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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RUVBL2 | 10856 | RuvB-like AAA ATPase 2 | 19 | RVB2, TIP48, TIP49b, Reptin52, ECP51, TIH2, INO80J, Rvb2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21763315 | 2011 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Unknown | - | RuvBl2 in Ets2 mediated regulation of hTERT in colon cancer which has functional and clinical consequences. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | INO80 complex subunits, "ATPases / AAA-type" |
| Description | This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008] | Chromosome | 19 |
| Location | 19q13.3 |
| Start | 49496738 |
| End | 49519183 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 22446 |
| OMIM ID | 604788 |
| HGNC ID | HGNC:10475 |
| Unigene ID | Hs.515846 |
| Ensembl ID | - |
| PharmGKB ID | PA34888 |
Protein Information
| Protein ID | NP_006657.1 |
|---|---|
| Protein Name | RuvB-like AAA ATPase 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 463 |
| Uniprot ID | O15204 |
| Ensembl Protein ID | ENSP00000256412 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 220;- |
| S | Phosphorylation | 262 |
| T | Phosphorylation | 265 |
| T | Phosphorylation | 338 |
| S | Phosphorylation | 339 |
| Y | Phosphorylation | 340 |
| S | Phosphorylation | 26 |
| T | Phosphorylation | 3 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1386 | ATF2 | 443 | NP_001871.2 | in vivo;yeast 2-hybrid | 11713276 |
| 7015 | TERT | 1754 | NP_003210.1 | in vivo | 18358808 |
| 8607 | RUVBL1 | 9143 | NP_003698.1 | in vitro;in vivo;yeast 2-hybrid | 11 080 158 105 242 100 000 000 000 000 000 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00009 | 269-362 | AAA |
| cl21455 | 269-362 | P-loop_NTPase superfamily |
| pfam06068 | 21-412 | TIP49 |
| pfam00004 | 73-123 | AAA |
| cl21455 | 73-123 | P-loop_NTPase superfamily |
| cd00984 | 73-117 | DnaB_C |
| cd00009 | 70-110 | AAA |
| pfam13481 | 68-100 | AAA_25 |
| COG0645 | 70-95 | COG0645 |
| COG1224 | 15-451 | TIP49 |
| PRK14957 | 295-436 | PRK14957 |
| TIGR02639 | 74-141 | ClpA |
| COG1223 | 12-108 | COG1223 |
| PRK14953 | 295-410 | PRK14953 |
| pfam03796 | 73-115 | DnaB_C |
| PRK07773 | 70-117 | PRK07773 |
| TIGR00665 | 73-117 | DnaB |
| COG2812 | 295-405 | DnaX |
| COG0305 | 73-120 | DnaB |
| PRK14962 | 295-456 | PRK14962 |
| CHL00176 | 73-107 | ftsH |
| TIGR02397 | 298-413 | dnaX_nterm |
| PRK14960 | 295-409 | PRK14960 |
| PRK14965 | 295-426 | PRK14965 |
| TIGR03600 | 31-117 | phage_DnaB |
| TIGR01243 | 71-126 | CDC48 |
| COG0542 | 73-114 | ClpA |
| smart00382 | 70-139 | AAA |
| PRK14961 | 295-409 | PRK14961 |
| COG0464 | 73-125 | SpoVK |
| COG0714 | 59-97 | MoxR |
| PRK08506 | 70-117 | PRK08506 |
Ontology Information
| HPRD ID | 6310 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Structural molecule activity (GO:0005198) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.