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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SASH1 23328 SAM and SH3 domain containing 1  6KIAA0790, dJ323M4.1, SH3D6A 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
17088907   2006Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 113 CRC and 15 normal tissue

Stage : UICC stage II, III, IV

real time RT-PCRDown-regulation 10-foldMultivariate analysis identified SASH1 downregulation as an independent negative prognostic parameter for patient survival.


Gene Details



NC_000006.11 (148663729..148873185)

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Gene Type protein coding
Gene Family SAM and SH3 domain containing, "Sterile alpha motif (SAM) domain containing"
Description -  
Chromosome 6
Location 6q24.3
Start 148663729  
End 148873185  
Strand +  
Gene Sequence

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Length 209457  
OMIM ID 607955   
HGNC ID HGNC:19182   
Unigene ID Hs.193133   
Ensembl ID ENSG00000111961   
PharmGKB ID PA134984521   

mRNA Information


mRNA ID ?NM_015278.3
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS5212.1



Protein Information


      
Protein IDNP_056093.3
Protein NameSAM and SH3 domain containing 1
Molecular Wt. (Da)0
Protein Sequence

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Length 1247  
Uniprot IDQ9NZV6
Ensembl Protein ID ENSP00000355084  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation90
SPhosphorylation101
SPhosphorylation407
SPhosphorylation248
SPhosphorylation721
SPhosphorylation813
SPhosphorylation614

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd09559633-698  SAM_SASH1_repeat1
cl15755633-698  SAM_superfamily superfamily
cd094921173-1242  SAM_SASH1_repeat2
cl157551173-1242  SAM_superfamily superfamily
cd11967557-613  SH3_SASH1
cl17036557-613  SH3 superfamily
pfam12485399-555  SLY
cl13866399-555  SLY superfamily
cd11968557-612  SH3_SASH3
cd11822558-609  SH3_SASH_like
cd09493636-693  SAM_SASH-like
cd09560636-698  SAM_SASH3
cd09561636-696  SAM_SAMSN1
cd11759558-612  SH3_CRK_C
pfam076471180-1239  SAM_2
cd094871181-1236  SAM_superfamily
cd095451179-1236  SAM_EPH-A4
cd11874558-605  SH3_CD2AP-like_2
cd095551178-1239  SAM_EPH-B6
cd00174558-609  SH3
cd11827569-611  SH3_MyoIe_If_like
cd11823564-612  SH3_Nostrin
cd095541180-1234  SAM_EPH-B4
cd094911180-1232  SAM_Ship2
cd094991181-1242  SAM_AIDA1AB-like_repeat1
cd094881178-1233  SAM_EPH-R
cd12055560-605  SH3_CIN85_2
cd11875558-605  SH3_CD2AP-like_3
pfam005361180-1239  SAM_1
cd094981180-1234  SAM_caskin1,2_repeat2
cd11877571-610  SH3_PIX
cd12054569-605  SH3_CD2AP_2
cd094901180-1232  SAM_Arap1,2,3
cd11805558-610  SH3_GRB2_like_C
smart00326556-610  SH3
cd11842558-612  SH3_Ysc84p_like
cd095471181-1240  SAM_EPH-A6
cd11883560-606  SH3_Sdc25
cd11766573-611  SH3_Nck_2
cd095511180-1234  SAM_EPH-B1
cd11873569-605  SH3_CD2AP-like_1
pfam07653558-610  SH3_2
cd12057569-613  SH3_CIN85_3
cd12142565-605  SH3_D21-like
cd094971182-1233  SAM_caskin1,2_repeat1
cd11976559-611  SH3_VAV1_2
cd095491178-1234  SAM_EPH-A10
cd11813558-612  SH3_SGSM3
cd095501181-1239  SAM_EPH-A8
cd095531180-1240  SAM_EPH-B3
cd094931181-1237  SAM_SASH-like
cd09527638-696  SAM_Samd5
cd095421181-1238  SAM_EPH-A1
cd11840573-610  SH3_Intersectin_5
cd09499636-694  SAM_AIDA1AB-like_repeat1
cd09500636-666  SAM_AIDA1AB-like_repeat2
cd07219959-1052  Pat_PNPLA1
cl11396959-1052  Patatin_and_cPLA2 superfamily
smart004541174-1241  SAM
PHA03247781-1081  PHA03247
pfam03154729-1071  Atrophin-1
PHA03247847-1065  PHA03247
PHA03247916-1080  PHA03247
PRK10263842-1143  PRK10263
PRK14951978-1080  PRK14951
PHA03247845-1059  PHA03247
PHA03307792-1069  PHA03307
PHA02682977-1059  PHA02682
PHA02682974-1065  PHA02682
PHA03378800-1089  PHA03378
PHA03247981-1058  PHA03247
PRK12323970-1066  PRK12323
PHA03307788-1064  PHA03307
pfam09770842-1074  PAT1
PRK14954995-1078  PRK14954
PTZ00449978-1072  PTZ00449
PHA03307866-1065  PHA03307
pfam09606843-1059  Med15
smart00454636-697  SAM
PRK14954979-1053  PRK14954
PRK14951976-1059  PRK14951
pfam15042974-1059  LELP1
PHA03418854-988  PHA03418
PRK07764847-1059  PRK07764
PHA03247981-1057  PHA03247
pfam071741002-1059  FAP
PRK14963982-1051  PRK14963
pfam15449869-1090  Retinal
PRK03427951-1059  PRK03427


Ontology Information


   
HPRD ID10537
Molecular ClassAdapter molecule
Molecular FunctionTranscription regulator activity (GO:0030528)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO