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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RALGDS 5900 ral guanine nucleotide dissociation stimulator  9RGF, RalGEF, RGDS 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
15526363   2004Cell line : -

Source : Cancer Hospital of Fudan University

Sample Type : CRCTumor

No. of Sample : 65

Stage : -

 Methylation specific PCR, Immunohistochemistry Methylation--

22786759   2013Cell line : LoVo, COLO320, HepG2

Source : -

Sample Type : CRCTumor

No. of Sample : 101 primary CRCs (67 stage III and 34 stage IV)

Stage : TNM Stage III,IV.

RFLP-PCR, ImmunohistochemistryMethylation--


Gene Details



NC_000009.11 (135973107..136024607, complement)

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Gene Type protein coding
Gene Family -
Description Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010]  
Chromosome 9
Location 9q34.3
Start 135973107  
End 136024607  
Strand -  
Gene Sequence

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Length 51501  
OMIM ID 601619   
HGNC ID HGNC:9842   
Unigene ID Hs.106185   
Ensembl ID ENSG00000160271   
PharmGKB ID PA34200   

mRNA Information


mRNA ID ?NM_001042368.2
Exon join(1..258,37069..37179,38732..38925,39500..39595, 40355..40548,40815..41233,41921..42136,42473..42576, 43205..43289,44890..44958,45388..45474,45959..45991, 46321..46442,46650..46745,47082..47283,47459..47701, 48839..48953,50459..51501)  
mRNA Sequence

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Length 3709  



CDS Information


   
Location241..2820
CDS Sequence

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CCDS ID CCDS43897.1



Protein Information


      
Protein IDNP_001035827.1
Protein Nameral guanine nucleotide dissociation stimulator
Molecular Wt. (Da)361901
Protein Sequence

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Length 914  
Uniprot IDQ14457
Ensembl Protein ID ENSP00000355231  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation586
YPhosphorylation531

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                      
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
408ARRB1146NP_004032.2in vitro;in vivo;yeast 2-hybrid12105416   
409ARRB2147NP_004304.1in vivo;yeast 2-hybrid12105416   
3265HRAS1813NP_005334.1in vitro;yeast 2-hybrid79   720   159   038   168   
3845KRAS1817NP_203524.1in vitro;yeast 2-hybrid7809086   
4301MLLT41164NP_001035090.1yeast 2-hybrid10545207   
5906RAP1A1545NP_002875.1in vitro;in vivo;yeast 2-hybrid10085114   
5911RAP2A1547NP_066361.1in vitro;in vivo;yeast 2-hybrid10085114   
5912RAP2B1548NP_002877.2in vitro;in vivo;yeast 2-hybrid10085114   
6237RRAS1299NP_006261.1in vitro;yeast 2-hybrid7809086   
22800RRAS22518NP_036382.2in vitro;in vivo;yeast 2-hybrid11788587   


Pathway Information


                                          
Pathway Name Pathway ID
Choline metabolism in cancer hsa05231
Colorectal cancer hsa05210
Pancreatic cancer hsa05212
Pathways in cancer hsa05200
Phospholipase D signaling pathway hsa04072
Rap1 signaling pathway hsa04015
Ras signaling pathway hsa04014


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00155382-644  RasGEF
cl02485382-644  RasGEF superfamily
cd00153798-883  RalGDS_RA
cl00155798-883  UBQ superfamily
cd06224120-250  REM
cl02520120-250  REM superfamily
smart00147382-649  RasGEF
pfam00617383-597  RasGEF
smart00229112-248  RasGEFN
pfam00618115-227  RasGEF_N
smart00314798-883  RA
pfam00788801-885  RA
cd01768801-883  RA
pfam05887309-363  Trypan_PARP
pfam05887309-368  Trypan_PARP
PRK04654302-379  PRK04654
PRK12323253-402  PRK12323
PRK11633302-363  PRK11633
PRK12323251-399  PRK12323
PHA03291308-380  PHA03291
pfam06566306-380  Chon_Sulph_att
pfam05616306-380  Neisseria_TspB
PHA03378253-364  PHA03378
PRK11633304-380  PRK11633
PRK14951308-392  PRK14951
PRK14954306-369  PRK14954
pfam05887251-361  Trypan_PARP
TIGR02927308-380  SucB_Actino
PRK09111308-379  PRK09111
PRK07003302-373  PRK07003
PRK11633309-345  PRK11633
pfam05466308-380  BASP1
pfam03154233-368  Atrophin-1
PHA03269308-380  PHA03269
PRK12323306-359  PRK12323
PRK14963273-388  PRK14963
PHA03247233-370  PHA03247
PRK14971305-380  PRK14971
pfam07223308-387  DUF1421
PHA03247302-383  PHA03247
pfam11235305-368  Med25_SD1
PRK14951252-374  PRK14951


Ontology Information


   
HPRD ID4649
Molecular ClassGuanine nucleotide exchange factor
Molecular FunctionHydrolase activity (GO:0016787)
Biological ProcessMetabolism (GO:0008152)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO