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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SART1 | 9092 | squamous cell carcinoma antigen recognized by T cells | 11 | Ara1, Snu66, SNRNP110 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 11156463 | 2000 | Cell line : - Source : Sample Type : CRC tumor and normal tissue No. of Sample : 33 Stage : - | Western blotting | Up-regulation | - | The SART1(259) antigen could be an appropriate target molecule for specific immunotherapy of approximately 40 percent of the human-lymphocyte-antigen-A24+ patients with colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008] | Chromosome | 11 |
| Location | 11q13.1 |
| Start | 65729160 |
| End | 65747607 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 18448 |
| OMIM ID | 605941 |
| HGNC ID | HGNC:10538 |
| Unigene ID | Hs.502883 |
| Ensembl ID | ENSG00000175467 |
| PharmGKB ID | PA34947 |
Protein Information
| Protein ID | NP_005137.1 |
|---|---|
| Protein Name | squamous cell carcinoma antigen recognized by T cells |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 800 |
| Uniprot ID | P62070 |
| Ensembl Protein ID | ENSP00000256196 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 392 |
| K | Sumoylation | 94 |
| K | Sumoylation | 141 |
| K | Sumoylation | 709 |
| K | Sumoylation | 742 |
| T | Phosphorylation | 430;- |
| T | Phosphorylation | 695;- |
| S | Phosphorylation | 596;- |
| S | Phosphorylation | 598;- |
| S | Phosphorylation | 591;- |
| S | Phosphorylation | 448;- |
| S | Phosphorylation | 463;- |
| T | Phosphorylation | 466;- |
| S | Phosphorylation | 486 |
| S | Phosphorylation | 474 |
| T | Phosphorylation | 764 |
| T | Phosphorylation | 123 |
| S | Phosphorylation | 521 |
| S | Phosphorylation | 789 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 59286 | UBL5 | 6028 | NP_077268.1 | yeast 2-hybrid | 15620657 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Spliceosome | hsa03040 |
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 12353 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.