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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SDCBP 6386 Syndecan binding protein (syntenin)  8ST1; SYCL; MDA-9; TACIP18 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20077526   2010Cell line : -

Source : Department of Pathology of Wrocaw Medical University

Sample Type : -

No. of Sample : -

Stage : -

Gene-annotation enrichment analysis of DAVID, Geneclip and ImmunohistochemistryUnknown-LYN, SDCBP, MAP4K4, DKK1, and MID1 are closely correlated with lymph node metastasis in CRC patients.

181 CRC clinical samples were included in this study.

SW480 cells line were used.

22968445   2012Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation.Up-regulation4.1-


Gene Details



Chromosome: 8; NC_000008.10 (59465728..59495419)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]  
Chromosome 8
Location 8q12
Start 58553169  
End 58582860  
Strand +  
Gene Sequence

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Length 29692  
OMIM ID 602217   
HGNC ID HGNC:10662   
Unigene ID Hs.200804    
Ensembl ID ENSG00000137575   
PharmGKB ID -   

mRNA Information


mRNA ID NM_005625.3
Exon join(1..135,11851..11916,17719..17797,19037..19146, 22732..22893,24865..25040,26455..26626,27349..27440, 28518..29692)  
mRNA Sequence

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Length 2173  



CDS Information


   
Locationjoin(8622..8627,11854..11916,17719..17797,19037..19146, 22732..22893,24865..25040,26455..26626,27349..27440, 28518..28572)
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_001007068.1
Protein NameSyndecan binding protein (syntenin)
Molecular Wt. (Da)32313
Protein Sequence

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Length 298  
Uniprot IDP05177
Ensembl Protein ID ENSP00000342007  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation46;-
YPhosphorylation46;-
YPhosphorylation46;-
YPhosphorylation46;-
YPhosphorylation90;-
YPhosphorylation90;-
YPhosphorylation91;-
YPhosphorylation85;-
YPhosphorylation91;-
SPhosphorylation6
SPhosphorylation6
SPhosphorylation6
SPhosphorylation6
SAcetylation2
SAcetylation2
SAcetylation2
SAcetylation2
SPhosphorylation60
SPhosphorylation60
SPhosphorylation54
SPhosphorylation60
SPhosphorylation60
SPhosphorylation6
TPhosphorylation187
TPhosphorylation187
TPhosphorylation181
TPhosphorylation186
TPhosphorylation186
TPhosphorylation206
TPhosphorylation206
TPhosphorylation200
TPhosphorylation205
TPhosphorylation205
SPhosphorylation2
SPhosphorylation2
SPhosphorylation2
SPhosphorylation2
SPhosphorylation2

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1947EFNB12072NP_004420.1in vitro;in vivo9920925   
1948EFNB22754NP_004084.1in vitro10473577   
2890GRIA1695NP_000818.2in vitro;yeast 2-hybrid11891216   
2892GRIA32378NP_000819.3in vitro;yeast 2-hybrid11891216   
2893GRIA4694NP_000820.3in vitro;yeast 2-hybrid11891216   
2897GRIK1693NP_000821.1in vitro;in vivo;yeast 2-hybrid12597860   
2898GRIK2692NP_068775.1in vitro;yeast 2-hybrid12597860   
2913GRM33070NP_000831.2in vitro;in vivo;yeast 2-hybrid11891216   
3568IL5RA998NP_000555.2in vitro;in vivo;yeast 2-hybrid11498591   
5795PTPRJ2955NP_002834.3in vivo12403354   
5868RAB5A1542NP_004153.2in vitro;in vivo15014045   
6382SDC11718NP_002988.3in vivo11179419   
6383SDC2803NP_002989.2in vitro9391086   
6659SOX41695NP_003098.1in vitro;in vivo;yeast 2-hybrid11498591   
6804STX1A1721NP_004594.1in vitro;in vivo15276154   
9152SLC6A58378NP_004202.2in vitro;in vivo;yeast 2-hybrid15276154   
29062WDR9111035NP_054868.3yeast 2-hybrid16169070   


Pathway Information


No matching records could be found.

Structure Information


PDB ID1N99
Resolution1.94
MethodX-RAY DIFFRACTION
Chains A,B  
Molecule Syntenin 1  
Model View



Domain Information




ID Location Description
cd00992112-191  PDZ_signaling
cl00117112-191  PDZ superfamily
cd00992196-269  PDZ_signaling
cl00117196-269  PDZ superfamily
cd00136123-191  PDZ
smart00228112-194  PDZ
cd00988123-200  PDZ_CTP_protease
smart00228196-271  PDZ
pfam00595114-191  PDZ
cd00990126-200  PDZ_glycyl_aminopeptidase
cd00989138-200  PDZ_metalloprotease
pfam00595198-270  PDZ
cd00136209-269  PDZ
pfam13180123-164  PDZ_2
cd00988217-269  PDZ_CTP_protease
cd00987129-201  PDZ_serine_protease
COG0793125-249  CtpA
TIGR00225125-200  prc
PRK1094259-269  PRK10942
COG0793217-272  CtpA
TIGR02860125-259  spore_IV_B
COG3975126-231  COG3975
TIGR02037127-164  degP_htrA_DO
COG026574-200  DegQ
PRK1013959-270  PRK10139


Ontology Information


   
HPRD ID484
Molecular ClassAdapter molecule
Molecular FunctionCatalytic activity (GO:0003824)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO