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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26185457 | 2015 | Cell line : - Source : �Renji Hospital (Shanghai, People�s Republic of China) Sample Type : - No. of Sample : - Stage : - | Enrichment of methylated DNA fragments and promoter microarray hybridization, | Hypermethylation | - | RPL22, RPL36, RPLP2, RPS7, and RPS9 were commonly regulated by transcription factors, and YY1 and IRF4 were hypermethylated. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | L ribosomal proteins |
| Description | Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. [provided by RefSeq, Jul 2008] | Chromosome | 1 |
| Location | 1p36.31 |
| Start | 6245080 |
| End | 6259679 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 14600 |
| OMIM ID | 180474 |
| HGNC ID | HGNC:10315 |
| Unigene ID | Hs.515329 |
| Ensembl ID | ENSG00000116251 |
| PharmGKB ID | PA34688 |
mRNA Information
| mRNA ID | ?NM_000983.3 |
|---|---|
| Exon | join(1..58,1864..1968,6566..6690,12804..14600) | mRNA Sequence | Download Select all |
| Length | 2099 |
Protein Information
| Protein ID | NP_000974.1 |
|---|---|
| Protein Name | ribosomal protein L22 |
| Molecular Wt. (Da) | 119178 |
| Protein Sequence | Download Select all |
| Length | 128 |
| Uniprot ID | O15379 |
| Ensembl Protein ID | ENSP00000302967 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 55968 | NSFL1C | 9425 | NP_057227.2 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Ribosome | hsa03010 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01776 | 21-119 | Ribosomal_L22e |
| cl03348 | 21-119 | Ribosomal_L22e superfamily |
| PTZ00198 | 21-119 | PTZ00198 |
Ontology Information
| HPRD ID | 10956 |
|---|---|
| Molecular Class | Ribosomal subunit |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.