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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RBBP6 5930 retinoblastoma binding protein 6  16P2P-R, PACT, SNAMA 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23799110   2013Cell line : -

Source : General Surgery Department of Shanghai Jiao Tong University Affiliated First Peoples Hospital?

Sample Type : CRC Tumor and normal tissue

No. of Sample : 203

Stage : AJCC Stage I-IV

 real time PCR, western blotting ,immunohistochemistry,Multivariate analysisUp-regulation-RBBP6 was overexpressed in colon tumorous tissues and was significantly associated with clinical stage, depth of tumor invasion, lymph node metastasis (LNM), distant metastasis, and histologic grade.


Gene Details



NC_000016.9 (24550866..24584184)

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Gene Type protein coding
Gene Family -
Description The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]  
Chromosome 16
Location 16p12.2
Start 24550866  
End 24584184  
Strand +  
Gene Sequence

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Length 33319  
OMIM ID 600938   
HGNC ID HGNC:9889   
Unigene ID Hs.188553   
Ensembl ID ENSG00000122257   
PharmGKB ID PA34253   

mRNA Information


mRNA ID ?NM_006910.4
Exon join(1..1206,6577..6676,9359..9395,13927..13971, 16029..16117,16235..16331,16722..16861,19919..20091, 22026..22129,22238..22575,23613..23709,23837..23915, 24024..24078,25211..25279,27557..27919,28206..28307, 29159..30913,31290..33277)  
mRNA Sequence

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Length 6853  



CDS Information


   
Location 1041..6419
CDS Sequence

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CCDS ID CCDS10621.1



Protein Information


      
Protein IDNP_008841.2
Protein Nameretinoblastoma binding protein 6
Molecular Wt. (Da)17039
Protein Sequence

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Length 1792  
Uniprot IDQ13546
Ensembl Protein ID ENSP00000259808  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation1277
SPhosphorylation516
SPhosphorylation730
SPhosphorylation772
SPhosphorylation1243
SPhosphorylation516
SPhosphorylation696
SPhosphorylation738
SPhosphorylation1179;-
SPhosphorylation1145;-
SPhosphorylation1328;-
SPhosphorylation1294;-
SPhosphorylation1328;-
TPhosphorylation1336;-
TPhosphorylation1302;-
SPhosphorylation1294;-
SPhosphorylation768;-
YPhosphorylation766;-
YPhosphorylation732;-
SPhosphorylation734;-
SPhosphorylation873;-
SPhosphorylation839;-
YPhosphorylation845;-
YPhosphorylation811;-
SPhosphorylation854;-
SPhosphorylation820;-
SPhosphorylation861;-
SPhosphorylation827;-
SPhosphorylation770;-
SPhosphorylation736;-
TPhosphorylation1258;-
TPhosphorylation1224;-
TPhosphorylation1468;-
TPhosphorylation1434;-
SPhosphorylation244;-
SPhosphorylation245;-
SPhosphorylation246;-
SPhosphorylation247;-
SPhosphorylation244;-
SPhosphorylation245;-
SPhosphorylation246;-
SPhosphorylation247;-
SPhosphorylation1648;-
YPhosphorylation1641;-
SPhosphorylation1651;-
SPhosphorylation1644;-
SPhosphorylation1617;-
SPhosphorylation1610;-
SPhosphorylation1614;-
YPhosphorylation1607;-
SPhosphorylation360;-
SPhosphorylation360;-
SPhosphorylation138
SPhosphorylation138
TPhosphorylation1269
TPhosphorylation1235
TPhosphorylation1271
TPhosphorylation1237
SPhosphorylation1273
SPhosphorylation1239
TPhosphorylation1274
TPhosphorylation1240
SPhosphorylation1622
SPhosphorylation1588
SPhosphorylation1646
SPhosphorylation1612
TPhosphorylation1222
TPhosphorylation1188
SPhosphorylation1625
SPhosphorylation1591
KAcetylation1571
KAcetylation1537
KAcetylation7
KAcetylation7
KAcetylation7
SPhosphorylation1699
SPhosphorylation1665
SPhosphorylation960
SPhosphorylation926
SPhosphorylation1705
SPhosphorylation1671
SPhosphorylation1709
SPhosphorylation1675
SPhosphorylation1203
SPhosphorylation1169
TPhosphorylation984
TPhosphorylation950
TPhosphorylation1194
TPhosphorylation1160
TPhosphorylation1173
TPhosphorylation1139
SPhosphorylation363
SPhosphorylation363
TPhosphorylation53
TPhosphorylation53
TPhosphorylation53
SPhosphorylation748
SPhosphorylation750
SPhosphorylation714
SPhosphorylation716
TPhosphorylation876
TPhosphorylation842
SPhosphorylation1052
SPhosphorylation1018
TPhosphorylation1087
TPhosphorylation1053
SPhosphorylation1221
SPhosphorylation1187
SPhosphorylation1621
SPhosphorylation1587
SPhosphorylation1626
SPhosphorylation1592
TPhosphorylation86
TPhosphorylation86
TPhosphorylation86
SPhosphorylation1272
SPhosphorylation1238
SPhosphorylation1422
SPhosphorylation1388
SPhosphorylation979
SPhosphorylation945

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                     
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
975CD818924NP_004347.1yeast 2-hybrid18851979   
2113ETS11260NP_001137292.1yeast 2-hybrid18851979   
4034LRCH410062NP_002310.2yeast 2-hybrid18851979   
4904YBX11095NP_004550.2in vitro;in vivo;yeast 2-hybrid18851979   
6208RPS14562NP_005608.1yeast 2-hybrid18851979   
9372ZFYVE94782NP_004790.2yeast 2-hybrid15231748   
59271C21orf6310760NP_478067.2yeast 2-hybrid18851979   
65109UPF3B2247NP_542199.1yeast 2-hybrid18851979   
119504C10orf10412554NP_775744.1yeast 2-hybrid18851979   
221241C18orf2016624NP_689941.1yeast 2-hybrid18851979   
253461ZBTB3810985NP_001073881.2yeast 2-hybrid18851979   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00162259-302  RING
cl17238259-302  RING superfamily
pfam08783Apr-76  DWNN
cl07884Apr-76  DWNN superfamily
smart00184259-299  RING
pfam13923259-299  zf-C3HC4_2
pfam13639259-299  zf-RING_2
pfam14634259-301  zf-RING_5
pfam00097259-299  zf-C3HC4
smart00343160-175  ZnF_C2HC
cl23351160-175  ZnF_C2HC superfamily
pfam13920255-301  zf-C3HC4_3
pfam00098160-175  zf-CCHC
cl23330160-175  zf-CCHC superfamily
pfam15227259-299  zf-C3HC4_4
pfam04564253-325  U-box
pfam13696155-180  zf-CCHC_2
cl16353155-180  zf-CCHC_2 superfamily
smart00504256-322  Ubox
COG52222-322  COG5222
PTZ00121904-1613  PTZ00121
PTZ00121910-1676  PTZ00121
PTZ00121901-1361  PTZ00121
pfam095281032-1495  Ehrlichia_rpt
TIGR00599257-324  rad18
pfam102431013-1240  MIP-T3
PTZ004491048-1453  PTZ00449
PTZ00108943-1176  PTZ00108
pfam095281283-1670  Ehrlichia_rpt
pfam10243999-1236  MIP-T3
PTZ001121286-1563  PTZ00112
PTZ00368151-177  PTZ00368
COG51601209-1541  ULP1
PRK053061000-1177  infB
PTZ004491288-1565  PTZ00449
TIGR006001113-1667  rad2
CHL001891071-1232  infB


Ontology Information


   
HPRD ID5128
Molecular ClassUbiquitin proteasome system protein
Molecular FunctionReceptor binding (GO:0005102)
Biological ProcessCell communication (GO:0007154); Cell surface receptor linked signal transduction (GO:0007166)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO