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General Information
- Evidence
- Gene
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20473941 | 2011 | Cell line : SW480, HT 29, SW837, SW48, T84, LS 513, HCT
116, SW1463, SW1116, LS 411N, NCI-H716, LoVo, NCI-H508, COLO 201, COLO
320DM, LS 123, LS 174T, DLD-1, Caco-2, LS 1034, SK-CO-1, RKO, SW403, SW620.
p53HCT 116 Source : ATCC Sample Type : - No. of Sample : - Stage : - | RNAi-based Experiments,Cell Viability Assay,Gene Expression Profiling Following RNAi, Estimation of Signal Flow Networks and Pathway analysis,Immunohistochemistry | Up-regulation | - | RPS2 and NOL5A as promising potential therapeutic targets in CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | S ribosomal proteins |
| Description | Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S5P family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with mouse LLRep3. It is co-transcribed with the small nucleolar RNA gene U64, which is located in its third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008] | Chromosome | 16 |
| Location | 16p13.3 |
| Start | 2012059 |
| End | 2014827 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 2769 |
| OMIM ID | 603624 |
| HGNC ID | HGNC:10404 |
| Unigene ID | Hs.356366 |
| Ensembl ID | ENSG00000140988 |
| PharmGKB ID | PA34806 |
mRNA Information
| mRNA ID | ?NM_002952.3 |
|---|---|
| Exon | join(1..20,199..378,462..551,1571..1678,1918..2091, 2171..2330,2557..2766) | mRNA Sequence | Download Select all |
| Length | 962 |
Protein Information
| Protein ID | NP_002943.2 |
|---|---|
| Protein Name | ribosomal protein S2 |
| Molecular Wt. (Da) | 29467 |
| Protein Sequence | Download Select all |
| Length | 293 |
| Uniprot ID | Q9Y6R7 |
| Ensembl Protein ID |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 281;- |
| S | Phosphorylation | 264 |
| T | Phosphorylation | 278 |
| T | Phosphorylation | 293 |
| K | Acetylation | 275 |
| K | Acetylation | 263 |
| Y | Phosphorylation | 133 |
| T | Phosphorylation | 262 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Ribosome | hsa03010 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00333 | 101-167 | Ribosomal_S5 |
| cl02842 | 101-167 | Ribosomal_S5 superfamily |
| pfam03719 | 184-257 | Ribosomal_S5_C |
| cl04231 | 184-257 | Ribosomal_S5_C superfamily |
| TIGR01020 | 54-263 | uS5_euk_arch |
| PTZ00070 | 54-273 | PTZ00070 |
| PRK04044 | 54-259 | rps5p |
| COG0098 | 71-258 | RpsE |
| TIGR01021 | 102-250 | rpsE_bact |
| PRK00550 | 102-246 | rpsE |
| CHL00138 | 106-219 | rps5 |
Ontology Information
| HPRD ID | 4575 |
|---|---|
| Molecular Class | Ribosomal subunit |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.