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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RELA 5970 v-rel avian reticuloendotheliosis viral oncogene homolog A  11p65 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24045388   2013Cell line : -

Source : Cipto Mangunkusumo Hospital, Jakarta, or Hasan Sadikin Hospital, Bandung.

Sample Type : CRC tumor

No. of Sample : 67

Stage : TNM Stage I-IV

ImunohistochemistryUp-regulation-�NF-kB expression was positive in 47 CRC tissues (70.1%), but in only 27 tumor-adjacent normal tissues (40.3%; p<0.0001).

25257945   2014Cell line : HT29

Source : Medical Gastroenterology Department at Stanley Medical Hospital, Chennai,NCCS

Sample Type : CRC tumor and adjecent normal tissue

No. of Sample : 22 Normal and 70 Adenocarcinoma

Stage : TNM Stage I-IV

Immunohistochemistry,Double immunofluorescence analysis,Immunoprecipitation. Up-regulation- NICD and NF?Bp65 were highly expressed in HT29 cells and in tumor tissue compared to normal tissue.


Gene Details



NC_000011.9 (65421067..65430443, complement)

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Gene Type protein coding
Gene Family -
Description NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]  
Chromosome 11
Location 11q13
Start 65421067  
End 65430443  
Strand -  
Gene Sequence

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Length 9377  
OMIM ID 164014   
HGNC ID HGNC:9955   
Unigene ID Hs.502875   
Ensembl ID ENSG00000173039   
PharmGKB ID PA296   

mRNA Information


mRNA ID ?NM_001145138.1
Exon join(1..147,768..794,885..1036,1138..1286,2758..2849, 3185..3307,4151..4255,4474..4686,7038..7118,7211..7285, 7973..9377)  
mRNA Sequence

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Length 2586  



CDS Information


   
Location141..1787
CDS Sequence

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CCDS ID CCDS31609.1



Protein Information


      
Protein IDNP_001138610.1
Protein Namev-rel avian reticuloendotheliosis viral oncogene homolog A
Molecular Wt. (Da)62004
Protein Sequence

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Length 551  
Uniprot IDQ13443
Ensembl Protein ID ENSP00000369249  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation543
SPhosphorylation311
KAcetylation218
KAcetylation221
KAcetylation310
SPhosphorylation276
KAcetylation122
KAcetylation123
KAcetylation218
KAcetylation221
KAcetylation310
KAcetylation122
KAcetylation123
SPhosphorylation536
KDeacetylation310
YNitration66
YNitration152

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
86ACTL6A5389NP_004292.1in vitro14743216   
672BRCA1218NP_009231.2in vitro;in vivo12700228   
695BTK2248NP_000052.1in vitro15849198   
801CALM1241NP_008819.1in vitro;in vivo12556500   
1052CEBPD297NP_005186.2in vivo9570146   
1326MAP3K81863NP_005195.2in vitro;in vivo995   043   014   743   216   
1660DHX94386NP_001348.2in vitro;in vivo;yeast 2-hybrid15355351   
1958EGR1549NP_001955.1in vitro10671503   
2521FUS660NP_004951.1in vitro;in vivo11278855   
2908NR3C1679NP_001019265.1in vitro;in vivo1   099   538   876   590   840   000   000   
3146HMGB11228NP_002119.1in vitro;in vivo12665595   
3659IRF1961NP_002189.1in vivo8746784   
3660IRF2962NP_002190.2in vitro8550813   
3661IRF34769NP_001562.1in vivo14557267   
4221MEN1564NP_000235.2in vivo1   450   851   511   526   470   
4791NFKB21239NP_001070962.1in vivo841   321   117   962   807   
4792NFKBIA1235NP_065390.1in vivo;yeast 2-hybrid95   668   831   761   229   500   000   000   000   000   000   000   000   000   000   
4794NFKBIE5181NP_004547.2in vitro;in vivo931   567   914   743   216   
5300PIN13031NP_006212.1in vitro;in vivo14690596   
5371PML23NP_150241.2in vitro;in vivo12540841   
5515PPP2CA8912NP_002706.1in vitro1   159   170   512   842   890   
5608MAP2K63155NP_002749.2in vitro16498455   
5966REL1286NP_002899.1in vitro815   281   217   401   068   000   000   
5971RELB6886NP_006500.2in vitro14743216   
5981RFC124NP_002904.3in vitro;in vivo12509469   
6188RPS310941NP_000996.2in vivo18045535   
6772STAT12777NP_009330.1in vivo16481475   
6774STAT326NP_644805.1in vitro;in vivo12057007   
6778STAT63302NP_003144.3in vitro9584180   
6885MAP3K74011NP_663304.1in vitro16498455   
8651SOCS14669NP_003736.1in vitro;in vivo1   469   059   617   183   360   
10270AKAP85258NP_005849.1in vitro14743216   
11124FAF15124NP_008982.1in vitro;in vivo14600157   
29110TBK15322NP_037386.1in vitro14560022   
79155TNIP218207NP_077285.3in vitro14743216   


Pathway Information


                                                                                                                                                                                                                                                                                                                  
Pathway Name Pathway ID
Acute myeloid leukemia hsa05221
Adipocytokine signaling pathway hsa04920
AGE-RAGE signaling pathway in diabetic complications hsa04933
Amoebiasis hsa05146
Apoptosis hsa04210
B cell receptor signaling pathway hsa04662
cAMP signaling pathway hsa04024
Chagas disease (American trypanosomiasis) hsa05142
Chemokine signaling pathway hsa04062
Chronic myeloid leukemia hsa05220
Cocaine addiction hsa05030
Cytosolic DNA-sensing pathway hsa04623
Epithelial cell signaling in Helicobacter pylori infection hsa05120
Epstein-Barr virus infection hsa05169
Hepatitis B hsa05161
Hepatitis C hsa05160
Herpes simplex infection hsa05168
HIF-1 signaling pathway hsa04066
HTLV-I infection hsa05166
Inflammatory bowel disease (IBD) hsa05321
Influenza A hsa05164
Insulin resistance hsa04931
Legionellosis hsa05134
Leishmaniasis hsa05140
Longevity regulating pathway - mammal hsa04211
MAPK signaling pathway hsa04010
Measles hsa05162
Neurotrophin signaling pathway hsa04722
NF-kappa B signaling pathway hsa04064
NOD-like receptor signaling pathway hsa04621
Non-alcoholic fatty liver disease (NAFLD) hsa04932
Osteoclast differentiation hsa04380
Pancreatic cancer hsa05212
Pathways in cancer hsa05200
Pertussis hsa05133
PI3K-Akt signaling pathway hsa04151
Prolactin signaling pathway hsa04917
Prostate cancer hsa05215
Ras signaling pathway hsa04014
RIG-I-like receptor signaling pathway hsa04622
Salmonella infection hsa05132
Shigellosis hsa05131
Small cell lung cancer hsa05222
Sphingolipid signaling pathway hsa04071
T cell receptor signaling pathway hsa04660
TNF signaling pathway hsa04668
Toll-like receptor signaling pathway hsa04620
Toxoplasmosis hsa05145
Transcriptional misregulation in cancer hsa05202
Tuberculosis hsa05152
Viral carcinogenesis hsa05203


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0788519-187  RHD-n_RelA
cl0827519-187  RHD-n superfamily
cd01177194-290  IPT_NFkappaB
cl15674194-290  IPT superfamily
pfam0055421-186  RHD
cd0782719-187  RHD-n
cd0793319-187  RHD-n_c-Rel
cd0788719-187  RHD-n_Dorsal_Dif
cd0788619-187  RHD-n_RelB
cd0788319-187  RHD-n_NFkB
cd00602194-290  IPT_TF
cd0793419-187  RHD-n_NFkB2
cd0793519-187  RHD-n_NFkB1
cd0788419-183  RHD-n_Relish
smart00429193-289  IPT
cd00102194-290  IPT
cd0792719-175  RHD-n_NFAT_like
cd01178196-290  IPT_NFAT
cd0788221-183  RHD-n_TonEBP
cd0788113-183  RHD-n_NFAT


Ontology Information


   
HPRD ID4556
Molecular ClassTranscription factor
Molecular FunctionTranscription regulator activity (GO:0030528)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO