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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RALA 5898 V-ral simian leukemia viral oncogene homolog A (ras related)  7RAL 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21199803   2011Cell line : -

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

Soft agar colony size and formation frequency,Immunoblotting.Up-regulation--

21715253   2011Cell line : -

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

-Up-regulation-Anti-RalA-selective therapies may provide an effective approach for KRAS mutant CRC.

RalA interaction with the Exo84 but not Sec5 exocyst component was necessary for supporting anchorage-independent growth.

CRC cell lines were obtained from ATCC.

RalGEFs are activators of the related RalA and RalB small GTPases and we found activation of both in CRC cell lines and patient tumors.

22790202   2012Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

-Up-regulation-Results emphasize cancer cell type differences in Ral function and hence the need for distinct Ral targeted therapeutic approaches in the treatment of CRC vs. PDAC.

RalA but not RalB is necessary for PDAC tumor cell anchorage-independent growth.


Gene Details



Chromosome: 7; NC_000007.13 (39663152..39747723)

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Gene Type protein coding
Gene Family -
Description The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq, Jul 2008]  
Chromosome 7
Location 7p15-p13
Start 39622955  
End 39708124  
Strand +  
Gene Sequence

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Length 85170  
OMIM ID 179550   
HGNC ID HGNC:9839   
Unigene ID Hs.6906    
Ensembl ID ENSG00000006451   
PharmGKB ID -   

mRNA Information


mRNA ID XM_011515467.1
Exon join(1..871,8942..9427)  
mRNA Sequence

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Length 2828  



CDS Information


   
Locationjoin(535..871,8942..9033)
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_005393.2
Protein NameV-ral simian leukemia viral oncogene homolog A (ras related)
Molecular Wt. (Da)23436
Protein Sequence

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Length 206  
Uniprot IDQ6UVK1
Ensembl Protein ID ENSP00000312506  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation11
SPhosphorylation183
SDephosphorylation183
SDephosphorylation194

Enzyme Information


   
EC3.6.5.2
Namesmall monomeric GTPase
ClassHydrolases; Acting on acid anhydrides; Acting on GTP to facilitate cellular and subcellular movement
SysnameGTP phosphohydrolase (cell-regulating)  
SubstrateGTP [CPD:C00044]; H2O  
ProductGDP [CPD:C00035]; phosphate  
Reaction (IUBMB)



PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
375ARF154NP_001649.1in vivo125   094   629   688   545   
801CALM1241NP_008819.1in vitro;in vivo;yeast 2-hybrid9188503   
5519PPP2R1B4384NP_859050.1in vivo17540176   


Pathway Information


                              
Pathway Name Pathway ID
Pancreatic cancer hsa05212
Pathways in cancer hsa05200
Phospholipase D signaling pathway hsa04072
Rap1 signaling pathway hsa04015
Ras signaling pathway hsa04014


Structure Information


PDB ID1UAD
Resolution2.1
MethodX-RAY DIFFRACTION
Chains A,B  
Molecule Ras-related protein Ral-A  
Model View



Domain Information




ID Location Description
cd0413915-177  RalA_RalB
cl2145515-177  P-loop_NTPase superfamily
smart0001015-178  small_GTPase
smart0017315-178  RAS
cd0087616-175  Ras
cd0413815-176  H_N_K_Ras_like
cd0414515-176  M_R_Ras_like
cd0417715-176  RSR1
cd0417515-175  Rap1
cd0414416-179  Ras2
cd0413615-175  Rap_like
cd0417615-175  Rap2
cd0414115-181  Rit_Rin_Ric
cd0015416-171  Rab
cd0413716-175  RheB
smart0017516-178  RAB
cd0186914-178  Rab1_Ypt1
cd0186814-175  Rab11_like
cd0186016-175  Rab5_related
cd0414816-179  RGK
cd0414716-176  Ras_dva
cd0186713-178  Rab8_Rab10_Rab13_like
cd0414616-176  RERG_RasL11_like
cd0412316-175  Rab21
cd0186216-173  Rab7
cd0414315-171  Rhes_like
cd0186115-168  Rab6
cd0414015-172  ARHI_like
cd0186614-175  Rab2
cd0186316-175  Rab18
cd0015716-173  Rho
cd0411116-178  Rab39
cd0412216-175  Rab14
cd0186414-175  Rab19
cd0411915-175  RJL
cd0411614-175  Rab9
cd0186514-168  Rab3
cd0411014-183  Rab35
cd0411316-175  Rab4
cd0412016-180  Rab12
cd0088220-173  Ras_like_GTPase
cd0410616-168  Rab23_like
smart0017417-168  RHO
cd0411215-204  Rab26
cd0412714-166  Rab27A
cd0411414-175  Rab30
cd0411516-177  Rab33B_Rab33A
cd0411716-178  Rab15
cd0413216-168  Rho4_like
cd0410916-180  Rab28
cd0087716-173  Ran
cd0414216-178  RRP22
cd0413016-168  Wrch_1
cd0412916-168  Rho2
cd0187416-168  Cdc42
cd0413316-168  Rop_like
cd0187016-168  RhoA_like
cd0410716-175  Rab32_Rab38
cd0413516-168  Tc10
cd0187516-175  RhoG
cd0187116-175  Rac1_like
cd0410116-173  RabL4
cd0412114-178  Rab40
cd0411816-168  Rab24
cd0410815-169  Rab36_Rab34
cd0412416-174  RabL2
cd0413116-168  Rnd
cd0189316-169  Miro1
cd0412616-204  Rab20
cd0417216-163  Rnd3_RhoE_Rho8
cd0413416-173  Rho3
pfam0847716-130  Miro
cd0410316-175  Centaurin_gamma
cd0991416-166  RocCOR
cd0417316-183  Rnd2_Rho7
cd0412816-171  Spg1
cd0417416-160  Rnd1_Rho6
cd0087816-168  Arf_Arl
cd0415213-131  Arl4_Arl7
COG222916-172  Srp102
cd0415919-167  Arl10_like
cd0416068-149  Arfrp1
cd0088020-168  Era_like
cd0415616-145  ARLTS1
cd0415315-133  Arl5_Arl8
cd01887119-166  IF2_eIF5B
cd0187316-173  RhoBTB
cd04163109-177  Era
pfam0002516-133  Arf
cd01898121-175  Obg
cd01854116-167  YjeQ_EngC
cd01876116-167  YihA_EngB
cd0189791-167  NOG
cd04164115-178  trmE
cd01855119-179  YqeH
cd0087916-141  Sar1
pfam0007116-176  Ras
PTZ0036915-206  PTZ00369
COG110016-179  Gem1
TIGR0023116-168  small_GTP
PLN0310814-182  PLN03108
PLN0311816-175  PLN03118
PLN0311014-175  PLN03110
PTZ001329-175  PTZ00132
PLN0307116-175  PLN03071
smart0017620-175  RAN
PTZ0009935-168  PTZ00099
COG116016-168  Der
COG048615-177  MnmE
PRK12298121-182  obgE
PRK12299121-182  obgE
TIGR0045015-138  mnmE_trmE_thdF
PRK00093103-168  PRK00093
PRK05291100-178  trmE
TIGR03918106-167  GTP_HydF


Ontology Information


   
HPRD ID4016
Molecular ClassUnknown
Molecular FunctionReceptor signaling complex scaffold activity (GO:0030159)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO