Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RAN | 5901 | RAN, member RAS oncogene family | 12 | TC4; Gsp1; ARA24 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20360909 | 2009 | Cell line : - Source : ATCC Sample Type : - No. of Sample : HCT116, HT 29 and LoVo Stage : - | Cell transfection array, cell proliferation assay, caspase activity assay, Hoechst staining, RT-PCR | Up-regulation | - | Silencing of PSMA7 and RAN induces cancer cells to undergo apoptosis, and PSMA7 and RAN might be promising new molecular targets for drug and RNA interference-based therapeutics against colorectal cancer. |
| 21304002 | 2011 | Cell line : - Source : Samsung Medical Center in Seoul, Korea. Sample Type : - No. of Sample : - Stage : - | RT-PCR, Western blotting | Up-regulation | - | - |
| 22956174 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : 287 CRC tissues Stage : - | Immunohistochemistry and western blotting | Up-regulation | - | Ran may play an important role in the development of CRC and may serve as a novel prognostic indicator of CRC. Important role of Ran are differentiation, disease stage, and metastasis in human CRC. |
| 22991145 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Fluorogenic derivatization-liquid chromatography-tandem mass spectrometry (FD-LC-MS/MS). | Up-regulation | - | Downregulation of 14-3-3?/?, cystatin-B, Ran and thioredoxin could be a result of their secretion, which then stimulates metastasis via activity in the sera and ascitic fluids.
|
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008] | Chromosome | 12 |
| Location | 12q24.3 |
| Start | 130871994 |
| End | 130877678 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 5685 |
| OMIM ID | 601179 |
| HGNC ID | HGNC:9846 |
| Unigene ID | Hs.10842 |
| Ensembl ID | ENSG00000132341 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_006325.4 |
|---|---|
| Exon | join(1..133,591..636,843..927,1010..1135,2553..2740, 3619..3789,3889..5685) | mRNA Sequence | Download Select all |
| Length | 1087 |
CDS Information
| Location | join(601..636,843..927,1010..1135,2553..2740,3619..3789, 3889..3933) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS9271.1 |
Protein Information
| Protein ID | NP_001287725.1 |
|---|---|
| Protein Name | RAN, member RAS oncogene family |
| Molecular Wt. (Da) | 14600 |
| Protein Sequence | Download Select all |
| Length | 128 |
| Uniprot ID | P01040 |
| Ensembl Protein ID | ENSP00000264474 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 147;- |
| Y | Phosphorylation | 147;- |
| Y | Phosphorylation | 147;- |
| Y | Phosphorylation | 155;- |
| K | Acetylation | 99 |
| K | Acetylation | 71 |
| K | Acetylation | 60 |
| K | Acetylation | 159 |
| K | Acetylation | 37 |
| Y | Phosphorylation | 146 |
| C | S-Nitrosylation | 112 |
| C | S-Nitrosylation | 120 |
| S | Phosphorylation | 135 |
Enzyme Information
| EC | 3.6.5.2 |
|---|---|
| Name | small monomeric GTPase |
| Class | Hydrolases; Acting on acid anhydrides; Acting on GTP to facilitate cellular and subcellular movement |
| Sysname | GTP phosphohydrolase (cell-regulating) |
| Substrate | GTP [CPD:C00044]; H2O |
| Product | GDP [CPD:C00035]; phosphate |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 25 | ABL1 | 1809 | NP_009297.2 | in vivo | 11420673 |
| 367 | AR | 2437 | NP_000035.2 | in vitro;in vivo;yeast 2-hybrid | 10400640 |
| 1104 | RCC1 | 1559 | NP_001041659.1 | in vivo | 10369786 |
| 4086 | SMAD1 | 3356 | NP_005891.1 | in vivo | 15761153 |
| 4087 | SMAD2 | 3221 | NP_005892.1 | in vivo | 15761153 |
| 4155 | MBP | 1158 | NP_001020272.1 | in vitro;in vivo | 12101123 |
| 5757 | PTMA | 1778 | NP_001092755.1 | in vitro | 11310559 |
| 7046 | TGFBR1 | 1822 | NP_004603.1 | in vivo | 15761153 |
| 26012 | NELF | 10485 | NP_001124441.1 | yeast 2-hybrid | 16169070 |
| 26206 | SPAG8 | 12039 | NP_758516.1 | in vitro;in vivo;yeast 2-hybrid | 15014887 |
| 57562 | KIAA1377 | 17212 | NP_065853.2 | yeast 2-hybrid | 16169070 |
| 64750 | SMURF2 | 6901 | NP_073576.1 | in vivo | 15761153 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Epstein-Barr virus infection | hsa05169 |
| HTLV-I infection | hsa05166 |
| Ribosome biogenesis in eukaryotes | hsa03008 |
| RNA transport | hsa03013 |
Structure Information
| PDB ID | 1I2M |
|---|---|
| Resolution | 1.76 |
| Method | X-RAY DIFFRACTION |
| Chains | A,C |
| Molecule | GTP-BINDING NUCLEAR PROTEIN RAN |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00877 | 11-176 | Ran |
| cl21455 | 11-176 | P-loop_NTPase superfamily |
| cd00154 | 11-166 | Rab |
| smart00175 | 11-169 | RAB |
| cd04123 | 11-169 | Rab21 |
| cd01860 | 10-169 | Rab5_related |
| cd04106 | 12-167 | Rab23_like |
| cd01869 | 11-169 | Rab1_Ypt1 |
| cd00876 | 12-168 | Ras |
| cd01863 | 11-168 | Rab18 |
| cd01864 | 11-168 | Rab19 |
| cd01862 | 11-169 | Rab7 |
| cd01868 | 11-161 | Rab11_like |
| cd04107 | 11-169 | Rab32_Rab38 |
| cd04124 | 12-161 | RabL2 |
| cd04113 | 11-168 | Rab4 |
| cd04114 | 11-169 | Rab30 |
| cd01861 | 11-161 | Rab6 |
| cd01867 | 11-166 | Rab8_Rab10_Rab13_like |
| cd04127 | 12-159 | Rab27A |
| cd00882 | 14-166 | Ras_like_GTPase |
| cd04110 | 11-169 | Rab35 |
| cd01866 | 11-168 | Rab2 |
| cd04116 | 11-161 | Rab9 |
| cd04122 | 11-168 | Rab14 |
| cd00157 | 12-128 | Rho |
| smart00173 | 11-166 | RAS |
| cd01865 | 11-161 | Rab3 |
| cd04132 | 8-161 | Rho4_like |
| cd04117 | 11-165 | Rab15 |
| smart00010 | 11-166 | small_GTPase |
| cd04111 | 10-166 | Rab39 |
| cd04112 | 11-168 | Rab26 |
| smart00174 | 13-130 | RHO |
| cd04145 | 10-166 | M_R_Ras_like |
| cd04119 | 12-153 | RJL |
| cd04176 | 10-168 | Rap2 |
| cd04175 | 10-169 | Rap1 |
| cd04115 | 11-168 | Rab33B_Rab33A |
| cd04120 | 12-171 | Rab12 |
| cd04108 | 12-165 | Rab36_Rab34 |
| cd01875 | 12-130 | RhoG |
| cd04139 | 11-168 | RalA_RalB |
| cd04101 | 12-166 | RabL4 |
| cd04138 | 10-168 | H_N_K_Ras_like |
| cd04109 | 11-170 | Rab28 |
| cd04134 | 12-166 | Rho3 |
| cd04144 | 12-168 | Ras2 |
| cd04136 | 10-169 | Rap_like |
| cd04129 | 12-131 | Rho2 |
| pfam08477 | 12-125 | Miro |
| cd01871 | 12-130 | Rac1_like |
| cd04130 | 12-128 | Wrch_1 |
| cd04177 | 10-169 | RSR1 |
| cd04118 | 12-161 | Rab24 |
| cd04121 | 11-166 | Rab40 |
| cd04147 | 12-194 | Ras_dva |
| cd04133 | 12-130 | Rop_like |
| cd04128 | 12-125 | Spg1 |
| cd04141 | 10-168 | Rit_Rin_Ric |
| cd01874 | 12-128 | Cdc42 |
| cd04131 | 12-127 | Rnd |
| cd09914 | 12-159 | RocCOR |
| cd04126 | 12-161 | Rab20 |
| cd01870 | 12-128 | RhoA_like |
| cd04143 | 11-165 | Rhes_like |
| cd04172 | 9-146 | Rnd3_RhoE_Rho8 |
| cd04140 | 11-161 | ARHI_like |
| cd00878 | 12-164 | Arf_Arl |
| cd04135 | 11-128 | Tc10 |
| cd04159 | 13-164 | Arl10_like |
| cd04146 | 12-156 | RERG_RasL11_like |
| cd04173 | 12-127 | Rnd2_Rho7 |
| cd04137 | 12-161 | RheB |
| cd04174 | 1-127 | Rnd1_Rho6 |
| cd04153 | 7-129 | Arl5_Arl8 |
| PLN00023 | 5-126 | PLN00023 |
| pfam00025 | 1-128 | Arf |
| cd04160 | 14-167 | Arfrp1 |
| cd04142 | 11-156 | RRP22 |
| smart00177 | Oct-95 | ARF |
| cd04157 | 13-164 | Arl6 |
| cd00879 | 12-128 | Sar1 |
| cd04148 | 11-126 | RGK |
| cd04155 | 12-126 | Arl3 |
| cd04158 | Dec-95 | ARD1 |
| cd04149 | 10-128 | Arf6 |
| PLN00223 | Oct-95 | PLN00223 |
| cd04156 | 12-128 | ARLTS1 |
| cd04103 | 12-168 | Centaurin_gamma |
| PTZ00133 | Oct-95 | PTZ00133 |
| cd04150 | Dec-95 | Arf1_5_like |
| cd04151 | Dec-95 | Arl1 |
| COG2229 | 12-129 | Srp102 |
| smart00176 | 16-215 | RAN |
| PTZ00132 | 1-216 | PTZ00132 |
| PLN03071 | 1-216 | PLN03071 |
| pfam00071 | 12-169 | Ras |
| COG1100 | 8-176 | Gem1 |
| PLN03110 | 11-212 | PLN03110 |
| PLN03118 | 9-174 | PLN03118 |
| PLN03108 | 11-168 | PLN03108 |
| TIGR00231 | 11-161 | small_GTP |
| PTZ00099 | 35-175 | PTZ00099 |
| PTZ00369 | 10-168 | PTZ00369 |
Ontology Information
| HPRD ID | 474 |
|---|---|
| Molecular Class | GTPase |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.