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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RRBP1 6238 ribosome binding protein 1  20ES/130, hES 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
26196185   2015Cell line : -

Source : -

Sample Type : Population based case control study

No. of Sample : 856

Stage : TNM Stage I-III

Immunohistochemisty Up-regulation-High RRBP1 expression facilitates CRC progression and predicts an unfavourable post-operative prognosis.


Gene Details



NC_000020.10 (17594323..17662934, complement)

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Gene Type protein coding
Gene Family -
Description This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12. [provided by RefSeq, Apr 2012]  
Chromosome 20
Location 20p12
Start 17594323  
End 17662934  
Strand -  
Gene Sequence

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Length 68612  
OMIM ID 601418   
HGNC ID HGNC:10448   
Unigene ID Hs.472213   
Ensembl ID ENSG00000125844   
PharmGKB ID PA34863   

mRNA Information


mRNA ID ?NM_001042576.1
Exon join(1..256,21756..22304,23595..23679,39157..39305, 40365..40487,45555..45707,46620..46738,48671..48824, 52323..52461,54602..54780,54902..54936,56682..56772, 57616..57708,60337..60429,60511..60594,60737..60826, 61477..61569,61914..61985,62556..62651,63605..63688, 65445..65552,66275..66358,66755..66853,67404..67547, 68064..68606)  
mRNA Sequence

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Length 3715  



CDS Information


   
Location 278..3211
CDS Sequence

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CCDS ID CCDS13128.1



Protein Information


      
Protein IDNP_001036041.1
Protein Nameribosome binding protein 1
Molecular Wt. (Da)83487
Protein Sequence

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Length 1410  
Uniprot IDQ96AE4
Ensembl Protein ID ENSP00000294623  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation185
SPhosphorylation185;-
SPhosphorylation843;-
SPhosphorylation843;-
SPhosphorylation844;-
SPhosphorylation844;-
SPhosphorylation526
SPhosphorylation526
SPhosphorylation135
SPhosphorylation135
SPhosphorylation830
SPhosphorylation830
TPhosphorylation360
TPhosphorylation360

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


      
Pathway Name Pathway ID
Protein processing in endoplasmic reticulum hsa04141


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam0510433-171  Rib_recp_KP_reg
TIGR02168698-1395  SMC_prok_B
TIGR02168764-1400  SMC_prok_B
COG1196695-1397  Smc
PTZ00121288-1020  PTZ00121
PTZ00121171-621  PTZ00121
COG1196696-1406  Smc
COG1196690-1399  Smc
TIGR02168674-1398  SMC_prok_B
COG0419814-1399  SbcC
COG1196797-1406  Smc
TIGR02169766-1053  SMC_prok_A
PRK02224806-1196  PRK02224
pfam12128767-1399  DUF3584
TIGR02168652-1012  SMC_prok_B
TIGR02168687-1395  SMC_prok_B
pfam12128753-1395  DUF3584
PRK02224752-1205  PRK02224
pfam12128698-1363  DUF3584
PTZ00121315-1055  PTZ00121
TIGR021681110-1401  SMC_prok_B
COG1196823-1400  Smc
COG1196822-1399  Smc
TIGR00927252-523  2A1904
PTZ00121815-1406  PTZ00121
COG11961110-1407  Smc
pfam09606219-575  Med15
pfam02463666-1400  SMC_N
PRK03918811-1400  PRK03918
TIGR00927221-473  2A1904
TIGR00927385-650  2A1904
PRK02224920-1402  PRK02224
TIGR00927287-541  2A1904
TIGR02169764-1396  SMC_prok_A
TIGR00927241-483  2A1904
pfam12128666-1215  DUF3584
TIGR021681134-1400  SMC_prok_B
TIGR021691110-1406  SMC_prok_A
PRK12678343-542  PRK12678
TIGR00927201-453  2A1904
PRK02224950-1400  PRK02224
COG0419939-1402  SbcC
TIGR00927332-581  2A1904
TIGR02169693-1397  SMC_prok_A
PRK11281757-1020  PRK11281
pfam13514770-1409  AAA_27
pfam13514717-1384  AAA_27
pfam02463695-1410  SMC_N
TIGR00618695-1261  sbcc
PRK112811100-1394  PRK11281
TIGR02169824-1400  SMC_prok_A
pfam03276187-329  Gag_spuma
pfam04111785-902  APG6
TIGR00927171-416  2A1904
TIGR021691112-1407  SMC_prok_A
pfam09606190-536  Med15
COG0419666-1207  SbcC
pfam08317760-883  Spc7
pfam13779290-464  DUF4175
COG30961108-1406  MukB
pfam04111761-885  APG6
pfam03157186-638  Glutenin_hmw
TIGR026801162-1400  TIGR02680
pfam03157174-542  Glutenin_hmw
pfam04156919-1040  IncA
PRK04863821-1047  mukB
pfam13779354-527  DUF4175
TIGR02169698-1359  SMC_prok_A
pfam03157186-586  Glutenin_hmw
TIGR00618771-1399  sbcc
pfam041561145-1258  IncA
COG0497817-1035  RecN
TIGR00618818-1400  sbcc
COG4942796-1056  EnvC
TIGR02168989-1318  SMC_prok_B
TIGR00927188-402  2A1904
COG3264751-956  MscK
pfam01576747-1407  Myosin_tail_1
PRK04863801-1266  mukB
pfam13779288-434  DUF4175
pfam04156791-901  IncA
TIGR02169921-1250  SMC_prok_A
PRK11637762-997  PRK11637
smart00787762-883  Spc7
PHA03169477-645  PHA03169
pfam05557976-1397  MAD
COG4717792-1402  YhaN
PRK09510296-525  tolA
PRK04863752-1015  mukB
TIGR04211773-883  SH3_and_anchor
PRK109291101-1394  PRK10929
TIGR02302276-538  aProt_lowcomp
PRK05035330-539  PRK05035
pfam061601116-1400  EzrA
PRK05035440-625  PRK05035
pfam097301116-1401  BicD
PRK11448814-890  hsdR
TIGR031851133-1400  DNA_S_dndD
PRK05035290-502  PRK05035
TIGR03185770-1023  DNA_S_dndD
TIGR026801109-1400  TIGR02680


Ontology Information


   
HPRD ID4961
Molecular ClassIntegral membrane protein
Molecular FunctionVoltage-gated ion channel activity (GO:0005244)
Biological ProcessIon transport (GO:0006811)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO