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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20001967 | 2010 | Cell line : SW620, LoVo, Colo205,SW480, Caco 2, HCT116 Source : - Sample Type : Paraffin-embedded specimens No. of Sample : 36 CRC tissues with recurrence and 28 without recurrence and 118 paraffin-embedded specimens Stage : TNM stage II,III | Real-time PCR,immunostaining | Down-regulation | - | Down-regulation of RGS2 might play an important role in CRC metastasis and predict poor prognosis in stage II and III CRC patients. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Regulators of G-protein signaling, "Endogenous ligands" |
| Description | Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009] | Chromosome | 1 |
| Location | 1q31 |
| Start | 192778169 |
| End | 192781407 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 3239 |
| OMIM ID | 600861 |
| HGNC ID | HGNC:9998 |
| Unigene ID | Hs.78944 |
| Ensembl ID | ENSG00000116741 |
| PharmGKB ID | PA34372 |
mRNA Information
| mRNA ID | ?NM_002923.3 |
|---|---|
| Exon | join(1..143,1128..1229,1332..1393,1943..2109,2364..3239) | mRNA Sequence | Download Select all |
| Length | 1375 |
Protein Information
| Protein ID | NP_002914.1 |
|---|---|
| Protein Name | regulator of G-protein signaling 2 |
| Molecular Wt. (Da) | 156227 |
| Protein Sequence | Download Select all |
| Length | 211 |
| Uniprot ID | O15327 |
| Ensembl Protein ID | ENSP00000262992 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 46 |
| S | Phosphorylation | 64 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 801 | CALM1 | 241 | NP_008819.1 | in vitro | 10747990 |
| 2769 | GNA15 | 760 | NP_002059.2 | in vitro;in vivo | 12885252 |
| 2778 | GNAS | 761 | NP_536350.2 | in vitro | 9794454 |
| 3312 | HSPA8 | 7205 | NP_006588.1 | yeast 2-hybrid | 16169070 |
| 5578 | PRKCA | 1498 | NP_002728.1 | in vitro;in vivo | 11063746 |
| 5579 | PRKCB | 1499 | NP_002729.2 | in vitro;in vivo | 11063746 |
| 5582 | PRKCG | 1502 | NP_002730.1 | in vitro;in vivo | 11063746 |
| 6331 | SCN5A | 2543 | NP_932173.1 | yeast 2-hybrid | 16169070 |
| 8508 | NIPSNAP1 | 10342 | NP_003625.2 | yeast 2-hybrid | 16169070 |
| 8655 | DYNLL1 | 3334 | NP_003737.1 | yeast 2-hybrid | 16169070 |
| 22981 | NINL | 11120 | NP_079452.3 | yeast 2-hybrid | 16189514 |
| 28964 | GIT1 | 6577 | NP_001078923.1 | yeast 2-hybrid | 16169070 |
| 51699 | VPS29 | 9499 | NP_476528.1 | yeast 2-hybrid | 16169070 |
| 54663 | WDR74 | 8548 | NP_060563.2 | yeast 2-hybrid | 16169070 |
| 55738 | ARFGAP1 | 6443 | NP_783202.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| cGMP-PKG signaling pathway | hsa04022 |
| Olfactory transduction | hsa04740 |
| Oxytocin signaling pathway | hsa04921 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd08709 | 84-197 | RGS_RGS2 |
| cl02565 | 84-197 | RGS superfamily |
| cd08713 | 85-197 | RGS_RGS3 |
| cd08711 | 73-197 | RGS_RGS8 |
| cd08723 | 87-197 | RGS_RGS21 |
| pfam00615 | 84-198 | RGS |
| cd08710 | 84-197 | RGS_RGS16 |
| cd08717 | 84-197 | RGS_RGS5 |
| smart00315 | 84-198 | RGS |
| cd08712 | 84-197 | RGS_RGS18 |
| cd08715 | 84-198 | RGS_RGS1 |
| cd08714 | 84-197 | RGS_RGS4 |
| cd08716 | 84-196 | RGS_RGS13 |
| cd07440 | 88-197 | RGS |
| cd08746 | 71-197 | RGS_RGS20 |
| cd08718 | 80-197 | RGS_RZ-like |
| cd08745 | 80-196 | RGS_RGS19 |
| cd08705 | 80-197 | RGS_R7-like |
| cd08706 | 84-197 | RGS_R12-like |
| cd08744 | 80-196 | RGS_RGS17 |
| cd08737 | 80-198 | RGS_RGS6 |
| cd08741 | 84-195 | RGS_RGS10 |
| cd08743 | 80-197 | RGS_RGS14 |
| cd08739 | 80-197 | RGS_RGS9 |
| cd08738 | 80-197 | RGS_RGS7 |
| cd08740 | 80-198 | RGS_RGS11 |
| cd08707 | 87-195 | RGS_Axin |
| cd08742 | 84-197 | RGS_RGS12 |
| cd08734 | 95-153 | RGS-like_1 |
| cd08721 | 94-195 | RGS_AKAP2_2 |
| cd08708 | 97-191 | RGS_FLBA |
| cd08719 | 88-195 | RGS_SNX13 |
| cd08722 | 97-195 | RGS_SNX14 |
| cd08735 | 117-200 | RGS_AKAP2_1 |
| cd08720 | 87-196 | RGS_SNX25 |
| cd08732 | 101-196 | RGS-like_4 |
Ontology Information
| HPRD ID | 4541 |
|---|---|
| Molecular Class | GTPase activating protein |
| Molecular Function | GTPase activator activity (GO:0005096) |
| Biological Process | Cytoskeleton organization and biogenesis (GO:0007010) |
Drug Information
No matching records could be found.