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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18340452 | 2008 | Cell line : - Source : Tumor Hospital of Habin Medical University Sample Type : CRC Tumor and adjescent tissue No. of Sample : 89 Stage : - | Two-dimensional gel electrophoresis, Western blotting and immunohistochemical staining. | Up-regulation | - | S100A11 could be helpful in the pathological study of colorectal cancer, especially for the classification of different stages in colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | S100 calcium binding proteins, "EF-hand domain containing" |
| Description | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. [provided by RefSeq, Jul 2008] | Chromosome | 1 |
| Location | 1q21 |
| Start | 152004982 |
| End | 152009511 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 4530 |
| OMIM ID | 603114 |
| HGNC ID | HGNC:10488 |
| Unigene ID | Hs.417004 |
| Ensembl ID | ENSG00000163191 |
| PharmGKB ID | PA34900 |
mRNA Information
| mRNA ID | ?NM_005620.1 |
|---|---|
| Exon | join(1..123,3236..3388,4213..4530) | mRNA Sequence | Download Select all |
| Length | 595 |
Protein Information
| Protein ID | NP_005611.1 |
|---|---|
| Protein Name | S100 calcium binding protein A11 |
| Molecular Wt. (Da) | 11609 |
| Protein Sequence | Download Select all |
| Length | 105 |
| Uniprot ID | Q92558 |
| Ensembl Protein ID | ENSP00000352425 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 10 |
| S | Phosphorylation | 94 |
| Y | Phosphorylation | 30;- |
| Y | Phosphorylation | 32;- |
| T | Phosphorylation | 69;- |
| S | Phosphorylation | 78;- |
| S | Phosphorylation | 5 |
| S | Phosphorylation | 6 |
| K | Acetylation | 3 |
| C | S-Nitrosylation | 13 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 60 | ACTB | 32 | NP_001092.1 | in vitro;in vivo | 1 462 386 310 851 010 |
| 301 | ANXA1 | 1060 | NP_000691.1 | in vitro;in vivo | 126 450 118 557 678 |
| 4691 | NCL | 1245 | NP_005372.2 | in vitro;in vivo | 14623863 |
| 6285 | S100B | 1505 | NP_006263.1 | in vivo;yeast 2-hybrid | 10913138 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05023 | Jul-95 | S-100A11 |
| cl08302 | Jul-95 | EFh superfamily |
| cd00213 | Aug-95 | S-100 |
| cd05031 | Aug-97 | S-100A10_like |
| cd05030 | Aug-93 | calgranulins |
| cd05025 | Aug-97 | S-100A1 |
| cd05026 | Jul-95 | S-100Z |
| cd05027 | Aug-95 | S-100B |
| cd05024 | Aug-97 | S-100A10 |
| pfam01023 | Oct-53 | S_100 |
| cl19180 | Oct-53 | S_100 superfamily |
| cd05022 | Aug-92 | S-100A13 |
| cd05029 | Nov-93 | S-100A6 |
| cd00051 | 27-84 | EFh |
| smart00054 | 60-87 | EFh |
| cl23347 | 60-87 | EFh superfamily |
| pfam00036 | 60-84 | EF-hand_1 |
| cl23489 | 60-84 | EF-hand_1 superfamily |
| pfam13833 | 34-83 | EF-hand_8 |
| pfam13499 | 27-84 | EF-hand_7 |
Ontology Information
| HPRD ID | 5230 |
|---|---|
| Molecular Class | Calcium binding protein |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.