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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RCN1 | 5954 | reticulocalbin 1, EF-hand calcium binding domain | 11 | Rcal, PIG20, FLJ37041 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21136890 | 2008 | Cell line : - Source : - Sample Type : CRC Tumor and normal tissue No. of Sample : 12 Stage : - | Western blot and immunohistochemistry | Up-regulation | 1.5 | Six proteins that were up-regulated in CRC (ZYX, RAN, RCN1, AHCY, LGALS1, and VIM). |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | EF-hand domain containing |
| Description | Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate cancer cell lines this protein localizes to the plasma membrane.[provided by RefSeq, Jan 2009] | Chromosome | 11 |
| Location | 11p13 |
| Start | 32112477 |
| End | 32127272 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 14796 |
| OMIM ID | 602735 |
| HGNC ID | HGNC:9934 |
| Unigene ID | Hs.97887 |
| Ensembl ID | ENSG00000049449 |
| PharmGKB ID | PA34303 |
mRNA Information
| mRNA ID | ?NM_002901.2 |
|---|---|
| Exon | join(1..520,6214..6407,7420..7598,9618..9678,12351..12550, 13435..14796) | mRNA Sequence | Download Select all |
| Length | 2529 |
Protein Information
| Protein ID | NP_002892.1 |
|---|---|
| Protein Name | reticulocalbin 1, EF-hand calcium binding domain |
| Molecular Wt. (Da) | 18996 |
| Protein Sequence | Download Select all |
| Length | 331 |
| Uniprot ID | O75077 |
| Ensembl Protein ID | ENSP00000264377 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 86 |
| S | Phosphorylation | 80 |
| T | Phosphorylation | 76 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 6310 | ATXN1 | 3333 | NP_000323.2 | yeast 2-hybrid | 16713569 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00051 | 210-273 | EFh |
| cl08302 | 210-273 | EFh superfamily |
| cd00051 | 172-230 | EFh |
| cl08302 | 172-230 | EFh superfamily |
| COG5126 | 158-309 | FRQ1 |
| pfam13499 | 257-307 | EF-hand_7 |
Ontology Information
| HPRD ID | 4091 |
|---|---|
| Molecular Class | Calcium binding protein |
| Molecular Function | Metallopeptidase activity (GO:0008237) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.