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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RRM1 6240 ribonucleotide reductase M1  11 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21220199   0Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : TNM Stage IV

Genotyping, real time RT-PCR, Western BlottingPolymorhpism-RRM1 -37A>C polymorphism may represent a useful biomarker to select mCRC patients most likely to benefit from GMB-based salvage therapy.


Gene Details



Chromosome 11 - NC_000011.10 (4094561..4138881)

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Gene Type protein coding
Gene Family
Description This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region.  
Chromosome 11
Location 11p15.5
Start 4094561  
End 4138881  
Strand +  
Gene Sequence

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Length 44321  
OMIM ID 180410   
HGNC ID HGNC:10451   
Unigene ID Hs.445705   
Ensembl ID ENSG00000167325   
PharmGKB ID -   

mRNA Information


mRNA ID XM_011520277.1
Exon join(1..471,7433..7521,12875..12975,15084..15143, 17041..17080,17340..17502,23760..23901,25285..25368, 27044..27205,27581..27660,28623..28824,32124..32273, 32475..32696,34514..34590,37726..37861,39003..39098, 40522..40710,43635..44321)  
mRNA Sequence

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Length 3234  



CDS Information


   
Location join(453..471,7433..7521,11486..11663,12875..12975, 15084..15143,17041..17080,17340..17502,23760..23901, 25285..25368,27044..27205,27581..27660,28623..28824, 32124..32273,32475..32696,34514..34590,37726..37861, 39003..39098,40522..40710,43635..43823)
CDS Sequence

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CCDS ID CCDS7750.1



Protein Information


      
Protein IDNP_001024.1
Protein Nameribonucleotide reductase M1
Molecular Wt. (Da)89939
Protein Sequence

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Length 792  
Uniprot IDP38646
Ensembl Protein ID ENSP00000297185  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KAcetylation17
KAcetylation376
TPhosphorylation422

Enzyme Information


   
EC1.17.4.1
Nameribonucleoside-diphosphate reductase
ribonucleotide reductase
CDP reductase
ribonucleoside diphosphate reductase
UDP reductase
ADP reductase
nucleoside diphosphate reductase
ribonucleoside 5'-diphosphate reductase
ribonucleotide diphosphate reductase
2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase
RR
ClassOxidoreductases; Acting on CH or CH2 groups; With a disulfide as acceptor
Sysname2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase  
Substrate2'-deoxyribonucleoside diphosphate [CPD:C04232]; thioredoxin disulfide [CPD:C00343]; H2O [CPD:C00001]  
Productribonucleoside diphosphate [CPD:C03723]; thioredoxin [CPD:C00342]  
Reaction (IUBMB)



PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
6241RRM21587NP_001025.1in vitro11781084   
55791C1orf10317975NP_060842.3yeast 2-hybrid16169070   


Pathway Information


                        
Pathway Name Pathway ID
Glutathione metabolism hsa00480
Metabolic pathways hsa01100
Purine metabolism hsa00230
Pyrimidine metabolism hsa00240


Structure Information


PDB ID2WGH
Resolution2.3
MethodX-RAY DIFFRACTION
Chains A, B  
Molecule RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT  
Model View



Domain Information




ID Location Description
cd01679167-741  RNR_I
cl09939167-741  RNR_PFL superfamily
cd02888188-620  RNR_II_dimer
pfam00317141-213  Ribonuc_red_lgN
cl08260141-213  Ribonuc_red_lgN superfamily
pfam03477Jan-89  ATP-cone
cl12279Jan-89  ATP-cone superfamily
cd00576239-565  RNR_PFL
PLN024371-792  PLN02437
pfam02867215-739  Ribonuc_red_lgC
TIGR02506145-742  NrdE_NrdA
PRK072071-790  PRK07207
COG020939-755  NrdA
PRK123653-744  PRK12365
PRK065393-756  PRK06539
PRK084471-741  PRK08447
PRK0920972-742  PRK09209
PRK070885-742  PRK07088
PRK09102126-745  PRK09102
PRK1236472-742  PRK12364
PHA025721-756  nrdA
TIGR02504151-733  NrdJ_Z
PRK08665151-701  PRK08665
PRK091031-749  PRK09103
TIGR02510143-745  NrdE-prime
PRK064061-712  PRK06406
TIGR04170136-742  RNR_1b_NrdE
PRK07632155-742  PRK07632
PRK07187192-628  PRK07187
PRK08188137-745  PRK08188
PRK07306201-741  PRK07306
PRK08115190-654  PRK08115
PRK08332426-686  PRK08332
PRK06556177-675  PRK06556
PRK06948246-636  PRK06948
PRK07562334-557  PRK07562
PRK08332137-292  PRK08332
PRK08332249-429  PRK08332


Ontology Information


   
HPRD ID6763
Molecular ClassCell cycle control protein
Molecular FunctionChaperone activity (GO:0003754)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P23921DB00242CladribineSmallMoleculeDrug
P23921DB00441GemcitabineSmallMoleculeDrug
P23921DB00631ClofarabineSmallMoleculeDrug
P23921DB01005HydroxyureaSmallMoleculeDrug
P23921DB01073FludarabineSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO