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• Evidence
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Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
19750230	2009	Cell line : - Source : Hospitals of Shiraz University of Medical Sciences and Howard University Hospital. Sample Type : - No. of Sample : 102 CRC samples,51 sporadic CRC samples from Iranian patients and 51 CRC samples from AA patients Stage : -	Methylation-specific PCR	Methylation	-	Methylation was detected in RET gene less than 50%.
22751117	2012	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	-	Methylation	-	RET is a potential tumor suppressor gene in colorectal cancer. RET inactivation is involved in the progression of colon adenomas to cancer. Restoration of RET in colorectal cancer cell lines results in apoptosis.
24560444	2014	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	Bisulfite sequencing	Methylation	-	RET methylation may serve as a useful and robust tool for clinical practice to identify high-risk stage II CRC patients with a poor prognosis. RET promoter CpG island methylation, analyzed by two different techniques, is associated with a poor prognosis in stage II CRC in two independent series and a poor prognosis in stage III CRC in one series.
21110809	2011	Cell line : - Source : - Sample Type : - No. of Sample : 3 independent series (including 233, 231, and 294 TNM stage II patients, respectively) Stage : TNM Stage II,III	-	Mutation	-	Mutations of RET are associated to a subset of colorectal cancer and are commonly found in hereditary and sporadic thyroid cancer.

Gene Details

Chromosome: 10; NC_000010.10 (43572517..43625799)
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Gene Type	protein coding
Gene Family	Cadherins / Cadherin-related
Description	This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008]
Chromosome	10
Location	10q11.2
Start	43077027
End	43130351
Strand	+
Gene Sequence	>gi|568815588:43077027-43130351 Homo sapiens chromosome 10, GRCh38.p2 Primary Assembly CCCTACCCGCTCCTCCGGCGCAGCCGGCGCTTACCTCGCTTCAGTCCCGCGACCGAAGCAGGGCGCGCAG CAGCGCTGAGTGCCCCGGAACGTGCGTCGCGCCCCCAGTGTCCGTCGCGTCCGCCGCGCCCCGGGCGGGG ATGGGGCGGCCAGACTGAGCGCCGCACCCGCCATCCAGACCCGCCGGCCCTAGCCGCAGTCCCTCCAGCC GTGGCCCCAGCGCGCACGGGCGATGGCGAAGGCGACGTCCGGTGCCGCGGGGCTGCGTCTGCTGTTGCTG CTGCTGCTGCCGCTGCTAGGCAAAGGTGAGTTCTGCCGGCCGCCGGCTCCCGCAGGGGCCAGGGCGAAGT TGGCGCCGAGCAGCGGAGCGGGCGCGTTCAGAAGCGCCTTTCTGTTTGCCGTGGGCAGCGGGCTGTGCGG TCGCCGGCCACCCGGCCTCGGCTGGGAGCGCAGTGGCTGCGGCGGGCGGCGGGCGAAGGGCAGGACGCCT CGGGCCGGGCGCCTCGGGCCGGGGCTGGGCGGGTCTCGGGCGGGAGCGGAGCGCGGGCCGGGCCGCGGGG GTCGGTGCTCAGAACCCTAGCCATAGCCGCAGGTCTCAATCTGGCCGCGCCCTGCGCCAAAGCCGCGTCC TGGAGCAAACGGGACAGCCGTTTCGGGGCCGACCTGGCGGACGGGTCAGGGAGCCCCGAAAGCCCGCGAT TCGTGCGGAGAGTTCTGTTTCGGCAGGAGACGGCTCCGTCCTGGTTTCCTTTTCCCGCTCAGCGTCCGTG CGTTCCTCCCCCAGCTCTGCCGTCCTGGCCAGCCGAGGGATTCGGAGGCTCTTTTGAAAAGATTGCTTTT CCCTCGTGCGTTTTTGCCGCCCTGTCTTTAAACACCTAAAAACCGTGGTTTCTGGGGTGGCTCCCCCCGA GGGGCCGCCGTGATAGGCGTCCCACCCGGCAGCCCTGGAGTCGTGTGGCGCTGCCTGGCAGAGATGCTGA AGATGCGGCCATAGGAGGCCCAGGGCTTGGGGTGGGGCAGGGGTTTGCGCCGCCAGCCAGCGTTGGTGCT GGGCCTGGTGAAACCTCAGGTGCCTTAGGATCCCAGCATTAGGTGTGGCCTTGCAAAGATGGTCATCGAC CCCACCCAAACTCTGGCAGAGTGAGCCGCAAGGCTGTGGAATCTTTGACCCCTTGGCACGCGTTTAAGTG TCCCTCAAACTGGCCCTGACTTGATCCCCTCCAAGCGCTTGTGTATGAACCAAGTTTCCCTCTAAGAGGG AAGGAGCCCTGGCCATCCTCCCTCACTCCTTACAAAGGGCTTTCTCTCCCCACAGCCTTTGGGAACAGAA GAAGCCATGGTCAGTCACCCTGTCTCTGGCCCCAGGCCCTGCACAAACTGAGTTTCCAGGCCTGCCTGAG ACTTCATTTGTGTGACCTGCGCCTCAGCTCAGCATATGCTGAGGCCAGAGCGGGTCCCCAGTCCACCTAG CGAGGGACAGGGGAGAAGCCCTTGCCTTTCTATCTTTTCTGAGTGTTAGGACTTTGGGGTCCCAGTGCTG CAGGGGGAAGACACGGGGCAGAAGCAAACAAGGCGCTCTGACGCTGTCTTGGGATTCTGGGCTGTGGCTT TGGCTTTGAGGTTGTGGGCAGGGGGCCAGGTGTGAACTGCTGCTGGTGTGCTGGGCAGAGGACTTCCCCA CACCCTTCCACAGCCTTGCGTTCAGTTGGGGTGGCCAGTGAGGCTGTGGGGGCCAGGCTCTGGGGGCCGG CTTGTGGCACTCAGCAGGCATGCAGGTAGCTTTCCGTGCCCAGACCCCTGGCCCACAGACAGCTTCCCGA ATCCAGAGATGGTGAGCCCCTAGCCCCTGGGATAACCCGGACACCACAGTTGGAGGCACTGGGAGTGAAG AGGCAGCCCCACTCCCTGGAGTAGACAGCTGGGGCCTTTGAAGAGGCTGCAGAGCTCTTTCCCAGGAGCC ACAGCTCCGGAGGTTCGAGCCGCACTCTTGGAGCTGCCAAGGACCGCCCCAGTGAGCCCCTCGGTGCTCC CCAACCACCCCAAGGGGACAGCTCGGCCTCAAGCGCCCTCTTGCGGACGCTGCACTTTAGTGGCTGGGCC TGATGACAGGCACAGACTGGGTCTCTAGAGGATGAGGGTTCTTCCACAGCTCACACATGCACACTCACAC TGGATCACCAAGACACACTCCTGCCCCTTCTCACAGCACTTGCTGCCAAGGCTGTGGACATGCACAGCGT GGTTCCTTCACACCCTGCCTCACCCACGTCCACACAGGGACCCCAGCCCCTCTCATCACTCATACACACA GGGACGCCACGTGTGTATATAGGGACACACACTCCTCATACCTGCAGGGCATAGCCTGTCAGCCCCAGGT ATGCTGGAACCAGAGTGAGAGAACCTCCATCTAAAAGTTACATTCATTTAAAAGTTGCTCTTAAAGGTTT CTGGCATTTCATTGCTCAACACAGATACAGCTGTCCCCGTTGCTTGGATGAGGAAACTGAGTCTCAGCTT CTGGGGTTCCCCCCAGGTCCCAGGCTGACCCTGCACCTCAACCTCCCACAGCTCCTCAGCAAGCCTCTTG TCTCTTGTCTTCCTGGCCTGACTTCTTGGGTCCTGTTTTGCAGCAAGGAAGGACATTCCCTCTCTGCCCC TGGGCCCCGGGGCCTTCTGTTCCCAGCATGGAAGAGCTGGGCACTGTGACTTGGCAGGGCCCGGATCCAA GCTGCCAGACCACCCTCTGCAGAGGGCCTAGGCAGCCCACCCCTGCCTGAAGCACCAGGTATCAGCGCGG GCAGCTCAGGCCAGGGGTACAGCTCCCCCTGCTTCATCCTTTTCCTTCTCCCCTTTCTCTGGCCAGAGGC TTCACCAGGTTCACCTGGGCCTGGCTTGCTTCCTCCTCCACTCCAGCTCACTAACCCTGTCTGGCCTCCA GAAGCTGCCTGCAGCCCTCACTGGTGGGCTGTGCCTGCTGGGGGCCTGCAAGCAGAGAGCAAATGGGGAA GTGCATTGAGCTGATTCACTAAATTGCCTTTCTTCTGCAGAATCACTTTAGGGACAGGCTGAGGAAATCA CTGTTTCCTTGGTGGTGTGAAGAAAATGGGATGCGATCACCTAGCGGGGAGCTAATAGCCTTTTAGCCAG TGGAGGAGAAAACCAATTAAAAATTATGATATCTGTTAAAATGGAACCTGGGGTGCCAAGGGGAAGGGAA GGCCCGGAAGCTGCCATCTCCCCTGAGACCTTCCCCCTCTGCAGCCTGGCCGAAGACCCTCTAGGTCCCC TCGTCTTAACTGGATAAGGCTAATACCAGCAGTAGCACCCCATGGGGGCTCACAGTGCACTGCCCCTGTG CTGTGCCTACTCACTTCATCTTTTCCAACAAGTCTGCAAGGGTCATGGTCTTGGCCCATTTCACAGGTGA GGAAACAGGTTCTCATAGCCTATGGACTCGAACCGGTAGAGAGGATGCGGGAGCTCCCCAGCCCTGGCCC TCTGGCTTGCTCCAGCCCGTTCTCTGGGCCAGTGGTGTGGGTCCAGGGTGGGGCTAAGGAGGGCTTCCAG GGAGGTTGCCCTGAGCCTGCCCACCCACTGGTGAGTCCCCCCACCTCGGGCTCCAGGTGCCCTCAGGACA TCCCAGCCCAGATCCCAGAGTAATGTGTGGCACCATGCACAGACGCTGAGATACTCTCTGGGTCTCGTCA GCTTTAGTTGATGTCTGGGAGTCCTATGGGTCTGGGGAGGAGCACCAGGCATGGCTGTGCCAGCAGAAGG GCCGACTGTGTGTGCTCTGTGGATGGCAGGAAGGCATCTTGCTGCCAGTGGCGGTGCAGATGTTCGGCTG GGACACCAGGCTGTGGCCCTTGCAGCCAACATATGCCTGAGGCCCTGGCATCGGATGGAAGCTACTGCTC TGAAGACAAGGGTGCAGGGATGGGGTTTGGGCATCAGGGATGGGGGTACAGCTGTGTTTCCTCATGCAGG ACAGGGCCTTCCTCCTCATTTTTCCCATCCTCCAGGACAGCCTGGGAGAAGAAAGCCAGGGAATAGGGGC AAAGCAGGGTGCAGCCCCCCATGCTCCCTGCTGCCCTCCTCCCCTCCTGCAGAGGCACTTCCTTTCCACT TCAGGAGCCCCTCCCCCAGAAGTGGGCCCCCCCCATCCCCCCTTCCTTCTTTGGAGGCTGCTTCCTGGTG CCAGGTTATGCTCCCTCCCCGTTCTCTGCTGTGCCCTCTATCTCCCCACTCCTCTGCAATTATTTTTCAG CAGAGTGACTTAATAGTAACAATAACAGTAACAATAATAGTAACAACAGCAGGCTGGGAGCACTCCTGAG GGAGCCTCGGCTCCTGCCCTGCTGCTCTAGGGCTGGGGACTCTCCAGAGCTGTCTCATGGCAGGGAGAGA CCGTAGTCAAGGAGACCCTGTGTAGGGACTTCCGCATGCGTGTGTGGCAAGGGGCGGGGACTGGGCAGTG ACCACCAGGCAGGGAGCACACCTCAGTCATGGTCACAGAGAAGGTGATGATGGCACCAGGGCTGTCTCTC CGTGCCCGTCTGCACCTGGGCCTGCCAGAGCCGTCTTCTGTGCCCCATGGGGTAGGGGAGCACCCCATGG CCCCTGGGAGGCTGCCAGTCAGTGGGACTATGAGGTCAAATGGGGAGGTCCCTTGGGGTCCATGACCCAG GCACTGCACCCCTTGGGGCTGGAAGGGGAGAAGGCCCCAGGCCCACCAGAGCCCCTCTGGCTCCCCCACT AGAACAGCAGCCAGGGCCGGCTCAGGGATTGAGGCGAAGCCTTGGTGCTTGATTCTTTGTCCCCTGAGGC AGGCTGTACCTCTCATAGGAGAACTTTGGAGGACGGGCCTTCTCCTGACCAAGGCTCTGGGACACTTGGC AGCCCCTGAGGTCCTGCTTTACCTCTCTGCTTTCTCCCCCCTTCTCTGAGCTCTGGGGCCAGGCCTGGGC ACTTGGATTGGCGCTGAGACAATGAGGCCTGAACCTCCATGGAGCTCTGGTCCCGCAGCTGTGTGATCAT GGGGGCCTCAGGGACCCCGCTCCCCTCCATTCCCCAAGCCTAGAGGCCATGAAGCCTGTGGGTCCCTGAA CTGTCCACCCTGAGACTGCAGGCAGGGCAGGGCTGGGCAAGAGCAGGCAGCAAGCTGTCCTTGTTCCCAC AGCTCCTCCTGGCTGGGCTCTTGGCCCCTGAAAAGCCTGGGGCAGGGAGATGGTGCCAGCAGGACCTTAA GGACAGCAGTTCAGGTCGCACCTGGCCCTGGAGGGAGCAGGTGGCCAGCTCCAAGCAAACACCTCTGTTT GCTTTTGCCTCAAGGAGTGGCTCCACAAAGTGTAGCAGCCCAGGCACCACCACAGAAAGGTCACCGCTGC ACCTGGACAGGTGTGCGCCTACCTGGTGGACCAGCGGGCATAGGCTTTCCTCCCTGATATCAGGGATACC TGGAGGGCCTGGTGCTGGGGCTCTGTGCTCAGGGGAGAACCTGTGGCCCTACAGCCCCAGGTTCTAGACC CCCTCCCAGATTCGGGTGCTGCAGCTGCGCTTCCACTCCTGGCCCTTGCTCCTCTGTGCTGCTGCTCTCC ATGCCCTGCAGGAGCCAGGGTTCCAAGGAAGCACCTGAGGGGCAGTGTGGCCCCAGGGCAGGAGCAGGAC AGTGGCCACCAAGCTGTTTCCAGTTCCCTTGTGTGCCTGTGACTCCAGAGGATTCTCGCCCTTGTGTTCC TGAGAGGGAAAAAGGAAACATGTATTTCCTAGAATTTAAGTAATGACTGGGGAGATGTGTGCTCTGGGTG CCGGGACGAGGGTGGGTGAGCTGGAGGTGCAGCATGAGCTGGTGCAGTTCTGGAGGGAGGGAGAGGGCTC ATTGGGTTTCTTCCTCATACTACTTGGCAGTGCAACTGGCACAGACCCGGCAGCTGTTGCTGGGCTAGGG GCCAGGGGCTTCCTCTTGCTCTGTTCCCCTTCCTGCTCCACCACCATTGCCTGTAGGGCGTCTGCCAGCC CCAGGAAGCCTAACACTTAGCCCAAGTGGGGCTCTGGGCCTGGCCCTCCTCACCCAGGGAAACAACGGGG CTCATGGGCGCTTGGTGACATGGGCACATTGCTCTGCCATCGTAAGGGGCCAGCCTGGCTATGGGACCCA GCACCGGTGGGCAGCCCACAGGTTGTCTCTGCAGGAGACTCCTCTGGCAGGTCACATACAGGATGCCCCA CAGCACCTTGAAAACTCGTGACCCGGGAAAGCCTCAAATTGTCTTTGCTCCCCTAGCCTCCCCACCACCT GTATATGCAGGGGCATGTGAGACTGTACTTGGTGACAGGAATGCCCCCCAGTCTCAGGGGCTTAACGCCA TCTACTATGTCCTTCTTGTGGCATAGCCTGGCATGGCCCTTACCCACTGGGTGGCCACACCTCCCAGCCC TTGTGCCTGGCTATGTGCACAGGAGGGCACAGAGCTTCAAGAAGCCTGAGGCTTAAGGAGCTTTGAGGCC TGGGAGGGGGCCACCGTCACTTTCCCTGTGTTCCGTGGGATCCTGTCACATGGTCGTTCTCACCCCAGGA GGCTTCAAGTACAGAGGACGCGGGGATGGGGGCACGCAGGGGTGTACCTGCACACACTTCTGCCTACCAG CTCTCCATCCCTTGTCCTGGTCCACATAGCAGGGGCTCCTGGCGGGCCCAGCAGCTGAGGGGGACAGAGG GGGAAACAGGGTAGCAAATAATTATGGTTTACTCTTTTTTAATTGTGAAATTTGTGTAACATAAGTTTAA CCATTTATAAGTGAACCATTTGGTGGCATTTAGCACATTTACAGCATTGAACAGGCATTGCCTTAGTTCC AAAAAATTTGCATCACCCCAAAAGGAAACCCCATACCCATTAAACAGCTGCTTCCTGTCCCCGGGCAACC CCCAGCCTGCGTTCTGTCTCTGCGGCTTGGCCTGTCCTGGAACATTTCATCTGCATGGACTGTTGTCTGG CTTCACTCAGCATAAGGTCTTCAGGGTTCCTCTAGGCTGTGGCACACATCAGCCCCTTCCTGTGAGGGGT AAATAGTGTGCCGTCACCCATTCATCTGGGGATGGACACGTGGGTGCTTTCCACCTTTTGGCAGTTATGA AAAATGCTGCCAGGGACATTCCTGTTATAAATACCTGAGTTCGTGCTTTCAGTTCTTTTGGGTACATACC TGGACATGAAATCGCTAGGTAATTCTGTTTTATATTTTGTGGAGCCGCCAAACTGTTTTCCACAGTGGTT GAATTGTGTTACATTCCCAAGGGTTACAATCTATCCACATTCTCACCACCACGCATTATTCTCTGTTATT CTCTGGTTCATGTCTCACTCTGGCCGTGCAGCCAGTGCACAGTGCTAGCTCGTTGTGGCTTTGGTTTGCC TTTCCCCGGTGATGGCGTGCTGGGCATCTTTTCCTGTGCATGCTGGCCAGTTGCATGTCTCTTTGGAGAA GCATCTCTTCGAGCCCTCTGCCTGTTGTCTAACTAGATGGCTGTCTTGCCATACAGCTGACTTTGCTGTT GCATCTGCATCAAGAGCTGCAGAGAAGCAGCTTTATCCAGGGCCGTCACTGTCAGTGATTGAGCCCCAGG TCCCTTGTGAGGAGAGTGTGGATTCGTCTGATTCCTCACATGGGCATTGAATCACCACTGCCCTCGAGGA CCTTGAGGACATTCTCGGAAGACCTGGACTCTGAGGCCACGTTGAGCACCAACATCTGGAAACCATGGTG TCACTGCTTGTGCATAAGAAGGGGCCTCTCAGGAACCGCCCTGTGAAGGATGGAGGAAGGGGAAGGTGCA AGGAGCCAGCAGACCCCCACCCCACTGACAAGACGAGACTCAGCAGCAGGGGAACCAGGGCCGCCCTCTC TCGCTCATCCTGAACCCTGACTCTAAAAATAACCAGGCTGATAATCGGATCCGCTGTAAGTTGATTATCA TCATTGCCGTGGTGTGATGTCATGCTGCCAGGCCCTGGGGCAGTTTTCTCAGGACAGCGGTGGATGCACC TAGGCAGCTCTGGAGGCCAGCATGGAGCTGGGGGGCCCTGAACCGAGGGTGGCAGGCAGCCTCTGTGGGC TCCTGCAAATCTGCTTGGTGGGGGTGGAACACTGGCATCCATAGGCAGGCACTCTGTGCTCCCAAGGAGG AGTTCCTGTCCCCATTCGCAGCTAGGGACAGAGCCAGGGAAGCCAAGTGCCCAGCCCTGGCAAACAGCGG GGAAGCACAGGGGCATGGGCTGGGCCGCTCTGCCCTGCGTTTCTGCTCCTTCCTGCTGCTGAACTCTCTC CTTTCTGCTGCTGAACTCTCTCCTTTGGACTAGGCCTTTGTCTTCTTGCCTCATCGTCAGTGGCCTGGGA GGACACTTGCAGTCTTAATCCTGTTTTGGCCCCATGTCCCTCACCCCCCAGGGGCCACCTAGGCCAGAGC CTGTCCTGATTTCCATCTCGGCCACCGTCTGCCCCTCGGCCCCTGGTCAGGAGCTCATTCTGTGGATACT CCTGCATAGACATCACGTGGACTCAAAGGGCATGAGGACCTCGGCTGAGAGGAGCTTACACATCAGTGCA AACCTCTCATTTTACACAGGGAGAAATCGAGGCCCTGAGGGAGGCGTGAGTTGTCACACATGGGGGTAGT GTCAGATGAAGACTTGGCACCACTTCCCTGGGCATCCCCTTCCCTGCATGGCATCCCCAGCCTTGGGTTT GGATTCTTCTTCACCCTTGATGTTGAGGTCTTTGCTCCCAGGACCTGGATAACAGCATCCAGATGCAGGT GGTGCCCCCGCATCGGGCTGCCTGGCTGTGACCTGGGGCATCAGGATTGTCAGCTTGTCTGGCCCCAGGT CTGTGCTGGGCTGAAACCTACTGTCTCAGAGGCTCCTGGCTCTCTCCCTCTGCTCTCCACTGCTCTTAAG AGCAGACCCTCAAGCCTTTTTTGTGTCCTCTCTCCAGGGAGAGCCCAGCTTCTACTCTGCAGCCCAATGC AGAAGGGGTGGTAGCTCACGGTGCCTCGGCTTCTCTGCATGCCTGTCACTGAACAGAGAAGCCCAGGCCA GACTGCAGCTTAATTCCTAGCCTCTGTGTGGCCTCCAGCAGGGTACCTAAGCTAGTGCTGCCTCATTTTC CTCCTGTGTGAGATGGGAATCCTCATGGTCCCTACCTCTGACAGTTGTTTTGATGCAGTGGGTGATGCAG ATGAAGCGCCCGGAGCAGACCTGCTCATGAGGAGCACACCGTGGATTCCTACTGGTTAATGTTGAACAGG GATGAGAAGGGGCTGGGGTAGGGCGAAAATGGGCAAGACCATCTCAGCTTGAGGAACATGAGCTGACAGA TTGACTTAAATTTGCACATGGACATGATCTGAGTCACTGCCTTGCTGAGTGCATGGGGACAGTTGCCCAG GCCAGAGGCACCAGGGTCAAAGCCAGTGGTGATGCCCTGGCCCCGTTGCCCCAGGCCAGGGCCAGTGAAC AATGTAATCAGCTGGGGCAGACTCTACAGCCCTGCAGCCAAGGGGGCCAGTGACCCTTACATGGTCATCC ACAGGCCACTTGGGTGGCCAGTCCTGTTCAGCCAGGCCTTGCCCTAGGAAAGAAATTAATTATAACCTAA TTGGCAGTTTCCTTTGCATAGAAGCCGGAAGCAACTGCCAGTGAGGCTGGTGATTAACTCTGCAGCAGCT GGGAAATTGCAGTTGGGCAGGAGCGCCCATCATCCTGGCCAGGCCGCTGCAGCTGGTCTGGGTATGGAAG TGTGGGTGGTGGCCATCGTGCAGCTTAGGGCCTGGGCCCCTCAGAGCAGAAGGCTGGGTCTGTGTGCAGA AGGTAGCCTTGGGCTGCCAGGTCCCCCAGTGCCCAGTTGCGGACCTCCTTCTCCCAAACCTCAGCCATGC CTGGACCCCTTCCCCACTCACGGCAGAAGGCTGCATGGCTTTTAGGGGTGTCAGGAGGCTCATGTCCTGG TTGCAGTTCTACCATGGGTGTGCAGCGGGAATTCTGGGCTTCTGTTTTCTGGCATGGGATGGGGTGAATG ATATCTCTGTTCTACAGCAGGGGCTCAGACTGGATGTGTGAGAAGAGCCTCAGTTAAGGAGGGCCATGTT CGTGCGTGCAGGGATCGTGGTGCCTCCCAGGCCAGGGCCGGGCCCCATCTCTCCTCCTCCTCAGCTGCTC TTCCAGCTACTGGCCACCCTGCCTGGCTGGAGGTCCAAGAGGAGAGGTATCTGAGGAGATCCTGCACTCC ACACCGGGTCTCCTGCCCAGCATTTTGGAAGAACCAATTCTTAAGTCTGGTACTGAGGCCGCACTGCCAT GATGATAACTGGTGTCACCAGGACACCAGGGAAGGAGCTGCCCTTGGTGTTTACTGAGCGCCCGGTATAT GCACTGAGCTGTCCATCATCTGCAGAGACCAGTGTTTTCTTGATGGTTTTACAGAGAGATGCTTAAACCC AGTGAACTAAGAATGGGACAGGCTGTCAGATTTTTCTCAAAGGAGGTATTGACTTGTTAGCGGGTACAAT TAGGCCGAGGAACCAGGGGCTGATGCAGTGTGCTCCCGAAGAGGGGCTTCTATGGACTCCAGTTACCAGA GCCTGCCCCAGGATTTTCCTTCACACCTGCTCTTTATGCCAGGGATCAAGCAGGGTTATAAATACAACAG CGGGCAGGATGAGCCAGTGGTGGCCCTGTGGGTCTTCACAGCCCAAATTTCCTTCCATGGTTAGTGTAGG TTAAACCTGGCAAAAAGCTGCTTTCATTTGGAAGTCTCAGGATGCCAGCAAAGTGATGAGAGTGGTAGGG ATAGAGGTGAGATGGGGGTGGTGCTGGTGATAGTGATGGTCATGGTGTTGGTGTTGGTGTTGGTAGTGGT GGTATTGGTGATGGTGATAGTGGAGGTCGTGATGATGGTTGTGGTGGAGGTGATGGTAATGTTGATGGTG GAAGTCATGATAGTGAGTGGTGGTTGTGGTGGTGGTGGTGGTGATGGTGAAGACGGTGGTGGTGGACGTG ATAGGGATATTGATGGTGGAGCTCATAATGGTGAAGGTGGTGATGGTGGTGGAGGCAGTTGTGGTGGTGA TGGTGCTGGTGGAGGCAACGGTGATGGTGGTGGTGATGGTGAAGACGGTGGTGGGAATGGTGGTGGTGGA GGCAATGGTGGTGGTGATGGTGGTGGTGGAGGCCATGGTATTAGTGAAGGTGATGGTGAAGGTGGTGGTG GAGGTCATGATGGTGAAGGTGGGGATGGTGGTGGTAGAGGCAGTGGTTGTGATGGTGGTGATGGAGGCGG TGGTGTTAGTGGAGGTGATGGTGATGGTGGTGGTGGAAGTCATGATGGTGAAGGTGGGGATGGTGGTGGT GGAGGCAGTGGTAGTAGTGGAGGTGATGGTGCTGGTGGTAGTGGTGAGGCAGTGGCGGGGAAGGTGGAGG TAATGGTAGTGGTAGAGGTGACGGTGATGTTGATGGTCGTGATGCAGCCATCTTCTGTGAGCATTTGCTT GGTGCCAGCCACTGATCTGTGAACTTCATGTGCATTAATTCCTTCTAGCTCCCAACACTCCTGTGTGGTG GGAGCTCTGAGTCTCAGTGGGTACAGAGGAGAAACTGAGATACAAATATATGTCCCTTGCTCCAGGCTCA TTACCACTGCAACACACACTTTCTCTCCATCACCCAGATGGAGTCCACAGCCTTGCCTGGAATCCACAAG CTTGCCCAACCTTCTTCTTCTTCCTAAGTTCATGCCCTCATGGCCCGAGGAGCTGGCCTCCTGTCTCCAA CCAGCATTCACCTCCGGCCCTGTGCTGTTGCTGCTCATCTGAACTGCCTCTACCTCCTGCTGCTTTTCCC CTCCTTTCACTCTGGCTCTGCCCCCAGCCCTCCCGTCCTGCCGGGCACTGGCTCCTGCTTGTGGCTGCAG CCCAGAGCAGTCCCTTCCCTTTAGCCTCCACTTGCCTGTCTGTGGCTGTCTCTTGGTCAGGCATTTTTTC AGAACGGGCAGCGTGGGGCAGCCCCCTTGGCCCCTCAGCCTGGGCTAGGCACTCTCCTCCATCCAGTGCT GGGCCCTTTAAACAGGTCAGGCAGCGTCCGCTCAGCAGAAGCGTGTGATGACTTCCCCAGCCGGCTGACC TCAGGGAGGGTGCACATGGGTGCCCCCAGTCAGCTCTCCTGACGTCCCTGCCGGGGTCAGGTGTCCCAGG GTCTCCAGCCTTAGGGTCTAACACATTCATCTCTCCAAAAGTAAGGATTCCTTGCCAGGGAAAGGGCTAA CAAGCTGCCTGTTTTCTTGGCCAGCAGGCATCCTCCCCATGAGCCCAGGGCTATGGGTGACCAGCAAGCC ATTAGCATATGCGTGTCCATCTGTCCTGCCTGGCTGGTGGGCTGCCAGGATAGCCGTTCCTTTTGCTGCC CAAGGAAGTACTCAGGACCCAGTTACTGTCACCTCTCCCAAGGCGTGCAGGTGGCGTAGGAAGTGCATGT CCGTTCTTTCTGTAGGACACACCTCAGGACCCCAGGGGACATTGTCAAGAGGCAGAACCAGGGTGCTCCT GCTGTGTACCAGGGCCGACAGCATTGTGTCGGGGAGCCCGCCCCCACATGCAAGGACACACCACACACAG GGAGGCGTGGAGCACATGTGGCCTGTCCCACCTGCTAACAGGCCGGCCATCGGGGCCCTCCTCTGGCTCA TAGGCAGGGCATCTGGAGGAAGCCGTCCCTGCCAAGAGCAGGTTGAGTGTATGGGCACTGTCTGTCAGCC TCATACTCTTGTTATCATCAGACAAGAACCCTGAGAGTTAAGGGAGGCAAAGGCCAGCAAGGTCAGGACT TGGGGCAGAGATCGGGGCTGGGACAGGAGCTTGTTCAGGACAGTGGGCAGGACTCCCACAGGTGGAGAGG ACAGGGATGGCCATGCACCTGGGAGCCCTGGGCCAGGCTGAGCGAGCGAGCACCAGGGCCCGGAGTGAGG GGCTGATGGCAGGGGCATGCAGGCAGCTGCACATACCAGGCTCTGTGTATGAAAGGGAAACTGGACATGT GTGAGTAGGCCCAGGCCTGGCAAATGGCTCAGAGAGACACCTGTGAACAGCTGTGTTTGGTGGCTGCCCT GGGCAGGGGTGAGGCTGAGAGCCCACTGAACCTCCTGAGTCAGAGGTGATGAGAGCCACCCCCAGGTGCA GGGAAGACACAGGGAATTTAGGAAGAGAGCAGGACGCCAGGCAGGGTGCACTTAATCGTCACTTGGAAAC CAGTGTCCAGTAGTGGCTGCCCGGGAGCCTCTTGGGTTGGCACTGGGCTCGTGTGAGGAGGAGGCGTGGC AAAGGGAAGGGCTCTGTGACAGAAGGCAGTTGAGACTGGGCCGCTTCTGGGCGCTGCCTCCTCTGCTGAG GCCTCAGATGGGTCCCTGCCTTGCTCAGGGCTGTGTGCTCCATGCTAAGCCTTGTCCTCCTGGGGGCTCA GGCACAACCAGGTGACTCTCAAGCCAGGGCCACATGCGTGCACCATGGGCCCCTCCCACATCCAAAAGCA AAATTATATTCTGCAACTGTGTTGGTATAAGACAAACACAATCCAGGCCACTTTATTATTATTTATTTCT TATTATATTTATTTCATCCTTTTGATTTTAAAATGAATTAAAACAAAAACCTTTTTTGCGCACCCAGGCG CATGCAGCAGTGGTGCCGGTCAGGAGCAGAGGTTCCTCCTCTGCAGGCTCCTGGCCCCCTGGGACCCTGG CACCGAGGGCTGGCCCTAGCGGCCCAGCCCTTGTGAGCCCTCACACCTGCCTAGAGATGGCGCGCTCCCT AGCCAGTCAGGGCGCTCTCGTGCCTGGATGCTGTGGTCTCATGAGTGGACAGCAGCTGAAGTGGGAACTG CAGCAGATACTGGCCGTGCCCAGGTGTGTACCTGCCCCAGGCAGGTGACCAGGGCAGCAGGGTGATGCCA GATGGGGCCAAAAATTTCATGCTTCTGTTTGACCTTGGTTCTAGCTGAAGATTTAGCTGTGTACACATCT TTAAAACTGGGATCCCCCTATAAAAACCAGATGCACAGGCAGCCGAAGAAAGAATGGATGAATTGGGCTA CATCAAAATGTAAAACTTCTGTGAACCAAGGCCACAATCAGAAGAGTGAAAACACAGCCCATGGAATGGG AGAAAAACTTGTAATTCATAGATCTGATCAGTGTTAATCCAGAATCTGTAGAGAACTCCTCACACTCAAC AACAGCAACAAAAAAACCTGATTCCAAAATGAGCACAGGGGGCCAGGTGCGGTGGCTCACTCCTGTAATC CTAGCACTTGGGGAGGCTCACGCAGGCAGATCACTTGAGGTCAGGAGTTCGAAAGCAGCCTAGCCAACAT GGTGAAACCTTGTCTCTACTAAAAATACAAAAAAATTAGCCAGGCGTGGTGGCAGGTGGCTGTAATCCCA GCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACTCAGGAGACAGAGGTTGCAGTTAGCCGAGATCG TGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCATACAAAAAAAAAAAAAAACCCAACAACAAC AACAAAAAAAATGAGCACAGGGCCTGGATGGACATTTCTCCGAATAAGATTTACAGATGGCCCCAAGAAG CACATGAAAAGATTCTCAGCATTGCCACTCATTAGAGAAATACAAATCAAAATCACCATGTGATACCATC TCACACCCATTTGGATGTCTACTATCAAAAAAAAAAAAAAAAAAAAAGAACCAGTGTTGGTAAGGATGTG AAGAAACTGAACCCTTGCGCACTGCTGGAAGGTAAATAGTGTAGCTGCTGTGGAGAACAGCAGGAAGGCT CCTCAAAGGTTAAACCTAGAGCTGACTTCGGCTCCAGCACCTCCACTCTGGATACATACAGGAAAGGAAG CAGGAAGCAGTCAGGATATATTTGTATGTCCCCATTTTCAGCAGCATTATTCATAGTAACCACAAAGAGG AAGTTACCCAAGTGTCCATTGACCAATGAATGGATAAGCAAAATATAATACAGACATACAATGGAATATT ACTTGGCTTTAAAAAGGAAAAAAAATTTGCCACATCCTATGCCATGGTTGAACCTCGAGGGCATTATGTC ACAGAAGGACAAGCACTGTATGATTCCACTTACATGAGGTCCCTGCAGTCGTCAAATTCGTGGAGACAGT AGAATGGAGGATTCCAGGAACTGGGAGAGGAGAGGAGGGGGAGTAATTGTCTCATGGGTACAGAATTTCA GTTTTACAGGATAAAAAGAGTGCTGTGGAAGGATGGTTTGCATGGCAGTGTGAATGCACTTAATGCCACT GAATTGTACACTTAAAAATTTTAAGATGATAAAGTTCATGTGTATTTTACCACAATTTAAAATAACTTTT TAAAACTAGAATCTCTCTTTATATACACCTCCAAATTTGTTATTTACAGTAGAGCCTCCCTTGATCCGTG TTTTTTCCCTAAATGCAAAGTTAGATTATAGTCCCAGGCAAAAGCAGCCTCCAGCTGGGACAGAGCCGAG GACCCAGGTTTGTGCAGCATGCTGCAGGTGGTCCTACCCGAGTGAGTCTGGCTGGCAGCTCCGGTGCCCA GGGCTCCTCAGGCACTGATAGATCATTTCCTGAGCTGAAAAGGAGTGGTTTTGTCCTCAGCCTCAGGCTT GTTTGCTCAGCACAGTGGCTGGCCCCACAAGGTTGCTGGTGCACTAGTGGGCACTGCACGTGTGCACAGG GCGCATCCACACAGCTCTATCCTGCCACTGACAGCCTGCCCGTGGCTCCAGTGCCCGTGAGACCATGTCA CAGTATCTCCCCGTCCTCTTACTCCCTTCCCCTTCCCAAATTCTGACCATTTCCCAAATGTGCCCAGCCC TTTCACACTCCTGTTTATGAAACCATTGTACTGGCTCGTTGATTCATTGATTCATTCATTGGTTCATAAA TTTATTCATTCAGCTCACAGAAAGTGAGTTGGCAGATGTGGCAGGAAGGTAGGCACCCTGTAAGAGTGAG GAGGAAGTGAGTTGGAGGGCAGAGGGGGCCCTGGGAGCCCTGATGAGGAGCTATGTTTTATTCTGCAAGC AGCGGACAGTTAACACAGGGCTCCACAGAGGGTGCCATGATTCAGTGGACCCTGGCTCCTCTGTGCGAGA TTGCCTGTCCTGCCCAGCATGTGGTCCAGGGTTGGACAGGGGTGGCAGAGGGGACTTGGGAGGTGGGGTG AGGGGTGAAAGAGAAAGGGATCTGGGGACTGAGGTGTGTGACCTGAGCAGTGAGGTGGGGCCATACCGTG ATGAGATGGGGAAGAGTTGGGGACAATTTGGGGTGAGGAGGGGCCAAACTGAGGCAAAGGAGTAGAGAGA GCAAGGCATGGAGATGCCCAGGCTGCTGATCAGCATGCTGCACACCAGCATAGAGACAGGATTAACAGCC CAGGGCCTGGATATGGCTGGTGAGTGAGCCACTGCCACCATCTGGAGGACAGGGTGCAGAGGAGGAAACC AGCCGAGGGGGTGAGCAGCCTCGGTAGCATCCCAGCGACGCTGGACAGCACCAAAGACAGAGGAGGTCCT GGGAGCAGCTGGGAGAAAGTGGGTTACCCAGGAGGGGCCGGCCTGAGCATGGGCCCTCAGCAGCAGCAGT GAGGCTGAAAGACGGGAGCCAGACCTTATGTAGAGTGGAGGAAAATAGCTGTCCACATGGAATTCTCCAC CCAGCAAAAATGGGCCTTCCATGAATGACGTCAAAAAATGAGGCAAGAAGAAGGCCAGGCGCAGGCTCCT GCTGGTGGGGGTGGGACACAGTGGCAGGTGGGGAGGCGGGAGGAGCAGCAGTGTGGCCAAGCATCCAGTT CAGCAGGGCCACGGGCTCCAGGGTGTTTGTTCAGCATAAATGTTCTGTGAAATGTATTCGTTGTACATGT CAAATATTTGACTATAGTAAGAGAAAACGTGAGTGGGAAGTGGGAGGGAAGCGGTGGGGGGGTGGGGGTG GGGTAACAGGTCACATCCTGAGAGGATAACAGTGCTCAGCATGGGGCTGGAGGGACCCCCATAGGGACAG CTGGCCTGGGGAGGCGGGGACCGCCTCTTTCCACCCCCAGCCCCCAGGGAGGAGCCCTGGGGCCTGTTTC CCATTCCCAGGAAGATGATTGCATTAGGAAATCGTCTCTTAAGGAGATTCTGCTGGGCCATAATAAAGCT GTCATCTGCATCGTCTGCCACCCATCAAGGGCAGGCGTGGGGCTGGTGTCGCATGAGGGGTTCTGCAGGA AGGGCCTGCTCTACACACATGCCCTACGCTGCTTCTAATTCATGCAGTTTTTGGATCATATCGTTGTTAT TGTTTTCTTTTTTGGAAGTCCCAAATTTCGGCCCTTGTGCTGCCATCCTAGGGAAGTTTTTCATGGTCTG GAGCTCCATTTGTGTTTCTGTGGCAGGGTCACCATGCCATGGCAAGGGTGACCTCACAGTGCCCCATCAG AGCTGCCGGGTGGTCGGCAGTGGGGGAGTGAGAGACCAAGGGCCACAGCCAGGAGCCAGTGGAGAGCTGG TGAGCCCCTGCCTCCACAGACAGGGCCAGGCCACGCTTAGTATGTGTGCACCGAGGGTGCAGGAAAATGT GTGTGCTTGTGTGTGAAAGCGGGTATATACCAGTATGAGCAAATACATGTGCTTGTTAGAGCCCTATTGG CAGTGTGAGAATGTGTGAGCATATGGGAGAACAAGTGTATAACAGTGTGTGCCCCCGTGGTGTGTAATGG TATGCGTCTGAGAGAATGAGTGTGTGTGAGAGAAGGAATGCATGTGTGCAATGTGTCCGCCTGAGTCTGA CCAGGAGACAGCCCCACGTGGTCCCTGAGACAGGAGCAGTAACATCAGAGGCACTAAGCTGTGATGAAAG AGGGATGAATGGGGGTGGGGAGAGCTCTGTGGGGCACCCTCAGCTGCAGGTGGGCACCAGGGAAGGAACC CCTTCCCAGCTGGGGTCAGAGCCTGAGGGAGGAGCTGGATGCTAGGCTGGGGCTGCTGTGCAGGCTCAGG TCTGGCAGGAACTATCCTTAGGGCACGGGAGCTGAGGCTGGGGGCTGCAGGAAGCTGATGGCTAGGCTCA GGTATGGGCTGCATCAGTGCCGAGGGATTGCATGCTTTGGGTATGTGCTAGGGTGGAGCACATAGCACAC CCTGTCTCGTGGACTGCCCGGGCAGCAGGACCTAGAAAAGGCAGGTGTAACAACCGGAGACAGGAGCAAC CCCTGGCCTGTCCCAGCATCTCTCCAAAGCCCTCCACCGATGAAGCTTGGCCTTGTGCTGCCTGCAAAGT AACCTGCTCCAGGCCCGCCTGGGCATGAGAACATGCACACCTGGACGGAGTGTGTGGATTGACAAGGTGT GTGCACGCGCACATGTGGGACGAGGGGGCTCAGGACTGGTCCCCTCTGCATCCAAAGATGAATAATTTAA ACAGCCCAGCCACGTGTGGAACATTGGAAACAGTCTAGCACTTCACTCTGTCAAACACTAGGGCAGACTC TTTCCTGCTGAGCTGGGCAGGGTGGGAGCAGATGGGGTCTTAGGTGGGCATGCCTCCATCTCTTTTTCTG TCTCCTGCATGCCCTGTGCGTGCATACATATACACACACTCATGACACACACTACATAGGCCTTGAAGGT TTCTGAGGTCTCTCTGAATGTGAGCAGCAACTTGGGTCTTTGGCAAGTGTGCTGTGAGCAAGCAGGACCT TCCCCCACCCCATCCTGCATGGTGCCTGGGCACAGCCAGCCTGAGGAACCAGAACCACGGTGGCGGGGGT CATTGAGGGTTGATGTGGGAATCCTCTTAGTTTCTCAGACAAGCGACACTGCCATTTGCACCGTCGGTGG GTGTGGTGTGTGCCAGGCCACCGCTGTGCTGCAGAAGTACAGGGTGGGCCCAGCCCTGGCAACCAAAGCT GTCCAGGCAGACACCTGTGTGCTAGGTTTGAGGGAGGATTCTGTCACCACGTGGCATTTGGGCTTTGAAG GCATGGGGTGGGAAAAGCTTTGTAAGTCCTGCTGGTGACCTTCCCATGGTGCCAGGAGTGGGAGTGTCTG TCACCAGACGTGGGTCTCGACCCACGGGCCTGGCCTTGGTCCACAGGCCAGGCGGCCCTTCTAGGCAGAA AGGCGGCAGCAGGATGGGAAGCCAACCAGCAGGGCACTGGGCCTCCTGGCAGGCTCAGCACCTGCTGGCG CCTGGCTTCCACCATCACTTTCTTAGCTGTTATCCTAACCCCCGAGACACAAAGCCTCACAGCATGTCCA GCTATTTCACTTGGTCAGGCTTCTCGCCACCCAGCCTTGCTGTTCTTATATGTGAAATGGGCAGTGAAGG GATCTGCACCCAGTGGCTGAGTCTGCAGTGAGAGCCTCATGATGATACACCCCTGTGCAGAGGTGCACGC CTGGCTGCACCTGCACTGGCCGTTCCTCCTCTCCTTAGCATGCCTCCCCCACTTCGAAGCTGGGGAAACT GAGGCCCAGAGGAGGCCAGTGTTCTGCAGAGTCTGCACAGTCCGGTGGTTCCTGATGCCAGCAGCTGTTC CCCAGCTCTCCCCTGTGGCTGACCCACCACGATTGGCTGCATCATTTGTGGGCCCCTTGATCTAGAATTA TGAAGAATTTCAAGACTGTAGCAAAGAGCATTAAACCAAGCGTGAGACCTCTGAGCAGGGCCCACTGGGA CTGCCCAGGCTGCAGTCCGCTGAGGCAGGTCCTGCACCCACCTCCTTCATTCTCCCACCTTGGACCATGT GTTTTTCCATCTAGAAGTGTCTGTGACAAGCGGGAACCTTAAGACAGCTGTGCCCAGCTGCAGAGACCAC CTGGGAGGCATTTTAAGTGCATTTAAGTCTGTTTCTGCTCGCAATCATTGCCTGACCCACAAATCCCTTT TGGCAGCAGGGAGACCAATTGGGATTGGGCCCCCCACGATCCTGTAGGGGTGGGCTCTGCCAGATGGGAG CAGGAAGGCCCGTTCTCCCCTGCACATGTGGGCTTTGTGGTGGGGGCTTTGGGAAGCCCAGGCCTGTCCT ACCTCTAGTCCCTGGACCACTAAAGGTGCTTGCACATCATGGAGGCCCCAGAGGAGCACCTGTGGGATTC CCAGACTGGATCTGCTCCTGCGACAGATGGGGTGCCAGGGCCCTACCCACTCTTCTGCAGCCTGGGCATC ACCAGAGCCACCCCACGGCCACCCAAGGGCAAATGGTTCTTATTGGGAAGACCAGGGCCAGAGGTGTGTG TCCCAGAGAAAACTAGACCCAGCTGAGCTGCATTGCCTCTCCCCACCTGAGCTCAGCCAACCCCTAGCAT CCTCTCTGGGGTAAGAACATGGACCCCACTGCCTGCATGGATAGCCCAGACATAGGATGCCACATGGGAT TGGGAGGGGGCTCATCGGGGCCAGGGCATCTGGACCCTCCTCGCCCTGTGAGGCCACTATGAGTTACAAT CTCTCACCCTCTGTCGCCAGAAATGCAGCACCCCCTCCCACCCCGAGGGCACTGTCATGGGAGCAGTGTT CCTGATGTACAGTGAGCACTTCAAGAGAAGCTTTCTCCTGTTCTATTTTCCCACTGTGGGACTCCAGACG TCTCACCTGTTCTCTTCCAGGCTCCCCTTGGCACTTGATTGTTTCCCCCAGGTGTGTCCTGGAGGAGCCC AGCGGCCCTGGGGGCGTTCTCAACTGCTGCTGCAGGCCCCGCCCTCCAGACCCCTCAGCGACCTCAAGCA GCAACCGTCTGGGTGGGAGCAAACTGATCAAAAAGAGAGATCGATTACATACAAGTGCAGTATTCCTAAT GTGTCCTTTGGATGTTGGTATTGTTTGGGCATTCTAGAGTCTATTTGCAGGTTCTTAATGGATTTTAAGC ATTTTTTGCCTATTTATCCATCTTTTTAAAAATTCATACGATTTTTTATTGTGGAAAAATATACACAAAA ATGATTTACAATGTAACTATTTTTAAGTATACATTTCAGGGACATTAAGTACATTCACATTGTTGTACAG CCATCACCACCTCCGTCCCTGAACTTTTCATCTTCCCAAACTTAAACTCTGTCCCTATCAAACACTAACT CCCCATCCTGTCTCCCCCAAGCCCTAGCAATCACCATCCTATGTTGTGTCTGTGAATTTGACTACTCTAG GGATCTCACATAAGTGGAATCGTGCAGTGTTCATCCTTTTGCAATGGGCTTATTTCACTTAGCATAATGT GCTCAAGGGTTATCAGTGTTATAGCCTGTGTCAGGATTTTCCTCCTTTTTTTTTTTTTTTTTTTGAGACA GGTCTTGTTCTGTTGTCCAGGCTGGAGTGCAATGGCACAATCTCGGCTCACTACAACCTCCGCCTCGTGG GTTCAAGCCATTCTCCTGGCTTAGCCTCTCAAGTAGCTGAGATTATAGGCGCCCGCCTTCATGCCCAGCT AATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCTAGGCTGATCTTAAACTCCCGACCTTA AGTGATCTGCCCACCTAGGCCTCCGAAAGTATTAGGATTACAGGCGTGAGCCACTGCGCCCGGCCAGATT TCCCTCCTTTCTAAGACTGAATATTCCATTGTATGTATAGACCATGTTTTGTTCATCCATTCATCCATTG ATGGCCACTGAGGTTGCTTCCACCTTTTGTCTATCGTGAATAGTGCTGTTGTGAACATGGGTGTGTAAAT ATCTATTTGAGACTTGGCTTTCAATTCTTTTGCGTATGTACCCAGAAGTGGGATTGGTAGATCATATGGT AATTCAATTTTTAAGTTTTTGGGAACTACCTTCTTGTTTTTCATGATAACTGTATATTATTTTCCATTTT CACCGACAATGTACATGAGTTCCAAAAACTATTTTAAAAGCTTTCCACTGTGGGAAATGTTGGCCACACA CAGTCAGCAGCATAGTGCACCGTGCCCCTGCTTGGGCTCACTCAGCCACAGCCGAGGCTAGCATCCTGCC TTCTTCAAGGAAGCTACGCCTCTGTCCACAGCGCCTTCAGTGATTCATTTTTCAGTTATTTAGGTAAAAA TTACATAGATAGGCCGGGCACGGTGGCTCATACCTGTAATCCCAGCACTTTGGGAGGCAGAGGCGGGCGG ATCGCCGGAGGTTGAGAGTTCGAGACCAGCCTGACCAACATGGAGAAACCCCATCTCTACTAAGAAAATA CAAAATTAGCTGGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTGGGGAGGCTGAGGCAGGAGAATCG CTTGAACCCGGGAGGTGGAAGTTGTGGTGAGCCAAGATTGCACCATTGCATTCCAGCCTAGGCAACAAGA GCAAAACTCCATCTCAAAAATAAATAAATAAATAAATAAATAAATAAATAAATAAATAAATAAAAATTAC ATAGATAAGATGCACGGACCTTAGCTGCACAATACTGACAAACGAATATGCCCACGTGATCTGCACCCTT CTCAGGATATGGGACCTTCACATTCCCCAGAAAGTGCCCTGTGGCCCTTCCCAATCTGTCCACCTCCCCC ACACCCCCGCCTGCCACAGGCAGCCAGTCTGATCCATTGCCTAACATCCGTCCAGAATCATGCCATGTGC GCTCTTCTCTGCCTGGCTTCCTCACCTTGGCATGGTTTGTGTGTGTGACCCATCCAGGTGTTTGCGTGTA TCCATAGTTCATCCTTTTCCATTGCTGGGCAGGATTCTGTGGCATGGCTGGACCACGGTGTGCCTGTCCA TCCACCTGCTGAAGGGCCTCTAGGCTCTTGACTTCTGTGAATCATCCTTCCATTTCCAACTATGGCATTT GATAGACGTATGTTTTCACTTTTCTTGGATGAATGGAGTGGAATTGCAGGGTCATATGGTAGGCGTATGT TTAGATAAAGATTTATGACTTTCCTGTAAAGTGCTTTCTTCATTTTTTGGCAACTGTTGCCTGCCCCACA TGGGTGGCAGTGTCTCCTGCCCTTGAACACTCTGGCTCTGGGTGACCTGTTGAGAAGTCTGTATGGTTCA GGTGCCCTTCCGGCTTGGATGATTGAGAATAGGCTTGTCACTGAGGATACTGCTTCCCCTGTTTCCTTTT CTTTTTCTGTTTTAAAGCAGTTCTTTTCTAGCCCGTGTGTAACTATACAAATAATTGAGTGTTCATGTTC TCAGGAACAGAGATGAAAAACTCCTGCTAAGATCGGAATTTTAAATTAATGATTTTTTTTTTTTTTGTCC TTGAAGAAGCCTTATTCTCACCATCCCTCACTCACTTCCCTACTTCCCACAGTGGCATTGGGCCTCTACT TCTCGAGGGATGCTTACTGGGAGAAGCTGTATGTGGACCAGGCAGCCGGCACGCCCTTGCTGTACGTCCA TGCCCTGCGGGACGCCCCTGAGGAGGTGCCCAGCTTCCGCCTGGGCCAGCATCTCTACGGCACGTACCGC ACACGGCTGCATGAGAACAACTGGATCTGCATCCAGGAGGACACCGGCCTCCTCTACCTTAACCGGAGCC TGGACCATAGCTCCTGGGAGAAGCTCAGTGTCCGCAGTAAGGGAGCCGCCCCAACACCCACCCCGTGCCC CACCCCACCCCTTCCTCAAGCCGCCCTTATCACAGCCGCTGACACTGAAGCTTGGCATGGCTTCCCCCCC ACCGCTGGTGTGGAAGGCGTCAGGGGTTAAGTGAGGCTGGCCTGCCTCTGTGTCCAGCCTGGAGAGAAGC CAGGACAAGCTTCAGGGCTGCGTGAGGCTGTAGGAGTTTGGAGACACACGGGAATCATCCGGGTACACTC TTCTGCCAGACCCGAATCCCTCTTCCAGTGGGGCTAAAAAGGATTAGGAGGTTTCGAGAGAGGGAGTAAG TGGGGCTGGAAAAATCCCAAGGTTTTGATTTAGCAAATGACCTGCAACTCTCTGGAGAAGCGGCAGTTCC CAAGGAAAGCCTGACTTCTTATCAGCAGCTGGCTGCCCTTGTACCTGGCAGGGACTTGGGCCTGTCCCAG GTGTCCAGGGAGGAAAGAGGAGCAGTCAGAGCCAGAGTCACGGCCACATGTGACATTGGTAATGGGAGGG GTGGGGGGGAAGCAGAGCCCCTGTGACAGGAAACGGTGATGCTGCACCTGGTAGCTCCCATCCCTAGCAC CCCTCCAGGGCCACAGCTTGCACAGCCCTCACAACCACCCTGAGCCCTGTCTGCTGGTGAGAGGCAAGCC TCAGGCTATGAATGCAGAGCAGGCATCCCTGCCCTACCCAGGCCTATCTGCCAGGGACAGCCAGGGTGCA GGGGAGGGAGGAGACTTGGGTGGGCAACTCCCTCCGGCGCAGCCCAGGCAGTTCCTGGAGGAGGCAGCAT CTGAGGTTGGTCGTGGTTCTACGCACTTAGTTGCTGCCCTCTTCATCCTGAGCCTCCAGGGTGGAGCTTG AGGAATGGGAGTCCCTGGGTGGGGGCCAGTGTGGAATTTGCCCTGGGCCTGCATTTCGTAGGAGGCCTAA GCCCTCCAAGGTGGGGAGAGGCTTCATGCACAGCCAGTTCCTGTGGAGGAAGAAACCACAGGGTAATTTA ACAGGGAGAGTTTGTGTAAAGAATTAATTACAACAGGGGATTGGAGCAATGAGGGACAGGCTAGCAAAAA GCAAAGAGAATGCCAGAGAATATGGGAAGAGCAGCTCTGAGGAGCAGCCGCCCACCTAGGGCTGAGATGG AGGCTGGGAAAGCCCTCGCAGCCCAGCTGAAATGGCTATGGCGCTTCGGTGATGGAACTTGCCGGAAATG CCCCCTCTAGGCATTGGGGAAGTATGTCTGCGGCCACTCCAAACCTCCTGAGGAGGGTGTGGCAGGGGGG GTGCTGGTCACCCCTTACTGGAGAAGTTGCCACCATCAGAGTTGGGGAGCCTTAGACCCAGTGCTCAACA CACCTCCCTGAGGAAGGGGCCTCTAAGCCAAGAACTGAATGATGAGAGCTAGGCCTGTGGGGCATTGGTG CTGGGCAGCAGGGCTGTGCAGCAGAGGTAAGGAGGTGGCAGGCAGAGCTGGAACACCAGTCTGAGCCTTG TGGACCTTGGTGGGGACCAGGGTTTACACCAGCCCTGGAGCTCCTGCCTCCTCCCCATTCCCGACTGCCT GGCAGATGTGGCCGATGCCCCCACAGACCTGACTTCTCTCTGCAGACCGCGGCTTTCCCCTGCTCACCGT CTACCTCAAGGTCTTCCTGTCACCCACATCCCTTCGTGAGGGCGAGTGCCAGTGGCCAGGCTGTGCCCGC GTATACTTCTCCTTCTTCAACACCTCCTTTCCAGCCTGCAGCTCCCTCAAGCCCCGGGAGCTCTGCTTCC CAGAGACAAGGCCCTCCTTCCGCATTCGGGAGAACCGACCCCCAGGCACCTTCCACCAGTTCCGCCTGCT GCCTGTGCAGTTCTTGTGCCCCAACATCAGCGTGGCCTACAGGCTCCTGGAGGGTGAGTGCCGACCTTGT GGGGCCGCCCCACAGTGCCTGCTACTGCTGGTCTTGCTCTGCGAGCCCTTGACACAAGCCATCTGGTTTA TTCTTCACCTTCATGCCATCAGTTCATTCAATATTCCAGAAGTACCTCTTGCATGCCTGCCAGGGGCCAG GTACTGTTCTAGGAGCTAAGGATATAACAATGAACACAACGGGTTGGAATCTTGCCTGCCTGCAGCTTTC ATTCTTGTGGGGCAGACAGAGCGTCTGAGCATGCCAAGGAAATCAGGTGGCTTCTGGAAGGAGCTAGCTG GGGAGGAAACTGGGAAGAGGGAAACGCTGAAGAGGAGGGGAACAGACGAGGAGACCTCCATTCCTCTATC GTAAATTGGGTGGTCAGGGTGGGGGCTAGCAGAGCAAAGGTGGGAGGGTGCCGGGTAGGCAGGCCTAGCC CCTTGGAGGGCACCACAGTGTGACCCTCGTGTGCCTGGAGTGCACTGAGCGACAGGGAAGAGCTGAGGCT GATGGGGCAGAATAGTTCCTGGGGCAGGGGGCAGGTCTGGGAGTGGCTTGCAGGGCTTTCTCCGGAGGAA CATGGGGAGCTATGGAAGACTTTGGAGGGAGGGAGTGCTGGCAGGACCTGACTTAGTTTTAAAAGGATTA GTCAGACTACTGTGTTAGGAATGGTTTGGGGTGGGAAGGTTCAGGGGCGAAGCTGGGAGACAATCAGAAG GCTACAGGAGAAACCTCTGAACAGGAGGATGTGGGGTGTGATGCCGGGATACGGGTGGAAGCCGAGGCAT GGCGAGAAGCAGGCAGCTGCAGCCAGTCAGAGGGTGGGATGAGCTGGATCCCAGTGGAGAGGGGAGAAGG CAGCTGACTAGGTGCAGGGAGGCCCCATTTGACCATCAGAAAGTCAGGAAGTGGGGCTCAACCAGGTCAC AGAGGCTGCACCGCTGGCAAGTGTGTCCTAAATTCACACTAACTTTATCACACAAACATGGCAAGAATAT TAAAATCTCAGTAAAGGAAGACAAGCCATCACTTATGCTTCCCCAGATTCCTTTCATTCTCTGGGGCAGG GTTGATGGAGCACTTGGTTTTTTGCATGCTGCCCTTTTTCACTAAAAATTATGTGATTAAATTTAGTTTA GTGGGGGGTTTTTTGTAATCACACTCAACAGAGGAAAGCATTATATGATAAGCATTTCCCACATACGTAA TTCATGCGCAAGGCATGGTTCTGCCTGGGAGGCTTGTGGAGTTGCCCCCGCCTCCTTGGGGTGGGTTGTG GGGTCTTCAGCGGTGACCTTCCGCCTTCAGCATGCCCCCTTTTCTGGATTATTTCTGGAGGACAAATCCG AGGTCAGGCTCGTTGAAGACTGTGTTGTGGTTCCTGGCCCTGCTTCAGGGGCGATGTAGTCTAGCGCGAG CTGCCATGCAGGGCACGGAGCATTCGCTTTTGTCTCGACATCCGGCCTTCAGAGGATGACCAGCCTGGCG ACGCACTGGACAAGGAGGTGTAGAGTGGGGATGCACACTAGGCGGTCGGAAATCATTATGCGTTAATGTC ACATCATACCCCAGATGTCCACTGTGTTTGTTTTCAAGTGGTAGAATCGTGGCTTTCTCACGTTCTCTAA AATGAACACATATTGCTTCCATAATTGAAAAAAAAAAAAACCTAACAGTTTTTAAAAAGCAGCCAAGGTC ACCAATATGGTGAAAGGCCGTCCCTACTAAAAATACAAAAATTAGCCGGGCATGGTGGCGGGCGCCTGTA GTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCCTGAACCCGGGAGTTGGAGGTTGCAGTGAGCCA AGATCGCGCCACTGCACTCCAGCCTGGGCAACACAGCGAGACTCCATCAAAAACAAAAAAAAAGCAGCCA AGGCCAGTAGCTGGCTCTCTAGGGCTGCAGTGCAGCTTGGGCTGAGGCAAAGCCACCCTTCCCCACACAA GGCCACTCCTGATCAAGGCCAGGTGGGCGGAGGGGTGTCCCAGTCCCTACTGGTTGATCAGGGTGCCTGG TCCTGGCTCTTCCCAACCAGCACGAGTGAGGACGCAGCTGCAGCAGGACGTAAGCACAGTCATCGCTGCA AACTGCAAACTCGTAAGCACAGTCATCGCTGCAAACTGCAAACTCGTGCTCCGAGCGCTGCCCTCCCCTG TGGAGCGGAGGAGGGGAGGCCTGGGGCCGCGGCGGTGTGCGCCCCGCTCTGACCGCAGAGCCCCCTTCCC GAGGAAAGCGGCTGGCCCGGTCCCGGCTGGTGATCACGCGGGGCCCCTGTCTGCTTGGTGCGCAGGTGAG GGTCTGCCCTTCCGCTGCGCCCCGGACAGCCTGGAGGTGAGCACGCGCTGGGCCCTGGACCGCGAGCAGC GGGAGAAGTACGAGCTGGTGGCCGTGTGCACCGTGCACGCCGGCGCGCGCGAGGAGGTGGTGATGGTGCC CTTCCCGGTGACCGTGTACGACGAGGACGACTCGGCGCCCACCTTCCCCGCGGGCGTCGACACCGCCAGC GCCGTGGTGGAGTTCAAGCGGAAGGAGGTGCTTGTCCGCGCGTGCTGTGGTCTACCCAGTGTCTGTCTCC GGCCACAGTTCGTTTCTCGGTCGGTTTAGTGTCCGTGTAGCCACCCAACCGTGTGGCCGACCATTCGCGC TTTCATTTGTCCTTCGCCTCCGTCTGCGCCGTCTGTCCTAGGGGGAGGGGAAGGGGGAGTCCTGCCAGCA CCCAGCTGGGCCTTGCCTCGGGAGGCAAGGACCAGGACGAGGCCCGAGGGCTCGCGTCTGGGGCATACTT GTGCCGCTGCAGGCGGGCGCGGCGCGCTGCCCGGGCGGGGAGCATCTGCCGGGAGGGCACTCCCTCCCAC CAGCAGTTAGCCCCCAACGGGAGGGCCCTTGAGTGACCACGAGCAGAGCCGGGGATTGGAGAAGGACGGG AAGGCGGATCACCTCCGGCGCCGCCCGCCCCGCCCTTCTCCGGCTCGCGCTGGTGGAGCGCGACCGCCAC CTGCTGGGCCTCGGCCTTCCTGCAGCCGGCCCACCCAGCAGGGGCCGTGGGAGAGTGGGCGTGGGGACTG AGGTAGGTAGTACGTTGCCTTGTTCCGCTTCTCTGGGCACACCACGTGCAGGTTTGGCAGGGAAAGGGGG TCTGGTCGAAAGCACAATTTGTGAGTAAAGGCTATGTGGGCCTCCCTGGGGTGACAGCAGAGGCCTGGTG GGCAGAGCCATCCAGGTGCCCAGCGGCTTTCCTCACAACCCCCTCCAGCCTGGGGTAGGAGGATGCTTGG AACAGAGCGCTCTGATGTACACCTGGCCTCGGAGCTCGGCTCTGCCGGCTGTTCCTGTGTGACCTTGACC TGACCTTCACCCTGTGGGGCCCAGCTTCCTCAGGGGAGAGTGGAGGTGCTCATCCTGCTCTCTGGGGACC TGGATGGGACCTGCCAGCAGGGTGCCTGGGCATCGGCTGTAATTCTCCTTATAAGAGGTCTGCATTGTAC CTGTTACACAGGCGAGGCTCAGTGGCTCAGGGAAGGTGACGGCCAGGCTGGCCAGTGACCCCGTGGGAAC TTGAACCCAGGTCAGACTGTCCCCAGACCTGGCTCTGACAACACACATCTGGTCCACCTATGGGCTGTGT GGGACGTGCAGCATTCTAAGGTCTCTGGTTTTGGGGGGTCTGAGGGGCCCATCTCGCCTGCACTGACCAA CGCCCTCTGCATCCTGCAGGACACCGTGGTGGCCACGCTGCGTGTCTTCGATGCAGACGTGGTACCTGCA TCAGGGGAGCTGGTGAGGCGGTACACAAGCACGCTGCTCCCCGGGGACACCTGGGCCCAGCAGACCTTCC GGGTGGAACACTGGCCCAACGAGACCTCGGTCCAGGCCAACGGCAGCTTCGTGCGGGCGACCGTACATGA CTATAGTAAGAGGGGCTGGTGGCACGGCCTGGCTAGGCCCCCAGGAAATGAGGTGCTCGCTCTTCATGGG CAAGCAGCACCCTACACACATGCACACCTGGCATGGCCCTCTGTGGCCCAAGCCACTTCCCCTCCACCCT CTGCCCAGCACTTCCTGTGTCTCTGCCAGGCCTGCCCTCCAGCCACCAGCAGGGCTTTCACCATGGGACC TCTCTCCCTGAGCTGATCCATGGCCGACCCTGGCAGGGCCCCACCACACCCCCCTGCTGACCTCACCAGG GCTCACCACCGACTGCAAACACACATGTCACCTGAGGCTTTCCTCCAGCCCCTGGCACTCCATCGTTGCC CCTAAGGCGTCCCAAGTGCTTACGGATTATTGCTCCAGCCTCAGCAGCTCTCTGCTAAACAGGCTGGTGT ACAGAAGCAGCCCCGAGCCAGGTCAGGGCTTCTGAGCCCATTATCCTGCCTGACTGCTGACATGCCACCA TGCTCACCTGCTTGCAGGGCACCTTTCAGCAGCGGCCTTGCTTCCTGCCTCCCTCCGCCACCTCCTGCAG ATTTCTCCTGGGATCGCCTTCCAAATAAACCACCTGCATTTGGGGTCTGTGTCTGGTGGAACCCCAGGCC ATGAGTCCTTCACCCCTTTCTGCCTGGCCTGGTCCTGTTCATTCCTCAGTCCTCCCCACCTCACCAAGCC TATGGAGGCCCCACTTGTCAGAGGGGAGACAGCCTCCTTGCCCTGGCACTGAACACCCTGTGTGCCAGAG TGCCCCTCCCATCATTGTTTCCACCACATGAGATCCACAGTGGCAGCACGCGGCAGGTACACCGATGGCA TGACTTCCAGGGCTTGGCCTGCGGGGTCATTGGGTCTGCTGGAGGTTCCTGCAGTGGAGGGTAGTTCTGC CATGCTCTGGGGGAGCTGTCTGGAGGGCTCTAGTGTGTCCTTCCCAGGGCCTTGGTAATGTAGACCTTTA ACCCCCCATGCCTCACACACACACACACACACACACACACACACACACACACACACCCTGTTACCCAAAA AACGAAACTCTGTAAAACATTTTAAAGAGGTTTATTCTGAGCCAGGATGAGTGACCACAGCCTGGAGAAA ACACAAACCCAAGAAGCCTTGAGTAAGTGGTCCCCAGGTCCAAGGTGGTGGAGTTACAGTTTGCTTTTAT ACATTTTAGGGAGACAGGAGTTACAAGCAAGGACATAAATCAACACACAGAAGGTATACATTGGTTTGGC CCCAAAATGCAGGGTATCTTAAAACAGGGGCTTACAGGTTAGAGGTAGATGCAGAGATTCTTTAATTTAC AGTTGGTTGAAAGAGTTAAGCTTTGCCTAAAGACTTCAGGTCAGTACAAAGGAATGTTAAGGAGGCCTGC TATGTGTCGCCTGATGCTATACAGGGTCAGGAGGGAAAGTAAACCACGTTATACCTGGGTAACTTAAAAA AAAAAGGTTTTTAACAAGATTTTATGGACCAGGCATAGTGGCTCACGCCTGTAATCCCAGCACTTTAGGG AGACCGAGGCGGGTGGATTGTTTGAGTCCAGGAGTTCGAGACCAGCCTAGGCAACATGGTGAAACCCTGT CTCTACAAAAAAAAAAAAAATACAAAAAATTAGCCAGGCGTGGTGGCACATGCCTGGATTCCAGGAACCT GGGAGGCTGAGGTGGGAGGATGGCTGGAGCCTGGGAGGTCAAGGCTGCAATGAGATGCAACAGAGCAAGA CTCTGTCTCAAAAAAGAAAACCAATGTTATGGTTTGTAGGGTGTTTCTTAACCCTTGCCTGGCATGGCCT TAGGTCCTGTTTATAATTTGGTATCTTACTGCCACAAAGAGTCCGATCTGTCAGTCTTATGATCTCTGTT TTAATGTTAATGCCGGTCAGTTGTGTCCAAACTCCAGCAGGAAGAGGGCCTAATAAGGCAAGTCCACCCT GCCTTCCTGTCATGGCCCAGAATTCTGTTTTTAAGGTTTTTCTGGTGTCCCTTGGCCAAGAGGGGATCTA TTCAGTTGGTCCGGGGACTCAAGATTTTAGTTTCAGTTTACAACTCTATACACAAACACCCCATACACAC AGGCACCAATACCCTATGCACAGACACCACACAAATGCATACTACACACTTACACATACCACACACACGC ATACCATGCAAGCATATCATACACACAGACACCCCATACAATGCGTACACATGCACACACACACAGGCTG CCTCAAATTGAGAAGGGTTCCTTGGACTTTCAGTTCAGTAAATCCCAACGTTTGAACATTGGTGCTAACT TAGGACCAGCCCCAGGCCTGTTGCATGGCACTGTATGTGTGAAAGTGCGTGTTTGCACCAGTGTGAGTGC AGGGCTGTGTCTGGGAAGAGGTGTGCTACACATGAGGAAGCAGCCAGAGCAGCTTGGTGGTCATTGTTGT GCCCCTACCTGCAGGGCTGGTTCTCAACCGGAACCTCTCCATCTCGGAGAACCGCACCATGCAGCTGGCG GTGCTGGTCAATGACTCAGACTTCCAGGGCCCAGGAGCGGGCGTCCTCTTGCTCCACTTCAACGTGTCGG TGCTGCCGGTCAGCCTGCACCTGCCCAGTACCTACTCCCTCTCCGTGAGCAGGAGGGCTCGCCGATTTGC CCAGGTGAGCCCATACCTATTGCCTGTCTGGGGAAGATTGAAAGGCCAAGGGACATGGGGGCACAGGGAG GCAGGTGACACTGCCTCTTGGCCCAACCAGCACAGAGTAGACTGGGTGGAGTCCTGAGCCCAGGGCCAGG AGGTACAGCTGTGTGCACAGAAGAGGCCTGGGAGAGCTCACAGTGGGCAGGGCTGGGGGCTCCTTGGGCC TCTCTTTTTTTCCCCTTTCCATTCTTGGTATCTTTAAAATGTATTTTCAAAAATGCAAGAGCAATACTGG GTAAATCTGCATATGGTGACTCGGAAGAATCTTCCTGGTGGATTGGTGAGAGTGGCTTGCAGAGATGTTG GTCCCACGTGACTCCCTTTGTGCAAAAGCAGATCTTCCCTGACAGGGATCTGCAAGTGTGCAGAGATCAC AGTGCTGTCCACAGTGGTGCCCTCAGGGGGAGGCAGGAAACGCTTCCACTTTTTACTTTTTGTAACTAGG TTTGCTAGAAAGCGTATATTTATATTTGTCTTTGGAAAATAATGATTAGAAATAGAAGGCATAAAAGTAA TAAATATTCATTAAAGAAGATGAGGCATGAGGCATGAGGCGTGATCCCTTCTACCCATAGGCGCCAGTGT TGCACATCGTGGTGTTCTTTCTGGGATGTTTCTCGTAAGCACTTATTAAGTTGACTTGAAACTGCAGCAC GCATGTTCTCGCATGCCGCTCTCCCTTGCAGAGCAGCCCGTGGCGCCTCCTCTTCAGGGGCCATCTGCCA GTTCTTTCGGGTGGTTCTGTGCCCGCATCAGCTCCTGGCAGCCACCCGTGTCCAGCCCACGAGGGAGCCC ACCCTTGGACATATCTAAGCTCCCCGACCACCTCCTTGGCCTTTAATGGGAGTGGGATCAGAGACAGAGG GGCGACAAGACAGAGGGCCCCGGGGGGTCTCATGGGGGGCGGGGCAAGAGCAGGCATTGCTGAAGTTGGG TCACCTGCCCTCTGTCAGGAGCAACGGGGGCCTGAATCCCAGTCCAGCCTCAGCCTCACTGTGGTCTCAC CTTTCTCCCCAGTTTGTAAAGCTGTGAATTAGGGACAGGAACCCTGAACAATTTTGAGAGTCACATGAGC ATTTGGAAGTGGGCTTTGTAGGGGAAAGTGAGGAGGCCCAGGAGGCTGGTTTTTGCTGTGGTCACTTGTG GGCCTGGGAGAGCCCAGCCCTGCTCTGGCCCGCCCCCATCTCGCCATCTGTGGAACTTTTGGTTTCAAGC AGCTGCAAGAGTTGCCAAGAGGTTGAAAGAATTCAGCTGCCTGACTCCAGGTCCTGGCATCCCCAGGAGA GGCCCCTCTTTCCCAGGGGCTCTGGTCAAAGTCCCAGAGCCTGGCATCCCCAGGAGAAGAGGCTCCTCTT TCCCAGAGGCTCTGCTCAAAGTCCCAGGGAGGCCCCCTGGTCCTGCATGGGCTGGGGCAACCATGCTCCC GAGTCTTGTGGCTGGGGTTCAGTGCTCTGACCAGGGGACACCAGGGCAGGGTGGACCTCTAAACCCTGTG CACTGAGGGAGGAGTGAGGGGTCCCCAGAGCACTGCTGGGGCAGCTGGGAGCAGCCAGGGAGGAGCCTGG GAGACATTCCGGCGGCTTTGTTGTCTGAGTGAGGGAGGAAAGGGGAGTAAAGGGTTGAGTCAGGGCCTGC CTGGGGCTTTTCCTGCCACCAAACTGAACCTCGAGGCCCTGGGTTGCCTTGACCTCCAGCTCCCAGGAAC AGGGGCAGCTGGTAACATGTGGCCTGAGTGGAACGGGGCAGGGCAGGGCTGGGGCAGGTGGGTGGGTATG AAGGCTCTGAGGGGTGGAGGACAGGGTGCTCGGGGGGGCTGCTGTCTCCAGGCCCAGTTGGGGGCTGTTC CAGGACTTAGGCTGTGTGGGAATCTCTACCCTCAGGCCATTACAGGCCGGTCCAGCTGCCTGGCTAAGGT GTTCCCCTGTGCCCCCCTAGATCGGGAAAGTCTGTGTGGAAAACTGCCAGGCATTCAGTGGCATCAACGT CCAGTACAAGCTGCATTCCTCTGGTGCCAACTGCAGCACGCTAGGGGTGGTCACCTCAGCCGAGGACACC TCGGGGATCCTGTTTGTGAATGACACCAAGGCCCTGCGGCGGCCCAAGTGTGCCGAACTTCACTACATGG TGGTGGCCACCGACCAGCAGACCTCTAGGCAGGCCCAGGCCCAGCTGCTTGTAACAGTGGAGGGGTCATG TGAGTGCCTGCTCCAGGGAGGGAGGGTCGGGGTCCTGGGGGCTTCTGGAGCCTGGGCCTCCTGCCCTTTG AGAAAAGCAGTACAGCTGCAAGGCTTAGCTGGGGAGTGGGGAAGGCATGGACCAGCTTCACCCTGAGTGA CCCAGCAGTAAATGGTTGCTCCTTCCAGATAACATACAGGACCTTGGGTAAATTTGAATTTTGGGTAAAC AACAAGCAGTTTTTTGGTATAGGTGTGTTCCATGCAACTTTTGCAGCTTCTCGAAAGACACACCTCTAGG TCCATCCATGCCCTCTTAGGAACATGCTGACACAGCTGCCATTCATGCCATTCATTGTGTATCTGAAATG TAGGTCCCACAGGGCGTCGTTGGCTGAATCTGGCTGCACTCACATCCTTCCTCCTGTACTTACCCCAGCC CAGGTGACCCCTGCTTTGTGACCATGATGTCCTGTACCCTGCCCTGCGCCCTGTGCTCCTGGCACTGTCT TTGCTGCCCTGGGTCTGTCACTCCGGTCCCCTTGGGCTCCATCCGTGGGCAGCTCAGCTGGTGCTGTTCC CTGTCCTTGGGCACTAGCTGGACGCTGGGCCCAGGCCAGCCCCCTGTGACCCTGCTTGTCTGCCACCTGC AGATGTGGCCGAGGAGGCGGGCTGCCCCCTGTCCTGTGCAGTCAGCAAGAGACGGCTGGAGTGTGAGGAG TGTGGCGGCCTGGGCTCCCCAACAGGCAGGTGTGAGTGGAGGCAAGGAGATGGCAAAGGTAAGCCCTGGA AACGCCCAAGGGAGGCCTGCAGGGGCGATGGCACCGGTGGAAACGGGGTCCTGGGGCCCTGCCAGCCTGG GGTGGCTCTCCCTGCTCCAGGTCTGCTTCTGGCACCTCATCCCCCATGTGGCTCTCGATGCCAGCATAGC GGGCAGCAGTGCAGGGCTTGGGAGAGGGCTTGTGAGTACAGTGAATGGTCCCCAGGCCGGATTCACTCTG GACTTGGGAAGGTCTGAACCAAAGTTGGGATGTGCTGGGGACAGAATGGCGTTTTTCTGGGAGGTCCTCG GCCAGGGGATGTGGTGTGGGCAGGGGACTCATTGTCTGCATCAGCCAGAGGCCAGCCTGGGTGTGCCCAC CACCATGAGGGGCCCTCACCATGCAGCCCTGAGAGGGTCCCGGCCTCTTTGCTGTAAGGGCCACCTGTGT GAGGAACCCCCCATACCTCCTCTCCCATAAGCCATGGCTCCCCAGGATGCTTCCGCTGGCAAGGCTCTGT ATATGGTGTTTCCCTACTCAGGCCTCCAGTTGCTCCTCCCTAGAGGGGCAGGATCTGCCTAGGAGGTGGT GGGGGCGTGTGGCGGGGCTCCCACATGGGTGACAGCCTGCTGTGTGTCCTGTGCAGGGATCACCAGGAAC TTCTCCACCTGCTCTCCCAGCACCAAGACCTGCCCCGACGGCCACTGCGATGTTGTGGAGACCCAAGACA TCAACATTTGCCCTCAGGACTGCCTCCGTAAGCAGGGTTTAATCAGGGCATGGGAACAGGTAGGAGATAG TAGGGGAAACCTGGATCCCACAGGCACTTCAGCCAGAGTTGCCAGGGCTGTCAGTTCTATGCATCAAGCT GAGCCTCCTGTGCATTTCAGCATCACCCTAGCCATGGGGAGGGAGCAGGCAGGGTCAGGGACAGGGGGAA GGCAGGGACCCACAGACTGTCCAGGCCCCTGCTGAGGTCCCAGAAGTCGGCACACACAGATTTCAGAAGC AGAGAATGGTCAGTAGGGACACTGACAGGGAAAGTGCGGCCCTGAGCCAGACGAGGGACACTGCAATGTG CGGGTCAGGCCACCAGGCTCCAGTTTTGGAGGCAGAGTCCTTTGTTCAGATGAAATGTTAGGAGGGGGCC TGGCTTCACCCATGGCTTCAGAAAGGCACTGTGACCAAGCCCTGCCCGGCTAAGCCAAGCTGCTGGGCCC CTGGCCTCACTGGGCCTATGCTTGCGACACCAGTTGGGGAGGGGGCTCCTTGGGACACTGCCCTGGAAAT ATGGGCGCCTGGGGTGGTCAGGCGCCCCAGGAGGCTGAGTGGGCTACGTCTGCCCTCAGGGGGCAGCATT GTTGGGGGACACGAGCCTGGGGAGCCCCGGGGGATTAAAGCTGGCTATGGCACCTGCAACTGCTTCCCTG AGGAGGAGAAGTGCTTCTGCGAGCCCGAAGACATCCAGGGTGAGTGGGTGGCGGCCGGGACCACCACCAC CTCCCAGCCCCACAGAGGTCTCAACAGCACATCTGAGGTCCCAACAAGGGAGGAAATTGCTGGGAGGCGA GTGGGCCCCATGAAACTTCCCTCCCTCCCTCTGGGCCTCTGTTACTCCACCCAGGAGAGGGGCCAGGGCC CCTGTAAAGTGTCTTCTGGCCATAAGTTCTATGATGGACAGGCCAGAAAAGCAGTTCTTCCACCAAACAA CTTGTCAGCCTGACAAGTCACTGTCCCTGTGACCATGCAGCTGGGACCCACCCAGGAACACATTTCAAGG TCAGCAGGTATGGTGGGTTGCACAGCCACACTGACTACACTCAGGGGTGCTGTTCTGCCTGAGCATAGGG ACACGTTTCTGTCATTGAGTTTTCTGGTATTATATAGCCCTACGTCCCTAGCCACTTAGCATTTTCATAA AGAAAATGCCAAAGACATTTGGAACAGAGGAAAATTTTGACCTCCCCTGCCAGCCCTCCAGTGCCAGCTG GTGTAATGAGCACAGCCTCTGCTGTGTGACCTTGGCAGGCTGCTCAGCCTCTCTGAGCCTCTGTCTCCAT CTGTAAGAGGGCAATAGTGGTCTAGGAGGGGGCAGTAAATGGCAGTACCCATGCTCGATGGGGTGTTCTC AGGCCTTCCCACACCTCCATGGCCACTTCCCAGCTGGCGCGGACACGGCAGGCTGGAGAGCCATGAGGCA GAGCATACGCAGCCTGTACCCAGTGGTGCCGAGCCTCTGGCGGTGCCAAGCCTCACACCACCCCCACCCA CAGATCCACTGTGCGACGAGCTGTGCCGCACGGTGATCGCAGCCGCTGTCCTCTTCTCCTTCATCGTCTC GGTGCTGCTGTCTGCCTTCTGCATCCACTGCTACCACAAGTTTGCCCACAAGCCACCCATCTCCTCAGCT GAGATGACCTTCCGGAGGCCCGCCCAGGCCTTCCCGGTCAGCTACTCCTCTTCCGGTGCCCGCCGGCCCT CGCTGGACTCCATGGAGAACCAGGTCTCCGTGGATGCCTTCAAGATCCTGGTGAGGGTCCCTGCGGGGCA GGGAAGATCCCCTGCCCTCCCCAGCTGCCTTCCAGGGAGGGAGGCCAGCTGGGGAGACAGAGGCCATCCT GTGAGGGGCTGCCAACGCTGGGCAGACGAGGCCTGTGTTCTGCCCCCATTTCCATAGGGCGCTGTGTGGG GACAGTCTGTGGGGTGGGACTGTGATGAGGTGCCGTTCCCATCTAGGTGAGAGGCAGTGGTCAGGGTCAC AGCATCGGGCAGGGGAGCAGCAGTGTGGATGGAGGGGCACTGAAGTCAGAAGGGGGTGCCTTTCTGGGGA GCCTGGCCTGCAGGTCTGCATGTGCTACTCAGAGCCTCCAGGCTGTGCCGAGTATCCTGGAGCCTCCTTG TCCCGGCCAGGCAGGCCTCTGCCCTCTCCTGGTGGTGGCCTGCCCCTTCAGTGTTCCTACTAGCACTGTC CAGGGCGCTGGAAGCCAAGCCCAGTTCTGGAAGTAACAGAGGCTCAGAGCCAAGGGTGTGAGTGAACGGT GAGCCACGCAGCTTATGGTGGCGTGAATAGCTCCTCGGCAGGAGCCTCCAGGGAGGAAGCTGAGCACCCA GTGGCCACAGGGCCCTGGCAGTTCCCATCTCAGGCTGGGAGGTGGCCTGGGATTCCTGGGAGGGGCCATA TCCCACAGTGCAGCTCAGCCTGAGGCCTCGGCCCTGGAGCCTCCGTTCAGGCAACACCCAGCCCTCGGTA AGGGTGTGAGCCAAGGAGGCCTTCCCAGATGTGGCCACTGCCGCTTCCCCACCAGCTTTCCTAATTGGTG GTCCCCATCCTGGCCTGGCTGCAGCTTAGCCTCATGGCAGGGCTCTAGGATGAGCCACCAGAGTCCTTCA TAAACCCAGTGGGTTTGTGTGAGGCTGCCCAGGAAGGCCGCACTGGTCTGGGCTGCTGCTGGCAGAGACC ACCACCCTAACCCCAGTCAGCTCCAGAGTCACACTCATCAGCACCAGGTCTTGGACCCATGACTCAACCT CAGTATTTGAGAGGATCAGGTTGATGTCGCCCTCATGTGCTTATTGCAGTCTCTAGAGTGTGGTAAACAG GTTTCCAGTGCCAGCTGTGGAGGTGACAGCGGCAGGGAAGCCATGGCAGTGTCGACACTGACCTTGACTG TGGGTTCCCAGGGAATGTGGGGCCAGACCAGGACAGCCCAGGAGCAGGAGACCTGGGGTGACGGATGCCC AGAGCTGGCACATCAAGGGAGGGTTCCTGGATCATGGCAGGCTTTGGCCTCCCTGGTCAGAGTTCAAGTA CTGGGGGCCAGGGTGGGGGTCTGGGAAGGCATCCGGAGCAGTCCCAAGTGGGCCCAATGTGTGGATAGAA CTTTGGTGGGAGGGCAGGGTGGTAGTGCCAGCAGGCAGGGTGAGCGGGTGCGTGAGGGCCAGTGGCAGCC CTTGAGGAGCAGTGCTTCCACACTCTGAGGCGGAACATGGTGGCGCCTTTCTTTGCAGGGGTGGCTATGT AGAGAAGTTGTCCTGGACACTTCCACTGTAGTCAGAGGTCCTGGGCTGGGCCTGGTGCTCATTTAGTCCT GGGGCAGGGGTCAGGGGAGACAGTAGACCAGGAACCAGAGAGGGTCGAAGTACTGAGTCCAAGCCATGCT GTGACCACACCTGTCATGTAGCAGCTTTCAGGGGCCTGGCTGTGGGGTCCTGCCCAGGGCAGAGACAGGC AGCGTTGCCGCTGGCTCAGATGACAGCCGGTTCTCTGCACATTGGAACTTGTCCATGGGGCCTCCTTTAA GGGTCTTGCCTTCTTCCTCCCCTGTCATCCTCACACTTTTCCCCCCTCTTCTCCCCCTTCCCTCATTTCC AACATAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGC GAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCG TGAAGATGCTGAAAGGTACCTGCCAGGCACAGGCACAGTGCCCCTGGGGGAGTCTCCGGGGCGGGGGGCG GGTGAGGCCCCTCCTGCCCAGCATGGGACCCTGAAGAGCCCCCAATGCTGTTCTAGAGCGGCTGCAGTTG GGGGACCCCTACCATGGGCCACTTGGGCCTAGAGAAGCAGAGCGAGGACTTTGCTCTCCCTGGAAGGCTC TAGAGGTGTTGCTGTGCCAGTGCCACTGAAGATCTAAGCTTTAAACATTTAAAAAGCCCTTTGATTTTGA GCTGACAGCTGTCTTCACTCCAGTCTGCCCCATTCATTCCTCTCAGCCCAGTGTCTCCTGGGGTCTTGGT GAAGAGACCACCAGTAAGGACTGGCCCTCAATCTCAAGAGACCCCCATGGGCCTGTCTGGCCTGCATGCC CAGTCATGCCACAAGTTTGGCTCTCGATGGGCACATGCACCTACCCACACAGGCATGCGACTGCACTGAG TAGCCCCCTCTTCTGTGGCCAGGCCCCAGCCCTGTGAACAGCCAGGCTGAATGGCGGTGAGGGAGAGTGG TTGGTGTACATAACAATTATCTGCAGTAGTCGGGGGCTGCACAGCACAGGGTGCTTCCAGATGCCTACCC AGCCCCAGACTGGGTTCACCTCCAAGCCAGTAAAACCCCGGACTCTCCAGGGGCACAGGGAGACCCTTGG ATTTCCATTGCAGCCATGCACAGCCCCAGGCTGCCCACACCTGGTCCAAGGGGTCCTGGGGCCCCAACTC CCAACTGTCCTCTCCCTTCCAGACAACCTTTCAGGACAGAGGAGGTGGCACGGCACAGCTGGGCAGTGGG ACAGCTGACCTGGGAGGGATGGCTTAGCCATGTGTTCTGACTCTTGGAATACCTTCAGGCCCAGGCACCT GCTGGGCATTCCAGCACAGCTCTGGCCACCATCGGGACGCATGTGCTGGGCAGGTGATCCCTGTGGTGCC TCGTCCTGTTTCCATCATGCCTCTACAGTTAGACTCTCTGGGGAATCATGCTATTCATTAAGAATAAGCC AGAATGTCAGGTGTGCAGTGCACTGGTAACACTGCTTTATCTCAGGTGCTAATGTGGGTCTTCTTGGTAA CTAACGGAGTGTGAGCTGCTGACGTGTGTGTGACGGATACATCAGCAGCACAGGAGATGCCTGGGCTCCA GGCTGGCCATCTCAGACAGGAGCGGGAAATGGGGAGCCTGGTCGCGGTGTGTGGACCTCCTTTATGGCTC TCCACCTTCTCCAGGGCCTCTCCCGACAAGTGGGTGTGTGGGTACCCCTCACCTTTCCAGAATGATTAAT GCGGGGAATTTCTGTGGACGACTGTCTTCTAAAGACAATGACTACAGGAACATAATGCCACATACACAGG TGGCCCAGCCCTGGGACACTCTGGGGAAAGATCCGGCATGTGTGGTTGCTGGCTCCTCAGGGTGCTTCTT CCTCAGGGTGGATGAGGCCCCTGTCCACTGATCCCAAAGGCTGGGAGAAGCCTCAAGCAGCATCGTCTTT GCAGGCCTCTCTGTCTGAACTTGGGCAAGGCGATGCAGGTCCATCCTGACCTGGTATGGTCATGGAAGGG GCTTCCAGGAGCGATCGTTTGCAACCTGCTCTGTGCTGCATTTCAGAGAACGCCTCCCCGAGTGAGCTGC GAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGC CTGCAGCCAGGATGGTAAGGCCAGCTGCAGGGTGAGGTGGGCAGCCACTGCACCCAGGCTGGGGGCTCCA TACAGCCCTGTTCTCCCTCTTTCTCCCTTTCCCTACTGCTCCTGCCCTGTTTCCTGTTCTCCCTCTTTCT GGAAGCCTGGCTCAGGCCCCAGCCTGGAGCTTGTGTCTAGCTGAGTCCACGGGCTGAGTGGTCACTTTCC ATCAGAGGGGCCCCGCGCTAGCGGCACTCCCTGGGCCCACAGGGCTACTCAGAGGTCTCTGGTGTGACAC TGCCATGTGTCCTCACCCAGTTCGGGGCTGGGCCCGTGGGGCAGGGAGCTCTAGGAATGGACAGTGCATC CTGGGTACTAGGGTACCCTGGGTACCACAGGGCACCAGGTGTGCTGTGACCTCAGGTGACCCCAGCCCCG CCCTGCATGGCAGGAACATTGTCACCATTTCTCAGATAAAGACCCAGGAGACCAGCCTGGTTTGTTGGTT TTCCAAACCACCATGCTGCTCAGGGGCTTCCCAGCATGCGTGTGTGGGTGTGTGCGAGAGGGATAGGGAA CCCAAACACCGGGAGTGCGCAGCAGGCACTGTGGTCGGCACCAGTAGAGTTGGAGGCTGGGCCTGGGACA GGACAGGTGGGAACAGGGAGCAGGCTGTGTGCAGAGCCCAGCGCCAGGCAGGAACCCTTGCATCTGCGCA GGCCTCTGCCTCCATCAGCATCCCCAGCCTGCACTGGGGCAGGACCCAGGAGGCAAAAAGGCTTGGCGTC CTAGCATCAGGGAGGGGTGCCTCCCAGGGCAGTGTCGCCTGCCTCAGGCACCTCGAGAAGGAGGCACCCA CACGAGCAGCAGGAGGCAGAGAGCAAGTGGTTCAAGAGAAAGCTGAGGCTTCAAGGTCTGCGCTCTCCAC AGAGCTGCAGCAGTGCTGCCTGAGGCAGGGCTGTGTCCACCCCCTTACTCATTGGGTGGCCGGGCCTGGG GACCCTGCGGCCTCCCACCCCTGGCTCCTGGAAGACCCAAGCTGCCTGACCCGCACGCCCAGGGCCCCCT CTCTCCGCCCCCAGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTC CGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACC ACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCA GTATCTGGCCGAGATGAAGGTGCGTGCATATGGCTCTGCACCCAGCCAGCCCCGGCCAGGCCACACCCTG ACCCACCACGCCCCTGCCACCCACACCCTGGCCTGCCACTCCCCCACCATGCCACACTCTAGCCCACCAT GCCCCTGCCATGGCATGCCATGCTATGGCTCACCACGCCCCTGCCATGTCACACCCTGACTCCACCACGC CCCTGCCATGCCACACCCCCGGCCCAGGTCTCACCAGGCCGCTACCCGGGCCACACACCACCCCTCTGCT GGTCACACCAGGCTGAGCCAGTGACCGCTGCTGCCTGGCCATGGCCTGACGACTCGTGCTATTTTTCCTC ACAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCG GATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGTGCCCAGTCCCG GGGATGAGGCGGGGCTCCCAGGGATCCCAGGTGCACCATGGGGCAGGCAGTGCCCTTGGGAAGCCTAGGA AAGATACCGAAGATTAGTGGAGCTCTAAGCTTTTTATAGCCCTCACCCCAAATCTTTCTGACCCTGGGTC CCCAAGGACCCAATTAGAACTCCGCTCAGCCTCTGCCATGTCCTTCTCCTCCAGGGCCTCCAGGGCACCC CTCCCTGGCAGCATACTGACCCGAGGCCCTTGCCGCACTTTTCAGAGGCCACCTCATGCTGCGGAACTAA CAGTCCTCTTCTGCAGAATAAAGGTCACCGTTCTGATATGACCTTAGCTCTTTTCTCAAAGAAGGGTGGG ATGAAATTAGCAGGATCGTCATTCTTTGCAAAAAGGAATGAACTGCTTTACAAGTGAGGCTTCTCCCGCA CAGGGGCCTTGGACACTGGGCTGGGTGAGTTTAGAGGCATAGGAACCCCCTGGACAGGATCCAGAAACGC AGCCCAGCTTTGTCCAAGTCTATGAAACAGGCAGTGGGCACCCTTGGGGACACCTGGTTCCCTACCATGG TCCTAGTCCCGGGACAACTGCCTTGGCCCTCTTAGTTTTTCTGCCCATGTCAGCCCCTCTCCTGCAGCCT CCCAGTGGCAGCCCAGGCAGGGCAAGTTCAAGGGGCTGCTCAAAGGCCATGCCGCCCAGACGTTCAGAGC AGACCCTGCTCAAAAAAGAAGAAGAAGAAAAAAAAAAACCACAAAAGGCGACTTCCTATGATTCAGCTTT GCTCTGAGGGGTCTGGAGAAGCCATTTGTGTTGCCAGGGGTTGTGAGCTGTTCCGTTTCTTCTGGGGTTT CCCTTGTGACAGCAGATCTCAGAACTGCTGTGGGGGGAAGTGGTAGGGGCTGGCCCCTGCCCTGTGGAGG GTGTGGACAGAGCCTTCCTGTTGATGCACTGGTCCTCCAGGGAGAGAAGCTGAAGGCATTCTTATACAAG ACGTGCAGGCTACACTGTCACACACTGCTGCCAAGACAGCCACACTGCACTAAGGACATAAATCCCTCAT GTGTTTAAGTAAAAGAAGTGACAGTAAGATTGTGTTCCAACCCAAGGCACACATTTTAAAAATGGACTTG CACCTTCAGGCTTGTCTGTGGAGAAGCTGTTTCTCAAGTCACCCTGGAAAGGATTTGTTAGGTCAGACCC CAGCACTGATGAGGGATGTAGGGGGCTGGGGGCACTCATTCAGAGATGCTAAAAGCACCCTGCAATACAA TAAGAGAGAAAAAACAGCCTCCCCCAAGGCACACAGACAAATCCCTTCCCTCAAGGCTCCTTCAGTGTGG TAGCTGCTGGCAAAGTGCCCAACATGGAAATGCTAGATGTTGGTTTCCCAAACACATTGGCCCTCAGAAC CCCAGGGGAGATCTTGCAGGGGGAGTTCCAGGCCCATGCATAGGGAAGCACTGCTCTGCACTACCAGCAG GCCTGTGGCATGTGACAAGCTGGCCCTGTGTGCCTGTGGGTGGGCAGCTGACTCCCGCCAGCATCTCAGC AATCCACAGGAGGTTCAGGCTGGAGCTCCAGCCCCTTCAAAGATGTGTGTGGCCAGTTCTGTGCCCAGGA GTGTCTACAGCACTCCTCTGGTTACTGAAAGCTCAGGGATAGGGCCTGGCCTTCTCCTTTACCCCTCCTT CCTAGAGAGTTAGAGTAACTTCAATGTCTTTATTCCATCTTCTCTTTAGGGTCGGATTCCAGTTAAATGG ATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTGTAAGTGTGGGTGTTGCTCT CTTGGGGTGGAGGTTACAGAAACACCCTTATACATGTAGTGGGGCCACGACGCCCGTCTGTGCAGCTTGG CCAGGGAATTGCACTGGCCCTGAGCACCTGTCTGCAGTGCTAGCCCTCTGCAATGACCCCCTCACTGAGG GGCCTTCATGATGTGTTCGTGAGGCAAATGGCTGGGCCAGGCCGGGCTGCAGTTCTGAAAGCTCCGGTAG AGCATGAGAGCCGAGCAGGTGGCCAGTAACCCAGCCTCCCCCACCCTTGCTAGTCCCATGCCTCCCTCTG GGTCCCTTGGTGACTCAGGCCCAGCCCAGCAGTTACCCTCCTGTGGTCCTGAGTAGGGCTTTGGGCTCAG GCAGAGCACCCAGTGACTTGCCCCCACCCACAAGTGGAGCTTGGGGACTCCACCTGAAGATGGCCTTGTG TGAGTTTATAGATTGGTGTGCCCCAAACTGCTCAAAGGTGGAAGCCAAAATCTCATTCTTCCAGGTCCAA TGACAAGAGCTGATCACTTTTAAAACACAGGATTCTTGCCTCTAAAGTGTTCTACAGTCAGCAGAGGTGT GATGTGCCTCTCTTTTTTTGTGGGGGGAGGGGATAGGGTCTCACTCTGTCACCCAGGTTGGAGTGCAGTG GCGCAATCCTGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCGATTCCTGTGCCTCAGCCTCCTGAGT AGCTGGGATTACAGGCACGTGCTACTTCGCCTGGCTCATTTTTTTGTATTTTTTGGTAGGGACAGGGTTT CACCATGTTGGTCACACTGGTCTTGAATCCTGACCTCAAATGATCCACCCACCTCAGCCTCCCAAAGTGC TGGGATTACAGGCGAGAGCCACCACGCCTGGCCAACATGTGCATCTTAAATACTGTGGGCTGTGAATAAG CAATTGGACAACAGCTTTCCGATTATATAAGCTGACTGTAGGCTAGTTGGAAAAGGCAGAGAAAAGCATA AAGAAGAGACTGAATGTCATTGGACCACACCGCCCAGTGACCTCTGGCTGCCCTCTGGTGTGCTCCGTGG TGTGCACATGTATGCTTTTTATTGCCCTAAATGGGCTCATGCGATGCTGTTTTGTGATATGATTTTGTTC CCATTGCAAAGCGAGTTTTCCTTCACAGTTAAAATGTTTTTCTATAGCTTTTTTTCCTTCTAAGATTTTA TGAAATTTTCCAAGCACATAGAAATGGCAAAAGAACTATACAAGGCACTCTGAGTCTGGTGGCCTGCATT CTCACCGCTTTAAGTGTGAGAATCTTAAGAATTATTAAGATTAATTCATGATATTAATTAATGTATCATT AATTCATTAATCATGAATTCATCTTAAGCCTCATGTGTCCCTTGTGCGTGTGGCTGCTCTGATGGGAGTG GCTTGGGCAAGGACTTCAGCTTCATGGAGTAGGGGCCAGGCAGGCAGGCAGCCCTTCCCCACCTTCATGC TACATCCATCTGAGCAGCCAGACCCAGGCTGACATCTGTGAGCATCTGTGCTTGAAGCCGACAGGGTCAG CAGGTGCTTGGTGGTGGGGGTGGATATCTGGGCCCCCCGGAGGGCTCTGTGAGGGCCAGGTGGAGCCACT CACTGGTCCTTTCACTCTCTGCAGATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGA AACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGC CAGACAACTGCAGCGAGGAGATGTGAGCGGGGACTGGCTTTGGCCCAGCCTCACTTGGGAAGGGAGGGGA CATCTGTGTGCATTCCCTCCCCATCCAGAGCAGCCCCAGGAGAAACCAGGAGAAGTGGGGGGTGGGGAGT GGGCAGGGCAGAGGTTAGAGAGCCATCCTTGGGTGTGGCAGTAGATGCTGGGGGTCCTACCCCACTGAGG GCTGGTGGGCTTCCTAGGGGGTCTTATAAAAATGAGTGAGAGCAGAGACTGGTGCAATGCAAGCTCAAGG GCTGAGAGCTGTCCCAGCAGGACACTTAGGGAGGAGAAGGTAATTCCAGATGGCCCAGGGGGCACGTGTT AAGGGGTGCCTGAGTGGAGGTGCAGAGCCAGGCAGGGGCAGCCTGGGCTGCAACCTGAGAGGTTGAAACC TTTACACTCTCAGGGGAGATGGTCTTAGAAACCAGGCTGAGAACAGATGAGAAAGGGCTGCCCAGAGGCA GAGATGCATGGTACATGCATTCCACAGAGTGTGCACACTGCTGGGGCGTGGAGGGGGCATGCTGGGCCGA GAAGCCAGGTACCACCTCCCTGGGCCCCCAGCTGGTGGCCAGCTGGAGCGCTGTGGTCTGCCTGGGCACC CAGGCAAGCAAGGACGGTGCAGGACAGACGTGTGATTGCCAAAGGTTCTTGTTTGTCTGTCTCCACACCT AAAAGCCCTCAATCAATTCATTCTTCTTGAGAGTTTTAAGGACTGGCACTTCTCACTTAGCTGCCAGAGC AAGCATAGTATCCAGTGAGCTGTTTACCAGTGTCTTTGCAAGGGAAGTAAAAATGAATCTCCCTTGGAGG GAAGGGAAGCTTGTAGGATTCTGGACCACAGCTCTGAGAGACCTGAGCACAGTGGCCCACGGGCTGGGAT CCTGCAACAGGCCATGCCCCAGTCCCACGAGGCTCAGAGATGTCAGCGATGCAGAAATAGCTTTGGAGTT GGAGACAGAGCACACTGGGCCCAGGGTACAGGGCAGGGTGCGATGGCTGTGGTGGGCTGTCCTTCTGAGA CCTGGCCCTGCTTGGATCATATTGGCCTGTCTGCTCTTCCCACCAGGTACCGCCTGATGCTGCAATGCTG GAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAG AGGAGAGTGAGTGCCTGGGTCCAATTCCCACAAGCTGAAAGTGGCTTGGGGAGACTCCAGCCTCACCCCA GGGCAGTAGTTTTAGCCCTCAGAGTTCCCAGTGTGGGGCCACAGTGGGATTGTGCAGAGAGAGAGAGTCA TGCTCTCCCCTGCATGCAGACAGCAGATTGAACCCTTCTCAGGCCAGGCCGCTTGGGCTTCTTTTCAAGT CATGAAGAAACCAAGATTCTTGACATTTAGGAAAAGCTCTCTACAGACAGGCATGGGAGGAAAATATTCC AAAGCCAAAAAGAAATAGTTTTCCATAATGGAAAATGAGAAAGTTGAGTTAAAGCAAGTGCCCAAAATTC AGATGCCCAGAGGGGGGTCCGGCTGGAGGAGGGCAGTGAGTAAGGAGCAGTGGAGACTGTGGCAAACAGC CAGCCCCCTCCAAAGGGTTCCTTGCTGGAGTACCTGTGGCCTGCAGAAAAAGGAGCCAGGAATGGGCTGG GTCTTCTGAATTTTATGAGGTTTATGTTGTCTCCCAGTTTTTATTGTTAACAATTCATTTAAATTTCCCA GAGCCGAACGCAGGCCAAACAAAGCATATCGGGGGGTGGCCAGAGTCAGCCTGTGTGCCTGGAAGTACAG TTTGTGAGGTCTACACATTTTCAACCAATATTCATCAGGCAGCTGCTAGGACCCATACTATGTCTCAGAG GCTGGGAATGCAGATAAACAAGACCAGCACAGCCCTGCCCTCACGGGGTTTACACACAGGCCTTGTCTTA ACATTGGCACATTTACTGAGTTGTCACTTCTTCCGACTTGGATAGCGGGATGCAGGACCTAGGACCCCAT AGGAAAACTTCACATCACTGTCTCGCTTGGATGAAAACTTCAAGTCCTGAGAATGCAGCGTTGTTCAAAA CAGAAGCGATCACTGGTGCTGGCCTTCCTAGAACAGTGCTGAGAAACAGCCGGGAAAACGCTGGGCCCCT CTGTGCACATTCAAGCTGGGCATTGAAAGGAGCAGACGCCAGTGGCCCCTCGTGCTGGGGAGCCCGTGCC TGTAGCAGGGTCCTGTGCACCCTGACAGCGCTGTCAGATTTCAGAACTCAGCCCTGACGTGACGTTCTAG ATGGCAGGGGTCCTTGGGGAAAGCTGGAAAACATCCTGCAGGCTGGGGCTGCGTCCTGGCATGTGGCTGC AGTGGGCTCCCCCAGAGCCCAAGGGTTTGTCAGCGGGCTGGTTCCGTGCTGCCCATCTCCGGGTTGGGCC AGGGGCAGCTAGATGAGGCGTCCCCCAAGGCTGCCCTCCAGGCCCTGGAGATAAGACGCTGAGGGAGCAC ATTTCTTTCCCCAGGGAGGTGACTTTCCAGGGGAAGAGACAGAATAGACAACACCCAGGGGAGTGATGGG GACCTCAGAGCAGGACCAGGCCAGCCAGGAGTCCTGGGAGCTCTATGCAGCCTGGCCCTGGTCTCTTGGA GAGGTCAGGAGATTGGTGCGAGGTGGAGACACAGCCAGAGCCTCTGCCCTGAGGATGGCTTGTTGTATAC TGAGTTGTATCTAGTTGTGGCACATGGCTTGGAGTGACCGGCCATCTCTGTCTTCCAGGACTACTTGGAC CTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGG TGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAG AATTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCCCTTTGCACTATCCTTCCTCTCTGTGATGCT TTTTAAAAATGTTTCTGGTCTGAACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTAAATGTCTGAC TTTGCATCCAGTTTACATTTAGGCATTATTGCAACTATGTTTTTCTAAAAGGATGTGAAAATAAGTGTAA TTACCACATTGCCCAGCAACTTAGGATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTCAGGGGAGAC CAAGAACAGGTTGAATAAGGCGCTTCTGGGGTGGGAATCAAGTCATAGTACTTCTACTTTAACTAAGTGG ATAAATATACAAATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGCACCACTCAGCCTGCACTGGG AGCACAGCCAGGTTCCCCCAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCG AGCAGCCACTGGCCAAGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATCAGGGGTAGCGAGGTTGCAG GAGCTGGCTGGCCCTGGGAGGACGCACCCCCACTGCTGTTTTCACATCCTTTCCCTTACCCACCTTCAGG ACGGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAAGAACATGGTCTGTGGTG CTGTGGTCTTACAATGGACAGTAAATATGGTTCTTGCCAAAACTCCTTCTTTTGTCTTTGATTAAATACT AGAAATTTTTTCTGTTTCCTAACTTCATCATTGATTGTTTGAAATCTTGGAGTTTCAAGCATTTTTTTCA AGCTGAGACGGTTCCTTTTGCATGCCTCCTGACTCACTGACTCCTCACTGGCTTTGTGTCTAGTGCCACA CTCCATTTGTGCTGACGATGCTATGAGGCTGGCCCGTGTGCACCCTCGATTTGGAAGGTCCTCTTCTCCG TTGTAGGCTCAGACAACAGACGAGTGCCTCCTTTACGTTAGAGAATGTTTTATAGAACGTTTCCGCTGCA GTAAGCCATTGAGTGCAGCAGTGTGCTGTTGCCCTACACTGCCTTAGAAAAAGAGTTAAGCAGTTCGACA AATATACATCAGATTAGAGAGTCTCAAGTTCATAAAAGTCAAAATTGGTAGTGTCTGTTAAGTTACATTT ACCAAGAGAGCACATGATATTTCCCCTAACTATAACAGTGTTTTTGGAAACCTGGAACACAAAACCATTA ATATAATTGGCACAGAAACCACGAGTTTGGTTTGAACATCAAAGGGAGTTTTGCCAAGGCCTTACTGTCT GCACTTGAAGTTTTGGTTCTTCAGTGCAGAACAAATGATCTGTTTTCATTTTTAGGCATGTCAGACCCGA ACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCC AAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGACACGTTTGATAGT TAACATTTCTTTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCGG CCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAG TTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGATAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACA CCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCTTTCTCTTCAGTGCCCAGCAGCACCCAGTGTT GGTCTGTGTCCATCAGTGACCACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTTACTACCTGGTG TATGAAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAATTTAAACATGA AGCACACACACAAAAAAGGCAGTAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAGAATGAGAGA CTGCGGGGGGGGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGGATG GGCCTGGGCTCAGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCATGCAACCTTTCCTTAGGAAGAC ATTTGGTTTTCATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTAC TATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCCCGGGCCCACCACATCATCC TCACGTGTTCGGTACTGAGCAGCCACTACCCCTGATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTC CCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATCCCACCTGCCACCAGCCTGCAGCACACCCCAC AGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGTACTCACTTTAA TTTGAATCTTATCAACTTACTCATAAAGGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCAATGACAATGA CCAAGGACTGCTACACCTCTGATTACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTATAGAGCCTG TGTGAAAGGCCCATGGATCAGCTCTTCCTGTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTTTCT TAGATTCTGACCATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGTTTGTGGTCACAGATGCACAAC ACTCCTCCAGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACTG TAACTTCGCAGAAAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGACTTAAAGCACTGATAGGACT TAAAATAGTCTCATTCAAATACTGTATTTTATATAGGCATTTCACAAAAACAGCAAAATTGTGGCATTTT GTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACACACCCAGAGGGAGAGT TTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACACTGTGATAAGT TCTTTTACAAATATCTATAGACATGGTAAACTTTTGGTTTTCAGATATGCTTAATGATAGTCTTACTAAA TGCAGAAATAAGAATAAACTTTCTCAAATTATTAAAAATGCCTACACAGTAAGTGTGAATTGCTGCAACA GGTTTGTTCTCAGGAGGGTAAGAACTCCAGGTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCTTGA CCAATTTATCCTTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAAAGTCCCCATCCTTATTAGCTC TACTGGAATTTTCATACACGTAAATGCAGAAGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTAA TCTGTCAGTTATTAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTT GTAATCAAGGTGACTAAGAAAATCAGTTGTGTAAATAAAATCATGTATCATAAAA    Download   Select all
Length	53325
OMIM ID	164761
HGNC ID	HGNC:9967
Unigene ID	Hs.350321
Ensembl ID	ENSG00000165731
PharmGKB ID	-

mRNA Information

mRNA ID	XM_011540027.1
Exon	join(1..305,23433..23696,25316..25603,27926..28167, 29350..29545,32005..32204,34181..34439,35073..35198, 35827..35937,36530..36649,37454..37710,39558..39705, 41347..41454,42505..42719,43055..43177,44920..44990, 46645..46782,47857..47956,49549..49696,51086..51259, 52492..53325)
mRNA Sequence	>5979 AGTCCCGCGACCGAAGCAGGGCGCGCAGCAGCGCTGAGTGCCCCGGAACGTGCGTCGCGCCCCC AGTGTCCGTCGCGTCCGCCGCGCCCCGGGCGGGGATGGGGCGGCCAGACTGAGCGCCGCACCCG CCATCCAGACCCGCCGGCCCTAGCCGCAGTCCCTCCAGCCGTGGCCCCAGCGCGCACGGGCGAT GGCGAAGGCGACGTCCGGTGCCGCGGGGCTGCGTCTGCTGTTGCTGCTGCTGCTGCCGCTGCTA GGCAAAGTGGCATTGGGCCTCTACTTCTCGAGGGATGCTTACTGGGAGAAGCTGTATGTGGACC AGGCGGCCGGCACGCCCTTGCTGTACGTCCATGCCCTGCGGGACGCCCCTGAGGAGGTGCCCAG CTTCCGCCTGGGCCAGCATCTCTACGGCACGTACCGCACACGGCTGCATGAGAACAACTGGATC TGCATCCAGGAGGACACCGGCCTCCTCTACCTTAACCGGAGCCTGGACCATAGCTCCTGGGAGA AGCTCAGTGTCCGCAACCGCGGCTTTCCCCTGCTCACCGTCTACCTCAAGGTCTTCCTGTCACC CACATCCCTTCGTGAGGGCGAGTGCCAGTGGCCAGGCTGTGCCCGCGTATACTTCTCCTTCTTC AACACCTCCTTTCCAGCCTGCAGCTCCCTCAAGCCCCGGGAGCTCTGCTTCCCAGAGACAAGGC CCTCCTTCCGCATTCGGGAGAACCGACCCCCAGGCACCTTCCACCAGTTCCGCCTGCTGCCTGT GCAGTTCTTGTGCCCCAACATCAGCGTGGCCTACAGGCTCCTGGAGGGTGAGGGTCTGCCCTTC CGCTGCGCCCCGGACAGCCTGGAGGTGAGCACGCGCTGGGCCCTGGACCGCGAGCAGCGGGAGA AGTACGAGCTGGTGGCCGTGTGCACCGTGCACGCCGGCGCGCGCGAGGAGGTGGTGATGGTGCC CTTCCCGGTGACCGTGTACGACGAGGACGACTCGGCGCCCACCTTCCCCGCGGGCGTCGACACC GCCAGCGCCGTGGTGGAGTTCAAGCGGAAGGAGGACACCGTGGTGGCCACGCTGCGTGTCTTCG ATGCAGACGTGGTACCTGCATCAGGGGAGCTGGTGAGGCGGTACACAAGCACGCTGCTCCCCGG GGACACCTGGGCCCAGCAGACCTTCCGGGTGGAACACTGGCCCAACGAGACCTCGGTCCAGGCC AACGGCAGCTTCGTGCGGGCGACCGTACATGACTATAGGCTGGTTCTCAACCGGAACCTCTCCA TCTCGGAGAACCGCACCATGCAGCTGGCGGTGCTGGTCAATGACTCAGACTTCCAGGGCCCAGG AGCGGGCGTCCTCTTGCTCCACTTCAACGTGTCGGTGCTGCCGGTCAGCCTGCACCTGCCCAGT ACCTACTCCCTCTCCGTGAGCAGGAGGGCTCGCCGATTTGCCCAGATCGGGAAAGTCTGTGTGG AAAACTGCCAGGCATTCAGTGGCATCAACGTCCAGTACAAGCTGCATTCCTCTGGTGCCAACTG CAGCACGCTAGGGGTGGTCACCTCAGCCGAGGACACCTCGGGGATCCTGTTTGTGAATGACACC AAGGCCCTGCGGCGGCCCAAGTGTGCCGAACTTCACTACATGGTGGTGGCCACCGACCAGCAGA CCTCTAGGCAGGCCCAGGCCCAGCTGCTTGTAACAGTGGAGGGGTCATATGTGGCCGAGGAGGC GGGCTGCCCCCTGTCCTGTGCAGTCAGCAAGAGACGGCTGGAGTGTGAGGAGTGTGGCGGCCTG GGCTCCCCAACAGGCAGGTGTGAGTGGAGGCAAGGAGATGGCAAAGGGATCACCAGGAACTTCT CCACCTGCTCTCCCAGCACCAAGACCTGCCCCGACGGCCACTGCGATGTTGTGGAGACCCAAGA CATCAACATTTGCCCTCAGGACTGCCTCCGGGGCAGCATTGTTGGGGGACACGAGCCTGGGGAG CCCCGGGGGATTAAAGCTGGCTATGGCACCTGCAACTGCTTCCCTGAGGAGGAGAAGTGCTTCT GCGAGCCCGAAGACATCCAGGATCCACTGTGCGACGAGCTGTGCCGCACGGTGATCGCAGCCGC TGTCCTCTTCTCCTTCATCGTCTCGGTGCTGCTGTCTGCCTTCTGCATCCACTGCTACCACAAG TTTGCCCACAAGCCACCCATCTCCTCAGCTGAGATGACCTTCCGGAGGCCCGCCCAGGCCTTCC CGGTCAGCTACTCCTCTTCCGGTGCCCGCCGGCCCTCGCTGGACTCCATGGAGAACCAGGTCTC CGTGGATGCCTTCAAGATCCTGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTT GGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAG GCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCT TCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTG TATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCC TGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCG CAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTT GCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGG CAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCG AGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATG GCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCC TGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTT CAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGC CTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAG ACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGA CTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCC CCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGA ACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAG ATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGAC ACGTTTGATAGTTAACATTTCTTTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCTGA GAATGGAAAGTCTACCGGCCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGTTCAGTTCCC AGGTGGCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGATAGCCG GTGATTTTCCCTCCTAGCAGACATGCCACACCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCA TTCCTTTCTCTTCAGTGCCCAGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGACCACCAACA TTCTGTGTTCACATGTGTGGGTCCAACACTTACTACCTGGTGTATGAAATTGGACCTGAACTGT TGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAATTTAAACATGAAGCACACACACAAAAA AGGCAGTAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAGAATGAGAGACTGCGGGGGG GGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGGATGGGCC TGGGCTCAGCATTCGAGATCTTGAGAATGATTTTTTTTTAATCATGCAACCTTTCCTTAGGAAG ACATTTGGTTTTCATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAGAGATTCCATGCC ATCTTTACTATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCCCGGGC CCACCACATCATCCTCACGTGTTCGGTACTGAGCAGCCACTACCCCTGATGAGAACAGTATGAA GAAAGGGGGCTGTTGGAGTCCCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATCCCACC TGCCACCAGCCTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTG TTAGGAGCAGGTAGGGCTTGTACTCACTTTAATTTGAATCTTATCAACTTACTCATAAAGGGAC AGGCTAGCTAGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACTGCTACACCTCTGATTAC AATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGCCCATGGATCA GCTCTTCCTGTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGACCAT GACTCATAAGCTTCTTGTCATTCTTCATTGCTTGTTTGTGGTCACAGATGCACAACACTCCTCC AGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACTGTA ACTTCGCAGAAAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGACTTAAAGCACTGATAG GACTTAAAATAGTCTCATTCAAATACTGTATTTTATATAGGCATTTCACAAAAACAGCAAAATT GTGGCATTTTGTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACA CACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTTGGGCTGTT TTTCAGATACACTGTGATAAGTTCTTTTACAAATATCTATAGACATGGTAAACTTTTGGTTTTC AGATATGCTTAATGATAGTCTTACTAAATGCAGAAATAAGAATAAACTTTCTCAAATTATTAAA AATGCCTACACAGTAAGTGTGAATTGCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCAG GTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCTTGACCAATTTATCCTTGACCAATAACC TAATTGTCTATTCCTGAGTTATAAAAGTCCCCATCCTTATTAGCTCTACTGGAATTTTCATACA CGTAAATGCAGAAGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTAATCTGTCAGTTAT TAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTTGTAATC AAGGTGACTAAGAAAATCAGTTGTGTAAATAAAATCATGTATCATAAAAAAAAAAAAAAAA    Download   Select all
Length	5629

CDS Information

   

Location	join(233..305,23433..23696,25316..25603,27926..28167, 29350..29545,32005..32204,34181..34439,35073..35198, 35827..35937,36530..36649,37454..37710,39558..39705, 41347..41454,42505..42719,43055..43177,44920..44990, 46645..46782,47857..47956,49549..49696,51086..51243)
CDS Sequence	>gi|126273511:191-3535 Homo sapiens ret proto-oncogene (RET), transcript variant 2, mRNA ATGGCGAAGGCGACGTCCGGTGCCGCGGGGCTGCGTCTGCTGTTGCTGCTGCTGCTGCCGCTGCTAGGCA AAGTGGCATTGGGCCTCTACTTCTCGAGGGATGCTTACTGGGAGAAGCTGTATGTGGACCAGGCGGCCGG CACGCCCTTGCTGTACGTCCATGCCCTGCGGGACGCCCCTGAGGAGGTGCCCAGCTTCCGCCTGGGCCAG CATCTCTACGGCACGTACCGCACACGGCTGCATGAGAACAACTGGATCTGCATCCAGGAGGACACCGGCC TCCTCTACCTTAACCGGAGCCTGGACCATAGCTCCTGGGAGAAGCTCAGTGTCCGCAACCGCGGCTTTCC CCTGCTCACCGTCTACCTCAAGGTCTTCCTGTCACCCACATCCCTTCGTGAGGGCGAGTGCCAGTGGCCA GGCTGTGCCCGCGTATACTTCTCCTTCTTCAACACCTCCTTTCCAGCCTGCAGCTCCCTCAAGCCCCGGG AGCTCTGCTTCCCAGAGACAAGGCCCTCCTTCCGCATTCGGGAGAACCGACCCCCAGGCACCTTCCACCA GTTCCGCCTGCTGCCTGTGCAGTTCTTGTGCCCCAACATCAGCGTGGCCTACAGGCTCCTGGAGGGTGAG GGTCTGCCCTTCCGCTGCGCCCCGGACAGCCTGGAGGTGAGCACGCGCTGGGCCCTGGACCGCGAGCAGC GGGAGAAGTACGAGCTGGTGGCCGTGTGCACCGTGCACGCCGGCGCGCGCGAGGAGGTGGTGATGGTGCC CTTCCCGGTGACCGTGTACGACGAGGACGACTCGGCGCCCACCTTCCCCGCGGGCGTCGACACCGCCAGC GCCGTGGTGGAGTTCAAGCGGAAGGAGGACACCGTGGTGGCCACGCTGCGTGTCTTCGATGCAGACGTGG TACCTGCATCAGGGGAGCTGGTGAGGCGGTACACAAGCACGCTGCTCCCCGGGGACACCTGGGCCCAGCA GACCTTCCGGGTGGAACACTGGCCCAACGAGACCTCGGTCCAGGCCAACGGCAGCTTCGTGCGGGCGACC GTACATGACTATAGGCTGGTTCTCAACCGGAACCTCTCCATCTCGGAGAACCGCACCATGCAGCTGGCGG TGCTGGTCAATGACTCAGACTTCCAGGGCCCAGGAGCGGGCGTCCTCTTGCTCCACTTCAACGTGTCGGT GCTGCCGGTCAGCCTGCACCTGCCCAGTACCTACTCCCTCTCCGTGAGCAGGAGGGCTCGCCGATTTGCC CAGATCGGGAAAGTCTGTGTGGAAAACTGCCAGGCATTCAGTGGCATCAACGTCCAGTACAAGCTGCATT CCTCTGGTGCCAACTGCAGCACGCTAGGGGTGGTCACCTCAGCCGAGGACACCTCGGGGATCCTGTTTGT GAATGACACCAAGGCCCTGCGGCGGCCCAAGTGTGCCGAACTTCACTACATGGTGGTGGCCACCGACCAG CAGACCTCTAGGCAGGCCCAGGCCCAGCTGCTTGTAACAGTGGAGGGGTCATATGTGGCCGAGGAGGCGG GCTGCCCCCTGTCCTGTGCAGTCAGCAAGAGACGGCTGGAGTGTGAGGAGTGTGGCGGCCTGGGCTCCCC AACAGGCAGGTGTGAGTGGAGGCAAGGAGATGGCAAAGGGATCACCAGGAACTTCTCCACCTGCTCTCCC AGCACCAAGACCTGCCCCGACGGCCACTGCGATGTTGTGGAGACCCAAGACATCAACATTTGCCCTCAGG ACTGCCTCCGGGGCAGCATTGTTGGGGGACACGAGCCTGGGGAGCCCCGGGGGATTAAAGCTGGCTATGG CACCTGCAACTGCTTCCCTGAGGAGGAGAAGTGCTTCTGCGAGCCCGAAGACATCCAGGATCCACTGTGC GACGAGCTGTGCCGCACGGTGATCGCAGCCGCTGTCCTCTTCTCCTTCATCGTCTCGGTGCTGCTGTCTG CCTTCTGCATCCACTGCTACCACAAGTTTGCCCACAAGCCACCCATCTCCTCAGCTGAGATGACCTTCCG GAGGCCCGCCCAGGCCTTCCCGGTCAGCTACTCCTCTTCCGGTGCCCGCCGGCCCTCGCTGGACTCCATG GAGAACCAGGTCTCCGTGGATGCCTTCAAGATCCTGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACT TGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAA AGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTTCGA GACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCT GCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCG CGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCAC CCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGT ATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAA GATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAG GGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATG TATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCC TGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATG TACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAG ACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCT GATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGA GCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTC CTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGC TAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGACACGTTTGATAGTTAA    Download   Select all
CCDS ID	CCDS7200.1

Protein Information

      

Protein ID	NP_066124.1
Protein Name	Ret proto-oncogene
Molecular Wt. (Da)	121563
Protein Sequence	>5979 MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVP SFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLS PTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLP VQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMV PFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLP GDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGP GAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGAN CSTLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEE AGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQ DINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAA AVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQV SVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSE LRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGS RNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLS RDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPS DSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFP RYPNDSVYANWMLSPSAAKLMDTFDS    Download   Select all
Length	1114
Uniprot ID	P56545
Ensembl Protein ID	ENSP00000311825

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
Y	Phosphorylation	1015
Y	Phosphorylation	1029
Y	Phosphorylation	1062
Y	Phosphorylation	1096
Y	Phosphorylation	687
Y	Phosphorylation	826
Y	Phosphorylation	905
Y	Phosphorylation	1015
Y	Phosphorylation	1029
Y	Phosphorylation	687
Y	Phosphorylation	826
Y	Phosphorylation	905
Y	Phosphorylation	1062
Y	Phosphorylation	806
Y	Phosphorylation	809
Y	Phosphorylation	900
Y	Phosphorylation	981
Y	Phosphorylation	1090
Y	Phosphorylation	806
Y	Phosphorylation	809
Y	Phosphorylation	900
Y	Phosphorylation	981
T	Phosphorylation	754
T	Phosphorylation	754
T	Phosphorylation	753
T	Phosphorylation	753

Enzyme Information

   

EC	2.7.10.1
Name	receptor protein-tyrosine kinase AATK AATYK AATYK2 AATYK3 ACH ALK anaplastic lymphoma kinase ARK ATP:protein-tyrosine O-phosphotransferase (ambiguous) AXL Bek Bfgfr BRT Bsk C-FMS CAK CCK4 CD115 CD135 CDw135 Cek1 Cek10 Cek11 Cek2 Cek3 Cek5 Cek6 Cek7 CFD1 CKIT CSF1R DAlk DDR1 DDR2 Dek DKFZp434C1418 Drosophila Eph kinase DRT DTK Ebk ECK EDDR1 Eek EGFR Ehk2 Ehk3 Elk EPH EPHA1 EPHA2 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EphB5 ephrin-B3 receptor tyrosine kinase EPHT EPHT2 EPHT3 EPHX ERBB ERBB1 ERBB2 ERBB3 ERBB4 ERK Eyk FGFR1 FGFR2 FGFR3 FGFR4 FLG FLK1 FLK2 FLT1 FLT2 FLT3 FLT4 FMS Fv2 HBGFR HEK11 HEK2 HEK3 HEK5 HEK6 HEP HER2 HER3 HER4 HGFR HSCR1 HTK IGF1R INSR INSRR insulin receptor protein-tyrosine kinase IR IRR JTK12 JTK13 JTK14 JWS K-SAM KDR KGFR KIA0641 KIAA1079 KIAA1459 Kil Kin15 Kin16 KIT KLG LTK MCF3 Mdk1 Mdk2 Mdk5 MEhk1 MEN2A/B Mep MER MERTK MET Mlk1 Mlk2 Mrk MST1R MTC1 MUSK Myk1 N-SAM NEP NET Neu neurite outgrowth regulating kinase NGL NOK nork novel oncogene with kinase-domain Nsk2 NTRK1 NTRK2 NTRK3 NTRK4 NTRKR1 NTRKR2 NTRKR3 Nuk NYK PCL PDGFR PDGFRA PDGFRB PHB6 protein-tyrosine kinase (ambiguous) protein tyrosine kinase (ambiguous) PTK PTK3 PTK7 receptor protein tyrosine kinase RET RON ROR1 ROR2 ROS1 RSE RTK RYK SEA Sek2 Sek3 Sek4 Sfr SKY STK STK1 TEK TIE TIE1 TIE2 TIF TKT TRK TRKA TRKB TRKC TRKE TYK1 TYRO10 Tyro11 TYRO3 Tyro5 Tyro6 TYRO7 UFO VEGFR1 VEGFR2 VEGFR3 Vik YK1 Yrk
Class	Transferases; Transferring phosphorus-containing groups; Protein-tyrosine kinases
Sysname	ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
Substrate	ATP [CPD:C00002]; [protein]-L-tyrosine
Product	ADP [CPD:C00008]; [protein]-L-tyrosine phosphate
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING)      View   

                                                                                                                                                                                                   

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
868	CBLB	5136	NP_733762.2	in vivo	16525057
1398	CRK	1267	NP_058431.2	in vitro	10208419
1432	MAPK14	2619	NP_001306.1	in vitro	16153436
2668	GDNF	2906	NP_000505.1	in vitro	8674117
2885	GRB2	150	NP_002077.1	in vivo	9393871
5576	PRKAR2A	1484	NP_004148.1	in vitro;in vivo	11886862
5594	MAPK1	1496	NP_002736.3	in vitro	16153436
5595	MAPK3	3479	NP_002737.2	in vitro	16153436
5599	MAPK8	3100	NP_620637.1	in vitro	16153436
5747	PTK2	2859	NP_005598.3	in vitro	16153436
6774	STAT3	26	NP_644805.1	in vitro;in vivo	115   360   471   263   758   000   000   000
9495	AKAP5	5255	NP_004848.3	in vivo	11886862
220164	DOK6	13244	NP_689934.2	in vitro	15286081

Pathway Information

                        

Pathway Name	Pathway ID
Central carbon metabolism in cancer	hsa05230
Endocytosis	hsa04144
Pathways in cancer	hsa05200
Thyroid cancer	hsa05216

Structure Information

PDB ID	2IVS
Resolution	2
Method	X-RAY DIFFRACTION
Chains	A
Molecule	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET
Model	View

Domain Information

ID	Location	Description
cd05045	723-1012	PTKc_RET
cl21453	723-1012	PKc_like superfamily
cd11304	173-267	Cadherin_repeat
cl15786	173-267	CA_like superfamily
cd05053	711-1009	PTKc_FGFR
cd00192	728-1006	PTKc
cd05099	714-1023	PTKc_FGFR4
cd05101	706-1009	PTKc_FGFR2
cd05098	713-1009	PTKc_FGFR1
cd05100	714-1019	PTKc_FGFR3
cd05054	716-1005	PTKc_VEGFR
cd05055	702-1009	PTKc_PDGFR
cd14207	716-1005	PTKc_VEGFR1
cd05102	716-1012	PTKc_VEGFR3
cd05103	716-1009	PTKc_VEGFR2
cd05106	702-1009	PTKc_CSF-1R
cd05032	717-1001	PTKc_InsR_like
cd05104	702-1009	PTKc_Kit
cd05105	704-1009	PTKc_PDGFR_alpha
cd05044	728-1006	PTKc_c-ros
cd05107	704-1010	PTKc_PDGFR_beta
cd05089	730-1019	PTKc_Tie1
cd05034	728-999	PTKc_Src_like
cd05047	730-1009	PTKc_Tie
cd05036	718-1001	PTKc_ALK_LTK
cd05048	718-1005	PTKc_Ror
cd05068	716-1006	PTKc_Frk_like
cd05035	724-1009	PTKc_TAM
cd05050	718-1007	PTKc_Musk
cd05039	717-1006	PTKc_Csk_like
cd05049	718-1007	PTKc_Trk
cd05060	728-1015	PTKc_Syk_like
cd05148	717-1005	PTKc_Srm_Brk
cd05051	718-1001	PTKc_DDR
cd14204	721-1011	PTKc_Mer
cd05061	717-1001	PTKc_InsR
cd05056	717-1006	PTKc_FAK
cd05088	730-1017	PTKc_Tie2
cd05041	730-1005	PTKc_Fes_like
cd05033	722-1008	PTKc_EphR
cd05052	717-1008	PTKc_Abl
cd05074	720-1006	PTKc_Tyro3
cd05057	718-1008	PTKc_EGFR_like
cd05038	719-1009	PTKc_Jak_rpt2
cd05075	724-1009	PTKc_Axl
cd05092	721-1007	PTKc_TrkA
cd05046	719-1007	PTK_CCK4
cd05067	716-1006	PTKc_Lck_Blk
cd13999	730-1005	STKc_MAP3K-like
cd05058	730-1006	PTKc_Met_Ron
cd05062	717-1001	PTKc_IGF-1R
cd05084	727-1005	PTKc_Fes
cd05043	732-998	PTK_Ryk
cd05085	727-1005	PTKc_Fer
cd05059	722-1005	PTKc_Tec_like
cd05040	728-1005	PTKc_Ack_like
cd05108	728-1024	PTKc_EGFR
cd05072	717-998	PTKc_Lyn
cd05116	728-999	PTKc_Syk
cd05109	728-1008	PTKc_HER2
cd05093	721-1017	PTKc_TrkB
cd05095	718-1007	PTKc_DDR2
cd05096	718-1001	PTKc_DDR1
cd05094	721-1008	PTKc_TrkC
cd05073	713-1006	PTKc_Hck
cd05063	728-1009	PTKc_EphR_A2
cd05082	717-1006	PTKc_Csk
cd05090	718-1001	PTKc_Ror1
cd05083	717-1008	PTKc_Chk
cd14203	728-1006	PTKc_Src_Fyn_like
cd05097	718-1005	PTKc_DDR_like
cd05065	728-1009	PTKc_EphR_B
cd05069	717-1006	PTKc_Yes
cd05070	717-1006	PTKc_Fyn
cd05110	728-1037	PTKc_HER4
cd05066	728-1009	PTKc_EphR_A
cd05113	721-998	PTKc_Btk_Bmx
cd05112	724-999	PTKc_Itk
cd00180	730-1005	PKc
cd14205	719-1008	PTKc_Jak2_rpt2
cd05115	721-1001	PTKc_Zap-70
cd05071	717-1006	PTKc_Src
cd05091	730-1005	PTKc_Ror2
cd05081	719-1008	PTKc_Jak3_rpt2
cd05064	718-1009	PTKc_EphR_A10
cd05080	719-1008	PTKc_Tyk2_rpt2
cd05111	719-1016	PTK_HER3
cd05114	724-1009	PTKc_Tec_Rlk
cd05079	719-1009	PTKc_Jak1_rpt2
cd14058	730-1009	STKc_TAK1
cd14061	730-1008	STKc_MLK
cd06606	725-996	STKc_MAPKKK
cd14206	730-1001	PTKc_Aatyk3
cd14146	730-1005	STKc_MLK4
cd14059	730-1006	STKc_MAP3K12_13
cd06627	726-996	STKc_Cdc7_like
cd05042	728-1005	PTKc_Aatyk
cd05087	728-996	PTKc_Aatyk1
cd14014	726-996	STKc_PknB_like
cd14062	730-1006	STKc_Raf
cd14066	730-1008	STKc_IRAK
cd05122	726-996	PKc_STE
cd13978	730-1000	STKc_RIP
cd14147	722-1008	STKc_MLK3
cd14065	730-1005	PKc_LIMK_like
cd14003	723-1001	STKc_AMPK-like
cd14148	730-1006	STKc_MLK2
cd14145	724-1001	STKc_MLK1
cd14060	731-1008	STKc_MLTK
cd14154	730-1008	STKc_LIMK
cd05037	724-1005	PTK_Jak_rpt1
cd14063	724-1008	PK_KSR
cd14151	717-1008	STKc_B-Raf
cd14221	730-1008	STKc_LIMK1
cd14222	730-1008	STKc_LIMK2
cd08215	728-1001	STKc_Nek
cd06623	723-996	PKc_MAPKK_plant_like
cd06612	730-996	STKc_MST1_2
cd14149	717-1006	STKc_C-Raf
cd13992	730-1008	PK_GC
cd14150	728-1008	STKc_A-Raf
cd06644	714-1012	STKc_STK10
cd05086	730-1005	PTKc_Aatyk2
cd08530	728-1001	STKc_CNK2-like
cd14064	730-1006	PKc_TNNI3K
cd13979	726-996	STKc_Mos
cd14002	731-995	STKc_STK36
cd14158	727-1008	STKc_IRAK4
cd06632	727-996	STKc_MEKK1_plant
cd06641	728-1003	STKc_MST3
cd14155	730-1012	PKc_TESK
cd05117	725-1011	STKc_CAMK
cd14027	730-1002	STKc_RIP1
cd06620	722-1020	PKc_Byr1_like
cd14008	730-995	STKc_LKB1_CaMKK
cd14007	726-1001	STKc_Aurora
cd06611	730-1004	STKc_SLK_like
cd06628	727-1003	STKc_Byr2_like
cd14156	730-1008	PKc_LIMK_like_unk
cd14057	747-1008	PK_ILK
cd05582	728-1030	STKc_RSK_N
cd14025	730-1011	STKc_RIP4_like
cd06605	728-1009	PKc_MAPKK
cd08222	725-1004	STKc_Nek11
cd06614	730-996	STKc_PAK
cd07829	730-954	STKc_CDK_like
cd06643	717-995	STKc_SLK
cd05078	724-1005	PTK_Jak2_rpt1
cd06610	754-996	STKc_OSR1_SPAK
cd14080	726-1003	STKc_TSSK-like
cd14161	728-1002	STKc_NUAK2
cd05123	730-995	STKc_AGC
cd08529	726-1001	STKc_FA2-like
cd14081	726-1001	STKc_BRSK1_2
cd06621	722-996	PKc_Pek1_like
cd06642	730-1003	STKc_STK25
cd14073	728-1001	STKc_NUAK
cd08228	723-996	STKc_Nek6
cd14000	730-996	STKc_LRRK
cd08224	723-1002	STKc_Nek6_7
cd13996	730-1005	STKc_EIF2AK
cd05118	725-996	STKc_CMGC
cd14121	730-1000	STKc_ULK3
cd06917	730-1003	STKc_NAK1_like
cd14164	726-996	STKc_TSSK6-like
cd14009	730-1001	STKc_ATG1_ULK_like
cd06629	725-1004	STKc_Bck1_like
cd14071	728-954	STKc_SIK
cd05581	722-951	STKc_PDK1
cd05077	757-1005	PTK_Jak1_rpt1
cd06624	730-1004	STKc_ASK
cd08229	723-996	STKc_Nek7
cd14072	723-954	STKc_MARK
cd06640	730-1011	STKc_MST4
cd13975	726-1011	PKc_Dusty
cd13997	730-996	PKc_Wee1_like
cd07833	725-954	STKc_CDKL
cd14119	730-1003	STKc_LKB1
cd14208	724-1005	PTK_Jak3_rpt1
cd06608	712-996	STKc_myosinIII_N_like
cd14079	723-942	STKc_AMPK_alpha
cd14052	728-1001	PTKc_Wee1_fungi
cd06609	730-996	STKc_MST3_like
cd14664	730-1006	STK_BAK1_like
cd06630	727-1003	STKc_MEKK1
cd06625	723-1001	STKc_MEKK3_like
cd06622	730-1001	PKc_PBS2_like
cd07832	725-954	STKc_CCRK
cd08225	728-1003	STKc_Nek5
cd07841	725-954	STKc_CDK7
cd05595	728-995	STKc_PKB_beta
cd08217	728-1001	STKc_Nek2
cd14193	730-989	STKc_MLCK4
cd14068	730-1001	STKc_LRRK2
cd08528	730-1002	STKc_Nek10
cd07830	725-996	STKc_MAK_like
cd14026	730-1009	STKc_RIP2
cd14190	730-954	STKc_MLCK2
cd14165	722-952	STKc_TSSK1_2-like
cd14162	726-1004	STKc_TSSK4-like
cd05619	723-995	STKc_nPKC_theta
cd13983	719-1004	STKc_WNK
cd14069	725-1004	STKc_Chk1
cd13987	730-951	STKc_SBK1
cd14103	730-1012	STKc_MLCK
cd14098	729-1001	STKc_Rad53_Cds1
cd13968	730-894	PKc_like
cd14042	732-1009	PK_GC-A_B
cd08220	728-1001	STKc_Nek8
cd14067	736-996	STKc_LRRK1
cd06615	730-958	PKc_MEK
cd14202	716-961	STKc_ULK1
cd06638	709-1001	STKc_myosinIIIA_N
cd13994	730-946	STKc_HAL4_like
cd06639	720-996	STKc_myosinIIIB_N
cd07838	730-944	STKc_CDK4_6_like
cd06619	729-996	PKc_MKK5
cd06648	720-995	STKc_PAK_II
cd14075	726-1004	STKc_NIM1
cd06613	730-996	STKc_MAP4K3_like
cd08219	728-996	STKc_Nek3
cd07840	730-954	STKc_CDK9_like
cd14076	725-942	STKc_Kin4
cd14045	742-1008	PK_GC_unk
cd14006	730-1000	STKc_MLCK-like
cd05076	777-1005	PTK_Tyk2_rpt1
cd06650	730-999	PKc_MEK1
cd14095	726-995	STKc_DCKL
cd05584	728-954	STKc_p70S6K
cd14046	728-899	STKc_EIF2AK4_GCN2_rpt2
cd14097	727-967	STKc_STK33
cd14192	728-954	STKc_MLCK3
cd08218	728-1007	STKc_Nek1
cd14185	726-995	STKc_DCKL3
cd14084	721-951	STKc_Chk2
cd08221	728-996	STKc_Nek9
cd05593	728-995	STKc_PKB_gamma
cd14044	747-1008	PK_GC-C
cd14116	722-1001	STKc_Aurora-A
cd06649	730-958	PKc_MEK2
cd14167	721-995	STKc_CaMKI_alpha
cd14077	723-945	STKc_Kin1_2
cd06633	730-1001	STKc_TAO3
cd14153	724-1008	PK_KSR2
cd06655	720-995	STKc_PAK2
cd14169	726-995	STKc_CaMKI_beta
cd14187	714-1004	STKc_PLK1
cd06631	727-996	STKc_YSK4
cd05580	722-957	STKc_PKA_like
cd14120	730-1000	STKc_ULK1_2-like
cd06616	717-1003	PKc_MKK4
cd07862	730-944	STKc_CDK6
cd14074	726-1004	STKc_SNRK
cd07836	730-966	STKc_Pho85
cd07871	726-992	STKc_PCTAIRE3
cd14133	728-996	PKc_DYRK_like
cd14038	730-952	STKc_IKK_beta
cd14152	726-1008	STKc_KSR1
cd05594	701-995	STKc_PKB_alpha
cd14201	717-961	STKc_ULK2
cd14047	730-944	STKc_EIF2AK2_PKR
cd05612	728-957	STKc_PRKX_like
cd05579	733-1001	STKc_MAST_like
cd06659	720-952	STKc_PAK6
cd13982	728-996	STKc_IRE1
cd06656	720-995	STKc_PAK3
cd14099	727-1001	STKc_PLK
cd07835	730-946	STKc_CDK1_CdkB_like
cd14105	726-1000	STKc_DAPK
cd07842	731-947	STKc_CDK8_like
cd14159	730-946	STKc_IRAK1
cd14194	726-954	STKc_DAPK1
cd14188	727-1001	STKc_PLK2
cd05611	728-1004	STKc_Rim15_like
cd14056	728-1008	STKc_TGFbR_I
cd06626	727-1004	STKc_MEKK4
cd14209	728-967	STKc_PKA
cd06617	723-1003	PKc_MKK3_6
cd07839	730-966	STKc_CDK5
cd06654	720-995	STKc_PAK1
cd07866	725-946	STKc_BUR1
pfam00028	172-261	Cadherin
cd06647	720-995	STKc_PAK_I
cd14166	721-995	STKc_CaMKI_gamma
cd05602	728-957	STKc_SGK1
cd14184	726-986	STKc_DCKL2
cd05570	728-1011	STKc_PKC
cd05571	728-995	STKc_PKB
cd07873	730-982	STKc_PCTAIRE1
cd14053	733-995	STKc_ACVR2
cd14043	762-1001	PK_GC-2D
cd14199	775-1001	STKc_CaMKK2
cd14163	726-942	STKc_TSSK3-like
cd14663	726-949	STKc_SnRK3
cd07863	730-944	STKc_CDK4
cd07872	730-982	STKc_PCTAIRE2
cd14001	756-947	PKc_TOPK
cd14198	728-954	STKc_DRAK2
cd05604	728-1043	STKc_SGK3
cd05589	730-962	STKc_PKN
cd07860	730-946	STKc_CDK2_3
cd13990	730-944	STKc_TLK
cd06653	723-1001	STKc_MEKK3_like_u1
cd14010	772-951	STKc_ULK4
cd06637	712-1017	STKc_TNIK
cd08223	725-996	STKc_Nek4
cd06652	723-946	STKc_MEKK2
cd05620	728-995	STKc_nPKC_delta
cd14118	746-1004	STKc_CAMKK
cd14186	726-996	STKc_PLK4
cd06658	720-957	STKc_PAK5
cd14083	721-940	STKc_CaMKI
cd06607	730-939	STKc_TAO
cd05630	728-995	STKc_GRK6
cd14106	724-954	STKc_DRAK
cd14196	726-954	STKc_DAPK2
cd14096	730-957	STKc_RCK1-like
cd06635	718-944	STKc_TAO1
cd14137	722-954	STKc_GSK3
cd14012	768-996	PK_eIF2AK_GCN2_rpt1
cd05592	728-995	STKc_nPKC_theta_like
cd14039	730-952	STKc_IKK_alpha
cd06636	712-964	STKc_MAP4K4_6_N
cd05614	723-1011	STKc_MSK2_N
cd07848	725-965	STKc_CDKL5
cd05577	730-1004	STKc_GRK
cd14087	730-967	STKc_PSKH1
cd14110	754-972	STKc_obscurin_rpt2
cd14078	726-995	STKc_MELK
cd14093	756-951	STKc_PhKG
cd13995	732-1003	STKc_MAP3K8
cd07861	730-1010	STKc_CDK1_euk
cd14168	728-995	STKc_CaMKI_delta
cd14131	728-996	PKc_Mps1
cd14117	726-951	STKc_Aurora-B_like
cd06634	720-996	STKc_TAO2
cd14085	732-952	STKc_CaMKIV
cd14183	726-995	STKc_DCKL1
cd14195	726-1011	STKc_DAPK3
cd14070	723-1004	STKc_HUNK
cd14189	727-951	STKc_PLK3
cd14051	729-996	PTKc_Wee1
cd14054	730-1005	STKc_BMPR2_AMHR2
cd05607	728-1025	STKc_GRK7
cd07846	725-1001	STKc_CDKL2_3
cd13989	730-965	STKc_IKK
cd07877	856-1014	STKc_p38alpha
cd05585	730-1035	STKc_YPK1_like
cd05603	728-957	STKc_SGK2
cd05578	731-995	STKc_Yank1
cd07864	730-946	STKc_CDK12
cd06657	708-965	STKc_PAK4
cd05632	728-954	STKc_GRK5
cd07857	853-951	STKc_MPK1
cd14082	728-949	STKc_PKD
cd14197	721-995	STKc_DRAK1
cd07831	725-954	STKc_MOK
cd07880	717-951	STKc_p38gamma
cd14144	728-1008	STKc_BMPR1
cd06651	727-946	STKc_MEKK3
cd13993	730-995	STKc_Pat1_like
cd14055	728-995	STKc_TGFbR2_like
cd05631	728-952	STKc_GRK4
cd14665	728-1004	STKc_SnRK2-3
cd05590	728-961	STKc_nPKC_eta
cd05616	728-995	STKc_cPKC_beta
cd07869	728-966	STKc_PFTAIRE1
cd13998	731-945	STKc_TGFbR-like
cd14040	730-952	STKc_TLK1
cd05572	730-995	STKc_cGK
cd14134	728-946	PKc_CLK
cd05613	723-952	STKc_MSK1_N
cd07878	717-954	STKc_p38beta
cd13988	730-983	STKc_TBK1
cd07856	728-1010	STKc_Sty1_Hog1
cd07865	718-946	STKc_CDK9
cd07851	717-954	STKc_p38
cd14191	730-1012	STKc_MLCK1
cd13985	728-1007	STKc_GAK_like
cd05615	730-995	STKc_cPKC_alpha
cd14139	730-905	PTKc_Wee1b
cd14200	861-1001	STKc_CaMKK1
cd14113	730-952	STKc_Trio_C
cd14041	730-952	STKc_TLK2
cd14143	730-1008	STKc_TGFbR1_ACVR1b_ACVR1c
cd14138	730-996	PTKc_Wee1a
cd14220	728-1008	STKc_BMPR1a
cd13977	730-945	STKc_PDIK1L
cd14011	856-952	PK_SCY1_like
cd05605	854-952	STKc_GRK4_like
cd07834	854-946	STKc_MAPK
cd07844	730-966	STKc_PCTAIRE_like
cd14049	730-996	STKc_EIF2AK1_HRI
cd14048	728-1001	STKc_EIF2AK3_PERK
cd07845	730-954	STKc_CDK10
cd05608	728-949	STKc_GRK1
cd07837	730-945	STKc_CdkB_plant
cd14181	756-951	STKc_PhKG2
cd14050	728-946	PKc_Myt1
cd07870	728-960	STKc_PFTAIRE2
cd14160	730-946	PK_IRAK3
cd14004	728-1004	STKc_PASK
cd14086	726-967	STKc_CaMKII
cd07853	854-945	STKc_NLK
cd07847	726-954	STKc_CDKL1_4
cd14212	729-964	PKc_YAK1
cd07879	717-1042	STKc_p38delta
cd06618	697-1001	PKc_MKK7
cd06645	720-996	STKc_MAP4K3
cd14094	730-995	STKc_CASK
cd14142	722-1008	STKc_ACVR1_ALK1
cd14662	728-1003	STKc_SnRK2
cd05591	728-951	STKc_nPKC_epsilon
cd07854	854-946	STKc_MAPK4_6
cd14111	850-952	STKc_SPEG_rpt2
cd07858	854-954	STKc_TEY_MAPK
cd14091	729-949	STKc_RSK_C
cd07855	854-954	STKc_ERK5
cd07859	854-954	STKc_TDY_MAPK
cd07852	855-954	STKc_MAPK15-like
cd14114	730-954	STKc_Twitchin_like
cd07849	854-954	STKc_ERK1_2_like
cd05587	854-979	STKc_cPKC
cd14109	730-955	PK_Unc-89_rpt1
cd14005	726-1001	STKc_PIM
cd14226	730-951	PKc_DYRK1
cd14100	853-1001	STKc_PIM1
cd14135	729-987	STKc_PRP4
cd14210	850-954	PKc_DYRK
cd14104	730-954	STKc_Titin
cd14033	730-953	STKc_WNK4
cd06646	720-996	STKc_MAP4K5
cd08216	726-957	PK_STRAD
cd14219	722-1008	STKc_BMPR1b
cd14174	730-954	STKc_Mnk1
cd05618	726-952	STKc_aPKC_iota
cd14088	774-951	STKc_CaMK_like
cd14176	756-967	STKc_RSK2_C
cd07843	705-946	STKc_CDC2L1
cd05609	861-961	STKc_MAST
cd05617	726-952	STKc_aPKC_zeta
cd14179	728-995	STKc_MSK1_C
smart00112	198-270	CA
cd14112	720-996	STKc_Unc-89_rpt2
cd14031	730-953	STKc_WNK3
cd14172	858-995	STKc_MAPKAPK3
cd14178	749-967	STKc_RSK3_C
cd05586	730-1005	STKc_Sck1_like
cd14182	768-951	STKc_PhKG1
cd14215	729-943	PKc_CLK2
cd14175	858-967	STKc_RSK1_C
cd14030	730-1001	STKc_WNK1
cd05573	722-957	STKc_ROCK_NDR_like
cd07868	727-964	STKc_CDK8
cd05598	728-945	STKc_LATS
cd14170	858-995	STKc_MAPKAPK2
cd07875	856-954	STKc_JNK1
cd14101	854-1001	STKc_PIM2
cd07876	856-945	STKc_JNK2
cd05583	730-952	STKc_MSK_N
cd14177	856-967	STKc_RSK4_C
cd05622	728-952	STKc_ROCK1
cd14141	733-946	STKc_ACVR2a
cd14107	730-1000	STKc_obscurin_rpt1
cd07874	856-945	STKc_JNK3
cd14229	730-954	STKc_HIPK3
cd14225	854-954	PKc_DYRK4
cd05621	728-952	STKc_ROCK2
cd13991	730-936	STKc_NIK
cd14224	854-958	PKc_DYRK2_3
cd14180	856-946	STKc_MSK2_C
cd14032	730-953	STKc_WNK2_like
cd05601	728-945	STKc_CRIK
cd14136	857-946	STKc_SRPK
cd14102	854-1001	STKc_PIM3
cd14090	727-951	STKc_Mnk
cd07850	838-954	STKc_JNK
cd14089	725-951	STKc_MAPKAPK
cd14173	730-951	STKc_Mnk2
cd07867	727-946	STKc_CDC2L6
cd05610	722-962	STKc_MASTL
cd14022	856-995	PK_TRB2
cd14108	853-954	STKc_SPEG_rpt1
cd14036	724-1012	STKc_GAK
pfam07714	724-1005	Pkinase_Tyr
smart00221	724-1005	STYKc
smart00219	724-1005	TyrKc
smart00220	726-1004	S_TKc
pfam00069	724-1004	Pkinase
COG0515	726-1112	SPS1
PLN00034	677-996	PLN00034
PTZ00024	726-966	PTZ00024
PTZ00426	728-957	PTZ00426
PTZ00267	668-996	PTZ00267
PTZ00263	716-957	PTZ00263
PRK13184	755-952	pknD
PHA02988	747-1001	PHA02988
PLN00009	730-946	PLN00009
PHA03209	728-945	PHA03209
PHA03212	774-1011	PHA03212
PTZ00283	695-996	PTZ00283
PTZ00036	720-1027	PTZ00036
TIGR03903	755-946	TOMM_kin_cyc

Ontology Information

   

HPRD ID	286
Molecular Class	Receptor tyrosine kinase
Molecular Function	Cell adhesion molecule activity (GO:0005194)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report   

Drug Information

Uniprot ID	DrugBank ID	Name	Type
P07949	DB00398	Sorafenib	SmallMoleculeDrug
P07949	DB08875	Cabozantinib	SmallMoleculeDrug
P07949	DB08896	Regorafenib	SmallMoleculeDrug
P07949	DB08901	Ponatinib	SmallMoleculeDrug

External Links

                                 

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO