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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RNF138 | 51444 | Ring finger protein 138 | 18 | NARF; HSD-4; STRIN; hNARF |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22703586 | 2012 | Cell line : - Source : Xinhua Hospital, School of Medicine, Shanghai Jiaotong University. Sample Type : CRC tumor and normal tissue No. of Sample : 40 Stage : - | Microarray, qRT-PCR, Pearson?�????s correlation analysis, TargetScan and miRanda. | Down-regulation | - | RNF138 is downregulated in in CRC but there is no correlation with miRNA.
|
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | RING-type (C3HC4) zinc fingers |
| Description | The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] | Chromosome | 18 |
| Location | 18q12.1 |
| Start | 32091855 |
| End | 32131561 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 39707 |
| OMIM ID | |
| HGNC ID | HGNC:17765 |
| Unigene ID | Hs.302408 |
| Ensembl ID | ENSG00000134758 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_016271.4 |
|---|---|
| Exon | join(1..381,846..1032,19900..20065,21891..22006, 31664..31720,32880..32991,34839..34946,37265..39707) | mRNA Sequence | Download Select all |
| Length | 3585 |
CDS Information
| Location | join(923..1032,19900..20065,21891..22006,31664..31720, 32880..32991,34839..34946,37265..37333) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS11903.1 |
Protein Information
| Protein ID | NP_001178253.2 |
|---|---|
| Protein Name | Ring finger protein 138 |
| Molecular Wt. (Da) | 28062 |
| Protein Sequence | Download Select all |
| Length | 245 |
| Uniprot ID | P02675 |
| Ensembl Protein ID | ENSP00000306099 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 124;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 57060 | PCBP4 | 16343 | NP_065151.1 | yeast 2-hybrid | 16713569 |
| 154313 | C6orf165 | 12863 | NP_001026913.1 | yeast 2-hybrid | 16189514 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00162 | 18-61 | RING |
| cl17238 | 18-61 | RING superfamily |
| smart00184 | 18-57 | RING |
| pfam00097 | 18-57 | zf-C3HC4 |
| pfam05605 | 155-215 | zf-Di19 |
| cl05267 | 155-215 | zf-Di19 superfamily |
| pfam13923 | 18-57 | zf-C3HC4_2 |
| pfam13639 | 18-58 | zf-RING_2 |
| pfam02891 | 17-60 | zf-MIZ |
| pfam14634 | 18-58 | zf-RING_5 |
| pfam14835 | 18-57 | zf-RING_6 |
| COG5222 | 18-57 | COG5222 |
| COG5574 | 13-61 | PEX10 |
| TIGR00599 | 13-58 | rad18 |
| COG5152 | 16-57 | COG5152 |
| COG5432 | 18-58 | RAD18 |
Ontology Information
| HPRD ID | 1307 |
|---|---|
| Molecular Class | Ubiquitin proteasome system protein |
| Molecular Function | Growth factor activity (GO:0008083) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.