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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ROBO2 6092 roundabout, axon guidance receptor, homolog 2 (Drosophila)  3KIAA1568 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24247621   2013Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 77 GC and 88 CRC either with high MSI (MSI-H) or low MSI/microsatellite stability (MSI-L/MSS).

Stage : -

Immunohistochemistry,single-strand conformation polymorphism (SSCP) and DNA sequencing.Frameshift Mutation-ROBO1 and ROBO2 frameshift mutations in GC and CRC.


Gene Details



NC_000003.11 (75955845..77699115)

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Gene Type protein coding
Gene Family Immunoglobulin superfamily / I-set domain containing, "Fibronectin type III domain containing"
Description The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]  
Chromosome 3
Location 3p12.3
Start 75955845  
End 77699115  
Strand +  
Gene Sequence

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Length 1743271  
OMIM ID 602431   
HGNC ID HGNC:10250   
Unigene ID Hs.13305   
Ensembl ID ENSG00000185008   
PharmGKB ID PA34621   

mRNA Information


mRNA ID ?NM_001128929.3
Exon join(1..286,30807..30928,1191340..1191666, 1570740..1570897,1574425..1574545,1586570..1586708, 1616101..1616228,1639664..1639788,1644144..1644315, 1651270..1651475,1655977..1656058,1656493..1656655, 1658280..1658446,1661639..1661760,1667825..1668056, 1670816..1670940,1673273..1673444,1682077..1682259, 1688468..1688510,1689949..1690076,1695536..1695817, 1701124..1701280,1710839..1711099,1715553..1715758, 1728196..1728369,1738030..1738230,1739380..1743290)  
mRNA Sequence

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Length 8393  



CDS Information


   
Location300..4484
CDS Sequence

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CCDS ID CCDS43109.1



Protein Information


      
Protein IDNP_001122401.1
Protein Nameroundabout, axon guidance receptor, homolog 2 (Drosophila)
Molecular Wt. (Da)158044
Protein Sequence

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Length 1378  
Uniprot IDO14508
Ensembl Protein ID ENSP00000339428  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                          
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
6091ROBO13890NP_002932.1in vitro12504588   
6749SSRP15061NP_003137.1yeast 2-hybrid16169070   
9353SLIT24776NP_004778.1in vitro10102268   
56893UBQLN45670NP_064516.2yeast 2-hybrid16713569   
84152PPP1R1B5097NP_115568.2yeast 2-hybrid16169070   
93145OLFM210127NP_477512.1yeast 2-hybrid16169070   


Pathway Information


      
Pathway Name Pathway ID
Axon guidance hsa04360


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0769330-129  Ig1_Robo
cl1196030-129  Ig superfamily
cd05726328-417  Ig4_Robo
cl11960328-417  Ig superfamily
cd00063522-615  FN3
cl21522522-615  FN3 superfamily
cd00096435-502  Ig
cl11960435-502  Ig superfamily
cd00063740-832  FN3
cl21522740-832  FN3 superfamily
cd00063646-731  FN3
cl21522646-731  FN3 superfamily
cd05724137-221  Ig2_Robo
cl11960137-221  Ig superfamily
cd05725242-310  Ig3_Robo
cl11960242-310  Ig superfamily
cd0572237-128  Ig1_Neogenin
smart00060522-604  FN3
cd0572435-128  Ig2_Robo
cd05723242-310  Ig4_Neogenin
pfam00041523-607  fn3
cd05724422-496  Ig2_Robo
cd00096242-307  Ig
cd05725435-505  Ig3_Robo
cd00096331-405  Ig
cd05745327-408  Ig3_Peroxidasin
cd0584831-127  Ig1_Contactin-5
cd04969328-408  Ig5_Contactin_like
cd04969432-505  Ig5_Contactin_like
cd05856437-505  Ig2_FGFRL1-like
smart00060740-823  FN3
pfam00041739-826  fn3
cd04969246-310  Ig5_Contactin_like
cd0496731-125  Ig1_Contactin
cd05730136-222  Ig3_NCAM-1_like
cd0009649-119  Ig
cd05747226-309  Ig5_Titin_like
cd05729242-310  Ig2_FGFR_like
pfam1389537-128  Ig_2
cd05764434-498  Ig_2
cd04969151-214  Ig5_Contactin_like
cd05736435-508  Ig2_Follistatin_like
cd07693137-221  Ig1_Robo
cd05731242-311  Ig3_L1-CAM_like
cd05738159-221  Ig2_RPTP_IIa_LAR_like
cd05729437-505  Ig2_FGFR_like
cd0573349-126  Ig6_L1-CAM_like
cd04967135-210  Ig1_Contactin
cd05730240-312  Ig3_NCAM-1_like
cd05870426-505  Ig5_NCAM-2
cd04978328-408  Ig4_L1-NrCAM_like
cd05728246-310  Ig4_Contactin-2-like
pfam13895139-221  Ig_2
cd0496952-128  Ig5_Contactin_like
cd05763334-408  Ig_1
cd05857242-310  Ig2_FGFR
cd05746437-503  Ig4_Peroxidasin
cd05748248-311  Ig_Titin_like
cd05732426-505  Ig5_NCAM-1_like
cd05763435-505  Ig_1
cd00096150-211  Ig
cd05745238-310  Ig3_Peroxidasin
cd05722135-221  Ig1_Neogenin
cd05728134-221  Ig4_Contactin-2-like
cd04972235-310  Ig_TrkABC_d4
cd04972418-505  Ig_TrkABC_d4
cd05849158-220  Ig1_Contactin-1
cd05728421-505  Ig4_Contactin-2-like
cd05728315-408  Ig4_Contactin-2-like
cd05765328-408  Ig_3
cd04968417-495  Ig3_Contactin_like
cd0587450-123  Ig6_NrCAM
pfam00047328-393  ig
cd05746242-309  Ig4_Peroxidasin
cd05738435-501  Ig2_RPTP_IIa_LAR_like
cd05730416-505  Ig3_NCAM-1_like
cd0573045-119  Ig3_NCAM-1_like
pfam13927417-492  Ig_3
cd05724318-398  Ig2_Robo
cd0576350-128  Ig_1
cd05856228-310  Ig2_FGFRL1-like
cd05732226-310  Ig5_NCAM-1_like
pfam13927224-297  Ig_3
cd05722227-297  Ig1_Neogenin
cd05747417-496  Ig5_Titin_like
cd05849225-309  Ig1_Contactin-1
cd0573149-119  Ig3_L1-CAM_like
cd07693313-393  Ig1_Robo
cd0572834-128  Ig4_Contactin-2-like
cd0497845-128  Ig4_L1-NrCAM_like
cd0585031-126  Ig1_Contactin-2
pfam13927313-393  Ig_3
cd04968313-408  Ig3_Contactin_like
cd07693417-505  Ig1_Robo
cd05851313-408  Ig3_Contactin-1
pfam13895315-393  Ig_2
cd07693225-300  Ig1_Robo
cd04968242-310  Ig3_Contactin_like
cd05848135-210  Ig1_Contactin-5
cd0587550-127  Ig6_hNeurofascin_like
cd05736245-310  Ig2_Follistatin_like
pfam1392730-114  Ig_3
cd0573848-128  Ig2_RPTP_IIa_LAR_like
cd05731436-498  Ig3_L1-CAM_like
cd05745439-505  Ig3_Peroxidasin
cd04974242-310  Ig3_FGFR
cd04967225-301  Ig1_Contactin
cd05852433-505  Ig5_Contactin-1
pfam00041645-713  fn3
cd04978147-210  Ig4_L1-NrCAM_like
cd05750245-308  Ig_Pro_neuregulin
cd05763243-310  Ig_1
cd0574729-118  Ig5_Titin_like
cd05747313-389  Ig5_Titin_like
cd05856323-408  Ig2_FGFRL1-like
cd05876246-310  Ig3_L1-CAM
pfam00047239-295  ig
cd04978434-505  Ig4_L1-NrCAM_like
cd05725150-221  Ig3_Robo
cd05764147-211  Ig_2
cd05852242-310  Ig5_Contactin-1
cd05722316-408  Ig1_Neogenin
cd0496830-117  Ig3_Contactin_like
cd05867147-210  Ig4_L1-CAM_like
cd05746331-399  Ig4_Peroxidasin
pfam13895230-310  Ig_2
cd05733436-495  Ig6_L1-CAM_like
cd05743434-495  Ig_Perlecan_D2_like
cd05723331-406  Ig4_Neogenin
pfam13927138-207  Ig_3
cd0572549-128  Ig3_Robo
cd05729152-211  Ig2_FGFR_like
cd05723436-503  Ig4_Neogenin
cd0573649-117  Ig2_Follistatin_like
cd04978239-311  Ig4_L1-NrCAM_like
cd0584931-126  Ig1_Contactin-1
pfam00047433-490  ig
cd05894139-221  Ig_C5_MyBP-C
cd05764242-311  Ig_2
cd05857434-505  Ig2_FGFR
pfam07686420-495  V-set
cd05845142-197  Ig2_L1-CAM_like
cd05737236-310  Ig_Myomesin_like_C
cd05743328-402  Ig_Perlecan_D2_like
cd05867328-408  Ig4_L1-CAM_like
cd05754317-391  Ig3_Perlecan_like
cd04968137-222  Ig3_Contactin_like
pfam07686137-221  V-set
cd05891236-310  Ig_M-protein_C
cd05867434-495  Ig4_L1-CAM_like
cd0576445-122  Ig_2
cd05732321-408  Ig5_NCAM-1_like
cd04979142-206  Ig_Semaphorin_C
smart00060648-715  FN3
cd04970374-418  Ig6_Contactin_like
cd05869233-310  Ig5_NCAM-1
cd0572352-121  Ig4_Neogenin
cd05760242-310  Ig2_PTK7
cd05729328-408  Ig2_FGFR_like
cd05869437-505  Ig5_NCAM-1
cd04976247-309  Ig2_VEGFR
smart00406434-488  IGv
cd05750151-210  Ig_Pro_neuregulin
cd05744152-210  Ig_Myotilin_C_like
cd05870233-310  Ig5_NCAM-2
cd05738332-408  Ig2_RPTP_IIa_LAR_like
cd0574544-117  Ig3_Peroxidasin
cd05851416-495  Ig3_Contactin-1
cd05773415-503  Ig8_hNephrin_like
cd05754218-308  Ig3_Perlecan_like
cd05893152-210  Ig_Palladin_C
cd05764328-408  Ig_2
cd04977424-502  Ig1_NCAM-1_like
cd05851237-311  Ig3_Contactin-1
cd00099324-393  IgV
cd0585130-117  Ig3_Contactin-1
cd05848225-300  Ig1_Contactin-5
cd0586745-117  Ig4_L1-CAM_like
cd05850225-300  Ig1_Contactin-2
cd05765147-210  Ig_3
cd05850135-219  Ig1_Contactin-2
cd04967314-403  Ig1_Contactin
cd05735243-314  Ig8_DSCAM
cd05736150-221  Ig2_Follistatin_like
cd05870317-398  Ig5_NCAM-2
pfam0004745-112  ig
cd05722428-494  Ig1_Neogenin
cd05750437-501  Ig_Pro_neuregulin
cd05866429-503  Ig1_NCAM-2
cd05869331-408  Ig5_NCAM-1
pfam13895424-495  Ig_2
cd0586845-117  Ig4_NrCAM
cd05858242-310  Ig3_FGFR-2
cd05882322-396  Ig1_Necl-1
cd05892152-210  Ig_Myotilin_C
cd05746158-210  Ig4_Peroxidasin
cd0497233-72  Ig_TrkABC_d4
cd0572950-118  Ig2_FGFR_like
cd0575050-122  Ig_Pro_neuregulin
cd0573449-128  Ig7_DSCAM
cd0586931-128  Ig5_NCAM-1
cd05730313-408  Ig3_NCAM-1_like
cd05848418-495  Ig1_Contactin-5
cd05757163-204  Ig2_IL1R_like
cd0585742-117  Ig2_FGFR
cd05738246-311  Ig2_RPTP_IIa_LAR_like
cd04983320-399  IgV_TCR_alpha_like
cd05894248-311  Ig_C5_MyBP-C
cd04970435-505  Ig6_Contactin_like
cd05848314-403  Ig1_Contactin-5
cd0585645-128  Ig2_FGFRL1-like
cd05854357-418  Ig6_Contactin-2
cd05875436-495  Ig6_hNeurofascin_like
cd0574650-119  Ig4_Peroxidasin
cd05856159-211  Ig2_FGFRL1-like
cd05858433-505  Ig3_FGFR-2
cd0573243-117  Ig5_NCAM-1_like
cd05852147-214  Ig5_Contactin-1
cd05852328-408  Ig5_Contactin-1
cd05744331-408  Ig_Myotilin_C_like
cd05739433-503  Ig3_RPTP_IIa_LAR_like
cd05734331-404  Ig7_DSCAM
cd05893242-310  Ig_Palladin_C
cd05741337-408  Ig_CEACAM_D1_like
cd0576049-129  Ig2_PTK7
cd04979320-394  Ig_Semaphorin_C
cd05854240-314  Ig6_Contactin-2
pfam07686320-395  V-set
cd04970240-314  Ig6_Contactin_like
cd05763150-221  Ig_1
cd05748338-409  Ig_Titin_like
cd05751143-221  Ig1_LILRB1_like
cd05754139-222  Ig3_Perlecan_like
cd05741453-497  Ig_CEACAM_D1_like
cd05765433-495  Ig_3
cd05851141-221  Ig3_Contactin-1
cd0587649-119  Ig3_L1-CAM
cd04973437-505  Ig1_FGFR
cd0575947-114  Ig2_KIRREL3-like
cd05754419-513  Ig3_Perlecan_like
cd05857325-408  Ig2_FGFR
cd05893437-505  Ig_Palladin_C
cd05743240-300  Ig_Perlecan_D2_like
cd05765240-310  Ig_3
cd05867240-310  Ig4_L1-CAM_like
cd05748442-498  Ig_Titin_like
cd05871152-206  Ig_Semaphorin_classIII
cd05736335-398  Ig2_Follistatin_like
pfam00047147-205  ig
cd04967418-500  Ig1_Contactin
cd05892331-408  Ig_Myotilin_C
cd05854435-505  Ig6_Contactin-2
cd05748156-211  Ig_Titin_like
cd0574935-127  Ig2_Tyro3_like
cd05864250-310  Ig2_VEGFR-2
cd0574856-119  Ig_Titin_like
cd05716327-393  Ig_pIgR
cd05717322-395  Ig1_Necl-1-3_like
cd0572645-128  Ig4_Robo
cd05737325-389  Ig_Myomesin_like_C
cd04970148-221  Ig6_Contactin_like
cd00099142-203  IgV
cd05744242-310  Ig_Myotilin_C_like
pfam07679225-310  I-set
smart00409424-505  IG
pfam07679314-408  I-set
pfam0767931-128  I-set
pfam07679135-221  I-set
smart00410424-505  IG_like
smart00410320-408  IG_like
smart00409320-408  IG
smart00410231-310  IG_like
smart00409231-310  IG
pfam07679418-505  I-set
smart00410139-221  IG_like
smart00409139-221  IG
smart0041037-128  IG_like
smart0040937-128  IG
smart00408238-300  IGc2
smart00408432-495  IGc2
smart0040845-117  IGc2
smart00408147-210  IGc2
smart00408327-398  IGc2
PHA02785258-490  PHA02785
PHA031321231-1372  PHA03132


Ontology Information


   
HPRD ID4550
Molecular ClassCell surface receptor
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessSignal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO