Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RXRA 6256 retinoid X receptor, alpha  9NR2B1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20145122   2010Cell line : -

Source : University of Arizona

Sample Type : -

No. of Sample : -

Stage : -

Endpoint ascertainment,SNP Selection, GenotypingPolymorhpism-Results indicate that allelic variation in�RXRA�affects metachronouscolorectal�neoplasia, perhaps of particular importance in the development of proximal lesions.

20558521   2010Cell line : -

Source : Cancer Care Ontario (Toronto, Canada), Fred Hutchinson Cancer Research Center (Seattle, WA, USA), Mayo Clinic (Rochester, MN, USA), University of Hawaii (Honolulu, HI, USA), University of Melbourne (Melbourne, Australia) and the University of Southern California Consortium (Los Angeles, CA, USA)

Sample Type : Population based Case control study

No. of Sample : -

Stage : -

GenotypingPolymorhpism-RXRA SNPs rs7861779 and rs12004589 and CASR SNP rs1801726 may be important markers for colorectal neoplasia.


Gene Details



NC_000009.11 (137218316..137332431)

View Larger Image
   
Gene Type protein coding
Gene Family Nuclear hormone receptors
Description Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]  
Chromosome 9
Location 9q34
Start 137218316  
End 137332431  
Strand +  
Gene Sequence

   Download   Select all

Length 114116  
OMIM ID 180245   
HGNC ID HGNC:10477   
Unigene ID Hs.590886   
Ensembl ID ENSG00000186350   
PharmGKB ID PA34890   

mRNA Information


mRNA ID ?NM_001291921.1
Exon join(1..197,75170..75420,81687..81837,82478..82657, 90696..90865,95214..95343,102646..102778,105443..105534, 107640..107745,110005..114124)  
mRNA Sequence

   Download   Select all

Length 5530  



CDS Information


   
Location170..1558
CDS Sequence

   Download   Select all

CCDS ID CCDS35172.1



Protein Information


      
Protein IDNP_001278850.1
Protein Nameretinoid X receptor, alpha
Molecular Wt. (Da)10854
Protein Sequence

   Download   Select all

Length 462  
Uniprot IDO43497
Ensembl Protein ID ENSP00000339302  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation260
SPhosphorylation260
TPhosphorylation82
SPhosphorylation21

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
142PARP11435NP_001609.2in vitro10082530   
547KIF1A3156NP_004312.2yeast 2-hybrid15604093   
602BCL3179NP_005169.2in vitro;yeast 2-hybrid9812988   
1514CTSL1293NP_001903.1in vitro99   188   489   837   884   
1647GADD45A528NP_001915.1in vitro;yeast 2-hybrid10872826   
2521FUS660NP_004951.1in vitro;in vivo9440806   
3486IGFBP3899NP_001013416.1in vitro;in vivo;yeast 2-hybrid10874028   
4654MYOD11166NP_002469.2in vitro9692544   
4790NFKB11238NP_003989.2in vitro10075655   
5451POU2F11250NP_002688.2in vitro10383413   
5465PPARA1369NP_001001930.1in vitro10195690   
5916RARG1573NP_000957.1in vitro;yeast 2-hybrid908   308   315   604   093   
5970RELA1241NP_068810.3in vitro10075655   
7025NR2F1584NP_005645.1in vitro;in vivo1311101   
10062NR1H37211NP_005684.2in vivo;yeast 2-hybrid90   135   441   211   756   700   000   000   
56893UBQLN45670NP_064516.2yeast 2-hybrid16169070   
64699TMPRSS35696NP_076927.1yeast 2-hybrid16169070   


Pathway Information


                                                                        
Pathway Name Pathway ID
Adipocytokine signaling pathway hsa04920
Bile secretion hsa04976
Hepatitis C hsa05160
Non-alcoholic fatty liver disease (NAFLD) hsa04932
Non-small cell lung cancer hsa05223
Pathways in cancer hsa05200
PI3K-Akt signaling pathway hsa04151
PPAR signaling pathway hsa03320
Small cell lung cancer hsa05222
Thyroid cancer hsa05216
Thyroid hormone signaling pathway hsa04919
Transcriptional misregulation in cancer hsa05202


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd06943229-440  NR_LBD_RXR_like
cl11397229-440  NR_LBD superfamily
cd06956133-209  NR_DBD_RXR
cl02596133-209  NR_DBD_like superfamily
cd06931232-454  NR_LBD_HNF4_like
cd06948267-455  NR_LBD_COUP-TF
cd06930265-428  NR_LBD_F2
cd06944268-457  NR_LBD_Ftz-F1_like
cd06916135-206  NR_DBD_like
pfam1182517-127  Nuc_recep-AF1
cl1329217-127  Nuc_recep-AF1 superfamily
cd06950258-444  NR_LBD_Tlx_PNR_like
pfam00104264-442  Hormone_recep
cd06157266-428  NR_LBD
smart00430272-428  HOLI
cd07069268-457  NR_LBD_Lrh-1
pfam00105133-202  zf-C4
cd07068235-457  NR_LBD_ER_like
cd06967134-210  NR_DBD_TR2_like
cd06961135-215  NR_DBD_TR
cd06960135-209  NR_DBD_HNF4A
cd06969134-206  NR_DBD_NGFI-B
cd06958135-206  NR_DBD_COUP_TF
cd07164135-210  NR_DBD_PNR_like_1
smart00399134-203  ZnF_C4
cd07167135-212  NR_DBD_Lrh-1_like
cd06929279-436  NR_LBD_F1
cd06964135-213  NR_DBD_RAR
cd07169135-212  NR_DBD_GCNF_like
cd07154135-206  NR_DBD_PNR_like
cd07168134-212  NR_DBD_DHR4_like
cd07070258-457  NR_LBD_SF-1
cd06968135-222  NR_DBD_ROR
cd06952256-448  NR_LBD_TR2_like
cd06946235-457  NR_LBD_ERR
cd06957135-209  NR_DBD_PNR_like_2
cd06970134-210  NR_DBD_PNR
cd07163135-209  NR_DBD_TLX
cd07165135-215  NR_DBD_DmE78_like
cd06965135-211  NR_DBD_Ppar
cd07158135-206  NR_DBD_Ppar_like
cd07179135-205  2DBD_NR_DBD2
cd06937246-456  NR_LBD_RAR
cd07170132-212  NR_DBD_ERR
cd07166134-209  NR_DBD_REV_ERB
cd06949230-458  NR_LBD_ER
cd07155135-209  NR_DBD_ER_like
cd07171133-211  NR_DBD_ER
cd06945249-452  NR_LBD_Nurr1_like
cd07156135-205  NR_DBD_VDR_like
cd06959135-205  NR_DBD_EcR_like
cd07161134-210  NR_DBD_EcR
cd07160134-210  NR_DBD_LXR
cd06940279-441  NR_LBD_REV_ERB
cd06953268-438  NR_LBD_DHR4_like
cd06962134-210  NR_DBD_FXR
cd06955134-214  NR_DBD_VDR
cd07162134-209  NR_DBD_PXR
cd06966134-219  NR_DBD_CAR
cd06932279-455  NR_LBD_PPAR
cd07172134-204  NR_DBD_GR_PR
cd07071282-455  NR_LBD_Nurr1
cd06963135-204  NR_DBD_GR_like
cd06951268-453  NR_LBD_Dax1_like
cd07157135-201  2DBD_NR_DBD1
cd06954279-441  NR_LBD_LXR
cd06939280-440  NR_LBD_ROR_like
cd06935279-456  NR_LBD_TR
cd06938279-441  NR_LBD_EcR
cd06941280-440  NR_LBD_DmE78_like
cd07348281-455  NR_LBD_NGFI-B
cd07173132-200  NR_DBD_AR
cd07350269-453  NR_LBD_Dax1
cd07349269-455  NR_LBD_SHP
cd07072282-441  NR_LBD_DHR38_like
cd06936259-428  NR_LBD_Fxr
cd06934279-428  NR_LBD_PXR_like
cd06933279-428  NR_LBD_VDR
cd07075258-438  NR_LBD_MR
cd07074258-394  NR_LBD_PR
cd06947258-437  NR_LBD_GR_Like
cd07076258-393  NR_LBD_GR
cd07073258-443  NR_LBD_AR
cd06942280-391  NR_LBD_Sex_1_like
pfam0315412-115  Atrophin-1
pfam1544916-129  Retinal


Ontology Information


   
HPRD ID9157
Molecular ClassNuclear receptor
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P19793DB00210AdapaleneSmallMoleculeDrug
P19793DB00307BexaroteneSmallMoleculeDrug
P19793DB00459AcitretinSmallMoleculeDrug
P19793DB00523AlitretinoinSmallMoleculeDrug
P19793DB00749EtodolacSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO