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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19499974 | 2009 | Cell line : - Source : Chinese patients Sample Type : CRC Tumor and adjescent tissue No. of Sample : 68 Stage : - | real time RT-PCR | Up-regulation | - | The significantly up-regulated RhoA and RhoC expressions suggest that they may contribute to the initiation, development, invasion and metastasis of colorectal carcinoma in Chinese patients. |
| 20828398 | 2010 | Cell line : HCT116 Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR, immunohistochemistry,TUNEL | Up-regulation | - | RhoA and RhoC might be potential targets for gene therapy in colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] | Chromosome | 1 |
| Location | 1p13.1 |
| Start | 113243749 |
| End | 113250025 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 6277 |
| OMIM ID | 165380 |
| HGNC ID | HGNC:669 |
| Unigene ID | Hs.502659 |
| Ensembl ID | ENSG00000155366 |
| PharmGKB ID | PA24951 |
mRNA Information
| mRNA ID | NM_001042678.1 |
|---|---|
| Exon | join(1..326,3598..3760,4285..4405,4711..4841,5691..6277) /gene="RHOC" | mRNA Sequence | Download Select all |
| Length | 1346 |
Protein Information
| Protein ID | NP_001036143.1 |
|---|---|
| Protein Name | ras homolog family member C |
| Molecular Wt. (Da) | 21875 |
| Protein Sequence | Download Select all |
| Length | 193 |
| Uniprot ID | Q99735 |
| Ensembl Protein ID | ENSP00000265498 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 392 | ARHGAP1 | 4108 | NP_004299.1 | yeast 2-hybrid | 16189514 |
| 1729 | DIAPH1 | 3670 | NP_005210.3 | in vitro | 15864301 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01870 | 5-179 | RhoA_like |
| cl21455 | 5-179 | P-loop_NTPase superfamily |
| smart00174 | 8-180 | RHO |
| cd00157 | 7-177 | Rho |
| cd04132 | 4-193 | Rho4_like |
| cd04129 | 5-183 | Rho2 |
| cd04131 | 5-179 | Rnd |
| cd01875 | 7-193 | RhoG |
| cd01871 | 7-178 | Rac1_like |
| cd04134 | 6-192 | Rho3 |
| cd04172 | 4-177 | Rnd3_RhoE_Rho8 |
| cd01874 | 7-179 | Cdc42 |
| cd04173 | 5-189 | Rnd2_Rho7 |
| cd04130 | 7-178 | Wrch_1 |
| cd04135 | 7-174 | Tc10 |
| cd04174 | 2-177 | Rnd1_Rho6 |
| cd04133 | 7-179 | Rop_like |
| cd00154 | 7-176 | Rab |
| smart00175 | 7-176 | RAB |
| cd00876 | 7-176 | Ras |
| smart00173 | 7-183 | RAS |
| smart00010 | 7-172 | small_GTPase |
| cd01873 | 7-177 | RhoBTB |
| cd01860 | 7-177 | Rab5_related |
| cd01863 | 7-172 | Rab18 |
| cd04139 | 7-171 | RalA_RalB |
| cd04123 | 7-172 | Rab21 |
| cd00882 | 9-173 | Ras_like_GTPase |
| cd01861 | 6-173 | Rab6 |
| cd01869 | 7-177 | Rab1_Ypt1 |
| cd01867 | 7-177 | Rab8_Rab10_Rab13_like |
| cd01868 | 7-173 | Rab11_like |
| cd04145 | 7-177 | M_R_Ras_like |
| cd04144 | 7-193 | Ras2 |
| cd04137 | 6-172 | RheB |
| cd04138 | 7-171 | H_N_K_Ras_like |
| cd01893 | 7-177 | Miro1 |
| cd01864 | 7-175 | Rab19 |
| cd04177 | 7-176 | RSR1 |
| cd01866 | 7-171 | Rab2 |
| cd04113 | 7-176 | Rab4 |
| cd04111 | 7-176 | Rab39 |
| cd01862 | 7-183 | Rab7 |
| cd04175 | 7-171 | Rap1 |
| cd04117 | 7-177 | Rab15 |
| cd04116 | 7-176 | Rab9 |
| cd04176 | 7-176 | Rap2 |
| cd04106 | 7-172 | Rab23_like |
| cd04136 | 7-171 | Rap_like |
| cd04110 | 7-186 | Rab35 |
| cd04114 | 7-176 | Rab30 |
| cd04146 | 7-171 | RERG_RasL11_like |
| cd01865 | 7-172 | Rab3 |
| cd04120 | 7-171 | Rab12 |
| cd04147 | 7-188 | Ras_dva |
| cd04115 | 7-134 | Rab33B_Rab33A |
| cd04140 | 7-173 | ARHI_like |
| cd04122 | 7-171 | Rab14 |
| cd04124 | 7-121 | RabL2 |
| pfam08477 | 7-120 | Miro |
| cd04141 | 7-176 | Rit_Rin_Ric |
| cd00877 | 7-163 | Ran |
| cd04108 | 7-171 | Rab36_Rab34 |
| cd04112 | 7-190 | Rab26 |
| cd04101 | 7-177 | RabL4 |
| cd04119 | 7-172 | RJL |
| cd09914 | 5-169 | RocCOR |
| cd04107 | 7-171 | Rab32_Rab38 |
| cd04118 | 7-172 | Rab24 |
| cd04127 | 7-172 | Rab27A |
| cd04109 | 7-183 | Rab28 |
| cd04143 | 7-179 | Rhes_like |
| cd00878 | 7-173 | Arf_Arl |
| cd04148 | 7-191 | RGK |
| cd04128 | 7-121 | Spg1 |
| cd04142 | 7-189 | RRP22 |
| cd04121 | 7-179 | Rab40 |
| cd04126 | 7-172 | Rab20 |
| cd04160 | 9-169 | Arfrp1 |
| pfam00025 | 7-172 | Arf |
| cd04152 | 8-188 | Arl4_Arl7 |
| cd04155 | 7-169 | Arl3 |
| cd04156 | 7-171 | ARLTS1 |
| cd04159 | 8-121 | Arl10_like |
| cd01892 | 10-129 | Miro2 |
| cd04153 | 7-176 | Arl5_Arl8 |
| cd00879 | 7-172 | Sar1 |
| PTZ00133 | Jul-90 | PTZ00133 |
| PLN00023 | 7-176 | PLN00023 |
| cd04149 | 7-138 | Arf6 |
| cd04150 | 7-123 | Arf1_5_like |
| cd04164 | 78-167 | trmE |
| pfam00071 | 7-180 | Ras |
| TIGR00231 | 5-159 | small_GTP |
| COG1100 | 4-176 | Gem1 |
| PLN03118 | 7-172 | PLN03118 |
| PLN03108 | 7-171 | PLN03108 |
| PTZ00369 | 1-193 | PTZ00369 |
| PTZ00132 | 7-122 | PTZ00132 |
| PLN03071 | 7-125 | PLN03071 |
| PLN03110 | 7-172 | PLN03110 |
| smart00176 | 11-122 | RAN |
| PTZ00099 | 28-172 | PTZ00099 |
| TIGR03596 | 101-189 | GTPase_YlqF |
| TIGR03594 | 111-188 | GTPase_EngA |
Ontology Information
| HPRD ID | 2047 |
|---|---|
| Molecular Class | GTPase |
| Molecular Function | Ligase activity (GO:0016874) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.