Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RARRES3 | 5920 | retinoic acid receptor responder (tazarotene induced) 3 | 11 | TIG3, HRASLS4 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 12838316 | 2003 | Cell line : - Source : - Sample Type : Paraffin-embedded CRC l tissues No. of Sample : 151 colorectal tissues (11 distal normal mucosa, 20 adenoma and 120 colorectal adenocarcinoma) Stage : Duke Stage A-D. | Immunohistochemistry | Down-regulation | - | RARRES3 expression was decreased only in carcinoma tissue, which suggests that altered RARRES3 expression occurs late in colorectal carcinogenesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008] | Chromosome | 11 |
| Location | 11q23 |
| Start | 63304273 |
| End | 63313930 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 9658 |
| OMIM ID | 605092 |
| HGNC ID | HGNC:9869 |
| Unigene ID | Hs.17466 |
| Ensembl ID | ENSG00000133321 |
| PharmGKB ID | PA34230 |
mRNA Information
| mRNA ID | ?NM_004585.4 |
|---|---|
| Exon | join(1..77,2716..2824,7821..8089,9349..9658) | mRNA Sequence | Download Select all |
| Length | 779 |
Protein Information
| Protein ID | NP_004576.2 |
|---|---|
| Protein Name | retinoic acid receptor responder (tazarotene induced) 3 |
| Molecular Wt. (Da) | 143087 |
| Protein Sequence | Download Select all |
| Length | 164 |
| Uniprot ID | O75530 |
| Ensembl Protein ID | ENSP00000263360 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3265 | HRAS | 1813 | NP_005334.1 | in vivo | 16005186 |
| 7051 | TGM1 | 1824 | NP_000350.1 | in vitro | 15846304 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam04970 | 2-125 | LRAT |
| cl04867 | 2-125 | LRAT superfamily |
| pfam08405 | 2-120 | Calici_PP_N |
| cl07140 | 2-120 | Calici_PP_N superfamily |
| pfam00877 | Apr-35 | NLPC_P60 |
| cl21534 | Apr-35 | NLPC_P60 superfamily |
Ontology Information
| HPRD ID | 4583 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Cell communication (GO:0007154) |
Drug Information
No matching records could be found.