Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RRM2B | 50484 | Ribonucleotide reductase M2 B (TP53 inducible) | 8 | P53R2; MTDPS8A; MTDPS8B |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23002339 | 2012 | Cell line : - Source : Shanghai Minimal Invasive Surgery Centre (Shanghai Jiao Tong University School of Medicine). Sample Type : CRC tumor and normal tissue No. of Sample : 56 CRC tissues and 56 adjacent normal mucosa & another 78 specimens of CRC tissues Stage : - | real time RT-PCR, Western blotting, Cell viability assay, Invasion assays, Flow cytometry | Up-regulation | - | Functional and correlative studies on RRM2 provide strong evidence that RRM2 overexpression may be associated with CRC progression. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010] | Chromosome | 8 |
| Location | 8q23.1 |
| Start | 102204501 |
| End | 102239118 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 34618 |
| OMIM ID | 604712 |
| HGNC ID | HGNC:17296 |
| Unigene ID | Hs.512592 |
| Ensembl ID | ENSG00000048392 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001172478.1 |
|---|---|
| Exon | join(1..292,13085..13201,14101..14234,14979..15073, 20172..20305,24961..25065,26230..26343,30834..34618) | mRNA Sequence | Download Select all |
| Length | 4776 |
CDS Information
| Location | join(245..292,13085..13201,14101..14234,14979..15073, 20172..20305,24961..25065,26230..26343,30834..30986) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS55267.1 |
Protein Information
| Protein ID | NP_001165948.1 |
|---|---|
| Protein Name | Ribonucleotide reductase M2 B (TP53 inducible) |
| Molecular Wt. (Da) | 48656 |
| Protein Sequence | Download Select all |
| Length | 423 |
| Uniprot ID | P35555 |
| Ensembl Protein ID | ENSP00000325527 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 6240 | RRM1 | 1588 | NP_001024.1 | in vivo | 1 458 345 011 517 220 |
| 6241 | RRM2 | 1587 | NP_001025.1 | in vitro | 14729598 |
| 7157 | TP53 | 1859 | NP_000537.3 | in vivo | 12615712 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Glutathione metabolism | hsa00480 |
| Metabolic pathways | hsa01100 |
| p53 signaling pathway | hsa04115 |
| Purine metabolism | hsa00230 |
| Pyrimidine metabolism | hsa00240 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01049 | 42-317 | RNRR2 |
| cl00264 | 42-317 | Ferritin_like superfamily |
| PLN02492 | 32-351 | PLN02492 |
| PTZ00211 | 31-351 | PTZ00211 |
| pfam00268 | 32-312 | Ribonuc_red_sm |
| COG0208 | 18-343 | NrdF |
| PRK09614 | 46-345 | nrdF |
| PRK07209 | 44-332 | PRK07209 |
| TIGR04171 | 56-332 | RNR_1b_NrdF |
| PRK09101 | 63-314 | nrdB |
| PRK13965 | 51-306 | PRK13965 |
| PRK13966 | 54-303 | nrdF2 |
| PRK08326 | 54-288 | PRK08326 |
| PRK13967 | 54-231 | nrdF1 |
| cd07911 | 54-257 | RNRR2_Rv0233_like |
| PRK12759 | 46-332 | PRK12759 |
| PRK05989 | 124-179 | cobN |
Ontology Information
| HPRD ID | 1491 |
|---|---|
| Molecular Class | Enzyme: Reductase |
| Molecular Function | Protein-tyrosine kinase activity (GO:0004713) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q7LG56 | DB00242 | Cladribine | SmallMoleculeDrug |