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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RBM3 5935 RNA binding motif (RNP1, RRM) protein 3  XIS1-RNPL 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
26331352   2015Cell line : -

Source : China, U.S. and Sweden.

Sample Type : CRC tumor and normal tissue

No. of Sample : 509,934 CRC in three databases (5,918 in WC, 503,002 in SEER and 1,014 in LC )

Stage : TNM Stage I-IV.

-Up-regulation-RNA binding protein RBM3 induces stemness in colorectal cancer cells through a mechanism involving suppression of GSK3? activity thereby enhancing ?-catenin signaling.

26013439   2015Cell line : HCT 116 and DLD1

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Immunohistochemistry,Functional analysisUnknown-The PRL, RBM3, Wrap53, p53 and DNA status are potential prognostic biomarkers for the young CRC patients.


Gene Details



NC_000023.10 (48432741..48439553)

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Gene Type protein coding
Gene Family RNA binding motif (RRM) containing
Description This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Multiple alternatively spliced transcript variants that are predicted to encode different isoforms have been characterized although some of these variants fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2008]  
Chromosome X
Location Xp11.2
Start 48432741  
End 48439553  
Strand +  
Gene Sequence

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Length 6813  
OMIM ID 300027   
HGNC ID HGNC:9900   
Unigene ID Hs.301404   
Ensembl ID ENSG00000102317   
PharmGKB ID PA34265   

mRNA Information


mRNA ID ?NM_006743.4
Exon join(1..221,816..931,1209..1315,1962..2067,2156..2252, 2674..2757,3113..6813)  
mRNA Sequence

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Length 4432  



CDS Information


   
Location235..708
CDS Sequence

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CCDS ID CCDS14301.1



Protein Information


      
Protein IDNP_006734.1
Protein NameRNA binding motif (RNP1, RRM) protein 3
Molecular Wt. (Da)22179
Protein Sequence

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Length 157  
Uniprot IDO00198
Ensembl Protein ID ENSP00000257572  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation117
YPhosphorylation118
YPhosphorylation129
YPhosphorylation155
RMethylation105
SPhosphorylation147
YPhosphorylation127
YPhosphorylation146

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd12449Jun-85  RRM_CIRBP_RBM3
cl17169Jun-85  RRM_SF superfamily
cd12382Jun-84  RRM_RBMX_like
cd12326Apr-82  RRM1_hnRNPA0
cd00590Aug-80  RRM_SF
pfam00076Aug-78  RRM_1
cd12399Jul-82  RRM_HP0827_like
cd12316Jul-79  RRM3_RBM19_RRM2_MRD1
cd12447Jul-82  RRM1_gar2
cd12325Aug-77  RRM1_hnRNPA_hnRNPD_like
cd12353Aug-78  RRM2_TIA1_like
cd12398Sep-82  RRM_CSTF2_RNA15_like
cd12413Aug-84  RRM1_RBM28_like
cd12284Aug-79  RRM2_RBM23_RBM39
cd12578Jul-82  RRM1_hnRNPA_like
cd12347Aug-79  RRM_PPIE
cd12384Jul-82  RRM_RBM24_RBM38_like
cd12363Aug-83  RRM_TRA2
cd12674Aug-82  RRM1_Nop4p
cd12335Aug-84  RRM2_SF3B4
cd12567Apr-79  RRM3_RBM19
cd12414Jul-82  RRM2_RBM28_like
cd12574Jul-77  RRM1_DAZAP1
cd12327Jul-82  RRM2_DAZAP1
cd12576Aug-77  RRM1_MSI
cd12361Jul-69  RRM1_2_CELF1-6_like
cd12318Aug-77  RRM5_RBM19_like
cd12236Aug-80  RRM_snRNP70
cd12321Jul-79  RRM1_TDP43
cd12619Aug-80  RRM2_PUB1
cd1240813-73  RRM_eIF3G_like
cd12380Aug-84  RRM3_I_PABPs
cd12448Aug-80  RRM2_gar2
cd12395Sep-79  RRM2_RBM34
cd12381Jul-79  RRM4_I_PABPs
cd12671Aug-82  RRM_CSTF2_CSTF2T
cd12370Jun-79  RRM1_PUF60
cd12328Jul-58  RRM2_hnRNPA_like
cd12330Jul-82  RRM2_Hrp1p
cd12377Aug-79  RRM3_Hu
cd12566Apr-79  RRM2_MRD1
cd12763Jul-82  RRM1_hnRNPA3
cd12323Jul-58  RRM2_MSI
cd12362Aug-79  RRM3_CELF1-6
cd12760Jul-57  RRM1_MSI2
cd12378Aug-79  RRM1_I_PABPs
cd12757Jul-77  RRM1_hnRNPAB
cd12412Jul-82  RRM_DAZL_BOULE
cd12235Aug-80  RRM_PPIL4
cd12240Aug-80  RRM_NCBP2
cd12577Aug-77  RRM1_Hrp1p
cd12761Jul-82  RRM1_hnRNPA1
cd12415Aug-82  RRM3_RBM28_like
cd12641Aug-82  RRM_TRA2B
cd12298Jul-79  RRM3_Prp24
cd12365Aug-79  RRM_RNPS1
cd12450Aug-82  RRM1_NUCLs
cd12313Aug-82  RRM1_RRM2_RBM5_like
cd12354Aug-79  RRM3_TIA1_like
cd12379Jun-81  RRM2_I_PABPs
cd12400Aug-80  RRM_Nop6
cd12762Jul-82  RRM1_hnRNPA2B1
cd12311Aug-80  RRM_SRSF2_SRSF8
cd12375Aug-82  RRM1_Hu_like
cd12237Aug-80  RRM_snRNP35
cd12329Jul-58  RRM2_hnRNPD_like
cd12579Jul-82  RRM2_hnRNPA0
cd12344Aug-78  RRM1_SECp43_like
cd12392Apr-79  RRM2_SART3
cd12593Aug-79  RRM_RBM11
cd12411Aug-84  RRM_ist3_like
cd12759Jul-56  RRM1_MSI1
cd1236616-79  RRM1_RBM45
cd12393Aug-79  RRM_ZCRB1
cd12334Aug-79  RRM1_SF3B4
cd12336Aug-80  RRM_RBM7_like
cd12552Aug-79  RRM_Nop15p
cd12306Sep-79  RRM_II_PABPs
cd12373Jul-82  RRM_SRSF3_like
cd12242Jul-58  RRM_SLIRP
cd12246Aug-82  RRM1_U1A_like
cd12618Aug-84  RRM2_TIA1
cd12231Jul-82  RRM2_U2AF65
cd12383Jul-79  RRM_RBM42
cd12389Aug-80  RRM2_RAVER
cd12283Sep-79  RRM1_RBM39_like
cd12642Oct-82  RRM_TRA2A
cd12332Jul-79  RRM1_p54nrb_like
cd12345Aug-82  RRM2_SECp43_like
cd12406Aug-82  RRM4_NCL
cd12251Aug-79  RRM3_hnRNPR_like
cd12655Aug-79  RRM3_HuC
cd12407Jul-82  RRM_FOX1_like
cd12387Aug-79  RRM3_hnRNPM_like
pfam1389324-82  RRM_5
cd12371Jul-79  RRM2_PUF60
cd12565Jul-82  RRM1_MRD1
cd12575Aug-77  RRM1_hnRNPD_like
cd12650Aug-82  RRM1_Hu
cd12656Aug-79  RRM3_HuD
cd12637Jul-69  RRM2_FCA
cd12654Aug-79  RRM3_HuB
cd1236719-64  RRM2_RBM45
cd12617Aug-84  RRM2_TIAR
cd12636May-68  RRM2_Bruno_like
cd12229Jul-80  RRM_G3BP
cd12273Aug-79  RRM1_NEFsp
cd12386Aug-79  RRM2_hnRNPM_like
cd12676Aug-65  RRM3_Nop4p
cd12319Aug-79  RRM4_MRD1
cd12632Jul-82  RRM1_CELF3_4_5_6
cd12653Aug-79  RRM3_HuR
cd12223Aug-79  RRM_SR140
cd12585Jul-58  RRM2_hnRPDL
cd12271Aug-79  RRM1_PHIP1
cd12756Aug-76  RRM1_hnRNPD
cd12417Aug-80  RRM_SAFB_like
cd12324Aug-82  RRM_RBM8
cd12401Sep-82  RRM_eIF4H
cd12580Jul-62  RRM2_hnRNPA1
cd12534Aug-82  RRM_SARFH
cd12583Jul-67  RRM2_hnRNPD
cd12584Jul-58  RRM2_hnRNPAB
cd12524Aug-79  RRM1_MEI2_like
cd12226Aug-82  RRM_NOL8
cd12758Jul-77  RRM1_hnRPDL
cd1267518-82  RRM2_Nop4p
cd12640Apr-79  RRM3_Bruno_like
cd12343Jul-79  RRM1_2_CoAA_like
cd12673Jul-60  RRM_BOULE
cd12352Aug-82  RRM1_TIA1_like
cd12346Aug-78  RRM3_NGR1_NAM8_like
cd12454Aug-79  RRM2_RIM4_like
cd12770Aug-86  RRM1_HuD
cd12372Aug-79  RRM_CFIm68_CFIm59
cd12446Jul-79  RRM_RBM25
cd12397Aug-82  RRM2_Nop13p_fungi
cd12418Jul-79  RRM_Aly_REF_like
cd12572Jul-58  RRM2_MSI1
cd12307Aug-79  RRM_NIFK_like
cd12453Aug-82  RRM1_RIM4_like
cd12312Aug-82  RRM_SRSF10_SRSF12
cd12592Aug-79  RRM_RBM7
cd12573Jul-54  RRM2_MSI2
cd12582Jul-56  RRM2_hnRNPA3
cd12581Jul-56  RRM2_hnRNPA2B1
cd12771Aug-82  RRM1_HuB
cd12340Jul-79  RBD_RRM1_NPL3
cd12360Aug-77  RRM_cwf2
cd12451Jul-82  RRM2_NUCLs
cd12652Aug-82  RRM2_Hu
cd12338Jul-80  RRM1_SRSF1_like
cd1264919-82  RRM1_SXL
cd12550Aug-79  RRM_II_PABPN1
cd12243Aug-74  RRM1_MSSP
cd12639Aug-79  RRM3_CELF3_4_5_6
cd12772Aug-86  RRM1_HuC
cd12570Jun-82  RRM5_MRD1
cd12320Jul-82  RRM6_RBM19_RRM5_MRD1
cd12225Sep-81  RRM1_2_CID8_like
cd12394Aug-80  RRM1_RBM34
cd12633Jul-70  RRM1_FCA
cd12391Aug-80  RRM1_SART3
cd12390Aug-89  RRM3_RAVER
cd1241630-68  RRM4_RBM28_like
cd12310Aug-82  RRM3_Spen
cd12376Aug-74  RRM2_Hu_like
cd12322Jul-60  RRM2_TDP43
cd12498Aug-82  RRM3_ACF
cd12638Apr-79  RRM3_CELF1_2
cd12402Sep-82  RRM_eIF4B
cd12304Dec-79  RRM_Set1
cd12588Jul-79  RRM1_p54nrb
cd12614Aug-82  RRM1_PUB1
cd1227826-73  RRM_eIF3B
cd12247Aug-72  RRM2_U1A_like
cd12315Jul-82  RRM1_RBM19_MRD1
cd12661Jul-79  RRM3_hnRNPM
cd12662Jul-79  RRM3_MYEF2
cd12769Aug-85  RRM1_HuR
cd12260Sep-82  RRM2_SREK1
cd12337Jul-82  RRM1_SRSF4_like
cd12355Jul-82  RRM_RBM18
cd12635Jul-69  RRM2_CELF3_4_5_6
cd12599Aug-80  RRM1_SF2_plant_like
cd12272Sep-80  RRM2_PHIP1
cd12609Jul-80  RRM2_CoAA
cd12775Feb-74  RRM2_HuB
cd12494Aug-79  RRM3_hnRNPR
cd12290Aug-68  RRM1_LARP7
cd12496Aug-82  RRM3_RBM46
cd12613May-82  RRM2_NGR1_NAM8_like
cd12774May-74  RRM2_HuD
cd12680Jun-75  RRM_THOC4
cd12634Jul-74  RRM2_CELF1_2
cd12556Aug-81  RRM2_RBM15B
cd12276Jun-80  RRM2_MEI2_EAR1_like
cd12551Aug-79  RRM_II_PABPN1L
cd12351Aug-80  RRM4_SHARP
cd12672Aug-56  RRM_DAZL
cd12227Aug-82  RRM_SCAF4_SCAF8
cd12279Apr-41  RRM_TUT1
cd12622Sep-78  RRM3_PUB1
cd12776May-70  RRM2_HuC
cd12341Jul-69  RRM_hnRNPC_like
cd12621Aug-78  RRM3_TIA1
cd12224Aug-79  RRM_RBM22
cd12670Aug-82  RRM2_Nop12p_like
cd12645Jul-87  RRM_SRSF3
cd12615Aug-82  RRM1_TIA1
cd1256226-82  RRM2_RBM5_like
cd12559Aug-82  RRM_SRSF10
cd12409Jul-79  RRM1_RRT5
cd12497Aug-82  RRM3_RBM47
cd12606Jul-80  RRM1_RBM4
cd12560Aug-82  RRM_SRSF12
cd12535Aug-79  RRM_FUS_TAF15
cd12302Oct-79  RRM_scSet1p_like
cd12230Jul-79  RRM1_U2AF65
cd12631Jul-74  RRM1_CELF1_2_Bruno
cd12773Aug-74  RRM2_HuR
cd12495Aug-79  RRM3_hnRNPQ
cd12233Aug-82  RRM_Srp1p_AtRSp31_like
cd1275426-82  RRM2_RBM10
cd12608Jul-82  RRM1_CoAA
cd12249Jun-81  RRM1_hnRNPR_like
cd1275532-82  RRM2_RBM5
cd12587Jul-79  RRM1_PSF
cd1228527-80  RRM3_RBM39_like
cd12679Aug-80  RRM_SAFB1_SAFB2
cd12244Aug-74  RRM2_MSSP
cd12305Aug-84  RRM_NELFE
cd1245819-79  RRM_AtC3H46_like
cd12359Jul-80  RRM2_VICKZ
cd12309Aug-79  RRM2_Spen
cd12651Aug-75  RRM2_SXL
cd12646Jul-80  RRM_SRSF7
cd12527May-80  RRM2_EAR1_like
cd12254Aug-79  RRM_hnRNPH_ESRPs_RBM12_like
cd12470Aug-78  RRM1_MSSP1
cd1236919-79  RRM4_RBM45
cd12658Jul-79  RRM1_MYEF2
cd12358Aug-82  RRM1_VICKZ
cd12350Aug-79  RRM3_SHARP
cd12610Aug-82  RRM1_SECp43
cd12342Jul-77  RRM_Nab3p
cd12385Jul-79  RRM1_hnRNPM_like
cd12597Jul-81  RRM1_SRSF1
cd12620Aug-78  RRM3_TIAR
cd12595Jul-82  RRM1_SRSF5
cd1237419-79  RRM_UHM_SPF45_PUF60
cd12403Aug-82  RRM1_NCL
cd12471Aug-78  RRM1_MSSP2
cd12586Jul-79  RRM1_PSP1
cd12660Aug-79  RRM2_MYEF2
cd12475Aug-72  RRM2_RBMS3
cd12571Jul-67  RRM6_RBM19
cd12404Aug-83  RRM2_NCL
cd1236839-69  RRM3_RBM45
cd12555Aug-79  RRM2_RBM15
cd12564Jul-80  RRM1_RBM19
cd1253722-79  RRM1_RBM23
cd1243824-78  RRM_CNOT4
cd12612Aug-82  RRM2_SECp43
cd12616Aug-82  RRM1_TIAR
cd12472Aug-78  RRM1_RBMS3
cd1258920-64  RRM2_PSP1
cd12405Aug-80  RRM3_NCL
cd1228220-81  RRM2_TatSF1_like
cd12483Jul-79  RRM1_hnRNPQ
cd12529May-80  RRM2_MEI2_like
cd1225315-81  RRM_PIN4_like
cd12241Aug-79  RRM_SF3B14
cd12476Aug-69  RRM1_SNF
cd1233322-68  RRM2_p54nrb_like
cd12594Jul-87  RRM1_SRSF4
cd1247826-82  RRM1_U2B
cd12596Jul-82  RRM1_SRSF6
cd12267Jul-75  RRM_YRA1_MLO3
cd12296Sep-81  RRM1_Prp24
cd1223822-82  RRM1_RBM40_like
cd12410Aug-85  RRM2_RRT5
cd12348Aug-81  RRM1_SHARP
cd12303Aug-80  RRM_spSet1p_like
cd1266519-79  RRM2_RAVER1
cd12533Aug-79  RRM_EWS
cd12482Jul-65  RRM1_hnRNPR
cd1253622-79  RRM1_RBM39
cd12466Aug-82  RRM2_AtRSp31_like
cd12523Aug-56  RRM2_MRN1
cd1267738-77  RRM4_Nop4p
cd12558Jul-82  RRM3_RBM15B
cd12473Aug-70  RRM2_MSSP1
cd12474Aug-70  RRM2_MSSP2
cd12607Jul-79  RRM2_RBM4
cd12659Aug-79  RRM2_hnRNPM
cd12280Aug-79  RRM_FET
cd12678Aug-80  RRM_SLTM
cd12388Jul-79  RRM1_RAVER
cd12420Aug-73  RRM_RBPMS_like
cd12248Oct-79  RRM_RBM44
cd12464Jul-58  RRM_G3BP2
cd12724Jul-62  RRM1_CPEB2_like
cd12287Nov-80  RRM_U2AF35_like
cd12561Aug-69  RRM1_RBM5_like
cd12268Aug-79  RRM_Vip1
cd12339Oct-79  RRM2_SRSF1_4_like
cd12590Aug-64  RRM2_PSF
cd12669Sep-83  RRM1_Nop12p_like
cd12598Jul-80  RRM1_SRSF9
cd12539Nov-80  RRM_U2AF35B
cd12463Jul-58  RRM_G3BP1
cd1225546-81  RRM1_LKAP
cd12423Aug-80  RRM3_PTBP1_like
cd1223219-79  RRM3_U2AF65
smart00360Jul-79  RRM
PLN03134Jul-82  PLN03134
TIGR01622Jul-85  SF-CC1
pfam14259Aug-78  RRM_6
COG0724Feb-88  RRM
TIGR01628Aug-79  PABP-1234
TIGR01661Aug-79  ELAV_HUD_SF
TIGR01628Aug-84  PABP-1234
TIGR01645Jul-79  half-pint
TIGR01628Jun-81  PABP-1234
TIGR01628Aug-74  PABP-1234
TIGR01642Feb-82  U2AF_lg
TIGR01661Aug-86  ELAV_HUD_SF
TIGR01661Aug-89  ELAV_HUD_SF
TIGR01645Jan-85  half-pint
TIGR01622Aug-79  SF-CC1
TIGR01648Aug-79  hnRNP-R-Q
TIGR01659Aug-89  sex-lethal
COG517523-78  MOT2
TIGR0165917-68  sex-lethal
TIGR01648Jul-79  hnRNP-R-Q


Ontology Information


   
HPRD ID4752
Molecular ClassRNA binding protein
Molecular FunctionMetallopeptidase activity (GO:0008237)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO