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General Information
- Evidence
- Gene
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- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16116035 | 2006 | Cell line : - Source : - Sample Type : CRC Tumor No. of Sample : Tissue sections from 26 colon cancer patients were recruited in this study. Stage : - | RT-PCR analysis , in situ hybridization. | Up-regulation | - | Differential expression of SAA in human colon cancer tissues and suggest its role in colonic tumorigenesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11. [provided by RefSeq, Feb 2016 | Chromosome | 11 |
| Location | 11p15.1 |
| Start | 18287754 |
| End | 18306424 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 18671 |
| OMIM ID | 104750 |
| HGNC ID | HGNC:10513 |
| Unigene ID | Hs.632144 |
| Ensembl ID | ENSG00000173432 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | ?NM_000331.4 |
|---|---|
| Exon | join(1..123,3236..3388,4213..4530) | mRNA Sequence | Download Select all |
| Length | 595 |
Protein Information
| Protein ID | NP_000322.2 |
|---|---|
| Protein Name | serum amyloid A1 |
| Molecular Wt. (Da) | 225137 |
| Protein Sequence | Download Select all |
| Length | 122 |
| Uniprot ID | O60936 |
| Ensembl Protein ID | ENSP00000268605 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00277 | 21-122 | SAA |
| cl02506 | 21-122 | SAA superfamily |
| smart00197 | 21-122 | SAA |
Ontology Information
| HPRD ID | 5006 |
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | Receptor signaling complex scaffold activity (GO:0030159) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P0DJI8 | DB00062 | Human Serum Albumin | BiotechDrug |
| P0DJI8 | DB00064 | Serum albumin iodonated | BiotechDrug |