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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RARRES1 | 5918 | retinoic acid receptor responder (tazarotene induced) 1 | 3 | LXNL; TIG1; PERG-1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
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- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16426842 | 2006 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 161 (26 adenoma, 13 distal normal mucosa and 122 primary colorectal adenocarcinoma) Stage : Dukes' stage D tumours | Immunohistochemistry | Down-regulation | - | Role of RARRES1 in colorectal epithelial differentiation, and the down-regulation of RARRES1 is related to stage D progression. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] | Chromosome | 3 |
| Location | 3q25.32 |
| Start | 158414892 |
| End | 158450642 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 35751 |
| OMIM ID | 605090 |
| HGNC ID | HGNC:9867 |
| Unigene ID | Hs.131269 |
| Ensembl ID | ENSG00000118849 |
| PharmGKB ID | PA34228 |
Protein Information
| Protein ID | NP_002879.2 |
|---|---|
| Protein Name | retinoic acid receptor responder (tazarotene induced) 1 |
| Molecular Wt. (Da) | 18048 |
| Protein Sequence | Download Select all |
| Length | 294 |
| Uniprot ID | Q14703 |
| Ensembl Protein ID | ENSP00000344223 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 4334 |
|---|---|
| Molecular Class | Not Available |
| Molecular Function | Cytoskeletal anchoring activity (GO:0016343) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P49788 | DB00755 | Tretinoin | SmallMoleculeDrug |