Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RALA | 5898 | V-ral simian leukemia viral oncogene homolog A (ras related)  | 7 | RAL  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21199803    | 2011 | Cell line : - Source : ATCC Sample Type : - No. of Sample : - Stage : - | Soft agar colony size and formation frequency,Immunoblotting. | Up-regulation | - | - |
| 21715253    | 2011 | Cell line : - Source : ATCC Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | Anti-RalA-selective therapies may provide an effective approach for KRAS mutant CRC. RalA interaction with the Exo84 but not Sec5 exocyst component was necessary for supporting anchorage-independent growth. CRC cell lines were obtained from ATCC. RalGEFs are activators of the related RalA and RalB small GTPases and we found activation of both in CRC cell lines and patient tumors. |
| 22790202    | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | Results emphasize cancer cell type differences in Ral function and hence the need for distinct Ral targeted therapeutic approaches in the treatment of CRC vs. PDAC. RalA but not RalB is necessary for PDAC tumor cell anchorage-independent growth. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq, Jul 2008]   | Chromosome | 7 |
| Location | 7p15-p13 |
| Start | 39622955   |
| End | 39708124   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 85170   |
| OMIM ID | 179550    |
| HGNC ID | HGNC:9839    |
| Unigene ID | Hs.6906     |
| Ensembl ID | ENSG00000006451    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | XM_011515467.1 |
|---|---|
| Exon | join(1..871,8942..9427)   | mRNA Sequence |    Download   Select all |
| Length | 2828   |
CDS Information
| Location | join(535..871,8942..9033) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | NP_005393.2 |
|---|---|
| Protein Name | V-ral simian leukemia viral oncogene homolog A (ras related) |
| Molecular Wt. (Da) | 23436 |
| Protein Sequence |    Download   Select all |
| Length | 206   |
| Uniprot ID | Q6UVK1 |    
| Ensembl Protein ID | ENSP00000312506   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 11 |
| S | Phosphorylation | 183 |
| S | Dephosphorylation | 183 |
| S | Dephosphorylation | 194 |
Enzyme Information
| EC | 3.6.5.2 |    
|---|---|
| Name | small monomeric GTPase |
| Class | Hydrolases; Acting on acid anhydrides; Acting on GTP to facilitate cellular and subcellular movement |
| Sysname | GTP phosphohydrolase (cell-regulating)   |
| Substrate | GTP [CPD:C00044]; H2O   |
| Product | GDP [CPD:C00035]; phosphate   |
| Reaction (IUBMB) | ![]() |
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 375 |    ARF1 |    54 |    NP_001649.1 |    in vivo |    125   094   629   688   545    |
| 801 |    CALM1 |    241 |    NP_008819.1 |    in vitro;in vivo;yeast 2-hybrid |    9188503    |
| 5519 |    PPP2R1B |    4384 |    NP_859050.1 |    in vivo |    17540176    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Pancreatic cancer |    hsa05212 |    
| Pathways in cancer |    hsa05200 |    
| Phospholipase D signaling pathway |    hsa04072 |    
| Rap1 signaling pathway |    hsa04015 |    
| Ras signaling pathway |    hsa04014 |    
Structure Information
| PDB ID | 1UAD |
|---|---|
| Resolution | 2.1 |
| Method | X-RAY DIFFRACTION |
| Chains | A,B   |
| Molecule | Ras-related protein Ral-A   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04139 | 15-177  | RalA_RalB |
| cl21455 | 15-177  | P-loop_NTPase superfamily |
| smart00010 | 15-178  | small_GTPase |
| smart00173 | 15-178  | RAS |
| cd00876 | 16-175  | Ras |
| cd04138 | 15-176  | H_N_K_Ras_like |
| cd04145 | 15-176  | M_R_Ras_like |
| cd04177 | 15-176  | RSR1 |
| cd04175 | 15-175  | Rap1 |
| cd04144 | 16-179  | Ras2 |
| cd04136 | 15-175  | Rap_like |
| cd04176 | 15-175  | Rap2 |
| cd04141 | 15-181  | Rit_Rin_Ric |
| cd00154 | 16-171  | Rab |
| cd04137 | 16-175  | RheB |
| smart00175 | 16-178  | RAB |
| cd01869 | 14-178  | Rab1_Ypt1 |
| cd01868 | 14-175  | Rab11_like |
| cd01860 | 16-175  | Rab5_related |
| cd04148 | 16-179  | RGK |
| cd04147 | 16-176  | Ras_dva |
| cd01867 | 13-178  | Rab8_Rab10_Rab13_like |
| cd04146 | 16-176  | RERG_RasL11_like |
| cd04123 | 16-175  | Rab21 |
| cd01862 | 16-173  | Rab7 |
| cd04143 | 15-171  | Rhes_like |
| cd01861 | 15-168  | Rab6 |
| cd04140 | 15-172  | ARHI_like |
| cd01866 | 14-175  | Rab2 |
| cd01863 | 16-175  | Rab18 |
| cd00157 | 16-173  | Rho |
| cd04111 | 16-178  | Rab39 |
| cd04122 | 16-175  | Rab14 |
| cd01864 | 14-175  | Rab19 |
| cd04119 | 15-175  | RJL |
| cd04116 | 14-175  | Rab9 |
| cd01865 | 14-168  | Rab3 |
| cd04110 | 14-183  | Rab35 |
| cd04113 | 16-175  | Rab4 |
| cd04120 | 16-180  | Rab12 |
| cd00882 | 20-173  | Ras_like_GTPase |
| cd04106 | 16-168  | Rab23_like |
| smart00174 | 17-168  | RHO |
| cd04112 | 15-204  | Rab26 |
| cd04127 | 14-166  | Rab27A |
| cd04114 | 14-175  | Rab30 |
| cd04115 | 16-177  | Rab33B_Rab33A |
| cd04117 | 16-178  | Rab15 |
| cd04132 | 16-168  | Rho4_like |
| cd04109 | 16-180  | Rab28 |
| cd00877 | 16-173  | Ran |
| cd04142 | 16-178  | RRP22 |
| cd04130 | 16-168  | Wrch_1 |
| cd04129 | 16-168  | Rho2 |
| cd01874 | 16-168  | Cdc42 |
| cd04133 | 16-168  | Rop_like |
| cd01870 | 16-168  | RhoA_like |
| cd04107 | 16-175  | Rab32_Rab38 |
| cd04135 | 16-168  | Tc10 |
| cd01875 | 16-175  | RhoG |
| cd01871 | 16-175  | Rac1_like |
| cd04101 | 16-173  | RabL4 |
| cd04121 | 14-178  | Rab40 |
| cd04118 | 16-168  | Rab24 |
| cd04108 | 15-169  | Rab36_Rab34 |
| cd04124 | 16-174  | RabL2 |
| cd04131 | 16-168  | Rnd |
| cd01893 | 16-169  | Miro1 |
| cd04126 | 16-204  | Rab20 |
| cd04172 | 16-163  | Rnd3_RhoE_Rho8 |
| cd04134 | 16-173  | Rho3 |
| pfam08477 | 16-130  | Miro |
| cd04103 | 16-175  | Centaurin_gamma |
| cd09914 | 16-166  | RocCOR |
| cd04173 | 16-183  | Rnd2_Rho7 |
| cd04128 | 16-171  | Spg1 |
| cd04174 | 16-160  | Rnd1_Rho6 |
| cd00878 | 16-168  | Arf_Arl |
| cd04152 | 13-131  | Arl4_Arl7 |
| COG2229 | 16-172  | Srp102 |
| cd04159 | 19-167  | Arl10_like |
| cd04160 | 68-149  | Arfrp1 |
| cd00880 | 20-168  | Era_like |
| cd04156 | 16-145  | ARLTS1 |
| cd04153 | 15-133  | Arl5_Arl8 |
| cd01887 | 119-166  | IF2_eIF5B |
| cd01873 | 16-173  | RhoBTB |
| cd04163 | 109-177  | Era |
| pfam00025 | 16-133  | Arf |
| cd01898 | 121-175  | Obg |
| cd01854 | 116-167  | YjeQ_EngC |
| cd01876 | 116-167  | YihA_EngB |
| cd01897 | 91-167  | NOG |
| cd04164 | 115-178  | trmE |
| cd01855 | 119-179  | YqeH |
| cd00879 | 16-141  | Sar1 |
| pfam00071 | 16-176  | Ras |
| PTZ00369 | 15-206  | PTZ00369 |
| COG1100 | 16-179  | Gem1 |
| TIGR00231 | 16-168  | small_GTP |
| PLN03108 | 14-182  | PLN03108 |
| PLN03118 | 16-175  | PLN03118 |
| PLN03110 | 14-175  | PLN03110 |
| PTZ00132 | 9-175  | PTZ00132 |
| PLN03071 | 16-175  | PLN03071 |
| smart00176 | 20-175  | RAN |
| PTZ00099 | 35-168  | PTZ00099 |
| COG1160 | 16-168  | Der |
| COG0486 | 15-177  | MnmE |
| PRK12298 | 121-182  | obgE |
| PRK12299 | 121-182  | obgE |
| TIGR00450 | 15-138  | mnmE_trmE_thdF |
| PRK00093 | 103-168  | PRK00093 |
| PRK05291 | 100-178  | trmE |
| TIGR03918 | 106-167  | GTP_HydF |
Ontology Information
| HPRD ID | 4016 |    
|---|---|
| Molecular Class | Unknown |
| Molecular Function | Receptor signaling complex scaffold activity (GO:0030159) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    

