Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SDCBP | 6386 | Syndecan binding protein (syntenin)  | 8 | ST1; SYCL; MDA-9; TACIP18  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20077526    | 2010 | Cell line : - Source : Department of Pathology of Wrocaw Medical University Sample Type : - No. of Sample : - Stage : - | Gene-annotation enrichment analysis of DAVID, Geneclip and Immunohistochemistry | Unknown | - | LYN, SDCBP, MAP4K4, DKK1, and MID1 are closely correlated with lymph node metastasis in CRC patients. 181 CRC clinical samples were included in this study. SW480 cells line were used. |
| 22968445    | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation. | Up-regulation | 4.1 | - |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]   | Chromosome | 8 |
| Location | 8q12 |
| Start | 58553169   |
| End | 58582860   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 29692   |
| OMIM ID | 602217    |
| HGNC ID | HGNC:10662    |
| Unigene ID | Hs.200804     |
| Ensembl ID | ENSG00000137575    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_005625.3 |
|---|---|
| Exon | join(1..135,11851..11916,17719..17797,19037..19146, 22732..22893,24865..25040,26455..26626,27349..27440, 28518..29692)   | mRNA Sequence |    Download   Select all |
| Length | 2173   |
CDS Information
| Location | join(8622..8627,11854..11916,17719..17797,19037..19146, 22732..22893,24865..25040,26455..26626,27349..27440, 28518..28572) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | NP_001007068.1 |
|---|---|
| Protein Name | Syndecan binding protein (syntenin) |
| Molecular Wt. (Da) | 32313 |
| Protein Sequence |    Download   Select all |
| Length | 298   |
| Uniprot ID | P05177 |    
| Ensembl Protein ID | ENSP00000342007   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 46;- |
| Y | Phosphorylation | 46;- |
| Y | Phosphorylation | 46;- |
| Y | Phosphorylation | 46;- |
| Y | Phosphorylation | 90;- |
| Y | Phosphorylation | 90;- |
| Y | Phosphorylation | 91;- |
| Y | Phosphorylation | 85;- |
| Y | Phosphorylation | 91;- |
| S | Phosphorylation | 6 |
| S | Phosphorylation | 6 |
| S | Phosphorylation | 6 |
| S | Phosphorylation | 6 |
| S | Acetylation | 2 |
| S | Acetylation | 2 |
| S | Acetylation | 2 |
| S | Acetylation | 2 |
| S | Phosphorylation | 60 |
| S | Phosphorylation | 60 |
| S | Phosphorylation | 54 |
| S | Phosphorylation | 60 |
| S | Phosphorylation | 60 |
| S | Phosphorylation | 6 |
| T | Phosphorylation | 187 |
| T | Phosphorylation | 187 |
| T | Phosphorylation | 181 |
| T | Phosphorylation | 186 |
| T | Phosphorylation | 186 |
| T | Phosphorylation | 206 |
| T | Phosphorylation | 206 |
| T | Phosphorylation | 200 |
| T | Phosphorylation | 205 |
| T | Phosphorylation | 205 |
| S | Phosphorylation | 2 |
| S | Phosphorylation | 2 |
| S | Phosphorylation | 2 |
| S | Phosphorylation | 2 |
| S | Phosphorylation | 2 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1947 |    EFNB1 |    2072 |    NP_004420.1 |    in vitro;in vivo |    9920925    |
| 1948 |    EFNB2 |    2754 |    NP_004084.1 |    in vitro |    10473577    |
| 2890 |    GRIA1 |    695 |    NP_000818.2 |    in vitro;yeast 2-hybrid |    11891216    |
| 2892 |    GRIA3 |    2378 |    NP_000819.3 |    in vitro;yeast 2-hybrid |    11891216    |
| 2893 |    GRIA4 |    694 |    NP_000820.3 |    in vitro;yeast 2-hybrid |    11891216    |
| 2897 |    GRIK1 |    693 |    NP_000821.1 |    in vitro;in vivo;yeast 2-hybrid |    12597860    |
| 2898 |    GRIK2 |    692 |    NP_068775.1 |    in vitro;yeast 2-hybrid |    12597860    |
| 2913 |    GRM3 |    3070 |    NP_000831.2 |    in vitro;in vivo;yeast 2-hybrid |    11891216    |
| 3568 |    IL5RA |    998 |    NP_000555.2 |    in vitro;in vivo;yeast 2-hybrid |    11498591    |
| 5795 |    PTPRJ |    2955 |    NP_002834.3 |    in vivo |    12403354    |
| 5868 |    RAB5A |    1542 |    NP_004153.2 |    in vitro;in vivo |    15014045    |
| 6382 |    SDC1 |    1718 |    NP_002988.3 |    in vivo |    11179419    |
| 6383 |    SDC2 |    803 |    NP_002989.2 |    in vitro |    9391086    |
| 6659 |    SOX4 |    1695 |    NP_003098.1 |    in vitro;in vivo;yeast 2-hybrid |    11498591    |
| 6804 |    STX1A |    1721 |    NP_004594.1 |    in vitro;in vivo |    15276154    |
| 9152 |    SLC6A5 |    8378 |    NP_004202.2 |    in vitro;in vivo;yeast 2-hybrid |    15276154    |
| 29062 |    WDR91 |    11035 |    NP_054868.3 |    yeast 2-hybrid |    16169070    |
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 1N99 |
|---|---|
| Resolution | 1.94 |
| Method | X-RAY DIFFRACTION |
| Chains | A,B   |
| Molecule | Syntenin 1   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00992 | 112-191  | PDZ_signaling |
| cl00117 | 112-191  | PDZ superfamily |
| cd00992 | 196-269  | PDZ_signaling |
| cl00117 | 196-269  | PDZ superfamily |
| cd00136 | 123-191  | PDZ |
| smart00228 | 112-194  | PDZ |
| cd00988 | 123-200  | PDZ_CTP_protease |
| smart00228 | 196-271  | PDZ |
| pfam00595 | 114-191  | PDZ |
| cd00990 | 126-200  | PDZ_glycyl_aminopeptidase |
| cd00989 | 138-200  | PDZ_metalloprotease |
| pfam00595 | 198-270  | PDZ |
| cd00136 | 209-269  | PDZ |
| pfam13180 | 123-164  | PDZ_2 |
| cd00988 | 217-269  | PDZ_CTP_protease |
| cd00987 | 129-201  | PDZ_serine_protease |
| COG0793 | 125-249  | CtpA |
| TIGR00225 | 125-200  | prc |
| PRK10942 | 59-269  | PRK10942 |
| COG0793 | 217-272  | CtpA |
| TIGR02860 | 125-259  | spore_IV_B |
| COG3975 | 126-231  | COG3975 |
| TIGR02037 | 127-164  | degP_htrA_DO |
| COG0265 | 74-200  | DegQ |
| PRK10139 | 59-270  | PRK10139 |
Ontology Information
| HPRD ID | 484 |    
|---|---|
| Molecular Class | Adapter molecule |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
