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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RANBP2 5903 RAN binding protein 2  2NUP358, ADANE 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23684749   2013Cell line : -

Source : -

Sample Type : CRC tumor

No. of Sample : 86

Stage : -

Exome Sequencing, Genetic Analysis, PCRMutation-Potential mutation hot spots were confirmed in 15 genes; ADAR, DCAF12L2, GLT1D1, ITGA7, MAP1B, MRGPRX4, PSRC1, RANBP2, RPS6KL1, SNCAIP, TCEAL6, TUBB6, WBP5, VEGFB, and ZBTB2; these were validated in 86 tumors with microsatellite instability.


Gene Details



NC_000002.11 (109335902..109402267)

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Gene Type protein coding
Gene Family Tetratricopeptide (TTC) repeat domain containing
Description RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]  
Chromosome 2
Location 2q13
Start 109335902  
End 109402267  
Strand +  
Gene Sequence

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Length 66366  
OMIM ID 601181   
HGNC ID HGNC:9848   
Unigene ID Hs.199561   
Ensembl ID ENSG00000153201   
PharmGKB ID PA34209   

mRNA Information


mRNA ID ?NM_006267.4
Exon join(1..233,9687..9754,11329..11440,11877..12029, 16087..16317,16659..16804,21044..21236,27266..27353, 29475..29684,31819..32000,32083..32258,32426..32549, 33553..33714,33981..34118,34380..34526,35460..35639, 35731..35814,38968..39103,42656..42750,43792..48943, 49815..49892,52256..52426,53044..53136,53423..53601, 56263..56491,57685..57786,61824..61984,62683..62956, 63083..63417,64151..66364)  
mRNA Sequence

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Length 11846  



CDS Information


   
Location162..9938
CDS Sequence

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CCDS ID CCDS2079.1



Protein Information


      
Protein IDNP_006258.3
Protein NameRAN binding protein 2
Molecular Wt. (Da)50640
Protein Sequence

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Length 3224  
Uniprot IDQ15121
Ensembl Protein ID ENSP00000353660  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation1399
TPhosphorylation19
SPhosphorylation21
SPhosphorylation2276
SPhosphorylation2280
SPhosphorylation2290
SPhosphorylation2510
SPhosphorylation788
TPhosphorylation2450
SPhosphorylation2454
SPhosphorylation955;-
TPhosphorylation1393;-
TPhosphorylation1396;-
SPhosphorylation3204;-
SPhosphorylation3207;-
YPhosphorylation2636;-
TPhosphorylation2639;-
TPhosphorylation1156;-
SPhosphorylation1160;-
YPhosphorylation2666;-
SPhosphorylation2668;-
SPhosphorylation2900;-
SPhosphorylation2917;-
SPhosphorylation18;-
SPhosphorylation394
TPhosphorylation779
SPhosphorylation781
YPhosphorylation795
TPhosphorylation799
SPhosphorylation796
SPhosphorylation948
SPhosphorylation1110
TPhosphorylation1144
SPhosphorylation1400
TPhosphorylation1412
SPhosphorylation1443
SPhosphorylation1447
SPhosphorylation1450
SPhosphorylation1456
SPhosphorylation1509
SPhosphorylation1573
SPhosphorylation1833
SPhosphorylation1869
SPhosphorylation1871
TPhosphorylation2128
TPhosphorylation2153
SPhosphorylation2241
SPhosphorylation2246
SPhosphorylation2251
SPhosphorylation2242
SPhosphorylation2270
SPhosphorylation2447
SPhosphorylation2493
SPhosphorylation2501
TPhosphorylation2504
SPhosphorylation2498
SPhosphorylation2499
TPhosphorylation2500
SPhosphorylation2518
SPhosphorylation2520
TPhosphorylation2613
SPhosphorylation2626
SPhosphorylation2628
TPhosphorylation2734
SPhosphorylation2741
TPhosphorylation2743
SPhosphorylation2802
SPhosphorylation2805
SPhosphorylation2807
SPhosphorylation128
TPhosphorylation1761
SPhosphorylation2278
SPhosphorylation2804
SPhosphorylation1534
YPhosphorylation2609
SPhosphorylation86
SPhosphorylation2273
SPhosphorylation2297
TPhosphorylation2300
KAcetylation115
SPhosphorylation2250
TPhosphorylation2293
SPhosphorylation2008
SPhosphorylation778
TPhosphorylation783
SPhosphorylation837
TPhosphorylation2610
TPhosphorylation1149
TPhosphorylation1146
TPhosphorylation2475
SPhosphorylation1955
SPhosphorylation1993
SPhosphorylation790
SPhosphorylation2287
TPhosphorylation2289
TPhosphorylation2679
TPhosphorylation2005
SPhosphorylation730
SPhosphorylation2809
TPhosphorylation898
TPhosphorylation951
SPhosphorylation1118
TPhosphorylation1310
SPhosphorylation1316
TPhosphorylation1531
TPhosphorylation1756
SPhosphorylation1768
SPhosphorylation1835
SPhosphorylation2263
SPhosphorylation2431
SPhosphorylation2526
TPhosphorylation1517
SPhosphorylation1520
SPhosphorylation2538

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2652OPN1MW2365NP_000504.1in vivo8857542   
4193MDM21272NP_002383.2in vitro12393906   
5901RAN3109NP_006316.1in vitro;in vivo10318915   
5956OPN1LW2366NP_064445.1in vivo8857542   
9759HDAC45610NP_006028.2in vitro;in vivo12032081   


Pathway Information


      
Pathway Name Pathway ID
RNA transport hsa03013


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd019263064-3222  cyclophilin_ABH_like
cl001973064-3222  cyclophilin superfamily
cd131772027-2143  RanBD2_RanBP2-like
cl171712027-2143  PH-like superfamily
cd146841186-1302  RanBD1_RanBP2-like
cl171711186-1302  PH-like superfamily
cd146852324-2440  RanBD3_RanBP2-like
cl171712324-2440  PH-like superfamily
cd131782925-3041  RanBD4_RanBP2-like
cl171712925-3041  PH-like superfamily
cd131762925-3041  RanBD_RanBP2-like
cd131761186-1302  RanBD_RanBP2-like
cd131762027-2143  RanBD_RanBP2-like
cd131762324-2440  RanBD_RanBP2-like
PTZ000603057-3224  PTZ00060
cd131791170-1302  RanBD_RanBP1
pfam006382922-3043  Ran_BP1
pfam006381183-1304  Ran_BP1
smart001602912-3040  RanBD
pfam006382024-2145  Ran_BP1
PLN031493063-3224  PLN03149
pfam006382321-2442  Ran_BP1
smart001602310-2439  RanBD
cd131792909-3042  RanBD_RanBP1
cd131792010-2143  RanBD_RanBP1
cd008351186-1302  RanBD_family
cd131792309-2440  RanBD_RanBP1
cd008352324-2440  RanBD_family
cd008352027-2143  RanBD_family
smart001601172-1301  RanBD
cd003173078-3219  cyclophilin
cd008352925-3041  RanBD_family
cd146852027-2143  RanBD3_RanBP2-like
cd131782027-2143  RanBD4_RanBP2-like
smart001602013-2142  RanBD
cd146842027-2143  RanBD1_RanBP2-like
cd146852925-3041  RanBD3_RanBP2-like
cd131782324-2440  RanBD4_RanBP2-like
COG06523075-3204  PpiB
cd131772925-3041  RanBD2_RanBP2-like
cd131771186-1302  RanBD2_RanBP2-like
cd131711186-1301  RanBD1_RanBP2_insect-like
pfam001603077-3222  Pro_isomerase
cd146851186-1302  RanBD3_RanBP2-like
cd131742926-3041  RanBD4_RanBP2_insect-like
COG51711951-2143  YRB1
cd131721186-1302  RanBD2_RanBP2_insect-like
cd131772324-2440  RanBD2_RanBP2-like
cd131722027-2143  RanBD2_RanBP2_insect-like
cd131722925-3041  RanBD2_RanBP2_insect-like
cd131722324-2440  RanBD2_RanBP2_insect-like
COG51712849-3049  YRB1
cd131781186-1302  RanBD4_RanBP2-like
cd146842925-3041  RanBD1_RanBP2-like
COG51711171-1304  YRB1
cd131741186-1302  RanBD4_RanBP2_insect-like
cd131732324-2440  RanBD3_RanBP2_insect-like
cd131712027-2141  RanBD1_RanBP2_insect-like
cd019233077-3209  cyclophilin_RING
cd019223077-3202  cyclophilin_SpCYP2_like
cd131731186-1303  RanBD3_RanBP2_insect-like
cd146842324-2440  RanBD1_RanBP2-like
cd131742027-2143  RanBD4_RanBP2_insect-like
cd131732027-2141  RanBD3_RanBP2_insect-like
cd131712324-2440  RanBD1_RanBP2_insect-like
cd019283077-3211  Cyclophilin_PPIL3_like
COG51712283-2445  YRB1
cd131712925-3042  RanBD1_RanBP2_insect-like
cd019273077-3210  cyclophilin_WD40
cd131742325-2439  RanBD4_RanBP2_insect-like
cd131732925-3043  RanBD3_RanBP2_insect-like
cd019253077-3192  cyclophilin_CeCYP16-like
pfam121852709-2770  IR1-M
cl136012709-2770  IR1-M superfamily
pfam121852631-2694  IR1-M
cl136012631-2694  IR1-M superfamily
cd019213077-3219  cyclophilin_RRM
PTZ002213066-3222  PTZ00221
cd131701186-1302  RanBD_NUP50
cd131702027-2143  RanBD_NUP50
cd019203077-3204  cyclophilin_EcCYP_like
cd131692324-2440  RanBD_NUP50_plant
cd131812027-2143  RanBD_NUP2
cd131802324-2435  RanBD_RanBP3
cd131702325-2440  RanBD_NUP50
cd131802027-2099  RanBD_RanBP3
cd131811186-1302  RanBD_NUP2
cd131692027-2141  RanBD_NUP50_plant
cd131801186-1263  RanBD_RanBP3
cd131702926-3041  RanBD_NUP50
cd131691186-1301  RanBD_NUP50_plant
cd131812925-3041  RanBD_NUP2
cd131802925-3035  RanBD_RanBP3
cd131812324-2440  RanBD_NUP2
PRK109033078-3202  PRK10903
pfam006411781-1809  zf-RanBP
cl026561781-1809  zf-RanBP superfamily
pfam006411479-1507  zf-RanBP
cl026561479-1507  zf-RanBP superfamily
pfam006411665-1693  zf-RanBP
cl026561665-1693  zf-RanBP superfamily
pfam006411606-1634  zf-RanBP
cl026561606-1634  zf-RanBP superfamily
pfam006411543-1571  zf-RanBP
cl026561543-1571  zf-RanBP superfamily
PRK107913078-3204  PRK10791
pfam006411724-1752  zf-RanBP
cl026561724-1752  zf-RanBP superfamily
cd009001195-1298  PH-like
pfam006411415-1443  zf-RanBP
cl026561415-1443  zf-RanBP superfamily
cd019243078-3203  cyclophilin_TLP40_like
cd131692925-3039  RanBD_NUP50_plant
pfam006411351-1380  zf-RanBP
cl026561351-1380  zf-RanBP superfamily
smart005471667-1691  ZnF_RBZ
smart005471608-1632  ZnF_RBZ
smart005471726-1748  ZnF_RBZ
smart005471783-1807  ZnF_RBZ
cd131751188-1302  RanBD5_RanBP2_insect-like
smart0002860-92  TPR
cl2289760-92  TPR_1 superfamily
pfam0051560-92  TPR_1
smart005471481-1505  ZnF_RBZ
smart005471545-1569  ZnF_RBZ
pfam0771960-92  TPR_2
cd131752927-3039  RanBD5_RanBP2_insect-like
cd131752326-2440  RanBD5_RanBP2_insect-like
smart005471417-1440  ZnF_RBZ
pfam1341458-126  TPR_11
COG045730-126  TPR
COG045722-139  TPR
pfam1341433-91  TPR_11
TIGR0291730-291  PEP_TPR_lipo
COG045722-106  TPR
TIGR0279532-138  tol_pal_ybgF
COG29563-123  YciM
TIGR0291751-184  PEP_TPR_lipo
pfam1343233-91  TPR_16
TIGR0291736-244  PEP_TPR_lipo
TIGR0252136-184  type_IV_pilW


Ontology Information


   
HPRD ID4929
Molecular ClassTransport/cargo protein
Molecular FunctionGalactosyltransferase activity (GO:0008378)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO