Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25007175 | 2014 | Cell line : - Source : - Sample Type : CRC Tumor and adjescent tissue No. of Sample : - Stage : - | Real-Time PCR and fluorescent amplicon specific-probes | Up-regulation | - | Significant up-regulation in tumors was found for S100A11, S100A7, LCE3D, S100A3 and S100A2 genes. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | S100 calcium binding proteins, "EF-hand domain containing" |
| Description | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. [provided by RefSeq, Jul 2008] | Chromosome | 1 |
| Location | 1q21 |
| Start | 153533584 |
| End | 153538306 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 4723 |
| OMIM ID | 176993 |
| HGNC ID | HGNC:10492 |
| Unigene ID | Hs.516484 |
| Ensembl ID | ENSG00000196754 |
| PharmGKB ID | PA34904 |
mRNA Information
| mRNA ID | ?NM_005978.3 |
|---|---|
| Exon | join(1..325,1944..2097,4240..4723) | mRNA Sequence | Download Select all |
| Length | 970 |
Protein Information
| Protein ID | NP_005969.1 |
|---|---|
| Protein Name | S100 calcium binding protein A2 |
| Molecular Wt. (Da) | 11582 |
| Protein Sequence | Download Select all |
| Length | 98 |
| Uniprot ID | O95999 |
| Ensembl Protein ID | ENSP00000359612 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 7157 | TP53 | 1859 | NP_000537.3 | in vitro | 15941720 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00213 | Apr-91 | S-100 |
| cl08302 | Apr-91 | EFh superfamily |
| cd05026 | Feb-92 | S-100Z |
| cd05025 | Apr-94 | S-100A1 |
| cd05029 | Feb-89 | S-100A6 |
| cd05027 | Apr-91 | S-100B |
| cd05030 | Apr-89 | calgranulins |
| cd05031 | Apr-92 | S-100A10_like |
| pfam01023 | Jun-49 | S_100 |
| cl19180 | Jun-49 | S_100 superfamily |
| cd05023 | Jul-91 | S-100A11 |
| cd05022 | Apr-76 | S-100A13 |
| cd05024 | Apr-91 | S-100A10 |
| cd00051 | 29-84 | EFh |
| pfam13499 | 29-80 | EF-hand_7 |
Ontology Information
| HPRD ID | 4654 |
|---|---|
| Molecular Class | Calcium binding protein |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P29034 | DB00768 | Olopatadine | SmallMoleculeDrug |