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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21677534 | 2011 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Antibody-based proteomic | Up-regulation | - | SATB2 is a sensitive and highly specific marker for CRC with distinct positivity in 85% of all CRCs, and that SATB2 and/or CK20 was positive in 97% of CRCs. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Homeoboxes / CUT class |
| Description | This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and mental retardation. Alternate splicing results in multiple transcript variants that encode the same protein. | Chromosome | 2 |
| Location | 2q33.1 |
| Start | 199269500 |
| End | 199471266 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 201767 |
| OMIM ID | 608148 |
| HGNC ID | HGNC:21637 |
| Unigene ID | Hs.516617 |
| Ensembl ID | ENSG00000119042 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_015265.3 |
|---|---|
| Exon | join(1..253,10735..10815,15171..15398,37753..37929, 89447..89573,90780..90903,102560..102662,122094..122566, 142357..142569,147309..147464,162310..162507, 198595..201767) | mRNA Sequence | Download Select all |
| Length | 5730 |
CDS Information
| Location | join(15230..15398,37753..37929,89447..89573,90780..90903, 102560..102662,122094..122566,142357..142569, 147309..147464,162310..162507,198595..199056) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS2327.1 |
Protein Information
| Protein ID | NP_001165988.1 |
|---|---|
| Protein Name | SATB homeobox 2 |
| Molecular Wt. (Da) | 82425 |
| Protein Sequence | Download Select all |
| Length | 733 |
| Uniprot ID | P14923 |
| Ensembl Protein ID | ENSP00000311113 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Sumoylation | 233 |
| K | Sumoylation | 350 |
| S | Phosphorylation | 446 |
| S | Phosphorylation | 449 |
| S | Phosphorylation | 450 |
| S | Phosphorylation | 452 |
| S | Phosphorylation | 39 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd11585 | 60-155 | SATB1_N |
| cl16936 | 60-155 | SATB1_N superfamily |
| cd00086 | 615-673 | homeodomain |
| cl00084 | 615-673 | homeodomain superfamily |
| pfam02376 | 352-437 | CUT |
| cl08348 | 352-437 | CUT superfamily |
| pfam02376 | 475-560 | CUT |
| cl08348 | 475-560 | CUT superfamily |
| smart00389 | 614-671 | HOX |
| pfam00046 | 616-668 | Homeobox |
| COG5576 | 609-678 | COG5576 |
Ontology Information
| HPRD ID | 4130 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Intracellular ligand-gated ion channel activity (GO:0005217) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.