
SPhosphorylation593
TPhosphorylation277
SPhosphorylation169
TDephosphorylation588
TPhosphorylation201
SPhosphorylation234
YPhosphorylation241
TPhosphorylation243
SPhosphorylation533
SPhosphorylation540
SPhosphorylation563
TPhosphorylation567
TPhosphorylation564
TPhosphorylation603

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                      
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1124CHN24173NP_004058.1in vitro11278894   
1894ECT211860NP_060568.3in vivo18201571   
4216MAP3K43886NP_005913.2in vitro9079650   
4294MAP3K102533NP_002437.2in vitro9427749   
4893NRAS1273NP_002515.1in vitro10655059   
5529PPP2R5E9040NP_006237.1in vitro;in vivo;yeast 2-hybrid18201571   
7277TUBA4A1851NP_005991.1in vivo11942621   
7283TUBG11853NP_001061.2in vivo11942621   
7409VAV11284NP_005419.2in vivo10748082   
8153RND23332NP_005431.1in vitro;in vivo12590651   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd04382346-539  RhoGAP_MgcRacGAP
cl02570346-539  RhoGAP superfamily
cd00029287-335  C1
cl00040287-335  C1 superfamily
pfam00620363-513  RhoGAP
smart00324360-533  RhoGAP
cd00159363-533  RhoGAP
cd04398361-532  RhoGAP_fRGD1
cd04395356-532  RhoGAP_ARHGAP21
cd04372362-533  RhoGAP_chimaerin
cd04374364-533  RhoGAP_Graf
cd04377351-532  RhoGAP_myosin_IX
cd04385362-504  RhoGAP_ARAP
cd04378362-533  RhoGAP_GMIP_PARG1
cd04403362-533  RhoGAP_ARHGAP27_15_12_9
cd04387357-534  RhoGAP_Bcr
cd04407351-532  RhoGAP_myosin_IXB
cd04408362-533  RhoGAP_GMIP
cd04386341-504  RhoGAP_nadrin
cd04376360-504  RhoGAP_ARHGAP6
cd04373351-517  RhoGAP_p190
cd04393357-513  RhoGAP_FAM13A1a
cd04400362-520  RhoGAP_fBEM3
cd04404361-505  RhoGAP-p50rhoGAP
cd04381362-504  RhoGap_RalBP1
cd04390361-519  RhoGAP_ARHGAP22_24_25
cd04409352-532  RhoGAP_PARG1
cd04384351-504  RhoGAP_CdGAP
cd04379358-507  RhoGAP_SYD1
cd04402361-533  RhoGAP_ARHGAP20
cd04406362-532  RhoGAP_myosin_IXA
cd04397362-504  RhoGAP_fLRG1
cd04389362-532  RhoGAP_KIAA1688
cd04391361-519  RhoGAP_ARHGAP18
cd04394362-506  RhoGAP-ARHGAP11A
cd04383345-521  RhoGAP_srGAP
cd04396362-507  RhoGAP_fSAC7_BAG7
cd04392375-505  RhoGAP_ARHGAP19
cd04375373-504  RhoGAP_DLC1
cd04388351-513  RhoGAP_p85
smart00109287-335  C1
cd04380339-533  RhoGAP_OCRL1
pfam00130287-335  C1_1
pfam0788812-167  CALCOCO1
TIGR0216813-105  SMC_prok_B
COG119613-107  Smc


Ontology Information


   
HPRD ID5560
Molecular ClassGTPase activating protein
Molecular FunctionCaspase activator activity (GO:0008656)
Biological ProcessApoptosis (GO:0006915)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO