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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23908689 | 2013 | Cell line : - Source : Cooperative Human Tissue Network (CHTN) and OriGene (Rockville, MD). Sample Type : CRC tumor and adjacent normal tissue No. of Sample : 72 Stage : - | Tissue microarrays,qRT-PCR,CpG Island Methylator Phenotype Analysis,MSI Analysis, IHC,Western Blot,Methylation-specific PCR. | Up-regulation | - | BLM and RECQL4 mRNA levels are significantly increased in CRC |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a DNA helicase that belongs to the RecQ helicase family. DNA helicases unwind double-stranded DNA into single-stranded DNAs and may modulate chromosome segregation. This gene is predominantly expressed in thymus and testis. Mutations in this gene are associated with Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes. [provided by RefSeq, Jan 2010] | Chromosome | 8 |
| Location | 8q24.3 |
| Start | 145736667 |
| End | 145743210 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 6544 |
| OMIM ID | 603780 |
| HGNC ID | HGNC:9949 |
| Unigene ID | Hs.31442 |
| Ensembl ID | - |
| PharmGKB ID | PA34316 |
Protein Information
| Protein ID | NP_004251.3 |
|---|---|
| Protein Name | RecQ protein-like 4 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 1208 |
| Uniprot ID | Q6UB98 |
| Ensembl Protein ID | ENSP00000262126 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
No STRING Network could be found.
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 11098 | PRSS23 | 7149 | NP_009104.1 | yeast 2-hybrid | 16169070 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00079 | 685-817 | HELICc |
| cl21455 | 685-817 | P-loop_NTPase superfamily |
| cd00046 | 497-643 | DEXDc |
| cl21455 | 497-643 | P-loop_NTPase superfamily |
| pfam00270 | 482-646 | DEAD |
| pfam00271 | 735-809 | Helicase_C |
| smart00490 | 741-809 | HELICc |
| pfam04851 | 481-538 | ResIII |
| smart00490 | 548-590 | HELICc |
| smart00487 | 473-656 | DEXDc |
| COG0514 | 465-830 | RecQ |
| TIGR01389 | 474-830 | recQ |
| TIGR00614 | 477-830 | recQ_fam |
| PRK11057 | 474-830 | PRK11057 |
| PLN03137 | 477-817 | PLN03137 |
| COG1201 | 480-807 | Lhr |
| COG0513 | 468-830 | SrmB |
| COG1205 | 458-849 | YprA |
| COG1202 | 466-809 | COG1202 |
| TIGR03817 | 459-812 | DECH_helic |
| PTZ00424 | 704-831 | PTZ00424 |
| PLN00206 | 466-825 | PLN00206 |
| TIGR04121 | 482-820 | DEXH_lig_assoc |
| PRK09751 | 702-806 | PRK09751 |
| PTZ00110 | 434-820 | PTZ00110 |
| PRK13767 | 481-806 | PRK13767 |
| COG1061 | 482-807 | SSL2 |
| PRK01297 | 698-876 | PRK01297 |
| PRK11776 | 681-810 | PRK11776 |
| COG4581 | 743-847 | Dob10 |
| PRK04837 | 751-813 | PRK04837 |
| PRK11192 | 704-818 | PRK11192 |
| PRK02362 | 744-823 | PRK02362 |
| PRK01172 | 744-809 | PRK01172 |
| PRK10590 | 740-807 | PRK10590 |
| PRK14701 | 468-584 | PRK14701 |
| COG1199 | 467-573 | DinG |
| COG1111 | 701-808 | MPH1 |
| COG1204 | 698-809 | BRR2 |
| PRK00254 | 744-807 | PRK00254 |
| PRK11634 | 685-819 | PRK11634 |
Ontology Information
| HPRD ID | 12178 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.