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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SART3 9733 squamous cell carcinoma antigen recognized by T cells 3  12KIAA0156, RP11-13G14, TIP110, p110 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
11920522   2002Cell line : -

Source : Kurume University Hospital

Sample Type : CRC tumor and normal tissue

No. of Sample : CRC 41 and normal tissue 7

Stage : -

Western blotting Up-regulation-The SART3 antigen could be an appropriate target molecule for specific immunotherapy for colorectal carcinoma patients.


Gene Details



NC_000012.11 (108915991..108955165, complement)

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Gene Type protein coding
Gene Family RNA binding motif (RRM) containing
Description The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing. [provided by RefSeq, Jul 2008]  
Chromosome 12
Location 12q24.11
Start 108915991  
End 108955165  
Strand -  
Gene Sequence

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Length 39175  
OMIM ID 611684   
HGNC ID HGNC:16860   
Unigene ID Hs.584842   
Ensembl ID -   
PharmGKB ID PA34948   

mRNA Information


mRNA ID ?NM_014706.3
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS9117.1



Protein Information


      
Protein IDNP_055521.1
Protein Namesquamous cell carcinoma antigen recognized by T cells 3
Molecular Wt. (Da)0
Protein Sequence

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Length 963  
Uniprot IDQ9UPN3
Ensembl Protein ID ENSP00000289893  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation852;-
SPhosphorylation16;-
SPhosphorylation10;-
SPhosphorylation8
TPhosphorylation7
SPhosphorylation703
TPhosphorylation705
TPhosphorylation720

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
367AR2437NP_000035.2in vitro;in vivo15031286   
9129PRPF37389NP_004689.1in vitro;in vivo;yeast 2-hybrid154   521   431   237   475   000   000   000   
10921RNPS17341NP_006702.1in vitro;in vivo;yeast 2-hybrid11477570   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd12392799-879  RRM2_SART3
cl17169799-879  RRM_SF superfamily
cd12391705-778  RRM1_SART3
cl17169705-778  RRM_SF superfamily
cd00590803-873  RRM_SF
pfam00076803-872  RRM_1
cd00590706-778  RRM_SF
cd12399802-878  RRM_HP0827_like
cd12450705-777  RRM1_NUCLs
cd12398804-873  RRM_CSTF2_RNA15_like
cd12298706-779  RRM3_Prp24
pfam00076706-775  RRM_1
cd12391803-867  RRM1_SART3
cd12418801-875  RRM_Aly_REF_like
cd12382802-876  RRM_RBMX_like
cd12225705-787  RRM1_2_CID8_like
cd12404803-866  RRM2_NCL
cd12236803-875  RRM_snRNP70
cd12365813-874  RRM_RNPS1
cd12412802-882  RRM_DAZL_BOULE
cd12414802-873  RRM2_RBM28_like
cd12306804-873  RRM_II_PABPs
cd12247801-874  RRM2_U1A_like
cd12415801-876  RRM3_RBM28_like
cd12231801-873  RRM2_U2AF65
cd12399705-778  RRM_HP0827_like
cd12566706-779  RRM2_MRD1
cd12316802-873  RRM3_RBM19_RRM2_MRD1
cd12297705-777  RRM2_Prp24
cd12447802-876  RRM1_gar2
cd12395705-778  RRM2_RBM34
cd12361802-869  RRM1_2_CELF1-6_like
cd12384705-773  RRM_RBM24_RBM38_like
cd12272705-778  RRM2_PHIP1
cd12373802-878  RRM_SRSF3_like
cd12566799-873  RRM2_MRD1
cd12413803-873  RRM1_RBM28_like
cd12450803-878  RRM1_NUCLs
cd12671803-873  RRM_CSTF2_CSTF2T
cd12449802-873  RRM_CIRBP_RBM3
cd12404701-777  RRM2_NCL
cd12298801-875  RRM3_Prp24
cd12389803-873  RRM2_RAVER
cd12567799-873  RRM3_RBM19
cd12390803-878  RRM3_RAVER
cd12297803-878  RRM2_Prp24
cd12271706-777  RRM1_PHIP1
cd12565802-875  RRM1_MRD1
cd12448803-866  RRM2_gar2
cd12283705-777  RRM1_RBM39_like
cd12385706-777  RRM1_hnRNPM_like
cd12451705-779  RRM2_NUCLs
cd12366811-875  RRM1_RBM45
cd12407708-773  RRM_FOX1_like
cd12409802-878  RRM1_RRT5
cd12649803-879  RRM1_SXL
cd12306706-778  RRM_II_PABPs
cd12315802-873  RRM1_RBM19_MRD1
cd12254803-864  RRM_hnRNPH_ESRPs_RBM12_like
cd12280803-874  RRM_FET
cd12398706-779  RRM_CSTF2_RNA15_like
cd12296705-773  RRM1_Prp24
cd12375803-874  RRM1_Hu_like
cd12447705-775  RRM1_gar2
cd12564708-763  RRM1_RBM19
cd12387706-777  RRM3_hnRNPM_like
cd12330802-873  RRM2_Hrp1p
cd12504807-870  RRM2_hnRNPH_like
cd12243803-858  RRM1_MSSP
cd12394705-777  RRM1_RBM34
cd12379803-874  RRM2_I_PABPs
cd12372803-866  RRM_CFIm68_CFIm59
cd12237800-873  RRM_snRNP35
cd12401705-777  RRM_eIF4H
cd12290705-782  RRM1_LARP7
cd12650800-876  RRM1_Hu
cd12340802-873  RBD_RRM1_NPL3
cd12320802-858  RRM6_RBM19_RRM5_MRD1
cd12448706-774  RRM2_gar2
cd12316707-773  RRM3_RBM19_RRM2_MRD1
cd12673801-868  RRM_BOULE
cd12771800-878  RRM1_HuB
cd12341802-867  RRM_hnRNPC_like
cd12324797-879  RRM_RBM8
cd12284707-778  RRM2_RBM23_RBM39
cd12380706-777  RRM3_I_PABPs
cd12251706-778  RRM3_hnRNPR_like
cd12395804-873  RRM2_RBM34
cd12400705-773  RRM_Nop6
cd12311708-777  RRM_SRSF2_SRSF8
cd12389705-777  RRM2_RAVER
cd12254705-778  RRM_hnRNPH_ESRPs_RBM12_like
cd12474803-887  RRM2_MSSP2
cd12284803-873  RRM2_RBM23_RBM39
cd12411803-873  RRM_ist3_like
cd12658706-775  RRM1_MYEF2
cd12508807-860  RRM2_ESRPs_Fusilli
cd12729805-860  RRM1_hnRNPH_hnRNPH2_hnRNPF
cd12380803-874  RRM3_I_PABPs
cd12418704-775  RRM_Aly_REF_like
cd12651803-863  RRM2_SXL
cd12412705-783  RRM_DAZL_BOULE
cd12376803-863  RRM2_Hu_like
cd12235803-876  RRM_PPIL4
cd12775797-882  RRM2_HuB
cd12773803-863  RRM2_HuR
cd12227801-874  RRM_SCAF4_SCAF8
cd12675802-866  RRM2_Nop4p
cd12671706-777  RRM_CSTF2_CSTF2T
cd12484706-781  RRM1_RBM46
cd12397706-775  RRM2_Nop13p_fungi
cd12571802-857  RRM6_RBM19
cd12241803-866  RRM_SF3B14
cd12344705-775  RRM1_SECp43_like
cd12631703-762  RRM1_CELF1_2_Bruno
cd12772800-878  RRM1_HuC
cd12250800-861  RRM2_hnRNPR_like
cd12372706-779  RRM_CFIm68_CFIm59
cd12666803-871  RRM2_RAVER2
cd12249800-876  RRM1_hnRNPR_like
cd12386803-863  RRM2_hnRNPM_like
cd12503805-873  RRM1_hnRNPH_GRSF1_like
cd12387803-873  RRM3_hnRNPM_like
cd12473803-887  RRM2_MSSP1
cd12769800-878  RRM1_HuR
cd12236705-777  RRM_snRNP70
cd12229801-873  RRM_G3BP
cd12730807-860  RRM1_GRSF1
cd12408805-863  RRM_eIF3G_like
cd12567702-779  RRM3_RBM19
cd12770800-878  RRM1_HuD
cd12386706-777  RRM2_hnRNPM_like
cd12454799-873  RRM2_RIM4_like
cd12564802-875  RRM1_RBM19
cd12402705-773  RRM_eIF4B
cd12470798-878  RRM1_MSSP1
cd12674803-878  RRM1_Nop4p
cd12251803-878  RRM3_hnRNPR_like
cd12411697-786  RRM_ist3_like
cd12384802-857  RRM_RBM24_RBM38_like
cd12414706-781  RRM2_RBM28_like
cd12675708-783  RRM2_Nop4p
cd12283804-858  RRM1_RBM39_like
cd12249706-774  RRM1_hnRNPR_like
cd12355802-873  RRM_RBM18
cd12657706-777  RRM1_hnRNPM
cd12393800-876  RRM_ZCRB1
cd12475803-887  RRM2_RBMS3
cd12632701-779  RRM1_CELF3_4_5_6
cd12332802-873  RRM1_p54nrb_like
cd12315706-764  RRM1_RBM19_MRD1
cd12686803-858  RRM1_PTBPH1_PTBPH2
cd12374814-863  RRM_UHM_SPF45_PUF60
cd12400803-873  RRM_Nop6
cd12534803-876  RRM_SARFH
cd12652803-863  RRM2_Hu
cd12307803-873  RRM_NIFK_like
cd12774803-863  RRM2_HuD
cd12355725-779  RRM_RBM18
cd12237705-777  RRM_snRNP35
cd12242705-777  RRM_SLIRP
cd12645802-881  RRM_SRSF3
cd12681801-870  RRM_SKAR
cd12472798-872  RRM1_RBMS3
cd12551705-779  RRM_II_PABPN1L
cd12378707-775  RRM1_I_PABPs
cd12415705-779  RRM3_RBM28_like
cd12228705-756  RRM_ENOX
cd12425803-876  RRM4_PTBP1_like
cd12273803-873  RRM1_NEFsp
cd12309803-873  RRM2_Spen
cd12260705-777  RRM2_SREK1
cd12367802-858  RRM2_RBM45
cd12225804-879  RRM1_2_CID8_like
cd12393705-778  RRM_ZCRB1
cd12614803-873  RRM1_PUB1
cd12354705-775  RRM3_TIA1_like
cd12552803-873  RRM_Nop15p
cd12676803-858  RRM3_Nop4p
cd12290803-861  RRM1_LARP7
cd12343802-873  RRM1_2_CoAA_like
cd12486802-867  RRM1_ACF
cd12328802-860  RRM2_hnRNPA_like
cd12407802-873  RRM_FOX1_like
cd12485802-867  RRM1_RBM47
cd12583706-764  RRM2_hnRNPD
cd12514708-778  RRM4_RBM12_like
cd12533803-875  RRM_EWS
cd12665803-857  RRM2_RAVER1
cd12358803-878  RRM1_VICKZ
cd12550803-873  RRM_II_PABPN1
cd12304803-875  RRM_Set1
cd12381802-881  RRM4_I_PABPs
cd12401804-876  RRM_eIF4H
cd12371706-764  RRM2_PUF60
cd12776803-863  RRM2_HuC
cd12318803-876  RRM5_RBM19_like
cd12487802-868  RRM1_DND1
cd12370802-873  RRM1_PUF60
cd12362803-873  RRM3_CELF1-6
cd12359802-877  RRM2_VICKZ
cd12285814-863  RRM3_RBM39_like
cd12599803-875  RRM1_SF2_plant_like
pfam13893819-876  RRM_5
cd12463799-859  RRM_G3BP1
cd12281801-882  RRM1_TatSF1_like
pfam13893722-779  RRM_5
cd12371801-863  RRM2_PUF60
cd12260804-877  RRM2_SREK1
cd12502807-874  RRM2_RMB19
cd12413705-777  RRM1_RBM28_like
cd12327802-878  RRM2_DAZAP1
cd12278822-863  RRM_eIF3B
cd12271803-873  RRM1_PHIP1
cd12325803-866  RRM1_hnRNPA_hnRNPD_like
cd12320708-764  RRM6_RBM19_RRM5_MRD1
cd12633802-858  RRM1_FCA
cd12720705-779  RRM_SYNJ2
cd12318705-765  RRM5_RBM19_like
cd12485706-774  RRM1_RBM47
cd12646802-882  RRM_SRSF7
cd12421803-858  RRM1_PTBP1_hnRNPL_like
cd12381707-777  RRM4_I_PABPs
cd12338802-863  RRM1_SRSF1_like
cd12227703-778  RRM_SCAF4_SCAF8
cd12599705-764  RRM1_SF2_plant_like
cd12436801-877  RRM1_2_MATR3_like
cd12672803-851  RRM_DAZL
cd12317803-857  RRM4_RBM19_RRM3_MRD1
cd12636802-861  RRM2_Bruno_like
cd12312803-865  RRM_SRSF10_SRSF12
cd12676703-763  RRM3_Nop4p
cd12365722-778  RRM_RNPS1
cd12571706-763  RRM6_RBM19
cd12329706-773  RRM2_hnRNPD_like
cd12402804-876  RRM_eIF4B
cd12375708-764  RRM1_Hu_like
cd12291705-778  RRM1_La
cd12505807-860  RRM2_GRSF1
cd12570802-857  RRM5_MRD1
cd12385802-873  RRM1_hnRNPM_like
cd12336803-873  RRM_RBM7_like
cd12749708-777  RRM4_RBM12
cd12245803-870  RRM_scw1_like
cd12480801-869  RRM2_U1A
cd12307705-759  RRM_NIFK_like
cd12347803-873  RRM_PPIE
cd12628802-874  RRM2_IGF2BP1
cd12680802-866  RRM_THOC4
cd12551803-873  RRM_II_PABPN1L
cd12550705-779  RRM_II_PABPN1
cd12226803-874  RRM_NOL8
cd12291803-873  RRM1_La
cd12577803-884  RRM1_Hrp1p
cd12670706-780  RRM2_Nop12p_like
cd12244803-868  RRM2_MSSP
cd12405703-773  RRM3_NCL
cd12241706-764  RRM_SF3B14
cd12340706-778  RBD_RRM1_NPL3
cd12347706-778  RRM_PPIE
cd12641803-876  RRM_TRA2B
cd12478705-779  RRM1_U2B
cd12345801-876  RRM2_SECp43_like
cd12486706-764  RRM1_ACF
smart00360802-873  RRM
smart00360705-777  RRM
COG0724636-858  RRM
TIGR01622553-877  SF-CC1
TIGR01628706-933  PABP-1234
COG0724706-912  RRM
COG5107100-460  RNA14
TIGR01628705-886  PABP-1234
TIGR01642638-873  U2AF_lg
pfam14259706-774  RRM_6
pfam14259803-867  RRM_6
TIGR01648706-861  hnRNP-R-Q
TIGR01661702-914  ELAV_HUD_SF
TIGR01659697-892  sex-lethal
PLN03134795-909  PLN03134
PLN03134703-787  PLN03134
TIGR01648746-929  hnRNP-R-Q
TIGR01648802-867  hnRNP-R-Q
COG5107126-427  RNA14
TIGR01645706-879  half-pint


Ontology Information


   
HPRD ID12288
Molecular ClassRNA binding protein
Molecular FunctionTransporter activity (GO:0005215)
Biological ProcessTransport (GO:0006810)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO