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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RHOBTB2 23221 Rho-related BTB domain containing 2  8KIAA0717, DBC2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23258531   2013Cell line : HT29

Source : -

Sample Type : -

No. of Sample : -

Stage : -

MTT and soft agarose colony-formation assays, Imunohistochemistry Down-regulation-miR-31 contributed to the development of colon cancer at least partly by targeting RhoBTB1.


Gene Details



NC_000008.10 (22844930..22877710)

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Gene Type protein coding
Gene Family BTB/POZ domain containing
Description The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]  
Chromosome 8
Location 8p21.2
Start 22844930  
End 22877710  
Strand +  
Gene Sequence

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Length 32781  
OMIM ID 607352   
HGNC ID HGNC:18756   
Unigene ID Hs.372688   
Ensembl ID ENSG00000008853   
PharmGKB ID PA38678   

mRNA Information


mRNA ID ?NM_001160036.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS55210.1



Protein Information


      
Protein IDNP_001153508.1
Protein NameRho-related BTB domain containing 2
Molecular Wt. (Da)0
Protein Sequence

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Length 727  
Uniprot IDQ9UI08
Ensembl Protein ID ENSP00000376652  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


      
Pathway Name Pathway ID
Ubiquitin mediated proteolysis hsa04120


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0187313-207  RhoBTB
cl2145513-207  P-loop_NTPase superfamily
cd0015715-206  Rho
smart0017417-208  RHO
cd0413215-219  Rho4_like
cd0187512-208  RhoG
cd0187115-206  Rac1_like
cd0413015-207  Wrch_1
cd0187414-208  Cdc42
cd0187016-208  RhoA_like
cd0412916-211  Rho2
cd0413115-208  Rnd
cd0413515-208  Tc10
cd0413315-208  Rop_like
cd0417316-234  Rnd2_Rho7
cd0417213-208  Rnd3_RhoE_Rho8
cd0015415-205  Rab
cd041749-232  Rnd1_Rho6
cd0413416-211  Rho3
smart0017515-208  RAB
smart00225501-593  BTB
cl02518501-593  BTB superfamily
cd0088218-201  Ras_like_GTPase
pfam00651491-598  BTB
cd0411118-189  Rab39
cd0413816-205  H_N_K_Ras_like
pfam0847716-143  Miro
cd0186116-208  Rab6
cd0189315-145  Miro1
cd0087616-205  Ras
cd0186315-205  Rab18
cd0186216-208  Rab7
cd0411716-200  Rab15
cd0410615-200  Rab23_like
smart0001016-200  small_GTPase
smart0017316-205  RAS
cd0412315-201  Rab21
cd0186516-201  Rab3
cd0412415-208  RabL2
cd0186715-200  Rab8_Rab10_Rab13_like
cd0186916-189  Rab1_Ypt1
cd0414513-206  M_R_Ras_like
cd0412115-213  Rab40
cd0412715-189  Rab27A
cd0414664-209  RERG_RasL11_like
cd0414116-205  Rit_Rin_Ric
cd0411216-189  Rab26
cd0186014-200  Rab5_related
cd0417716-205  RSR1
smart00225421-470  BTB
cl02518421-470  BTB superfamily
cd0186816-189  Rab11_like
cd0417616-205  Rap2
cd0413916-205  RalA_RalB
cd0411815-189  Rab24
cd0411615-205  Rab9
cd0411514-158  Rab33B_Rab33A
cd0413616-205  Rap_like
cd0414416-211  Ras2
cd0417516-205  Rap1
smart00225267-304  BTB
cl02518267-304  BTB superfamily
cd0991415-143  RocCOR
pfam00651258-302  BTB
cd0411915-202  RJL
pfam0007116-208  Ras
TIGR0023114-202  small_GTP
COG110011-208  Gem1
PTZ0036916-205  PTZ00369


Ontology Information


   
HPRD ID11474
Molecular ClassGTPase
Molecular FunctionGTPase activity (GO:0003924)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO