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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ROBO1 6091 roundabout, axon guidance receptor, homolog 1 (Drosophila)  3DUTT1, FLJ21882, SAX3 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24247621   2013Cell line : -

Source : -

Sample Type : Public database

No. of Sample : 77 GC and 88 CRC either with high MSI (MSI-H) or low MSI/microsatellite stability (MSI-L/MSS) .

Stage : -

SSCP, DNA sequencing, immunohistochemistryFrameshift Mutation-ROBO1 and ROBO2 frameshift mutations in GC and CRC


Gene Details



NC_000003.11 (78646388..79817059, complement)

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Gene Type protein coding
Gene Family Immunoglobulin superfamily / I-set domain containing, "Fibronectin type III domain containing"
Description Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]  
Chromosome 3
Location 3p12.3
Start 78646388  
End 79817059  
Strand -  
Gene Sequence

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Length 1170672  
OMIM ID 602430   
HGNC ID HGNC:10249   
Unigene ID Hs.744218   
Ensembl ID ENSG00000169855   
PharmGKB ID PA34620   

mRNA Information


mRNA ID ?NM_001145845.1
Exon join(90..247,178038..178175,642460..642543,829072..829398, 1021099..1021256,1050116..1050236,1050586..1050724, 1053475..1053602,1079227..1079351,1082082..1082253, 1097698..1097903,1099434..1099515,1099697..1099865, 1099950..1100116,1105885..1106006,1106738..1106969, 1108192..1108313,1110730..1110901,1116070..1116267, 1120344..1120370,1121809..1121851,1128101..1128255, 1131891..1132226,1133957..1134064,1136694..1136838, 1140430..1140678,1149958..1150364,1153199..1153351, 1160958..1161266,1167690..1167886,1169072..1170761)  
mRNA Sequence

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Length 6895  



CDS Information


   
Location209..5164
CDS Sequence

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CCDS ID CCDS46872.2



Protein Information


      
Protein IDNP_001139317.1
Protein Nameroundabout, axon guidance receptor, homolog 1 (Drosophila)
Molecular Wt. (Da)152989
Protein Sequence

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Length 1651  
Uniprot IDO14786
Ensembl Protein ID ENSP00000265371  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation940;-
SPhosphorylation901;-
SPhosphorylation1435;-
SPhosphorylation1396;-
TPhosphorylation942;-
TPhosphorylation903;-
TPhosphorylation944;-
TPhosphorylation905;-
TPhosphorylation1240;-
TPhosphorylation1201;-
SPhosphorylation1055
SPhosphorylation1016
SPhosphorylation1297
YPhosphorylation1311
SPhosphorylation1258
YPhosphorylation1272
SPhosphorylation1306
SPhosphorylation1267
SPhosphorylation1492
SPhosphorylation1453
TPhosphorylation1494
TPhosphorylation1455
YPhosphorylation1114
YPhosphorylation1126
YPhosphorylation1075
YPhosphorylation1087
YPhosphorylation932
YPhosphorylation893
SPhosphorylation1604
SPhosphorylation1606
SPhosphorylation1565
SPhosphorylation1567

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
10381TUBB34044NP_006077.2yeast 2-hybrid16169070   


Pathway Information


      
Pathway Name Pathway ID
Axon guidance hsa04360


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0769367-166  Ig1_Robo
cl1196067-166  Ig superfamily
cd05726365-454  Ig4_Robo
cl11960365-454  Ig superfamily
cd05724174-258  Ig2_Robo
cl11960174-258  Ig superfamily
cd05725279-347  Ig3_Robo
cl11960279-347  Ig superfamily
cd00063561-647  FN3
cl21522561-647  FN3 superfamily
cd00063778-870  FN3
cl21522778-870  FN3 superfamily
cd00063684-770  FN3
cl21522684-770  FN3 superfamily
cd0572274-165  Ig1_Neogenin
cd04969283-347  Ig5_Contactin_like
cd07693174-258  Ig1_Robo
cd00096279-344  Ig
cd0572472-165  Ig2_Robo
cd05745365-445  Ig3_Peroxidasin
cd05723281-347  Ig4_Neogenin
cd00096368-442  Ig
smart00060561-643  FN3
cd05724459-533  Ig2_Robo
cl11960459-533  Ig superfamily
cd05730173-253  Ig3_NCAM-1_like
cd05731283-348  Ig3_L1-CAM_like
cd05747267-346  Ig5_Titin_like
cd04968265-348  Ig3_Contactin_like
cd05729271-347  Ig2_FGFR_like
cd05764279-347  Ig_2
cd04968350-445  Ig3_Contactin_like
cd05728264-347  Ig4_Contactin-2-like
pfam00041778-864  fn3
cd05764474-535  Ig_2
cd05738476-532  Ig2_RPTP_IIa_LAR_like
cd00096473-539  Ig
pfam00041562-646  fn3
cd0009685-156  Ig
cd04969469-542  Ig5_Contactin_like
cd04968454-543  Ig3_Contactin_like
cd07693262-347  Ig1_Robo
cd05763279-347  Ig_1
cd05730453-542  Ig3_NCAM-1_like
cd04967262-338  Ig1_Contactin
cd05728171-258  Ig4_Contactin-2-like
cd04969365-445  Ig5_Contactin_like
cd05725368-445  Ig3_Robo
cd0496989-165  Ig5_Contactin_like
cd0573386-163  Ig6_L1-CAM_like
smart00060778-861  FN3
pfam1389574-165  Ig_2
cd05745274-347  Ig3_Peroxidasin
cd05851350-445  Ig3_Contactin-1
cd0584868-164  Ig1_Contactin-5
cd05730257-347  Ig3_NCAM-1_like
cd05857271-347  Ig2_FGFR
cd04967172-254  Ig1_Contactin
cd05746283-346  Ig4_Peroxidasin
cd05724355-445  Ig2_Robo
cd05746474-537  Ig4_Peroxidasin
cd05725473-542  Ig3_Robo
cd05722172-258  Ig1_Neogenin
cd05728356-445  Ig4_Contactin-2-like
cd0497882-165  Ig4_L1-NrCAM_like
cd05732463-542  Ig5_NCAM-1_like
cd04978365-445  Ig4_L1-NrCAM_like
cd04969188-251  Ig5_Contactin_like
cd0587487-160  Ig6_NrCAM
cd05738187-258  Ig2_RPTP_IIa_LAR_like
cd05876282-348  Ig3_L1-CAM
cd05750282-345  Ig_Pro_neuregulin
cd0496768-162  Ig1_Contactin
pfam13927261-334  Ig_3
cd05763371-445  Ig_1
cd05747350-435  Ig5_Titin_like
pfam13895267-347  Ig_2
cd05743365-437  Ig_Perlecan_D2_like
cd00096187-253  Ig
cd05748286-347  Ig_Titin_like
pfam00047365-430  ig
cd05765365-437  Ig_3
pfam13927454-529  Ig_3
cd04972262-347  Ig_TrkABC_d4
cd05869463-542  Ig5_NCAM-1
cd0576385-165  Ig_1
cd05852282-347  Ig5_Contactin-1
cd05851276-348  Ig3_Contactin-1
cd05849189-257  Ig1_Contactin-1
cd05722443-528  Ig1_Neogenin
cd05732351-445  Ig5_NCAM-1_like
cd05848262-337  Ig1_Contactin-5
pfam13927350-429  Ig_3
cd05754265-345  Ig3_Perlecan_like
cd0573186-165  Ig3_L1-CAM_like
cd05736279-349  Ig2_Follistatin_like
cd05729461-533  Ig2_FGFR_like
cd05728459-542  Ig4_Contactin-2-like
cd05856461-542  Ig2_FGFRL1-like
cd05869362-445  Ig5_NCAM-1
cd05746368-436  Ig4_Peroxidasin
pfam13895176-258  Ig_2
cd0572871-165  Ig4_Contactin-2-like
pfam13895353-446  Ig_2
cd05870463-542  Ig5_NCAM-2
cd07693454-538  Ig1_Robo
cd05856271-347  Ig2_FGFRL1-like
cd0574766-159  Ig5_Titin_like
cd04978184-247  Ig4_L1-NrCAM_like
pfam13895453-543  Ig_2
cd05725187-258  Ig3_Robo
pfam00041684-750  fn3
pfam1392767-151  Ig_3
cd05848172-256  Ig1_Contactin-5
pfam00047277-332  ig
cd05748193-253  Ig_Titin_like
cd05754354-428  Ig3_Perlecan_like
cd05867184-247  Ig4_L1-CAM_like
cd05738369-436  Ig2_RPTP_IIa_LAR_like
cd07693350-441  Ig1_Robo
cd05748479-543  Ig_Titin_like
smart00406367-430  IGv
cd05848351-440  Ig1_Contactin-5
cd05729180-248  Ig2_FGFR_like
cd05745195-258  Ig3_Peroxidasin
cd05729362-437  Ig2_FGFR_like
cd0586782-154  Ig4_L1-CAM_like
cd05732277-347  Ig5_NCAM-1_like
cd05726471-544  Ig4_Robo
cd05851454-543  Ig3_Contactin-1
cd05743280-337  Ig_Perlecan_D2_like
cd0573685-154  Ig2_Follistatin_like
cd0587587-164  Ig6_hNeurofascin_like
cd05849262-346  Ig1_Contactin-1
cd0496867-154  Ig3_Contactin_like
cd05722353-445  Ig1_Neogenin
cd05734368-441  Ig7_DSCAM
cd04974277-347  Ig3_FGFR
cd0573082-156  Ig3_NCAM-1_like
cd0572585-165  Ig3_Robo
cd05735280-351  Ig8_DSCAM
cd05763474-542  Ig_1
cd05723368-443  Ig4_Neogenin
cd05730364-435  Ig3_NCAM-1_like
cd05850262-337  Ig1_Contactin-2
cd05754176-245  Ig3_Perlecan_like
cd05744368-445  Ig_Myotilin_C_like
cd0585068-163  Ig1_Contactin-2
cd04970277-351  Ig6_Contactin_like
cd0574581-154  Ig3_Peroxidasin
cd05733188-247  Ig6_L1-CAM_like
cd05856360-437  Ig2_FGFRL1-like
cd0573885-165  Ig2_RPTP_IIa_LAR_like
cd04972455-538  Ig_TrkABC_d4
cd00099361-429  IgV
cd04978471-542  Ig4_L1-NrCAM_like
cd0576482-167  Ig_2
cd05745476-542  Ig3_Peroxidasin
cd05750188-247  Ig_Pro_neuregulin
cd05867365-445  Ig4_L1-CAM_like
cd05870351-445  Ig5_NCAM-2
cd04967351-440  Ig1_Contactin
cd05750473-540  Ig_Pro_neuregulin
cd04967455-532  Ig1_Contactin
cd05764184-253  Ig_2
cd0586882-154  Ig4_NrCAM
cd05736474-532  Ig2_Follistatin_like
smart00060684-752  FN3
cd05850172-256  Ig1_Contactin-2
cd0572389-158  Ig4_Neogenin
cd0584968-163  Ig1_Contactin-1
pfam0004782-149  ig
cd04976195-258  Ig2_VEGFR
cd05723473-538  Ig4_Neogenin
pfam13927175-244  Ig_3
cd05743471-527  Ig_Perlecan_D2_like
cd05893368-445  Ig_Palladin_C
cd05858278-347  Ig3_FGFR-2
cd05869272-347  Ig5_NCAM-1
cd05870278-347  Ig5_NCAM-2
cd04978279-347  Ig4_L1-NrCAM_like
cd05731473-543  Ig3_L1-CAM_like
cd05892368-445  Ig_Myotilin_C
cd05747454-537  Ig5_Titin_like
cd0585167-165  Ig3_Contactin-1
cd05741399-442  Ig_CEACAM_D1_like
cd05764365-435  Ig_2
cd04976286-346  Ig2_VEGFR
cd04983357-428  IgV_TCR_alpha_like
cd05852470-542  Ig5_Contactin-1
cd05864287-347  Ig2_VEGFR-2
cd05849455-537  Ig1_Contactin-1
cd05722263-334  Ig1_Neogenin
cd05734473-532  Ig7_DSCAM
cd0573280-154  Ig5_NCAM-1_like
cd05733282-339  Ig6_L1-CAM_like
cd05857362-445  Ig2_FGFR
cd05854277-351  Ig6_Contactin-2
cd05894479-542  Ig_C5_MyBP-C
cd05848455-532  Ig1_Contactin-5
cd05726184-247  Ig4_Robo
cd05739278-346  Ig3_RPTP_IIa_LAR_like
cd0497270-109  Ig_TrkABC_d4
cd05737283-347  Ig_Myomesin_like_C
cd05746195-247  Ig4_Peroxidasin
cd05720364-428  Ig_CD8_alpha
cd0585779-165  Ig2_FGFR
cd04979179-260  Ig_Semaphorin_C
cd05856179-248  Ig2_FGFRL1-like
cd04974365-445  Ig3_FGFR
cd04979273-352  Ig_Semaphorin_C
cd04973483-536  Ig1_FGFR
cd0573486-165  Ig7_DSCAM
cd0574893-159  Ig_Titin_like
cd05859267-348  Ig4_PDGFR-alpha
cd05891283-347  Ig_M-protein_C
cd05723188-251  Ig4_Neogenin
cd04968174-247  Ig3_Contactin_like
cd05868365-445  Ig4_NrCAM
pfam00047470-527  ig
cd05876473-543  Ig3_L1-CAM
cd0586983-155  Ig5_NCAM-1
cd04984362-430  IgV_L_lambda
cd05882359-428  Ig1_Necl-1
cd05899347-428  IgV_TCR_beta
cd05760282-347  Ig2_PTK7
cd05760196-248  Ig2_PTK7
cd05748375-446  Ig_Titin_like
cd05859482-543  Ig4_PDGFR-alpha
pfam07686345-432  V-set
cd05875282-339  Ig6_hNeurofascin_like
cd07702195-241  Ig2_VEGFR-1
cd05852184-251  Ig5_Contactin-1
cd05864196-258  Ig2_VEGFR-2
cd05857193-247  Ig2_FGFR
cd05852365-445  Ig5_Contactin-1
cd05733368-440  Ig6_L1-CAM_like
cd05738283-348  Ig2_RPTP_IIa_LAR_like
cd05894287-348  Ig_C5_MyBP-C
cd04970185-258  Ig6_Contactin_like
cd05736196-247  Ig2_Follistatin_like
cd05757200-241  Ig2_IL1R_like
cd05731368-437  Ig3_L1-CAM_like
cd05739470-540  Ig3_RPTP_IIa_LAR_like
cd0572987-165  Ig2_FGFR_like
cd05744474-542  Ig_Myotilin_C_like
cd04970473-542  Ig6_Contactin_like
cd05732184-247  Ig5_NCAM-1_like
cd0587686-159  Ig3_L1-CAM
cd05736369-435  Ig2_Follistatin_like
cd0575087-156  Ig_Pro_neuregulin
cd05875473-534  Ig6_hNeurofascin_like
cd05894193-258  Ig_C5_MyBP-C
cd05763187-259  Ig_1
cd0576582-154  Ig_3
cd05717359-429  Ig1_Necl-1-3_like
pfam07686268-347  V-set
cd05731188-247  Ig3_L1-CAM_like
cd05874188-247  Ig6_NrCAM
pfam07679262-347  I-set
pfam07679351-445  I-set
pfam0767968-165  I-set
pfam07679172-258  I-set
pfam07679455-542  I-set
smart00409268-347  IG
smart00410268-347  IG_like
smart00410357-445  IG_like
smart00409357-445  IG
smart00410461-542  IG_like
smart00409461-542  IG
smart0041074-165  IG_like
smart0040974-165  IG
smart00408276-337  IGc2
smart00410176-258  IG_like
smart00409176-258  IG
smart00408365-435  IGc2
smart0040882-154  IGc2
smart00408469-532  IGc2
smart00408184-247  IGc2
PHA02785309-531  PHA02785


Ontology Information


   
HPRD ID3299
Molecular ClassAdhesion molecule
Molecular FunctionHydrolase activity (GO:0016787)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO