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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RUNX3 | 864 | Runt-related transcription factor 3 | 1 | AML2; CBFA3; PEBP2aC |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20442291 | 2010 | Cell line : HT-29, HCT116, SW480, DLD1, WiDr, Ls174T, Colo205, Colo320, RKO, LoVo, SW403, Colo201, CaCo2, SW837, Ls513, Ls1034, SW620, OUMS23, CCK81, CoCM1, RCM1, and HCC56 Source : ATCC, Japanese Collection of Research Bioresources. Sample Type : - No. of Sample : - Stage : - | Real time RT-PCR, Western Blotting ,Apoptosis detection and Chromatin immunoprecipitation | Down-regulation | - | RUNX3 is a gastric and colon tumor suppressor, functioning downstream of TGF-beta. RUNX3 downregulates c-Myc expression by two parallel pathways-directly at the transcriptional level and through attenuation of beta-catenin/TCFs, downstream of BMPs in colorectal cancer cells. Upregulation of RUNX3 by BMP reduces c-Myc expression. |
| 21109941 | 2011 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 70 Stage : - | Genomic DNA preparation and RUNX3 MS-PCR, real time RT- PCR | Down-regulation | - | UC-NonCa group had both higher copy numbers and RUNX3 expression levels than the UC-Ca group. |
| 15273736 | 2004 | Cell line : - Source : KCLB (Korean Cell Line Bank) (Seoul, Korea) or ATCC (American Type Culture Collection) and 87 paired tumor and normal mucosal tissue samples were obtained from 87 patients with primary colorectal adenocarcinoma. Sample Type : CRC tumor and Normal tissue No. of Sample : 87 CRC tumor and 87 normal tissue Stage : - | RT-PCR, Mutation screening, Methylation specific-PCR, and sequence analysis and LOH analysis | Methylation | - | This study suggests that transcriptional repression of RUNX3 is caused by promoter hypermethylation of the RUNX3 CpG island in colorectal cancer cell lines. 32 colorectal cancer cell lines and two gastric cancer cell lines were include. |
| 22234069 | 2011 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Methylation Specific -PCR | Methylation | - | RUNX3 promoter hypermethylation may be a promising biomarker for the early diagnosis of ESCC, GC and CRC.
|
| 22274925 | 2013 | Cell line : HT 29, SW 403, SNU 407, SNU 1033, Caco 2, FHC Source : The Korean Cell Line Bank (Seoul, Republic of Korea) and ATCC Sample Type : - No. of Sample : - Stage : - | Methylation specific-PCR, RT-PCR,DNA methyltransferase activity, Immunoprecipitation and Western blotting | Methylation | - | ROS silenced the tumor suppressor, RUNX3, by epigenetic regulation and may therefore be associated with the progression of colorectal cancer. |
| 23104301 | 2013 | Cell line : - Source : - Sample Type : Population-based case-control studies No. of Sample : 1509 CRC cases and 2307 controls Stage : - | TaqMan assay | Methylation | - | TaqMan assay used to genotype rs4939827 and logistic regression to assess the association of rs4939827 with risk of CRC. Minor allele (G) of the germline intronic SMAD7 variant rs4939827 is associated with a lower risk of CRC with earlier tumor stage and CRC without methylation of the tumor suppressor RUNX3. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | Chromosome | 1 |
| Location | 1p36 |
| Start | 24899511 |
| End | 24965157 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 65647 |
| OMIM ID | 600210 |
| HGNC ID | HGNC:10473 |
| Unigene ID | Hs.170019 |
| Ensembl ID | ENSG00000020633 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001031680.2 |
|---|---|
| Exon | join(148..644,35306..35571,37428..37584,45814..45918, 57741..57899,62492..65647) | mRNA Sequence | Download Select all |
| Length | 4340 |
CDS Information
| Location | join(587..644,35306..35571,37428..37584,45814..45918, 62492..63036) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001026850.1 |
|---|---|
| Protein Name | Runt-related transcription factor 3 |
| Molecular Wt. (Da) | 45791 |
| Protein Sequence | Download Select all |
| Length | 429 |
| Uniprot ID | P50995 |
| Ensembl Protein ID | ENSP00000265447 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 162 |
| K | Acetylation | 200 |
| K | Acetylation | 206 |
| K | Acetylation | 148 |
| K | Acetylation | 186 |
| K | Acetylation | 192 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 865 | CBFB | 418 | NP_074036.1 | in vitro | 7622058 |
| 7088 | TLE1 | 2557 | NP_005068.2 | in vitro;in vivo;yeast 2-hybrid | 9751710 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00853 | 53-186 | Runt |
| cl02989 | 53-186 | Runt superfamily |
| pfam08504 | 313-415 | RunxI |
| cl07214 | 313-415 | RunxI superfamily |
| PHA03247 | 177-311 | PHA03247 |
| pfam04487 | 268-362 | CITED |
| COG5099 | 210-397 | COG5099 |
Ontology Information
| HPRD ID | 3983 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Calcium ion binding (GO:0005509) |
| Biological Process | Signal transduction (GO:0007165); Cell communication (GO:0007154) |
Drug Information
No matching records could be found.