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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RRM2 | 6241 | Ribonucleotide reductase M2 polypeptide | 2 | R2; RR2; RR2M |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
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- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15814641 | 2005 | Cell line : - Source : Taqman PCR , Spearman rank correlation, Hierarchical clustering analysis. Sample Type : - No. of Sample : Nontumor and tumor sample from 52 patients Stage : Duke Stage C | - | Up-regulation | >1.2 | A group of 11 genes ((FPGS, DHFR, GGH, NME1, NME2, RRM2, UMPH2, UNG, UMPS, TP53, and TK1) which showing overexpression may provide valuable insights for optimizing treatment selection for patients with colorectal cancer. |
| 20473941 | 2010 | Cell line : SW 480, HT 29, SW 837, SW 48, T 84, LS 513, HCT 116, SW 1463, SW 1116, LS 411N, NCI H716, LoVo, NCI H508, COLO 201, COLO 320DM, LS 123, LS 174T, DLD-1, Caco-2, LS 1034, SK-CO-1, RKO, SW 403, SW 620. p53HCT 116 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry, RT-PCR, Cell Viability Assay, Gene Expression Profiling | Up-regulation | - | Confirmed the involvement of HMGA1, RRM2 and TACSTD2 and defined their signaling pathways in the context of CRC, which may now enable identification of alternative means for targeting these genes. |
| 21873171 | 2011 | Cell line : HCT 116 Source : - Sample Type : - No. of Sample : - Stage : - | Cell proliferation and colony formation assays | Up-regulation | - | RRM2 represents a novel therapeutic target, thus highlighting the potential utility of RRM2 inhibitors in colorectal cancer with oncogenic KRAS. RRM2 expression is essential for cell proliferation and anchorage independent growth. |
| 23002339 | 2012 | Cell line : HCT 116, SW 480 and SW 620 Source : Shanghai Minimal Invasive Surgery Centre (Shanghai Jiao Tong University School of Medicine) Sample Type : CRC tumor and normal tissue No. of Sample : 56 CRC tissues and 56 adjacent normal mucosa Stage : - | Tissue microarray, Immunohistochemistry, RT-PCR and Western blotting | Up-regulation | - | RRM2 overexpression was positively correlated with invasion depth, poorly differentiated type, and tumor node metastasis stage. RRM2 silencing by siRNA may inhibit the hyperplasia and invasiveness of CRC cells, suggesting that RRM2 may play an important role in the infiltration and metastasis of CRC, which is a potential therapeutic strategy in CRC. |
| 23113760 | 2013 | Cell line : - Source : COH National Medical Center and Zhejiang University. Sample Type : Case control study No. of Sample : 437 CRC cases Stage : - | Immunohistochemistry, real time RT-PCR | Up-regulation | - | RRM2 is an independent prognostic factor and predicts poor survival of CRCs. It is also a potential predictor for identifying good responders to chemotherapy for CRCs. The Kaplan-Meier analysis displayed that high expression of RRM2 had a negative impact on the OS (overall survival) and PFS (progress-free survival) of CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009] | Chromosome | 2 |
| Location | 2p25-p24 |
| Start | 10122568 |
| End | 10131419 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 8852 |
| OMIM ID | 180390 |
| HGNC ID | HGNC:10452 |
| Unigene ID | Hs.226390 |
| Ensembl ID | ENSG00000171848 |
| PharmGKB ID | PA29942 |
mRNA Information
| mRNA ID | NM_001165931.1 |
|---|---|
| Exon | join(1..330,416..490,820..963,1169..1285,2150..2283, 4308..4402,4520..4653,6281..6385,6474..6587,6667..8852) | mRNA Sequence | Download Select all |
| Length | 3452 |
CDS Information
| Location | join(52..330,416..490,820..963,1169..1285,2150..2283, 4308..4402,4520..4653,6281..6385,6474..6587,6667..6819) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS54334.1 |
Protein Information
| Protein ID | NP_001025.1 |
|---|---|
| Protein Name | Ribonucleotide reductase M2 polypeptide |
| Molecular Wt. (Da) | 44747 |
| Protein Sequence | Download Select all |
| Length | 389 |
| Uniprot ID | P35221 |
| Ensembl Protein ID | ENSP00000304669 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 20 |
| S | Phosphorylation | 20;- |
| T | Phosphorylation | 33 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Glutathione metabolism | hsa00480 |
| Metabolic pathways | hsa01100 |
| p53 signaling pathway | hsa04115 |
| Purine metabolism | hsa00230 |
| Pyrimidine metabolism | hsa00240 |
Structure Information
| PDB ID | 2UW2 |
|---|---|
| Resolution | 2.8 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE M2 SUBUNIT |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01049 | 80-355 | RNRR2 |
| cl00264 | 80-355 | Ferritin_like superfamily |
| PLN02492 | 70-389 | PLN02492 |
| PTZ00211 | 68-389 | PTZ00211 |
| pfam00268 | 70-350 | Ribonuc_red_sm |
| COG0208 | 68-389 | NrdF |
| PRK07209 | 82-376 | PRK07209 |
| PRK09614 | 84-372 | nrdF |
| TIGR04171 | 101-374 | RNR_1b_NrdF |
| cd07911 | 92-336 | RNRR2_Rv0233_like |
| PRK08326 | 93-336 | PRK08326 |
| PRK09101 | 101-352 | nrdB |
| PRK13965 | 89-344 | PRK13965 |
| PRK13966 | 92-341 | nrdF2 |
| PRK13967 | 92-269 | nrdF1 |
| PRK12759 | 84-380 | PRK12759 |
Ontology Information
| HPRD ID | 294 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Aspartic-type signal peptidase activity (GO:0009049) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P31350 | DB00242 | Cladribine | SmallMoleculeDrug |
| P31350 | DB05260 | Gallium nitrate | SmallMoleculeDrug |