Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| REG4 | 83998 | regenerating islet-derived family, member 4 | 1 | REG-IV, RELP, GISP |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25155043 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 172 Stage : - | Immunohistochemistry | Up-regulation | - | High expression of REG4 is associated with poor therapeutic response, adverse outcome and an aggressive phenotype in rectal cancer patients treated with neoadjuvant CCRT, justifying REG4 is a surrogate marker to predict CCRT resistance. |
| 25295732 | 2014 | Cell line : - Source : Helsinki University Central Hospital. Sample Type : CRC tumor and normal tissue No. of Sample : 840 Stage : DukeStage A-D | Immunohistochemistry | Up-regulation | - | REG4 IHC expression to be an independent marker of favorable prognosis in non-mucinous CRC. |
| 25338725 | 2015 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR, western blotting, tissue microarray, immunohistochemistry, Multivariate analysis | Up-regulation | 2 Fold | Reg4 expression may be useful in the prediction of colon cancer prognosis when combined with MMP-7. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | - | Chromosome | 1 |
| Location | 1p13.1-p12 |
| Start | 120336641 |
| End | 120354203 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 17563 |
| OMIM ID | 609846 |
| HGNC ID | HGNC:22977 |
| Unigene ID | Hs.660883 |
| Ensembl ID | ENSG00000134193 |
| PharmGKB ID | PA134888932 |
Protein Information
| Protein ID | NP_001152824.1 |
|---|---|
| Protein Name | regenerating islet-derived family, member 4 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 158 |
| Uniprot ID | P83110 |
| Ensembl Protein ID | ENSP00000303766 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03594 | 30-156 | CLECT_REG-1_like |
| cl02432 | 30-156 | CLECT superfamily |
| smart00034 | 30-155 | CLECT |
| cd03589 | 30-155 | CLECT_CEL-1_like |
| cd00037 | 40-156 | CLECT |
| cd03590 | 30-155 | CLECT_DC-SIGN_like |
| cd03593 | 30-155 | CLECT_NK_receptors_like |
| pfam00059 | 47-156 | Lectin_C |
| cd03588 | 30-155 | CLECT_CSPGs |
| cd03602 | 47-154 | CLECT_1 |
| cd03598 | 41-156 | CLECT_EMBP_like |
| cd03603 | 50-126 | CLECT_VCBS |
| cd03595 | 38-156 | CLECT_chondrolectin_like |
| cd03596 | 41-156 | CLECT_tetranectin_like |
| cd03592 | 42-154 | CLECT_selectins_like |
| cd03600 | 37-156 | CLECT_thrombomodulin_like |
| PHA02642 | 29-113 | PHA02642 |
| TIGR00864 | 35-158 | PCC |
Ontology Information
| HPRD ID | 17015 |
|---|---|
| Molecular Class | Secreted polypeptide |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.