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General Information
- Evidence
- Gene
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- Protein
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- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22993347 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | Implication of syndecan-1 in the remoDeletionng and angiogenesis of colorectal cancer tissue, through interaction with other extracellular matrix components and VEGF, probably influencing the tumor progression and aggressiveness. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, Proteoglycans / Cell Surface : Syndecans |
| Description | The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008] | Chromosome | 2 |
| Location | 2p24.1 |
| Start | 20200797 |
| End | 20225433 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 24637 |
| OMIM ID | 186355 |
| HGNC ID | HGNC:10658 |
| Unigene ID | Hs.224607 |
| Ensembl ID | ENSG00000115884 |
| PharmGKB ID | PA35588 |
mRNA Information
| mRNA ID | NM_001006946.1 |
|---|---|
| Exon | join(1..172,348..632,20010..20091,21143..21621, 22212..22347,22499..24637) | mRNA Sequence | Download Select all |
| Length | 3309 |
CDS Information
| Location | join(567..632,20010..20091,21143..21621,22212..22347, 22499..22668) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS1697.1 |
Protein Information
| Protein ID | NP_001006947.1 |
|---|---|
| Protein Name | Syndecan 1 |
| Molecular Wt. (Da) | 29488 |
| Protein Sequence | Download Select all |
| Length | 310 |
| Uniprot ID | P04798 |
| Ensembl Protein ID | ENSP00000369050 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Glycosylation | 206 |
| S | Glycosylation | 216 |
| S | Glycosylation | 37 |
| S | Glycosylation | 45 |
| S | Glycosylation | 47 |
| S | Glycosylation | 206 |
| S | Glycosylation | 216 |
| S | Glycosylation | 37 |
| S | Glycosylation | 45 |
| S | Glycosylation | 47 |
| G | Proteolytic Cleavage | 245 |
| G | Proteolytic Cleavage | 245 |
| G | Proteolytic Cleavage | 82 |
| G | Proteolytic Cleavage | 82 |
| Y | Phosphorylation | 309;- |
| Y | Phosphorylation | 309;- |
| Y | Phosphorylation | 299 |
| Y | Phosphorylation | 299 |
| Y | Phosphorylation | 286 |
| Y | Phosphorylation | 286 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1511 | CTSG | 289 | NP_001902.1 | in vitro | 9565572 |
| 1991 | ELANE | 554 | NP_001963.1 | in vitro | 9565572 |
| 3082 | HGF | 799 | NP_000592.3 | in vitro | 11830493 |
| 3576 | IL8 | 909 | NP_000575.1 | in vitro | 12902511 |
| 4192 | MDK | 1200 | NP_002382.1 | in vitro | 9089390 |
| 5764 | PTN | 1199 | NP_002816.1 | in vitro | 7592855 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell adhesion molecules (CAMs) | hsa04514 |
| ECM-receptor interaction | hsa04512 |
| Malaria | hsa05144 |
| Proteoglycans in cancer | hsa05205 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01034 | 243-308 | Syndecan |
| cl20212 | 243-308 | Syndecan superfamily |
| smart00294 | 275-293 | 4.1m |
| cl02555 | 275-293 | 4.1m superfamily |
Ontology Information
| HPRD ID | 11813 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.