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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26404086 | 2015 | Cell line : - Source : - Sample Type : Population based Case control study No. of Sample : 16,517 cases and 14,487 controls.samples of African descent (1894 cases and 4703 controls).195 colon adenocarcinomas and 59 normal colon tissues Stage : - | - | Down-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011] | Chromosome | 14 |
| Location | 14q21-q22 |
| Start | 60062694 |
| End | 60337557 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 274864 |
| OMIM ID | 600865 |
| HGNC ID | HGNC:10467 |
| Unigene ID | Hs.368626 |
| Ensembl ID | ENSG00000139970 |
| PharmGKB ID | PA34880 |
mRNA Information
| mRNA ID | ?NM_021136.2 |
|---|---|
| Exon | join(1..450,124359..125132,143172..143921,263348..263555, 265334..265472,266919..266988,267582..267628, 267717..267775,274053..274864) | mRNA Sequence | Download Select all |
| Length | 3327 |
Protein Information
| Protein ID | NP_066959.1 |
|---|---|
| Protein Name | reticulon 1 |
| Molecular Wt. (Da) | 50680 |
| Protein Sequence | Download Select all |
| Length | 776 |
| Uniprot ID | P78396 |
| Ensembl Protein ID | ENSP00000255465 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 48 |
| S | Phosphorylation | 352 |
| S | Phosphorylation | 487 |
| S | Phosphorylation | 67 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 598 | BCL2L1 | 2497 | NP_612815.1 | yeast 2-hybrid | 11126360 |
| 79666 | PLEKHF2 | 15147 | NP_078889.1 | yeast 2-hybrid | 16189514 |
| 84067 | FAM160A2 | 8002 | NP_115503.2 | yeast 2-hybrid | 16189514 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam02453 | 591-758 | Reticulon |
| cl03599 | 591-758 | Reticulon superfamily |
| PHA03307 | 370-567 | PHA03307 |
| pfam09528 | 208-568 | Ehrlichia_rpt |
Ontology Information
| HPRD ID | 4625 |
|---|---|
| Molecular Class | Integral membrane protein |
| Molecular Function | Receptor signaling complex scaffold activity (GO:0030159) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.