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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RASAL1 8437 RAS protein activator like 1 (GAP1 like)  12RASAL 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
18992247   2009Cell line : CRC cell lines

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

real time RT-PCR,immunohistochemistry,Immunoblotting,Methylation Analysis,Cell Proliferation AssayDown-regulation-RASAL1 expression is reduced in CRC cells that contain wild-type KRAS gene.


Gene Details



NC_000012.11 (113536624..113574044, complement)

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Gene Type protein coding
Gene Family Pleckstrin homology (PH) domain containing
Description The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010]  
Chromosome 12
Location 12q23-q24
Start 113536624  
End 113574044  
Strand -  
Gene Sequence

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Length 37421  
OMIM ID 604118   
HGNC ID HGNC:9873   
Unigene ID Hs.528693   
Ensembl ID ENSG00000111344   
PharmGKB ID PA34234   

mRNA Information


mRNA ID ?NM_001193520.1
Exon join(1..164,641..842,5299..5355,8062..8175,8367..8428, 14602..14731,16797..16878,16981..17112,19079..19167, 20189..20306,20452..20605,20976..21040,21328..21440, 23962..24154,28015..28155,28999..29143,30354..30526, 31942..32079,32159..32294,34231..34351,35560..35612, 36172..37421)  
mRNA Sequence

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Length 3832  



CDS Information


   
Location 302..2722
CDS Sequence

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CCDS ID CCDS55888.1



Protein Information


      
Protein IDNP_001180449.1
Protein NameRAS protein activator like 1 (GAP1 like)
Molecular Wt. (Da)89548
Protein Sequence

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Length 804  
Uniprot IDQ9UKX7
Ensembl Protein ID ENSP00000345895  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


      
Pathway Name Pathway ID
Ras signaling pathway hsa04014


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd05135263-549  RasGAP_RASAL
cl02569263-549  RasGAP superfamily
cd05128265-548  RasGAP_GAP1_like
cd05395263-549  RasGAP_RASA4
cd13369552-689  PH_RASAL1
cl17171552-689  PH-like superfamily
cd04025134-255  C2B_RasA1_RasA4
cl14603134-255  C2 superfamily
cd04519265-547  RasGAP
cd040546-126  C2A_Rasal1_RasA4
cl146036-126  C2 superfamily
pfam00616322-511  RasGAP
cd05134264-543  RasGAP_RASA3
cd05137253-544  RasGAP_CLA2_BUD2
cd01244568-678  PH_GAP1-like
cd05394264-545  RasGAP_RASA2
cd05391259-548  RasGAP_p120GAP
cd05392284-567  RasGAP_Neurofibromin_like
cd05136260-544  RasGAP_DAB2IP
cd13372541-680  PH_CAPRI
cd083836-126  C2A_RasGAP
cd08675135-250  C2B_RasGAP
cd084019-126  C2A_RasA2_RasA3
cd05132330-549  RasGAP_GAPA
cd000307-107  C2
cd04017135-233  C2D_Ferlin
cd00030135-233  C2
cd05130300-554  RasGAP_Neurofibromin
cd01238568-707  PH_Btk
pfam00168135-216  C2
smart00239135-231  C2
pfam00168Jul-88  C2
cd04026118-234  C2_PKC_alpha_gamma
smart00239Jun-99  C2
cd04024135-233  C2A_Synaptotagmin-like
cd05127342-553  RasGAP_IQGAP_like
cd13370564-686  PH_GAP1m_mammal-like
cd08391135-225  C2A_C2C_Synaptotagmin_like
cd040407-136  C2D_Tricalbin-like
smart00233566-672  PH
cd04040135-253  C2D_Tricalbin-like
cd08405Apr-90  C2B_Synaptotagmin-7
cd04031121-215  C2A_RIM1alpha
cd04038135-218  C2_ArfGAP
pfam00169566-672  PH
cd083917-111  C2A_C2C_Synaptotagmin_like
cd04033Jul-90  C2_NEDD4_NEDD4L
cd04033135-216  C2_NEDD4_NEDD4L
cd13371566-679  PH_GAP1_mammal-like
cd05133359-548  RasGAP_IQGAP1
cd04037136-213  C2E_Ferlin
pfam00779681-709  BTK
cl02465681-709  BTK superfamily
cd04042Jun-85  C2A_MCTP_PRT
cd08377Jul-88  C2C_MCTP_PRT
cd04009121-213  C2B_Munc13-like
cd00821568-667  PH
cd04038Jul-94  C2_ArfGAP
cd05131359-552  RasGAP_IQGAP2
cd08387118-216  C2A_Synaptotagmin-8
cd04042135-244  C2A_MCTP_PRT
cd040144-107  C2_PKC_epsilon
cd040247-122  C2A_Synaptotagmin-like
cd08377135-217  C2C_MCTP_PRT
cd08386Apr-89  C2A_Synaptotagmin-7
cd08682139-233  C2_Rab11-FIP_classI
cd002767-104  C2B_Synaptotagmin
cd04035134-228  C2A_Rabphilin_Doc2
cd08384131-237  C2B_Rabphilin_Doc2
cd08386118-216  C2A_Synaptotagmin-7
cd040439-126  C2_Munc13_fungal
cd08376139-217  C2B_MCTP_PRT
cd04041135-236  C2A_fungal
cd04047140-230  C2B_Copine
cd040277-124  C2B_Munc13
cd04054135-244  C2A_Rasal1_RasA4
cd08376Jul-93  C2B_MCTP_PRT
cd08676133-233  C2A_Munc13-like
cd04018155-213  C2C_Ferlin
cd040263-107  C2_PKC_alpha_gamma
cd04037Aug-86  C2E_Ferlin
cd08688Jul-87  C2_KIAA0528-like
cd08375129-216  C2_Intersectin
cd12207422-548  RasGAP_IQGAP3
cd04009Jun-90  C2B_Munc13-like
cd083877-109  C2A_Synaptotagmin-8
cd04041Jul-98  C2A_fungal
cd08405139-221  C2B_Synaptotagmin-7
cd086762-107  C2A_Munc13-like
cd08402Jul-99  C2B_Synaptotagmin-1
cd040227-124  C2A_MCTP_PRT_plant
cd08385Apr-89  C2A_Synaptotagmin-1-5-6-9-10
cd13255565-675  PH_TAAP2-like
cd084047-108  C2B_Synaptotagmin-4
cd08393117-216  C2A_SLP-1_2
cd04043139-220  C2_Munc13_fungal
cd04045134-229  C2C_Tricalbin-like
cd04046138-254  C2_Calpain
cd086829-125  C2_Rab11-FIP_classI
cd04032135-220  C2_Perforin
cd13279566-664  PH_Cla4_Ste20
cd13298566-671  PH1_PH_fungal
cd08403118-238  C2B_Synaptotagmin-3-5-6-9-10
cd0401714-128  C2D_Ferlin
cd08402118-215  C2B_Synaptotagmin-1
cd08384Jun-93  C2B_Rabphilin_Doc2
cd084037-104  C2B_Synaptotagmin-3-5-6-9-10
cd08378139-249  C2B_MCTP_PRT_plant
cd08521118-216  C2A_SLP
cd04035Feb-91  C2A_Rabphilin_Doc2
cd00276139-219  C2B_Synaptotagmin
cd086817-122  C2_fungal_Inn1p-like
cd05129323-556  RasGAP_RAP6
cd04010135-254  C2B_RasA3
cd04020138-223  C2B_SLP_1-2-3-4
cd08688135-231  C2_KIAA0528-like
cd08382135-217  C2_Smurf-like
cd04011Sep-85  C2B_Ferlin
cd04022138-237  C2A_MCTP_PRT_plant
cd04019135-256  C2C_MCTP_PRT_plant
cd08410118-215  C2B_Synaptotagmin-17
cd08388May-90  C2A_Synaptotagmin-4-11
cd08404139-220  C2B_Synaptotagmin-4
cd040312-107  C2A_RIM1alpha
cd08382Jun-75  C2_Smurf-like
cd04021Apr-90  C2_E3_ubiquitin_ligase
smart00107674-705  BTK
cd04030118-185  C2C_KIAA1228
cd0405219-125  C2B_Tricalbin-like
cd04036139-244  C2_cPLA2
cd08410Jul-87  C2B_Synaptotagmin-17
cd08373152-213  C2A_Ferlin
cd04044134-226  C2A_Tricalbin-like
cd04032Jul-93  C2_Perforin
cd08385135-215  C2A_Synaptotagmin-1-5-6-9-10
cd0401524-108  C2_plant_PLD
cd04027139-222  C2B_Munc13
cd08400May-57  C2_Ras_p21A1
cd0404519-90  C2C_Tricalbin-like
cd08381117-233  C2B_PI3K_class_II
cd0837914-58  C2D_MCTP_PRT_plant
cd01264588-672  PH_MELT_VEPH1
cd04039138-230  C2_PSD
cd10571569-667  PH_beta_spectrin
cd08390118-217  C2A_Synaptotagmin-15-17
cd04036Jul-87  C2_cPLA2
cd04047Dec-90  C2B_Copine
cd12206321-552  RasGAP_IQGAP_related
cd13289569-670  PH_Osh3p_yeast
cd04029118-218  C2A_SLP-4_5
cd13277567-667  PH_Bem3
cd040197-115  C2C_MCTP_PRT_plant
cd08375Jul-86  C2_Intersectin
cd04049Jul-85  C2_putative_Elicitor-responsive_gene
cd08681135-233  C2_fungal_Inn1p-like
smart00323243-604  RasGAP
COG5261322-554  IQG1
COG5038Apr-90  COG5038
COG5038142-244  COG5038
PLN0300825-165  PLN03008


Ontology Information


   
HPRD ID10360
Molecular ClassGTPase activating protein
Molecular FunctionGTP binding (GO:0005525)
Biological ProcessCell proliferation (GO:0008283)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO