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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RGS16 | 6004 | regulator of G-protein signaling 16 | 1 | A28-RGS14, RGS-r |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19760045 | 2009 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 124 CRC and normal tissue Stage : - | - | Up-regulation | - | RGS16 is useful as a predictive marker for patient prognosis of CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Regulators of G-protein signaling |
| Description | The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008] | Chromosome | 1 |
| Location | 1q25-q31 |
| Start | 182567758 |
| End | 182573548 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 5791 |
| OMIM ID | 602514 |
| HGNC ID | HGNC:9997 |
| Unigene ID | Hs.413297 |
| Ensembl ID | ENSG00000143333 |
| PharmGKB ID | PA34367 |
mRNA Information
| mRNA ID | ?NM_002928.3 |
|---|---|
| Exon | join(1..198,1075..1185,1930..1994,2282..2448,3901..5791) | mRNA Sequence | Download Select all |
| Length | 2432 |
Protein Information
| Protein ID | NP_002919.3 |
|---|---|
| Protein Name | regulator of G-protein signaling 16 |
| Molecular Wt. (Da) | 12343 |
| Protein Sequence | Download Select all |
| Length | 202 |
| Uniprot ID | P46940 |
| Ensembl Protein ID | ENSP00000268182 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| C | Palmitoylation | 12 |
| S | Phosphorylation | 195 |
| C | Palmitoylation | 2 |
| C | Palmitoylation | 98 |
| Y | Phosphorylation | 168 |
| Y | Phosphorylation | 168 |
| Y | Phosphorylation | 168 |
| Y | Phosphorylation | 168 |
| Y | Phosphorylation | 177 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2770 | GNAI1 | 756 | NP_002060.4 | in vitro | 10878019 |
| 2771 | GNAI2 | 764 | NP_002061.1 | in vitro | 146 346 629 079 700 |
| 2773 | GNAI3 | 765 | NP_006487.1 | in vitro | 100 725 119 079 700 |
| 2775 | GNAO1 | 757 | NP_066268.1 | in vitro;yeast 2-hybrid | 9 079 700 927 120 110 000 000 |
| 2776 | GNAQ | 2998 | NP_002063.2 | in vitro | 14634662 |
| 2779 | GNAT1 | 8850 | NP_653082.1 | in vitro | 108 780 198 917 514 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd08710 | 66-179 | RGS_RGS16 |
| cl02565 | 66-179 | RGS superfamily |
| cd08711 | 56-179 | RGS_RGS8 |
| cd08713 | 67-179 | RGS_RGS3 |
| cd08709 | 66-179 | RGS_RGS2 |
| pfam00615 | 65-180 | RGS |
| cd08712 | 66-179 | RGS_RGS18 |
| cd08717 | 66-179 | RGS_RGS5 |
| cd08723 | 69-179 | RGS_RGS21 |
| cd08714 | 66-179 | RGS_RGS4 |
| cd08715 | 69-180 | RGS_RGS1 |
| smart00315 | 65-180 | RGS |
| cd08705 | 62-179 | RGS_R7-like |
| cd08718 | 62-179 | RGS_RZ-like |
| cd08745 | 62-178 | RGS_RGS19 |
| cd08746 | 57-179 | RGS_RGS20 |
| cd08706 | 66-179 | RGS_R12-like |
| cd08716 | 66-178 | RGS_RGS13 |
| cd07440 | 70-179 | RGS |
| cd08743 | 59-179 | RGS_RGS14 |
| cd08737 | 62-180 | RGS_RGS6 |
| cd08739 | 62-179 | RGS_RGS9 |
| cd08744 | 62-178 | RGS_RGS17 |
| cd08741 | 69-177 | RGS_RGS10 |
| cd08738 | 62-179 | RGS_RGS7 |
| cd08740 | 62-180 | RGS_RGS11 |
| cd08742 | 66-179 | RGS_RGS12 |
| cd08707 | 68-177 | RGS_Axin |
| cd08708 | 79-177 | RGS_FLBA |
| cd08719 | 73-177 | RGS_SNX13 |
| cd08734 | 72-173 | RGS-like_1 |
| cd08721 | 78-177 | RGS_AKAP2_2 |
| cd08720 | 79-178 | RGS_SNX25 |
| cd08732 | 80-178 | RGS-like_4 |
Ontology Information
| HPRD ID | 3642 |
|---|---|
| Molecular Class | GTPase activating protein |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Signal transduction (GO:0007165); Cell migration (GO:0016477); Morphogenesis (GO:0009653); Immune response (GO:0006955) |
Drug Information
No matching records could be found.