Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RSPO2 | 340419 | R-spondin 2 homolog (Xenopus laevis) | 8 | CRISTIN2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22895193 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Exome sequencing, RNAseq and SNP array analysis. | Gene Fusion | - | The RSPO fusions weremutually exclusivewithAPC mutations, indicating that they probably have a role in the activation of Wnt signalling and tumorigenesis. Recurrent gene fusions involving R-spondin family members RSPO2 and RSPO3 that together occur in 10% of colon tumours. |
| 19251594 | 2009 | Cell line : - Source : - Sample Type : Mouse model No. of Sample : 135 mice tumors: 42 tumors from 11 of the triple transgenic mice from the first cohort (dataset 1) and 93 tumors from 36 mice in the second cohort (dataset 2) were included in thisstudy. Stage : - | linker-mediated PCR and DNA sequencing. | Mutation | - | RSPO2 gene is disregulated/ mutated which affect Wnt signaling. |
| 20145154 | 2010 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Microarray analysis, Reporter assay, Chromatin immunoprecipitation assay. | Up-regulation | - | Microarray analysis of H1299/EGFP and H1299/FOXQ1 revealed that FOXQ1 overexpression upregulated several genes that have positive roles for tumor growth, including VEGFA, WNT3A, RSPO2, and BCL11A.
|
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1; MIM 116806) signaling (Kim et al., 2006 [PubMed 16357527]).[supplied by OMIM, Mar 2008] | Chromosome | 8 |
| Location | 8q23.1 |
| Start | 107899316 |
| End | 108083685 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 184370 |
| OMIM ID | 610575 |
| HGNC ID | HGNC:28583 |
| Unigene ID | Hs.444834 |
| Ensembl ID | ENSG00000147655 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_178565.4 |
|---|---|
| Exon | join(1..489,879..1141,94442..94630,122869..123012, 125418..125606,182496..184370) | mRNA Sequence | Download Select all |
| Length | 3149 |
CDS Information
| Location | join(1048..1141,122869..123012,125421..125606, 182496..182611) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS64953.1 |
Protein Information
| Protein ID | NP_001269792.1 |
|---|---|
| Protein Name | R-spondin 2 homolog (Xenopus laevis) |
| Molecular Wt. (Da) | 18437 |
| Protein Sequence | Download Select all |
| Length | 179 |
| Uniprot ID | P47211 |
| Ensembl Protein ID | ENSP00000299727 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00064 | 99-142 | FU |
| cl00066 | 99-142 | FU superfamily |
| smart00261 | 91-132 | FU |
| PTZ00382 | 77-124 | PTZ00382 |
| cl20112 | 77-124 | PTZ00382 superfamily |
Ontology Information
| HPRD ID | 673 |
|---|---|
| Molecular Class | Ligand |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.