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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RARB 5915 retinoic acid receptor, beta  3HAP, NR1B2, RRB2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21360524   2011Cell line : -

Source : -

Sample Type : CRC tumor

No. of Sample : 51 adenocarcinomas, 35 tissues adjacent to tumour and 19 normal controls

Stage : Dukes A, D

Methylation specific multiplex ligation-dependent probe assay ,bisulphite pyrosequencingHypermethylation-Five sites (ESR1, CDH13, CHFR, APC and RARB) were significantly hypermethylated in cancer compared with adjacent tissue.


Gene Details



NC_000003.11 (25215638..25639423)

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Gene Type protein coding
Gene Family Nuclear hormone receptors
Description This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]  
Chromosome 3
Location 3p24
Start 25215638  
End 25639423  
Strand +  
Gene Sequence

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Length 423786  
OMIM ID 180220   
HGNC ID HGNC:9865   
Unigene ID Hs.654490   
Ensembl ID ENSG00000077092   
PharmGKB ID PA34226   

mRNA Information


mRNA ID ?NM_000965.4
Exon join(1..244,286862..287010,326851..326992,395427..395587, 406215..406391,419172..419376,420189..420347, 422089..423601)  
mRNA Sequence

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Length 2840  



CDS Information


   
Location 67..1434
CDS Sequence

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CCDS ID CCDS2642.1



Protein Information


      
Protein IDNP_000956.2
Protein Nameretinoic acid receptor, beta
Molecular Wt. (Da)0
Protein Sequence

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Length 455  
Uniprot IDO60512
Ensembl Protein ID ENSP00000320965  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                          
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
4135MAP615989NP_149052.1yeast 2-hybrid15604093   
6256RXRA1577NP_002948.1in vitro7565739   
6257RXRB1578NP_068811.1in vitro;yeast 2-hybrid133   177   815   604   093   
6258RXRG1579NP_008848.1yeast 2-hybrid15604093   
8648NCOA14070NP_003734.3in vitro875   479   212   665   583   
10957PNRC18412NP_006804.1yeast 2-hybrid15604093   


Pathway Information


                  
Pathway Name Pathway ID
Non-small cell lung cancer hsa05223
Pathways in cancer hsa05200
Small cell lung cancer hsa05222


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd06937186-416  NR_LBD_RAR
cl11397186-416  NR_LBD superfamily
cd0696482-166  NR_DBD_RAR
cl0259682-166  NR_DBD_like superfamily
cd06929224-395  NR_LBD_F1
cd06935219-413  NR_LBD_TR
cd06954186-413  NR_LBD_LXR
cd0691688-159  NR_DBD_like
pfam0010586-155  zf-C4
cd06157228-387  NR_LBD
cd06941224-415  NR_LBD_DmE78_like
cd06938239-412  NR_LBD_EcR
cd0696187-167  NR_DBD_TR
cd06940224-400  NR_LBD_REV_ERB
cd0696088-162  NR_DBD_HNF4A
cd06945184-415  NR_LBD_Nurr1_like
cd0696887-167  NR_DBD_ROR
smart0039987-156  ZnF_C4
cd0716588-167  NR_DBD_DmE78_like
cd0696783-162  NR_DBD_TR2_like
cd0716788-162  NR_DBD_Lrh-1_like
cd06939183-413  NR_LBD_ROR_like
cd0696986-159  NR_DBD_NGFI-B
cd0716687-168  NR_DBD_REV_ERB
cd0716883-162  NR_DBD_DHR4_like
cd06932236-412  NR_LBD_PPAR
cd0715888-159  NR_DBD_Ppar_like
cd0716986-162  NR_DBD_GCNF_like
cd06943232-393  NR_LBD_RXR_like
cd07072193-417  NR_LBD_DHR38_like
cd0695688-162  NR_DBD_RXR
cd0717988-160  2DBD_NR_DBD2
cd0696587-162  NR_DBD_Ppar
smart00430232-387  HOLI
cd0695888-159  NR_DBD_COUP_TF
cd0716488-162  NR_DBD_PNR_like_1
cd0716387-166  NR_DBD_TLX
cd0715588-162  NR_DBD_ER_like
cd0715488-159  NR_DBD_PNR_like
cd0717188-164  NR_DBD_ER
cd0695788-168  NR_DBD_PNR_like_2
cd0717088-162  NR_DBD_ERR
cd0715688-158  NR_DBD_VDR_like
pfam00104228-395  Hormone_recep
cd07348186-413  NR_LBD_NGFI-B
cd0697088-165  NR_DBD_PNR
cd0716188-174  NR_DBD_EcR
cd0696686-173  NR_DBD_CAR
cd06934180-413  NR_LBD_PXR_like
cd0695988-158  NR_DBD_EcR_like
cd07068229-415  NR_LBD_ER_like
cd07071186-417  NR_LBD_Nurr1
cd06930230-387  NR_LBD_F2
cd0696288-167  NR_DBD_FXR
cd0716288-167  NR_DBD_PXR
cd0716088-168  NR_DBD_LXR
cd0695584-168  NR_DBD_VDR
cd06936228-399  NR_LBD_Fxr
cd06933177-416  NR_LBD_VDR
cd06946229-415  NR_LBD_ERR
cd06931236-413  NR_LBD_HNF4_like
cd0715786-155  2DBD_NR_DBD1
cd06948194-414  NR_LBD_COUP-TF
cd0717386-154  NR_DBD_AR
cd0717286-153  NR_DBD_GR_PR
cd06949229-415  NR_LBD_ER
cd0696388-157  NR_DBD_GR_like
cd06942222-385  NR_LBD_Sex_1_like
cd06952230-393  NR_LBD_TR2_like
cd06953223-390  NR_LBD_DHR4_like
cd06950230-395  NR_LBD_Tlx_PNR_like
cd06944239-414  NR_LBD_Ftz-F1_like
cd07069230-414  NR_LBD_Lrh-1
cd07070230-415  NR_LBD_SF-1
cd07075224-335  NR_LBD_MR
cd06947230-298  NR_LBD_GR_Like
cd07074224-335  NR_LBD_PR
cd07073224-298  NR_LBD_AR


Ontology Information


   
HPRD ID9343
Molecular ClassNuclear receptor
Molecular FunctionTranscription regulator activity (GO:0030528)
Biological ProcessRegulation of gene expression, epigenetic (GO:0040029)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P10826DB00210AdapaleneSmallMoleculeDrug
P10826DB00459AcitretinSmallMoleculeDrug
P10826DB00523AlitretinoinSmallMoleculeDrug
P10826DB00799TazaroteneSmallMoleculeDrug
P10826DB04942TamibaroteneSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO