Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RNF34 | 80196 | ring finger protein 34, E3 ubiquitin protein ligase | 12 | RIFF, FLJ21786, RIF |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16407826 | 2006 | Cell line : HCT116,SW480,COLO320 Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR,Western blotting,Proliferation assay,Flow cytometry | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | RING-type (C3HC4) zinc fingers |
| Description | The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012] | Chromosome | 12 |
| Location | 12q24.31 |
| Start | 121837886 |
| End | 121862155 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 24270 |
| OMIM ID | 608299 |
| HGNC ID | HGNC:17297 |
| Unigene ID | Hs.292804 |
| Ensembl ID | - |
| PharmGKB ID | PA34436 |
Protein Information
| Protein ID | NP_001243787.1 |
|---|---|
| Protein Name | ring finger protein 34, E3 ubiquitin protein ligase |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 372 |
| Uniprot ID | Q96JY0 |
| Ensembl Protein ID | ENSP00000356844 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 255 |
| S | Phosphorylation | 254 |
| S | Phosphorylation | 257 |
| S | Phosphorylation | 256 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 9093 | DNAJA3 | 9758 | NP_005138.3 | yeast 2-hybrid | 12118383 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd15769 | 59-105 | FYVE_CARP1 |
| cl22851 | 59-105 | PHD_SF superfamily |
| cd00162 | 325-363 | RING |
| cl17238 | 325-363 | RING superfamily |
| cd15750 | 60-105 | FYVE_CARP |
| pfam13920 | 321-365 | zf-C3HC4_3 |
| cd15770 | 60-102 | FYVE_CARP2 |
| cd15758 | 62-105 | FYVE_RUFY1 |
| cd15731 | 62-90 | FYVE_LST2 |
| cd15721 | 62-103 | FYVE_RUFY1_like |
| cd15719 | 62-98 | FYVE_WDFY3 |
| cd00065 | 62-103 | FYVE_like_SF |
| cd15730 | 62-90 | FYVE_EEA1 |
| pfam13923 | 325-359 | zf-C3HC4_2 |
| COG5236 | 319-360 | COG5236 |
Ontology Information
| HPRD ID | 10951 |
|---|---|
| Molecular Class | Ubiquitin proteasome system protein |
| Molecular Function | Ubiquitin-specific protease activity (GO:0004843) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.