CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
SDHB	6390	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	1

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
23645213	2013	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	Cell growth assay, colony formation assay, cell cycle analysis, nude mouse xenograft, cDNA microarray	Down-regulation	-	SDHB expression is significantly decreased in human colorectal cancer tissues, and reconstitution of SDHB in colorectal cancer may be a potential therapeutic approach to inhibit aggressiveness of colorectal cancer.

Gene Details

Chromosome 1 - NC_000001.11 (17018722..17054170, complement)
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Gene Type	protein coding
Gene Family	Mitochondrial respiratory chain complex / Complex II
Description	Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.
Chromosome	1
Location	1p36.1-p35
Start	17018722
End	17054170
Strand	-
Gene Sequence	>gi\|568815597:c17054170-17018722 Homo sapiens chromosome 1, GRCh38.p2 Primary Assembly ACCCGGGAAACCGGAAGCCGCCTCCCACTTGGTTGCTCGTACGCGGCTAGTGGGTCCTCAGTGGATGTAG GCTGGGCGCCGCGATGTTCGACGGGACACCGGCGGAGAGCGACCTCGGGGTTAAGGGGTGGGGCTGACGT CAGGAGCCAAGATGGCGGCGGTGGTCGCCCTCTCCTTGAGGCGCCGGTTGCCGGCCACAACCCTTGGCGG AGCCTGCCTGCAGGTGAGTCCTGGAGCCTCAGAGAGGGAAAAGTCAGGAAAGCCACAGAGACTGCCTGGA GCTGATGGGGCTGCGGAGAGACTGAGGAAGCATAGGGCAAGGCCTCAGGGAGATGGAGGACCTCCTCCCC CTGGTGCAGTGCTTTGGTTTGGCTTCGAGCATCCCTGTCAAGTTATCTTTCTGCGCCTCGCAGCAGCTTG TGAGTTAGGGCACGGGCAATTTTTTACAGCTAAGGGTGCGGGGGGGGGGGACGTTCAGAAAGGGGACTTG AATTGCTCAAGGTCACATGGCAAGCGAATGACTGCTGGAACCAGAATTTGAATCCAGACATTGGAGTTCC AAGCCCTTTTTCTGCCACCAAACTATCGCCTCTGTAGAAAAGGGAGACCTGCGGGGTGTGAAGGATGGGA ATTGGGAAGCGAGGTAATTCCTCAAGGGTGCGAGGTTGAGGACCGGGATGGGTGAGGAAAGGACATGTGA ATTGTTGGGGACAGGGCAGGGGAAGGGAGAGATGGAGGGAAATGCACCCAGCCCCCTACCTCGAAGGATC CCGGAGGTGGGTGGTGGGGGTTGCAGGAAAGACTGGGTTCCTTAAAGCAGTGTCACCACAGTTTCACTAG TATCCTCTCAGTGTTTCTGACTCTAAAGGTCATATAATAATACGGACCTCATAGAGTTGACATGGAATGA CAGGTAGAGGGCTTGGCGCTGTTCTTGTTTATTACTATGCCGTGTGCAGTAACAGATTTTCCCACGCCCC TTGTATGGCCAAGAAACAACACATTTCTGACCTGCCTTCTAAGTGGGAACATTTAGAAGGGGAAGGGAAA TTGCTTTTGTATACATAAGGGACTAAGGATTTGCAAATCCTTTCTAAGTCTGTTCCTCTTCTGGGATTCT CAACAACCCCTTTAAGGTGGGCAAGCAAGAATCCTTACCCTCCTTTTTGGAGCTTTGAAAACTTGAGGCC CCCAGAAAGAAAATTTTTGGCTTGCTCAAAATATCACATTCCCAAGAAGCAGACCTGAGGCAGTTTTTTA ACATGGTACCAGAAAAACTCCTTAGCATAGATCTTGGGACATGGTTGGTGTCCAAGAAATTTTAGTTCCT CTTCCTCTCTTGCACTTAAATGAGGACATCTTTCATCTTAAGTGCCTGCTATGGCTGCATAACACAGTAC ATATTGCCCATGTTCCAATCCTGGTTCTATCCAGCATGCTGTGTGTGAACTTGGATCCACTCTGTCTGCA TCAGCCTTTCTGAAAAGGGGAGATAGAGGAAGAAGACAGCCTACCAGAGCCTCAAGCTGACATCCTCTCA GTATTAAATTGATGATTGATAATGAGCTTGTTTACCTGTTCCTTTTATAGTTGCTGAGCAAACAATTAAA TTGTGAGAGCCCCACTAACGAGAGAGTTCCAAGCCCCTCTTCTAAGAATGCATTGTAGAAAAGGCTAATT TCATAGGTCATTTTTGTAATTCCAGGCAAGGTCTTTGCAGGGCCTCCTGAGGGCAACAGAAAATAGAAGA GCCCCAAGGCCTCCCCTTCCTTGTGGGAATGTACATGTATACCCACAAAAGCCACCTCAAAAGAATTCAG TAATGAGCTTGGTGTGTTACCTGTGGGTAACATTCAGGTTCAGGTTCTGAATTCTTTTTATGCTTATAGT CTGACCACTGAACCACAATTCTGCCTGTAAGTATTTGACTGTAGTATATTAACTATTGTTTGTGTTGCCT TATTTCTTCATCTGGACTATGAACTCCTTTAGGACAAGAACTACCTACTTAAAAGTGTGTATCTTGCCAG GTGCAGTGGCTCATGCCTGTAATTCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACCTGAGGTCAGGA GTTCAAGACCAGCCCGGCCAACATGGTGAAACCCCGTCTCTACTAAAAAAATAAAAAAAAAATTAGCTGG GCGTGGTGGTGGGCGCCTATAATCCTAGCTACACAGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGA GGTGGAGGGTGCAGTGAGCTGAAATCGCACCATTGCACTCCATCCTGGGCGACAAGAGCGAAACTCAGTC TCAAAAAAAAAAAAAAAATTTAAAAAATGTGCATCTTGTTCCTTAGGCTGGCAGGGCTAGGATACCTATT TACAAATCAGAATAATACAAAGACTGATAAGGTTGCCAATCTTGTAGAGCAAAAATTTTTTTCTGGGCTA TGCTAGAAACTTGACCCCCCCTCCCCCGGGTTATCTTATGAGGCAGATATTAATACTACCCACCCTTTAC AAAGGAAGAAATAGAATCCGAAAAGCTAATAATTTGCAGAAGAATACACAGCTTGTAAGTGATAGAGCTT GGATTTCAAGCATCACCAATCACACTTTTCAGCAAGCCTGCACCTTGTATTTTACTCAGGCTTATCTTCA TACAGTCCTTTTTGCTTTCTTCCTCTCTATTTCCCCACCTTCTTCTCTGGCCTCCAAATCTTTATCCACT CCATCCAACTCCAAGCCTGCACCCTAAGGACACTTTACTGGAGGAACAACAACCAGCCTTCAGCACCATT CAGAATTCACCCTTCTCAGTTCAGTTGTTGCTTACCTTGCTTAAATTATAAACTATGAAATTCATACTAT CCAAGATTTCCTAGGAATGTACTTTCTGCCTTGAATACTCATTAGTCTTTAGATTAACGTAAAAATGCTT TCAAGGGGCCCTCTTTCCTTTTGGATTTGTAGTATAAATTGCTGGGCAGGTAACAAGGGGAAAAAAATCA TATAGTCTCATTGTATGATTAGAGCAACAACTTCTTTTGTTCCTTGGATCTCATTGTGAAATGGAATTAT CTTTTTGCACTGTTGCGTTTTATGTTTGCGTTTTCACCACTGGTTATAATGGCTAAAAGGTTGGATTTTT GAATCAAGTGACCTGTGTTGCTATATGATCCTATCCTCGTCTTTTAACTGGGAACAACAAAACATTTTTC ATAGAGATGTTATAAAGATTAGAGATTATTTGGCACCGTGTGTGACAGATTATAAAGGTTCGATGAATGA AATCTGGCAAATTTTTAGATATATGTATTCAACGAATTTTTTGGTGGAACACAGATAACATAATCCTGAG AATTAACTCTTTGTACAGACCTCAAGATGAGCAAAGCTCTATCACTTTCAGAACCATGACCACTCTGGTG ATTTTGATTTCAGAATCTTCTTTCATTCTGGTAAACCCCCTTTGCCCCACCAAATATTGTATGAAATACA TTTTTTTTTTTTTTTGAGACAGAGTCACGCTCACGTTGTTGCCCAGGATGGAGTGCAGTGGCGGAATCTT GGCTCACCGTACCCTCCGCCTCCCGGATTTCAAGCAATTCTCCTGCCTCGGCCTCCCAAGTAGCTGAGAT TACAGGTGCCCGCCATCGTGCCTGTCTAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTG GCCAGGCTGATCTCGAACTCCTGACCTCAGGTAATCCACCTGCCTCGGCCTCCCAAAGTACTGGGATTAC AGGCATGAGCCACCACGCCTGGCCTATAAAATACATTTTTGACACAAAACAAATTTAAATTAGTTGTACT GAAAAAAAAAAAATGATGACATTTTGGGGCACTCCAAAACTGATGTTGGGATATGTCGACTTAGATATTC AGTGTAGTACATCCTGGCATTGCTCTTATTTCACATCATTCATATGATAAGACTTTTTAAAAATTTAAAT TAGCTCTAATACAAACTTAGTCTCTTTTGGAAAGATAATACGTGATCAATTATCCGTGTAGAGTGGATAT GAAACAGATATTTAAATGTTATAAAGAAATGTTGAAGGGAAAACCTCATTGCAGGTAACCACAGTCATCC CACAGGCCTTGTGGTTCTGATACCCAGCTTGATAGAGCCTAATGCCTGTTGCCCACTGACAATACTAAAT CAGGCTTTAGAACTAGGGGGTTATGCCTGGCACAGTGGCTCACACCTGTATGTAATCCAGCACTTTGGGA GGCTGAGGCAGGTGGATCACGACATCAGGAGTTCAAGACCATCCTGGCTAAAACGGTGAAACCCCATCCC TACTAAAAATACAAAAAAGTTAGCCGGGCGTGTGACACGCGCCTGTAATCCCAGCTACTTGGGAGGCTGA GGCAGGAGAATTGCTTGAACCCAGGAGGCAGAGAGATCTCGCCACTCCACTCCAGCCTGGGTGACAGAGT GAGACTGTCTCACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGAACTAGGGGATTATGCTCCAGTCCCA GATTCTGTTTAAAGCCCGGTTAGGGGCCAGGCGCGGTTGCTCACACCTGTAATCCCAACACTTTGGAACG CTGAGGCAGGTGGATCACTTGAGGCCAGGAGTTTGAGCCCAGCCTGGCCAAATGGCAAAACCTTGTCTGT ACTAAAAATACAAAAATTAGCTGGACTTTATGGCACATGCCTGTAATCCCAGCTACCCGGGTGGCTGAGA CAGGAGAATTGCATGAGCCTGAGGGGTGGAGGTTGCAGCGATCCAAGATCGCGCCACTGCACTCCAGCCT GAGCAACAGAATGAGACTCTCCAAAAAAGAAAAAAAAAAGTCCAAGTTAGGGCCAGACACAATGGCTCAC ACCTGTAATCCCAACACTTTGGGAGGCTGAGATGGGAGGATTGCTTAAGCCCAGAAATTCCATACCAGCT TAGCCAACATGGCAAGACCCTGTCTCTACAAAAATTAGCTGGACATGATGGTGTGCACCTATAGTCCCAG CTACTTGGGAGGCTGAGTCAGGATGATCGCCTGAGCCCAGGAGTTAAAGGCTGCAGTGAGCCATGATCTC CAGCCTGGGCAATAAAGCTAGACCATGTGTCTATAAAAATAAAAAATAAAGGCCGGGCAAGGTGGCCTGT ACCTATAATCCCAGCACTTTGGGAGGCCAAGGCAGGCGGATCACCTGAGGTCAGGAGTTCAAGACCAGCC TGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATATAAAAATTAGCTCGGCGTGGTGGCAGGCACCTG TAGTCCCAGCTACTCAGGAGGCTGAGGCAGAAGAATCACTTGAAGTCGGGAGGTGGAGGTTGCAGTGAGC CGAGATCGCGCCATTGTACTCCAGCCTGGGGGACAAGAGTGAGACCCCATCTCAAAATAAATAAATAAAT AAATATTTTAAAAAATAAATGAAAAATAAAAGTGTCCAAATTAGAAGTAAAAACTTGAAGTAGCCCCATT TTTTAAAAGGCATATTGTCCCACTTACCCTACTATCTGCCTCAGGCACAGCAGCCACCCACTCTGGAAAA TAGTTTTGTCAGTTGCTTAAAAAAAACTAAACTTGTAGCTACCATACAGCCCAACAATTACACACCTGGG TGTTTATCCTGAGAAATGAAGATGTAACGTTCACACAGAAATTTGTCCACAAATGTTCATCTCAGCTTTA TTCATGTCACCAAAAATTAGAACACCCCCAATGTCCCTCAGTAGTTACATGGTTAAGCAAATTGTGGTAC ATGATACCTTGGAGTGCTACTCAGCTATAACAAGAAAAAAGCTATTGCTGTACACAGCAACTTGGATGAA TCTCCGGAGAATTCGGCTGAATAAAAAAAGCCAATTCCAAAAGGCTACATACCAGATGATTATATTGATA TAACATTCTTGAAATGACCGAATTTGAGAAGTAGAGAACAGATTAGTGATTGCTAGGGCTTACGGAGTAC AGGGGAGGTAGGGTGGGAGGAAGTGGACAGGGCTATAAAAGGGCAATGTTAGTGATCCTGTGCTTATGGG AATGTCCCCTATCTTGACTAGCACTGTCAGTATTCTGGTTGTGCTGGTGTGCTACAGTTTGCAAGATGTT CCTGTTGGGGAGACTGGGTAAAGAGTATGTGGGCCCTGGCATGGTGGCTCATGCCTATATCCCAACTCTT CGGGAGGGCCAGGCAGAGGATCACTTGGGGCCAGGAGTTCAAGACCAGCCTAGGCAACACAGTGAGACCC CTATCTCTACAAAAATAAATGTAAAAAAACTAACTGGGCATGGTGGCGCATGCCTGTAGTCCTAGCTACT GGGGAAGCTGAGATGGGAGGATCGCTTGAGTCCAGAAGGTTGAGGCTGCAGTGAGCTGTGATCATGCCAC TGCACAATCAGTGACAGAGCAAAACTCTCTCTCTTTTTTTTTTTTTTTTAGCTTGAGTTTCACTTTGTCA CCCAGGGTGGTATACAGTGGCACAGTCTTAGCTCACTGCAACCTTTACCTCCCAAGTTCAAGCCATTCTC CTGCCTCAGCCTCCCTAGTAGCTGGGATTACAGGCACACGCCACCACACCCTGCTAATTCGTTTTTTTGT ATTTTTAGTAGGGACGGGGTTTCACCATGTTGGCTGGGCTGGTCTTGAATCCCTGATCTCAGGTGATTTC CCAACCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGAGAAGAGTATGTGGAGTCTCAGTATTATTTTCT TCTTTTTGTTTTGTTTTGTTTCTTTGAAACAGCGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCGC AATCTTGGCTCACTGCAATCTCCGTCTCCCAGGGTCAAGCGATTCTCCTGCCTCTGCCTCCCGAGTAGCT GGGATTACAGACATGTGCCACCACACCGGGCTAATTTTTGTATCTTTAGTAGAGACGGAGTTTCACCATG TTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATTCGTCTGTCTTGGCCTCCCAAAGTACTGGGAT ACAGGTGTGAGCCACTGCACCTGGCCTCAGTATTATTTTCTATAAATGCATATGAATCTATAATTATTAA AAAATAAAAAGGTTGGCCAGGCACGGTGGCTCACGCCTGTAATCCTAGCAGTTTGGGAGGCCAAGGCAGG CAGATCACCTGAGGTTGGGAGTTTGAGACTACCCTGACCAACATAGACAAACCACATCTCTACTAAAAAT ACAAAATTAGCCGGGCCTGGTAGCACATGCCTGTAATCCCAGCTACTCGGGAGACTGAGGCAGGAGAATT GCTTGAACCGGGGAGGCGGAGGTTGTGGTGAGCCAAGATTGCACCATTGCACTCCAGCCTGGGCAACAAG AGCAAAACTCAGTCTCAAAGATAAATAAATAAATAAATAGTTTAATTTTTTAAAAAAGCATTTAACTATG GTTATATGCAGTAACATATGAATCTCAGAAGCATTATGTTGAGTGAAAGAAGCTAGACATGAGACTACGT ACCGTATGATGCCATTTATATGAATTCTGTAAAAGGCAGACTCGTGATGATAGCTGATCAGTTGCTAAGG GTAGGAAAAGGGGACTTATGTTTGCCATCAAGGGCACAAAAGACCTTTTTGGATGGAAATACTCTGTTGT AATTGTGGTAGGATTACATTGCTTTGTCAAAACTCATTATACCCTTAAAATTAGTGAATTTTATTATAAT GAATTATACCTTATTAAATCTCACAGAAAAAAGACCAAAAAAAAAATGGGACATTAAGCAAGCAAAGTCC ACTGGAGTTGATACCTTCAGGAATCTTTCCTCTCACTTCCTCCCAAATACCACAAGGTGGCATTAGATGT TCATGTCAGTTTACAAAATGGGGTTCCCGGTGAAAAACATTTGTAGAAATGGCTTTCCTTTTGTTGATGA TTTTAGCCAGCTTGGTGATAAGGTAAAACATAGCTTTCATCTTAACTTTCATTTTCTTCATATATTTTCT TCTTTTCTACTGTTAGCTGATGTTTGTATTTTCAGCTTCAGTTAATACGGGACACTTTACCAAGAAATAA TGTTACTGGTAGACGGTCTTGACCACAAGTCGTCAAGGTTTTTAGCATGTTGAACAAAAAATTGGACAAA ACACACAAGCAAAGCAACAGAAGACGAAAGCATAGATTTATTGAAATGAAAGTACACTCCATAGAGTAGG AGTGGGATTGAGCAAGTGGTTCAAGAGCCCCAGCTGCACAGTCTTCTGGGATTAAAGTACCCTGTACGGG TTTCCTATTAGTTACACCCTATGCAAATGAAGACTTGGCCCGAGACGAATCAGAGGCTGTAGTGAAGACT CCCTGTCTCTAAACCCTGTTCTCCTGCCTCAGTAATAAACACCACTGCATCTTTTTGTAATTAGTCAATT AACCTTCCGAGTTTTTACTTTTCTATATCAGTTTATTTTAAAAATTAGCAGTCCTGGAGTATAGTCTTTT CTTTCTTTTTTTCTTTTTTATTTTGTATTTTTGAAAAAGAGTCTCACTCTGTTGCCCAGGCTAGAGTGCA GTGGCATGATCTTGGCTCACTGCAGCCTCAACCTCTCGGGCCCAAGCAGTCCTCCCACTTCTGCCTCCTG AGACGCACACTACGACACCCAGCTAATTTTTTTATTTTTTGTAGAGATGGGGTTTTGCCATGTTTCCCAG ACTGCTCTCAAACTCATGGGCTCAAGCAATTCTCTCACTTCTGCCTCCCAAAGTGCTGAGACTGCAGGCA TGAGCCACCACCCTCAGACCACACCCCACACTCCTTCCCCTTAATTCTGGTTTGTCAAGCCTCCACTTAG ATGACATGTGAGGAAGCCTTCTCTGACTCTTCACTCATTGAAGTCTCTGCTGTATTCATCCAGAGCTCCC TGTACTTTCCCAACAGTATCGCTCTTTATATTCATCGTGAATGTTTAATTTAACTCTTGTTCACTACAAA GTAAGTTCTGTGAAGATGAAGGTTTTTGTGTATTAAGTGCTGTGTCACTAGCCCCTAATACCATGTCTGA TATATTAGCATATGATAGGTGCTTAATACTTGTTGGATATTGAATGCCTGCCTTTTCTAAGAAGATTATG TGTCAGTAATGTGTGAGTTTATATCCAGCGTTACATCTGTTGTGCCAGCAAAATGGAATTATCTTGTATT TCTAATTTTTTTTTCCTTTTTGTGAACTTTAAAAAATTTCAGGCCTCCCGAGGAGCCCAGACAGCTGCAG CCACAGCTCCCCGTATCAAGAAATTTGCCATCTATCGATGGGACCCAGACAAGGCTGGAGACAAACCTCA TATGCAGACTTATGAAGTTGACCTTAATAAGTGAGTATCTCTGTGAAAGCCAGCTATTGAAGGAGAGTTC TTGATTTGATTTAGGGACATGCTTTTCACATCCTTGGAAGGCTTAAAAATCTGAGATCATCCGATGGCTC TGTTTTTAAAACAAGAATGAGCTTGGGCCGGGCACGGTGGCTCACGCCTATAATCCCAGCACTTTGGGAG GCTCAGGCGGGCAGATCATCTGAGGTTGGGAGTTCAAGACCAATGTGGCCAACATGGTGAAACTCCCCTC TCTACTAAAAATACAGAAATTAGCTGGGTATAGTGGCTCATGCCTGTAATCCCAGCCACTCAGGAGGCTG GGGCACAAAAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATCATGCCATTGCACTCCAG CCTGGGCAACAGAGTGAGACTCTGTCTCCAAAAAAAAAAAAAAAATGAGGTTGTTACCTGATTCAGAAGA ATAATACCAAAATAATTCCCAAATGAAAGTATGACAAATTTCTAGAAATACTGGTATAATTAACTTTATG CACAGTATTTAAAGTCATTTAATATATTACCATTTTTTTAATGCTGAATGTATTGATTATATCTTATACA TCTGGACCTGTGTTTTCTATAATAATAACAGAACCGCCAGAAACTTGCCTTGAATGGACAAGGTAGGGAT GTGGTTAAAATGTTAAAAATTGGACTGGCGTGTTAGTTTTCTATTTCTGTCAGAGCAAATTACCACAAAC TTAGTGACTTAAAACAACCTAAATGTATTATCTTATAGTTCTGTAGGTCAAAAGACTGGTATAGTCTCAT CAGACTAAAATCAAGGTGTCAGCAGGCTGCATTCCTTTCTGGAGCCTAGAGGAAAATATTTTTTGCTCAT TTGCGCTATTGGTGGAATGCAGTTCCTTGTGGTTGTGAGCCCGAGGTCTCTGTCATTCTGCTGACTGTAA GCTGAGGGCTGTTCCAAGCTTCCAGAGGCTGCCGCACTCCTTGGCTCTTGGCCTCTTCTTCCATCGTCAA AAGCAGCAGCAGCAGGTTGAGTTCTTCTTCACATCACATCTCTCAAAACCACTCTTTTTCCAACATCTTT CACTTTTAAGGAACTCCACAGTTAGCCAAAGAAAAGAAAGAATCTAGCAAGTTAGTCTCTAGCCTCCTGC TGCTCCACTCCACGCCCCCATATAACCAGAACTGTTCTCTGATCTGTTTTATGTGTAAGTGAATAAGTGT TTTATTTGTTTCAAACAAAAGCTTCTGTGGCACCAAAAAAAAGTTTGAATACCACGAATACTCTAAATGC TTACTTTGACTTTCTGTGGTGACAAGTAAGTGCTGTTAATGAGGTAGCATTAATTGATATATAACCTTCT TAAATAGACAAAATTTTCAAATACTCAGCAACCAAAAGTCCCTAGCAAAATTCAAAGGAATAGAAATTGC ACAGACCACAGTTTTGGACCGAAATACAATAAAACTAAACTCATATTAAAAATATAAACAGGCCGGGCGC GGTGGCTCATGACTATAATCCCAGCACTTTGGGAAGCCGAGGCAGGTGGATCACTCGGGGTCAGGCATTC AAGACTAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAATATAAAAATAAGCTGGGCGTTGTGGC AGGTGCCTGTGATCCCAGCTATTTGGGAGGCTGAGGCATGAGAATCACTTGAACCTGGGAGGCGGAGGTT GCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCAAAAAAAAA AAAAAAAAAAAAAAAACTCATAAAACAAAAAACCCTACTGCTTAGAAACTAAAAAAAAGTACACTTCTAA CTATTTGATCAGGAACACGTAAAAAATATTGCCAGATACTTAGAAAATAAAGACGTTGCAAATCAAAACT TAGAGAATGTCAGAGAATGTGGCTAAAACTGGAAGAGTTAAATTCCTTTTTTTTTGAGTCAGGGTCTCGC TGTCACCCAGGTTACAGTGCAATGGCATGCTCACGGTTCACTGTAGCCTCAACCTCCCAGGCTCAAGCAA TCCACCTGCCTCATCCTCCTGAGTAACTGGGACTATAGGCACATGCCACCACACCCAGCTAAGTTTTGTA TTTTTTGTAGAAATTGAGTTTCACTATGTTGCCCAGCCTGGTCTCAAACTCCTGGGCTCAAGCAATCCAC CCATTTTAGCTTCCCAAAGTCCTAGGATTACAGGCATGAGCCACAGCACCCAGCCCATAACGATTTTTTA GTGATAAAAAATTTAAAGAATCTTTGGGTTTACTTCCAGTTTTGTCACAGTAGCTCTCATCAGACTAACC CTCCTACAAATAACAATGATCAACTCCGGAAAAAAATATAAGAAACAACTGCCTGAACAGTAGAGAAGGA CCACGAGTGGGCAGACATTGGAGGGGAGTTGATACTTGGAAGAATGAAATGGCATTGGACAAATTACCAT TTTACTCTTACATGATTTTGCTGAGGACAAGTCCAAGTTGGTATGGGAAGTAACGGGACTAACAGTTGGA TGGAAAACCACAATCCGACTGGGTGCATTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAAGCA GGCCGACATGGTGAAACCCCATCTCTACTAAAAATATAAAAATTAGCCAGGCATGGTGGCACATGCCTGT AATCCCAGCCACTTGGGAGGCTAATGGGGGAGAATCACTTGAACATGGGAGGCGGAGGTTGCAGTGAGCC AAGATCACACCACTGCACTCCAGCCTGGGCAACAGAGTGAGACTCTGTCTCAAAAAAAAAAGAAAAAAAA ATCTTAGCTTGAATAACGAGAAGACACATTTTGGGCCTTCCACAACCACTAGGAAATGAGGGGGAAAGCC TAGAAAGAAGAGAAACACAGAGGAGGAGCACTAAATGCTGTTCATGAACTCTGCCCACATCTTGCGTGCA GCCATATTAATTGCCTGTGTAAAATTTTAAAATCCACACTTTTCAGAAAAACATAATGCAATCCAGATTC TCTACAGCATATTAATTTTTCTTTTTTTTCTTTTTTATTTTTTTATTTTGAGTCTGAGTTTCACTCTGTC ACCTGGACTGGAGTACAGTGGTGCGATCTTGGCTCACTGCAACCTCCGCCTCCCGGGTTCAAGCGATTCC CTTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCGCGTCACACACCGTCTAATTTTTGTAGTAGAG TTGGGGTTTCGCCATGTTGGCCAGGCTGGTCTTGATCTCCTGGCCTCAGGTGATCCACCCACCTCAGCCT CCCAAAGTGCTGTGATTACAGGCATGAGCCACCGCGCCCAGTGGAATTTAAAGAATTTTTAAATTTCCTC ATAGATAAAGGAAATTATGCTCATAATGAAATAGGAAATTTCAGTGGAGAAGTAGAAACTATTGAAAAGC CAAATGGAAAATCTAGTACTGAAAAATATAATATTTGAAAAGGAAAATTTACCGGATGGCCTTAACAGCA GATTGGAAATGGCAATAAGAAGAATCAGCAAACTTAAAAATATTAATAGAAATTATATAGTTTTTTGTTG TTGTTTGTTTGTTTGTTTCTTGAGACGGAGTCTTGCTCTGTCATCCAGGCTGGAGTGCAGTGGCGCAATC TTGGCTCACTGCAACCTCTGCCTTCCAGGCTCAAGCGATTCTCCCACCTCAGCCTCCTGAGTAGCTGGGA TTACAGACGTGCACCACCACGCCCAGCTAATTTGTTGTATTTTTAGTAAAGACAAGGTTTCGCCATGTTG GCAGGCTGGTCTTAAACTCCTGACCTCAAGTGATTCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTCCA GACGTGAGCCACCATGCCCGGCCGAAATTATCTGTTCTTAAGAAAAAGAAAGATTTTTGAAAAGGGAAAG CGCTCCTGTGATCTATGGAACAGCATCAAAAGGTCTAGGGCAGGCATGGTGGCTCATGTCTGTAATCCCA GCACTTTGGGAAGCTGAGGCAAAAGGATCACTTGAGGCCAAGAGTCCAAGACCAGCTTGGGCAACCTGTG AGACCTTGTCTCTACTAAAAAAATTTTTTCTTTGAAAAATTAGCCAGGCGTGGTGGCACATACCTGTAGT CCTAGCTACTTGGGATGCTGAAGCAGGAAGACAGCTTGAGCTTAGGAACTTGAGGCTGCTATGAGCTATA ATTGTGCCACTGTACTCCAACCTGGGCAGCAGAGTAAGACCATGCATGGGTGAGTGGATGGATGGATGTA ACACACATGTAATTGGACTTCCAGAAAAAATGGAGAGAAAGAAAAGGCAAAATAAATATCTATTTGAAGA ACTCATGGCCAAGAATTTCCTGAGCCCATGAAAGACATAATTCACATATCCAAGAAGCTTAGTGAACCCC AACTAGGTAAATAAAAATAAAACTATGCCCTGTTCCATGAAGTCAAGTTGCTGACGACCAAAAATAGGAG AAAATCTTGAAAGCAGCTGGAGAAAAACAACATGTTACATACAAGGAAACCAGGTGAAAAATTGCTGACT TCTCATCAGAAACTAGAGGCCAAGAGACAGTGAAATACCATCTTTAAAGTACTAAAAGAAAAATTGTCAG CCTGGAATTCCACGTTCAGAAAAAAAGATTCTTCAAGATGATTATGAAATAAAAACATTTTCAGGTAAAC AGAAAAGAAAAGAATTCATGGCCAGAAGACCAGTACTACATGAAATGCTATAGGAAGTTAGTCAGGCTGA GGAAAAATAATACCAGGTGGAAACTTGGCTCTTAGAAAAGGAATGAAGAGCGCTGGACATAGTAGATATA AAAGGATTTTTCCTCTTAATTTTGTTAAAATTAATATGACTGTTTAAAGCAAAGTTATTATATTATATTC TGTAATATATAACTCACATAGATGTAAGGCATATGATAACTATAGCGTAGGGGCTGGGAACAGCAGGTAA ATAGACCTATAATAATGTAGCAGGATTCTTGCATTACATAAAGTTGCACAATAGTAACTCTAAACAGGTA TAAAGAGTTAAAGATGTAAATTATGTAAAGTATAATTCTAGAGTAACTTTTTTTCTTCTTCTGAGACAGG GCCTCACTCTGTCATCCAGGCTGGAAGGCAGTAGCACAATCATGGCTCACTAAACCCTCCCAGGCTCAAC CAAGCAATCCTCCCTCCCTGAGACCTCCTAGGCTCAAGCAATCCTCCCACCTCAGCCTCCCATGTCCCTG GGACTACAGGCATGTACCACTATGCCTGGCCAATTTTTTTTTTTTTTTTTTTTTTGTAGAGACAGGGTCT CACTATGTTGCCCACACTGGTCTCCTGGGCTCAAGCAGTCCTCCTGCATCAGCCTTCCAAAGTGCTAGGA TTACAGGTGTGAGCCACCATGCCCAGCCAAGAGTAATTATTTTTTTAAATGCAAAGAGATATAGCTAAAA AGCCAATATATAAATTAAAATTGATTTCTAAAAATATTTACTTAGTCTAAAAATATTACTTAGAATAAGA AAAGAAGAAGAGAACAGCAGCAAAATGATGGAACAAATAGTAAAATGATAGACCTAAATCCGGCCACGTC AATAACTGTATTGAATGTAAAAACTATTAAATACTCCCAGTTAAAAAGCCAACAGTGTCAGAATAGATTT TTTTAAAAAAAGCAAAACCCAACCATATGCTGTTTTAAGTGCAAGAAAAAGCGCAAGAAAAAATAAAGAA ATACATTTGAAAATCAATGTGATTCACCATATTAACAGAATAAAGGGGGAAAACCCATTTGATTGCTTTA ATATATGCAGAAAAGCATTTGGCAAGATTCAACACTCATTCATGATTTTTAAAAATGATAATGGGTTAAA TAATTTTCACAGTGTGTATATTTTAACAGAATAAATAAATAAAACTATAAGGAATTTGAATTAAAAGGAA TAGTCCTAATTTTACTTAAATAATAACTGCTAATAGGAAAAGAAGGGAACTTCATCAGCCAGATGAAGAC TGTGAAAATCACAGCTAATAGCATACTTTATTGTGAGATATTGAACACTTTCCCCATAAGATCAGGAATA AGGAAGGTTGTCCACTCTGTATTTGAGTTCAACATTGTACTGAAGGTTCTAGCCAGTCCATGAAAGGCAA GTAAAAGAAGTAGAAGGCATATGTAAGCTTGGAAAGGAAGAAATTAAACTAACTGTAGTCACAGGTAACA TGATTGTTTACATAGAAAATTTCAGGGAGTCTACAAAACTAAAAGAATAAGTAAATTTAGCAAGGCTGCA GGATGTAAGGTCAATATGCAAAATACTATTTGTGTGTGTGTGTATTTCAATGGCTACAGATAATTCTATT TATGCTAACATCAGCCATTCAAAATTTTACTGGAGGCTTAGCCAGGGAAATTGGGTGAGAAAAAGAAAGA AAAGGAAATTGGAAAAGAAGAAGTAAAACTGTCTCTCATAGATAACATAATCTTTTACACAAAACCTTGG GCAGGCTCAGTGGCTTGTGCTTATAATCCCAGCATTTTGGAAGGCTGAAGCAGGAGAATTTTTTTTTTTT GAGACAGAGTTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGCACAATCTTGGCTCACCGCAACCTCC GCCTCCCGGATTCAAGCAATTCTCCTGTCTCAGCTTCCCAAGTAGCTGGGATTACAGGCGCCTGCCACTA CGCCCAGCTAATTCTTTTGTATTTTTGGTGGAGATGGGGTTTCTGCGTGTTGGTCAGGCTGGTCTCGAAC TCCTGACCTCAGGTGATCTGCCCACCTCGGCCTCCCAAAGTGCTGGGATTGCAGGTGTGAGCCACTGTGC CTGGCCTGAAGCAGGAGAATTGCTTGAGCCTGGGAGTTGGAGACCAGCCTGGGCAACAAAATGAGACCCC CATCTCTACAAAAAAGCAAACAAAAAATTAGCCAGGCTGGGTGCGATGGCTCACGCCTGTAATCCCAACA TTCTGAGAGGCCAAAGCAGGCAGATGACTTGAGTCCAGGAGTTCAAGACCACCCTGGACAACATGGCAAA ACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTAGCACACACCTGTAATCCCAGCTTCTTG GAAGGCTAAGGCACAAGAATTGCTTGAACCTAGGTGGCAGAGGTTGCAGTGAGCCAAGATCACGCCACTG CACTCCAGCCTGGGCAACAGAGCAAGACTGTGTCTCAAAAAATTTGCCAGGTGTGGTGGCACACTCCTGT AGTCCGAGCTACTTGGGAGGGTGGGGTGGGAGGATCACTTGAACCCAGGAGGTCGAGGCTGCAGTGAGCC ATGATTCCATGCCCTACACTCCAGCCTGGGCAACAGAGGGAGACGCTGTCTCAAAAAAAAAAAAGAAAAG AAAATATAAGACATTGCCCCCTAGGAACTATTAGAACTAATGAACAAATTCAGCAAGGTTGGAGGACACA AAACTGGTATACAGAAATCAAATGTAGTTTAGTTTTTTATTATGCATAATTTGTCCATGTTTATTTCAAC CTATGTCTGTCAGTCTTCATTTTATATTGTACCATGTTTTAATTATAGTTCTATTTCCTTCTAATCCGAC TCTGAAACCCTACTTTGTAGCTATGTATACACACACAAAAAATAGCTATATTCTTTCATTTTCACAACAG CATAATTCTTTTTCTGAAAATACTGGCGTGTAGCAGATATTAGCAGATAAATGTATTTTTCTAGGCTAGG CATGGTGGCTCACACTTGTAATACTAGCACTTTCTTTGTGAGGCCAAGGCAGGAGGATTGCTTGAGGCCA GGAGTTTTGAGACCAGCCTGGGCAACAATAGCAAGACTTAGTCTCTACAGAAAAAATGTGTGTGTGTGTG TGTATACATATATATTTATATATGTATTTATATTTATATATTCATATTTATATAAATATTTATATTTATA TATTCATATTTATATAAATATTTATATTTATATATTCATATTTATATAAATATTTATATTTATATATGTA AAACCCTGCTTACCTAGAAAAAAGCCTGTAAGTACTGTTAAAAAAACAAAAATTGGATTTCTATACACTA GCAATGAACAATCCTAAAATGAAATTTAAAAACTATTTTCCATATAACAGCATCAAAAAAGAAATTCTTA GGAACAAATTATATGGGCAATAAGACAAAACCCCATCTCTACAAAAAAAGTTAGCTGGGCTTGATGACCT TCCTGTGCCTATAGTCCCAGCTACTTGGAGGCTGAGGTGGGAGAATCACTTGAGCCTGGGAGGTCAAACC TGCAGTGAGCTGTGATCACAACACTGCACTCCATCCAGCCTGGGCGACAGAGTGAGATCCTGTCTCAAAA ATCAAATAAGTAAAAGACTTATATGCTGAAAAACTGTAAAACATTGTTGAAAGAAATTTAAGAAGACATA AATAAATGGAAAGACATGCCCTGTTTGTGGGTTGGAAGACTTAATGTTGTTAAGGAGGCAGTGGTCTCCA AATTGATTTCCAGATTCATTGCAATCCCCATCAAAATCCCACCTGCCTTTTCTGCAGAAGTTGACAAGTT GATTCTAAAAATCTTATAGAAATGCAAGGGACCCAGAATATCAAACAATTTTGGTATCTATGTAAAATCT GAGAAAATTTATGTTGTACTCTTTAATGAGCCCTACCTATTAGGAAATTTAGCATGAAACAGCTTAAAGA GAGGACTTTGACTTTTTAATATTTTTCTCTGTCCCAGTATGATCTGCAGGATTACTTTTTACCTTTGATT TGAATTTATTTATTTATTTATCTATTTATTTATTTATTTTTTTGAGACAGTCTCGCTCTGTCTCCCAGGC TGGAGTGCAGTGGTGCGGTCTCGGCTCACTGCAACCTCCGCCTCTGGGGTTCAAGCAATTTTCCTGCCTC AGCCTCCCAAGTAATTGGGACTACAGGCACGTGCAACCACACCCAGCTAATTTTTTGTATTTTTAGTAGA GACGGTTTCACCACGTTAGCCAGGATGGTCTCAATCTCCTGACCTCATGATCCACCCGCCAAGGCCTCCC AAAGTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCCACCTGGCCAATTTGAAATTTTTATAGG CTGCAAATATTAGCCTTTGTAATGTAAAAAAAACAAAGATGTTGTTGTCATTTAAAATATGCTAGGACAA GAACAGGCAGATCATTAGAATAAAAATGTAGCAACAAAACAGACTCAATTTTATCTAAGTTCCCAGTATT AAATATGGGAGAAAGGTATTACAAATAAGAAGCAAAAGAGGATTTAGTCAGTGATTTGGGACAACTGATA CAGTTTTTGCAGTTTTAGGGGAGTAACTTAAAATTTTTTTTAAGTAGAAAAAAATGTAAAGTATTTATCA GACCTCAGGAAGGGCAGTGGTCTGTTTAGGCTTAAAAGTGATAGATAATGTTATAAAAGAAAGAATAGCC ACCTTTATTAATGTAAACATTTAACTCATGTATGTTTAAAATTCTGTTACCAAAATTAGAAGTCAAATAG CACATTACTATTGGCAGTGAGGGAGGAAGCAGAAATGGCAACAGATATAATATATAAGAGCCTCAGATCA TGAAAAAGAATTTCCAAGACCCTGGTAAACAGAGGCAAAGAATGTGGACAGACTGAGTCTCTAGAATGAG TCCTCTGGAACAGAGCTTTGTGCGGGCAGGTGGTATTCGTCTCTTTTATTCTCTGCTACATCCCCAGCAT CTAGAACAGAACCTGGCAGAGTAAATGTTCAATAAATAATTGGGAAATAAAGAAAAATTAGTAAATTTAT GACAAACATTCAACCTATGTAGTATTCAAAAGTCTCGATTTAAAACACTGAAAACAATAACACTTCTCCA GTATCAGAATAGCAAAGGTTTTTAAAGCTTCCAATTCCCAGTGTTAGCAGAGGTCCAGCAGAAAGGACGT CTACATAGTGCTGATACAAATACAGATAATGGGCCAGACGCAGTCGCTCACACCTGTAATCCCAGCATTT GGGAAGGCTGAGGCAGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGGAAAACC TATCTCTACTAAAAATACAAAAATTTGCCGGGTGTGGTGGCATGCACCTGTAATCCCAGCTACTCGGGAG GCTGAGGCAGGAGAATCGCTTGAACCCGGAAGGTAGAGGTTGCAGTGAGCCGAGATCGCACCATTGCCTC ACACCCATAATCCCAACACTTTGAGAATCCAAGGCAGGAGGATCACTTGAGTCCAGGAGTTAGAGACCAG CCTGGGCAACATGGCGAAATCCCACCTCTACAAAAAAATACAAAAATTAAGCTGGATGTGGTGGCACATA CCTGTAGTCCCAGCTACTGGGGGGCTGAGGCAGGAGGATCTCTTGAGGCTGGGATGCGGAGGTTACAGAT CTGAGATCGTGCCACTGCACTCCAGCCTGGGTAACAGAGCAAGACCCCGTCTCAAGAAAAAAAAGAAAAA AAATGAAATACAGATAGTACTAAAGGAAATGACGTATTTTTAAGTATATTTTTAATCTCATGCATAGAAA ATTAGTGAGTGGAATGGGGGCAGGGTGGCAACCAGAAAATAGATTTGTGGAGCACTTACTGTATGCCAGG TACTATGAAAAATTACATATTTTTATGTAATTTTCACAGTAACCCTGTGGTGTAAATATTAACTCTACAG ATAAACTGAGGTTCAGAGAGTAATTTCCGTAGAATCACAGTTTCTGCATGATGATTATTATAGTTAAACT ATGATTTATATGTCAGATGCTGCTGTAAAGATCTCGTGTGTATTAACTCACCTCCAGCAATCCTGTGGGA TGCAGGTGCTGCTCTCTGCACTCAGTGGATTAAATGCCTAGGCAGAAATTAAATCATTTGCCTGCAAGCT GGTAAGTGGCTCAGCCATGGTGCAGACCAGTCTCTTGGCTGCCAGGCCGGCACTCCAGGTCCCACGCCCA GGGATGCTCCGCTTAGTACCATGTCACTGCCCTTGTATGTTCTAGGAGGCTCACAGTGATTTGACTGGGG GACTGTGAGTGATTGGGTGTCTTTTATTCTCTGTACTATGTCTTCTCTTATGGTTATGTATTATTAATTA CTATTTAAAACTATTGTCTACATCCTAAAAATCAAACTAAAATTTGAAATAAATTATTTGGAAAAACTTT GCAGGGAGCTTCAGAAGTAAAAAACAAAAACTCGGCCACTGTATGGAAGTTGTGTCATACTTGTCTACTA CTACTTTAGCTTTCCATTTCCTAGAAATGTGTTTGCACTGTGATCATCAAAATAGAACTGTGCAGTACTT AAAATGTAAGAATCTGCAAAAACAAAACTACAGAACAAATTCCGAAGGTGACCTGAGAAGACCAAATGGA TAAGCTAATACATCCAGGTGTCTCCGATTATATTATGATAAAGTGTAGGGAGGTTGAACGTTACATAAAT ACCACTGGATATTTTTCTTTGTTAGATGTGGCCCCATGGTATTGGATGCTTTAATCAAGATTAAGAATGA AGTTGACTCTACTTTGACCTTCCGAAGATCATGCAGAGAAGGTGAGCATTTCATTCCTGTTGGGCTCCAG ATACTTGTGGTCTTCCAAAGAGGCTTGGGCTGGCCAAAGCTGATAGAGACATCTGGAAAACAGCTGCAGC TCTCTGCTGGGTGAACTTGCTGTGCAACCTAATTCCTTTTCTTGGGTAAATGCATCCAAAATTCTAACCA TGGTGCAAGTTCTGGTTTCTGAGTTTACTTTCCTTCAGGAGCATTCTATCCTGTGGTTACTGCATCTGGC GGTCCCTGTGAGCTGCTCCACGCTTCAAGGCCTAGCTAGGACCTGCTGGCTGGCACCTTCCATGCTGCTG AGCTCTTTTATTAAGGGAGCAGTGGAGAGTTTCTGTCTGGCACTTATGCTTGTCCAGCAGGGGAGATGTG TGAGTCTCCCTCAGCTCCCAGCATGACATGTCCTTGGTAGCTGTGTTCTGGATTGGCTGGTACAGTGTCT CCCTCAGCATGTGGTTACTTGTGCTGCTGGTGCCACATGAGCCCATTTGAGGCAGTGTGCAGACTAACAT TTTCTACATGAATAGCAATGTATTCATTTTCTGTATTAGAAAAATATAATTACTGCCGGGTGCGGTGGCT CACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCAGCTGGCGTCAGGAGTTCGAGATCA ACCTGGCCAACATGGTGAAACCTTGTCTCTACTAAAAATACAAAAATTAGCCGGGCGTGATAGCGGACGC CTGTAATCCTGGCTACTCGGGAGGCTGAGGCAGGAACCCGGGAGGTGGAGTTTGCAGTGAGCCAAGATCA CGCCACTGCACTCCAGCCTGGGCAATAGAGCGAGACAGTCTCAAAAAAAAAAAAAAGAAAAATATAATTA CTAATGATGGTATAATAGGGATATAAGTGGTTTTTTAATGTGAATTTAAGCAAAACAAGTTAAAGAAAAC CCAAGAGATACTTTAAAGAAAGTTGATTCAGGTGGTTCTCAGGTATAGCAAAAATTGCACAGGGTGCAGT GAAGACCGACTGGCCTGATGTCCGTGGAGCCAGACTGTGTGCCCGGCTCTGTTCTGTGCACTGGACATGA GGTAGATGACTGTGCTTATTATCTACCTTCAATTTAAAGGTGAGGCCCAGAGAGGGTAATGGACTTCCAC AAGGACACATAGAGAGTGACTTGAGAGCCGGGAGTCAGCCAAAGCTGTCAGACTCCAGACTCCAGATCTG CTCTCTCAGGCACTGACTTGGCTTGGAACACCTGGGATAAAACAAAAGCAGAGAGTAGCTTGATTCTGTG AGGACACTGAGCTTTTTTCTAAGAAAACCTTAAAAAAAAAGGAAAAGCCAGTATTGATACCGGCCCATGG CTTTTTATCTGTTCAGCTGTACATTTCAAGCATTTCAAGTCTTTTAAGACATCTGTTTTGATTCAGCTAA TCTTATTTAGCGTTGCAAATGCTGATGGATATTATGATAGTTCGGCTGAGTCCTGCTGTTCAGGGAACAT TCTGCGGCAGTTAAACAGCAGCCTTCCCCATTAAGTCCTGGCAACACAGGAAAGGTAGATGCTTTTCAGT AACCTTTCCCTGTAGGACTCTTTCAGAACCAAGAACATAAGGTGTGACCCATCTGGACTAAAAAAAATAA AGCAGAATTGTATCAATTGCTACTCCTTTTTATTCCCATCTTGTTTTTCTTATTTTTTTTTTAATTCCCA TCTTGTAAGAGAATTCCCAGGGAGCCTTTTTGAGAGAAAGTTCATTGGATTTATTTTTTTAATTTTTATG CCATTTCTTGTAAAAGCAAACTGCTCTAGTTGGATGCCAGGTATACATAAATGTATTGATAATATCCAGT CTCTTGGGGAACTCTAGGAGTATTTGCTTAAGACACATCTTTGGGTTCCCTTACACTCTTTCTAAGATTT ACAGGAGAAGGAGAGTCTTACTGTCTTTTCTAGTCTTATGAAAGTGATAACCGACTGGGCGCAGTGGCTC ACGCCTGTGATCCCAGTACTTTGGGAGGTCTAGGTGGTAGGCTAGCTTGAGGCTAGGAGTTTAAGACCAG CCTGGGAAACATAGACTCCCTTTCCATTAAAAAAAAAAAAAAAAAAGGTGAGGCCAGGCATTCAGAGGCC GAGGCGGGCAGATCACAAGGTCAGAGTTCGAGACCAGCCTGACCAACGTGGTAAAACCCCGTCTCTACTA AAAATACAAAAATTAGCCAGGTGTGGTGGCGGGCGTCTATAATCCCAGCTACTCAGGAGGCTGAGGCAGG AGAATCACTTGAACCCGGGAGGCAGAGGTTGCAGTAAGCCGAGATCGTGCCACTGCACTCCAGCCTGGGC GACAGAGCAAGACTCCATCTAAAAAAAAAAAAAGATGATAACCAGTGCAACTTTCTCAAGCAATCAGGTT TCTCTGACCTAATGATCTTCAAAAAACAGCTTCAGAGGACTGGCACTAGAGGTTTAGAGTACATAATCAT TTTTAAATTCCAAAACACCCAGGAAATTTCCATATACAGGAAGTAGGTCCAGGCTAAGAAAATTCTCATG TCGGGGTCCTGGGTCAGCACGTTTTTTGTTTAGTTTGCTTTGCTTTGCCTCAGTTTCATATTAGTTCATT CTTCTCCTCTTTGGAAAGTCCATGCTGAGTCAGCTTTTGTGGATTTCATAGCCCCAGGGTACTATGCTGC GTATTTTATGAAGACAATAGAAGAAGCCTTACCTCTGTCAAGTGTAGTGGCTCAGGCCTGTAATCCCAAC ACAGTGGGAGGCAAAGGCAGAAGGATTACTTGAGGCCGTGAGTTAGAGACCAGCCTGGGCAATATAGTGA GACACCTGCTCTACAAAAAACAATTATTTTTTTCTTTTTTTTGAGATGGAATCTTGCTCTGTCACCCAGG CTGGAGTGCAGTGGCGCGATCTCTGCTCACTGCAACCTTCTCCTCCTCAGTTCAAATGATTCTCCCGCCT CACCCTCCTGAGTAGCTGGGATTACAGGCACCCACCACGACTTATATTTTTAGTAGAGACAGGGGGTTAC CATGTTGGCCAAACTGGTCTCGAACTCCTGACCTCAAGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTG GGATTCCAGGTGTGAGCCACTTCACCCAACCTACAAAGAATTTTTTTGAATTCGCCGCACATGGCGGCAT GTGCCTGTAGTCCCAACTACTCAGGAGGCTGTGGTGGGAGGATCGCTTGAGCCCAGAAGTTTGAGGCTAA AGTGAGCTACAGTGAGCTATGACTCCACCACTGTACTTCAGCCTGGGTGACACAGCAAGACTCAGCCAAG AAAAAAAAAGAAGAAGAGCTATCTCTTAATAATCTGTATCCAGGTCACTTCAACCTTAAGATGACCAAGA CAATGTTGATTTACTTTACTTTTGGGTATTGTGTCTGTTAGATTTGTGTTCAAATAACAGTGGCTTTAAA AAATCTAGGTTTCCAGGCGTGAGCCACCACACCCACCCCTACTCAGGAGGCTGAGGCAGGAGAATCACTT GAACTGGGGAGGCGGAGGTTGCAGTGAGCCAAGATCGCGGCATTGCACTCCAGCCTGGGCAACAAGAGCA AAACTCCTTCTCAAAGAAAAAAAAAAAAAATAGGCTTGACGGGTGTGTGGTGGCCCAGACCTGTAATCCC AGTGCTTCGGGAGGCCAAGGCAGGCAGATTACTTGAGCCCAGCAGTTCAAGCCCAGCCTGGGCAACATAA CAAAACCCTGTCTCTGCAAGTCTCGTCTCTACAAAAAATACCAGAAAATTAGCTGGGTGTGGTGGGCTAC TTCTGTAGTCCCAGCTACTTAGGAGGCTGAGGTGGGAGGATCACTTGAGCTCAGGCATTGAGGACTGCAG TGAGCTGTGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGTGAGACCCTTTCTTTAAAAAAAAAAAA AAAAAAAAAAAAAAAAACAGGCTGATTTTTCTTCAAAACACGTGACACATGGAGCTAGAACTGCTGTGGA AACTCCATGGTGCCAGCAGCGCCCAGGCCTCTGGCCTCCTCCAGTGCCATACTTGGCATGTGGCTTCTAA CCTCAAGGTTGCCACATGGTCATAGAGTAGTTTTTGGAACTCAAGCCATTAGAACCACATTCGAGGCAGG AAGAAGGAAGGAAGGGAGAAAAGCCAACAGGCACCTCTGTCAGAGGAATGTTGCATGTCAGTGCTGCCCC TGATGGCACAGCAAGGAGGATCCAGAAGAAAGTATTTGGGGCAGGACTGATTCCGGATATGGGTGAGGAT GTGTTAAATGTGTGTCTCTTTCAGGCATCTGTGGCTCTTGTGCAATGAACATCAATGGAGGCAACACTCT AGCTTGCACCCGAAGGATTGACACCAACCTCAATAAGGTCTCAAAAATCTACCCTCTTCCACACATGTAT GTGATAAAGGATCTTGTTCCCGTGAGTTTCTGCATCTCTCTGGTTTTGTTTTTATTTGCATGGGGGGCAG TGCTATGTGTGTTACGCTATTAGTTTTTCAGGGCAGGATTTGTTTGAGTATTTAAGGCTCCTCTTCTAGT CAGATAGTAAATAGATGGGACTGTTTCCTATATTATGGCAGGAGGAGGACCACAGTGTCACTGAGAGATT AGGAAAATCTCCAGATCTGAGACAGTGTGGCCAGAGTTTAATTAAAGAATTTGAATGGCAGAAGATAAAC GCCTAGAAAATCCTCCAGCAGCTCATTTGGTGAGGTTTGTTTGAGAATAATGGGGCACAGAATTTTAGAA TTGGAACATTCCCAGAAATGAATAATTTGGCCATAACTACAAAGAAATCATGTGGAAAATGCCAGTTGGG AAAGCAACAGCTGTTTATGAGTCCCACTTTAATTTCTACCTCCCTATATTTGAACACCTTTGCTGACGTG GTGTTTTCAAGGGCAGAAAGGACTGTGGGATTGGCAGGTTTCCCAAGTAGGTGAGGGAGAGGTTTCCTAA CCATGCTTAACATTGTGACCATTTTTCCTTTTGTAATCTTTGCATATATTCATGACAAAGGAAAAGAGTC TGGCTTCTGCCTGGCATAGAGTGGACGAGTAGTCAGTGTCCAAGAAATGGGGTAAATAAAGCTGAGGTGA TGATGGAATCTGATCCTTTTCTTCTTCTTCTTCTTCTTCTTCCTCTTAACCACAGGATTTGAGCAACTTC TATGCACAGTACAAATCCATTGAGCCTTATTTGAAGAAGAAGGATGAATCTCAGGAAGGCAAGCAGCAGT ATCTGCAGTCCATAGAAGAGCGTGAGAAACTGGTCATTAGTCCCTATTTATTGTTTCAATCTGAAGAATT TATTGCAAAGATGATTGCCAGGAGTGTGGCTTGGCAGGGAACATAAGCTGATGCAAGCCATTTAGTGTAT TCTGGAGAGGAACTGGCACAAGGGTGGGGCACTCATCCTCTTAGGGCCGGGTGAGTAGTGTGAACCCGTG AATGGCCCAGAGTGGACCAAGGAGCTAGAGCCCTGTGCCCCGCCTGCAGGGGCGGGTGGTTGCTGTGTGG CTACTCCATCTTTTTCAAAAGAAACCAGTATGTAAATTGCCTGGGCTTTAAAAAGTGACCACTAAGTCAG AACTGTTCCCTCACTGGGGGCAAAATGAAACACATATGCTGGCCAGTTGTAACTACCACCGTCCTGCTTT ACAAATGGGAGTGAAATGTTAATGGCAAAACAGAGTCATCGATATTCTTTCCTGACACCATACTTCTGGT GATCTGTGGGGTGGGATTATTCCTGGCCTGCTCACTCTCTGGGAGTTGCCATTCCTGTGTACAAGCTGTA AAATCTTAAAGCGGAGGCATCATTATCAAGTTTTCAGTCTTTCTTCTTCTACACTACTTCTACTCCTCTG CGAAGAAGTCTTCTCTGATTTGCATACTCCCTGCATACTTGTGGACGTGAGGTAGGAAGGGGACCAAATG GAGACAGAGCCCCACCTGCAGGTCTGCACAGGGCCAAGGGCAATGGCTGTGTCTTCTTCCTTTCTGGATC CCTAGGCCCTGGCGCATGTTATTTTATCCATAAATATTAGTTATGTAAATACTGTAAAAATATATATAAA TTTTTTAAAAGGCCAGATGCAGTGGTGCATTCTGATAGTCCCAGCTACTCAGGAGGCTGAGGTAGGAGGA TCACCTGAGCCCAGGAGTTTGAGAGTCTGAGAGTTTGAGGCCAGCCCGGGCAACATAGCCCAGGTTTTGT CTCTAAAACATATACATATATGTGAATATATGAAAAGTATCAGTTGTATGAATGAATAAATTAATTCTAC CTTTTGAGACTTGGTAAATATTTAGCATCCTCTCCTGTTGCCCATAAAACGTTAAGAAAGGGGAGTCCGG CCAGGTGCAGTGGCTCATCTGTAATCCCAGCACTTAGGGAGGCCGAGGTGGGCGGATCACTTGAGGTCAG TTGTTCGAGACCAGCCTGGCCAACGTGATAAAACCCCATCTTTACTGAAAATACAAAAATTAGCTGAGTG TGGTGGCTCACACCTATAATCCCAGCTACTCAGGAGGCCAAGGCAGGAGAATCTCTTGAACCCGGGAGGT GGAGGTTTCAGTGAGCCAAGGTTGTGCCACTGTACTTCAGCCTGGGCAACAGAGCAAGACTCCGTCTCAA AGAAAAAAAGAAAAGAGAAAAAGGGGAGTCCTAGTAAGTGTGCCCAGTCTGTCACCATCAAGATAGTGAG GGTCAGCACAGTGGCCTGCAAGTCAGAGTAAGCCTGGGATGAGACTTCAGAGCTGCTCTTCTCAGACTGC AGCTCTGCTCCTCAGTTTCTACCTCCCAGAGTCTTGTGCATCCCAGAGTCCAGGCTGAACCGGGCCCTCT GGCCCAGCGAGTCCTTTGCATTCCTAGGCAAGGCTGGTGCGTAGCTAGTGAACATCTCCCTGATGTGGTA TTATTAGGGATTGAAGAGTTCCCCTGAGCATGTTTGGTTTTCTAGATACAAGTTGAGTATTCCTTATCCT AAATGCTTGGGTTTCAGTGTTTGGGGTTTCATATGTTTTCAGATTTTGGAATATTTGCCTTACACTTACT AGTTGAGCACCCCAAATCCGAAATCTGAAATCCATGCTCCAGTGAACATTTCCTTTGAGCAGCATATTGG TGCTCAAAAAGTTTCAGATTTTGGAACATTTTGGATTTCAGATTTTCAGATTTGGGATGCCCAACCTGTA ATAGAAATTTACTCATTTACTCATTTACATACCAAACATTTAACATTTTTTGGCTTCCTTAAATTAGTAT GCTGAACTTAATAAATAATTGGAAAATGTGGAGAAATTTATGTATGTATTTATTTTTAATTGGGCAGCCC CCAAACCAAAATAGGTTCAGAGAGGCTCCATCATTTTTTAAATAAGCTATAATTTTCAGCCTGGGGAACA TAGGGCGACCCTGTCTCTACAAAAACTTTAAAACTTAGCCAGGCATGGTGGTATGCACCTATAGTCCCAG CTACTCAGGAGGCTGAGATGGGAGGATTGCTTGAGCACAAGAGTTCCAGGCTGCAGTGAACTGTGATTGT GCCACTGCACTCCAGCCAGGGGCACACAGCAAGACCCTGTCTCAAAAAAAAAAAAAAAAAGAATTTATAA TTCCACCACCAAAACATAATCTCTGTTAATATTTATAGTTTCCTTTGTTTTTTGTTTATTACATTATATT TTTATGTAGCTGGGATCAAAATGTAAATATGCTTTTATATCCTGCTTTTTTCACTTATGTTATTGTGAGC ATTTTCTTCATATTCTTAAAATTGTTCATAAGCATTAACTTACACTTTGCTTTCTACTGCTTCAGATGTA TGCACCATGCGCCATAAAACCATTTCACTGTTGCTGGACAATGAAATTGTTTCCAATTTTTTACTGTTAG AAATAAGGCTAGATGAACATCTTTATCCTTCAAGTTCTGCCCAAAACATTCTAATTTCTTATTACAGATT TTTCTAGGAGTGGGTTAAAGAATATGACTATTCTTAAGGCTCTTAATCCTGTGACCTTATGCCTTCTAGA CCAGTGGGGCCAGTTGACACTCCCACCAGCTGTCTGGACATAACATAGATTTGGTTGAAGACTCATGGTT CAATCACAACCATCAGTTCTGTCTCATCTGTTCTCAACTGTCACTTCAGGTGTCAGTGGGCCCCTTTCAT TTTGCTGTTTTTAATCCATTTCTGTTGTTTCCAAACTCAGAAAGTCCGGTTTGTGTTTGGGACTTGTTGG GCAGATTGACCCAGTGTGGCAGGTGTGAAAGTGCAGGAAGCCAGAGCCAGCTGCCGGGGCCACATCCTGG TTCTGCTGCCTATAGTGGCACGTCCCTGGGCACATGGCCTAACTCACTCTCCTCGCCTTGGTTCCTTACC TGTAAGTGGAACTTGCTGGAGTCACCTCACAGGATTACTGTGATGATCAGTTAAGGAAAGCGTGTAAGGC GCAGGGCCTCCGTCAGGATTGGCAGTGGCAGTCACTGGGGATGATGTTGATGTTCCCAGTGAAAACCTGA GGGCCCTTCTGCTGAGCCCAGGGCAGAAGCAGCTACAGACTCTTGCTGCTTCAGCCCCTAGGCTTTTGAA TCTCTCCCGTCTTGACCTCATTCCAGGAAGCTGGAATTTATGGGAGTTGTTTTTGTGTTCTTGTTTTCTA TTTCTTTTTTAGACAAGTGAGAGGTTCTTGTTTATTAAAGGGAAAGTGCACTATACGTGGATTTAAGAAC CCTGGGCAGATGTTTACATTTCACTTGCAAGATCTTTATTAATCTGCTAAATATCTGCAAATCACCCCTT GGATTTTGCTAAGAAAATTCACATGCAAGTAGGCACTTTGTTCATGCACTGACCCCAAAGGTAACATTTA ATCAGCTGAAGACATAGCAGAGTCTCTCCCGTCACAAGCTCCTGCCTCTCTTTTCTCCCCATACAGGACG GGCTCTACGAGTGCATTCTCTGTGCCTGCTGTAGCACCAGCTGCCCCAGCTACTGGTGGAACGGAGACAA ATATCTGGGGCCTGCAGTTCTTATGCAGGTGAGGTGCTCCTTAATTGCTTTAAGAGAAATTGAAACTCAA GCATCCAGAAGTCCAAGAGGACAATAGATTGCTGTAAGCCAGCCATTCTGAGGGGCCTGGTTTCCTTCAT TGCCATCCAGTCCAAACAGGGTAATTGGTTGCATTGTATTCACTTGCTTTCGGTAAATCTGGGGCCTTGT CTGCAAATTGCCTTTGTTTCAGTGCAGTGAGGGTCACCCCAAAGGGGTGCAAACCATGCCTTGCAGATGT TTAAAATGTATTTCCGTTTGCCTGGTGGTCAGAGGCTCCCCCTCTCCCTCTCATAGGATTTGTAACATAA GACTTGTAGCGAGCAAGCAGGGGAGAAAGCAGTGTCTTTGAAGGGCAGCTGCCCAGCTATGAGATTGGAA GCTGTTTCCCAGCTAATGAAAGCCTGGATTTAGGGGTTGCTTAGAAAGAAAATAGTATTGATGTTCACTG CAAAGAAAGTCACTGTCTTTGTTCCCAGAAAGCTTGTGCTTTTTTAGATACGTGCTTTTCACAGACTCTA GGCAACTCAAAAACCAACTTCTCTTTCTCATTTTCCCACAAAAAGAGAAGTTACAGGTTTGTGTGACCAC ATGAGCAATATTGATTCCCAGCCATGTGAAGATTGGATAATGAAGTACACTCATACTTGTCACTTTTGCC AGCTGCTCCGAGTTGGGGATGTAGAGGTCCTCTAAGTAACACTGCTAGAGCAGGCCTATGGTCATGTGAT TAACTCGTTTCAGCCTGCTGATCTCAGGCTGCTGAGAGCGCTGTGTAAGTTCAAAGAATCATTAAGTGGG ACAAATACTATCTGTAGACAGGTCTGTTAAATCATTCCTTTACTCAGAGACAGCAAGTCCAGCATGGGTA GGTGCCATGAAGACAGATAAGAGTTATATGATACAGTCCCTGCCTTCACCAAATTATAAGCTGGGTAGGA AGCTATTGAGCAATGTGAAATAATTAGGAGATGATACCCAGTGTGTATAATTAAGCACCCGGGTACCAGG TGCAGTATGGATCAAAGGTTTGCAGGGACCATTAATCAAGTGAAGCTACAAGTGTTGGGAACCTTTCCTT GAAAGATGGACAAGAATTAAAGAGTATGGAGATGAGGCATCTAAGCTGAGTGAATTCCCTTTCCTCTGCA CTCCCAGAGCTTTGAGTTGAGCCAGGGTGCCGCTCTGGCCTGTTGATTGGCAGCTCAGCTAATCATCCCT GGTTTTCCAGGCCTATCGCTGGATGATTGACTCCAGAGATGACTTCACAGAGGAGCGCCTGGCCAAGCTG CAGGACCCATTCTCTCTATACCGCTGCCACACCATCATGAACTGCACAAGGACCTGTCCTAAGGTACGTG GGGCTGGTGACCCTCAGCTCTGCCTCAGAGCTGACACGCCAGAAGTAGCATGTGCTCACAAAGAGGTGAT TGGCAGAGAGCAACCCTAGTCATTTGAGAAGGAAAGGGACCAGCATATGCCTGTCCTTTCAGTGTGAGCC TAGGGGCTAGTTTGGCTCTTAGTTGCAAGGAGTAGACTGACTCGGGCCACCTCAGGAGCAGGCTTTATTT GTAGGCTACACAGGGACATTGTGGGAGTTAAGGATGCACAGGAACCCATGAGCAGGTACCTGCGTTCAAC CTTCCCAGGAAACAGAAAGCGAAAGCCGTTGGAACGTGGGCAGCTGTGAGGACTTCATTTCTTCTCCATC TTTCTCGCGATGTCAGCTGCTAATCTGCTCTGCTCTCTAGCAGCCTGTTCTTTCCTTCGGCTCTGTGGAG GTTTTCTCTGACTCAAAGCTCTGGCTTTCGTTCCTCTTCCTGCTCGCATTTGCTGCTGCTTTTGGCTCAC TCTGGCCTGGATTTTGCCTCCCAGCACACTTCCAGCTTCAGCCACCCGCCTGCCTCCCAGCACTTCTCAG CACAGTTTCCTGAGAGGGTGTCGCATTGGCCCAGCTCACCTTCTCATGCCTGCACATCAGAGGCCACAGC TGGCTACAGACCGGCTGCCCTTTGGCCAGGTTCTGTCTCAGTCTGTTTTGTGGTACTATCACAGAATTTC AGACTGGGTAATTTTATAAAGAAGTTTATTTGACGCACAGCTCTAGAGGCTGGCGCCAGCATCTAACAAG AACCTTCGTGCTGTATTACCCCATGGCAAAAGGCAGAAGGGCAAGAGAAAGGGAGCCCAAGCTCAGCCTT TTTTTTTTTTGGAGACAGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGCACGATCGATCTCAGC TCACCACAACCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCATTCGCCTCCCGAGTAGCTGGGATTACA GGCAGGCACCACTCATGCCTGGCTAATTTTGTATTTTTAGTAGAGATAGGGTTTCTCTATGTTGGTCAGG CTGGTCTCGAACTCCCGACCTCAGGTGATCCACCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGT GAGCCACCGCGACCGGCCCCTCTCATCTGTTTTTTTTAAAAGACAGGGTCTCACTGTGTTGCCCAGGCTG GGGTGCAGTGGCGCAATCATAGCTCACTGCAGCCTGGAACTGCTGGCCTTAAGTGATCCTCCTACCTCCT GAGTAGCTGGGACTACAGGCACACACCACCACACCTGACTAATCCAAACTCATCCTTTTATCAGGAACTT ACTCCTATGATAATGGCAATCCATTTGTGAGGGCAGAGCCTTCATAATCTAATCACTTCTTAAAGGTCCC ACCTCTCAATACTGTTGCATTGGGGATTAGGTTTTCAACACATGAGCTTTTGGGGACACATTCAAACCAT AGCAGGTGTCAGCCCTGGTCCAGTCAGCCTTGCCCAGTGGGCAGGGAAGGGCTAGGGCTGTGTGGTTCAG AACACGGCTGCCCTCCGAGCAAAGACTGTGGGTGATTTCACTCAAAAGTTGCAGTGAGTCAGTGGGCGGC AAGGTGGAAAACTGTAGGGTGGCCAGTTAGCCGTAAAAAAAGATCACACTGTGTGTTTGAAAACATGAAA TCCAAGCTGTAGAATTCACTTATTTTTTGCCTGGAAACCCTCTGTGTTTCCAGTGGCCTCGCTGGGGGAG CCCACAGGCTTCAGCTCCCTATTGCCTGGGCTTCCATCTGGGTCCTGTCCCCAGGACTGTGGTTTACCAT GATTGTGCCTGTGAATAGCTACTGACCTCTGAGGCAAGTTATGCTATAAAAGTGCTTGGAACAGTGCCTG GCACATAGTAAGCACCCAATAAATGTCACCTTATGTTATTTTTTAAAAAAACATGAGTACTGGGCTTGTT TGAGACAGAGATAGCATCTTCAGTGGTGGGGCCTGGCTGTGTGTTTCTTCAGAAGCTCTGCGAGTGACTC TAAGGTGCATTCCTGGTCACAAACCTGTGCATGGAGGGGATGGGTGCAGCAGACAACTGAGACAGCCAAG AACAGGTTCTCTGTGCCTTGCCCTCCCTTCTGTAAAACAGGGCTGGAAGTTGGGACTGAGACATAGACAT AGGCCGATCATGAAACTGGAAGGGACTTGAAAACCATCAAGTTTAATCCCCTTATACAGATGGGGAAATT GAGCCCCAGGTGGGGAGGGGAGTGACTCGCCCCAGATCACTGTCAGGTCAGTGGGAAGGTAGGACTAGAG TTAGGCCGTCTGCCTCCCCATCCAGTGCTCTTTCTTCCTGCATGGATTGGGTATGTACCAACCTTCTAAG TCTAAACACCCTTACTGACCCTGTGGGGACCGGAAATACACAGGTAGATCCAGATTCAGAAGGATATACA GTGAAAATTCTCCCTCCCACTCCACCCAGCCACCTCCCTAGAAGTCAGATTCTTGTGTGAACTTCAGAGG TGTTTTATGCTGCACACAAATGCATATGTGTCCTCTTCTGTCTTTCTTATATCACATTTATCTGTATTTT TTCACCCACTATATTTTGGAGATTATCCCATGTTGGTATATGAAGAGTGTCTTTTTGACCAGCCTGGACA ACATAGTGAGATCCCATCTCTACAAACAAAATTTTTTTTAATTAGCCAGGTGTGGTGGCACGCACCTGTA GTTTCAGTTACTTGAGAGGCTGAGGCCGGAGGATCACTTGAGCCAGGTGTTCCAGGCCACAGTGAACTAT GATCACACTTCAGCCTGGATGACAGAGCAAGACCCTGTCAAAAAAATATATATTTTTTCTTTCTCTTCTT CTCTCAAGATCTCTTTTCTTTCTTTCCTTTTCTTCTTTCTTTCCACAACACTTTTTTAGGGGGGTAGACT TATCCTTCTAAAATGAGGGGAACCTTCACTAACGTCAGATGAGTACTTGTCTCATTTTACCAAGTACTTG CTTGGTAAAAGCAAGTACTTGGTAAAGTACTTCCTACTTTCTACTTCAATGAAGCTGGCATTCAGTGGGT TTAATTATTGTGCCTCCTGCAAAGCAGATGTTAACAGCTGTAGGGGCAAACTGCAGCTAATACCAATGGT ATTGGCCAGTTGAAATCATCATGGTTTTACAAAGGGTTAATAGAGAGGGTAGTTTCTTCCACATACTTTT GAGAGCTGGTATATGCTGATTTCTGCTGCTGCCTATTTAATAATGATGATGTAAAAGATTTAGAGATGTC TGGCTGATTTTGACATTGGCCTGTAGTCCTAGAAGAGACACTACCCTGAGTGTCTTTGAGCAGTCAGAGA GTGCACCTCTGCCCTGGGCCTGTTTACCTGTTAGAGTGAGCCACACAAGAAGGAATTCAACGTGGCAGAG CTCTTGCCAGAGGGAGCTGACCATCTTCAAATGTTAAAAAAGGTAGACAGAAGAGAGCCCTTAGCCCAAC CCCTATGGTTTTGAGGGACTTGATTTGCATTCACCTTGCTTGGACACTGAACCAGCTGAGGAAGGAGTTT CACCCAAGATTGTGGGTTTTCCCTTTCAGTTTCAGTTATCATTTGTTATTGATTCTTTTCTCTTTTTTCA AGGGTCTGAATCCAGGGAAAGCTATTGCAGAGATCAAGAAAATGATGGCAACCTATAAGGAGAAGAAAGC TTCAGTTTAACTGTTTCCATGCTAAACATGATTTATAACCAGCTCAGAGCTGAACATAATTTATATCTAA TTTGAGTTCCTTTAAAGATCTTGGTTTTCCATGAATACAGCATGTATAATAAAAATTTTAAGAAATAAAT GTTATTCTACTTTATTAACAAAAAAAAAA Download Select all
Length	35449
OMIM ID	185470
HGNC ID	HGNC:10681
Unigene ID	Hs.465924
Ensembl ID	ENSG00000117118
PharmGKB ID	-

mRNA Information

mRNA ID	NM_003000.2
Exon	join(1..223,9283..9410,21026..21111,25435..25571, 26306..26422,30097..30198,31441..31563,35213..35449)
mRNA Sequence	>6390 ACCCGGGAAACCGGAAGCCGCCTCCCACTTGGTTGCTCGTACGCGGCTAGTGGGTCCTCAGTGG ATGTAGGCTGGGCGCCGCGATGTTCGACGGGACACCGGCGGAGAGCGACCTCGGGGTTAAGGGG TGGGGCTGACGTCAGGAGCCAAGATGGCGGCGGTGGTCGCCCTCTCCTTGAGGCGCCGGTTGCC GGCCACAACCCTTGGCGGAGCCTGCCTGCAGGCCTCCCGAGGAGCCCAGACAGCTGCAGCCACA GCTCCCCGTATCAAGAAATTTGCCATCTATCGATGGGACCCAGACAAGGCTGGAGACAAACCTC ATATGCAGACTTATGAAGTTGACCTTAATAAATGTGGCCCCATGGTATTGGATGCTTTAATCAA GATTAAGAATGAAGTTGACTCTACTTTGACCTTCCGAAGATCATGCAGAGAAGGCATCTGTGGC TCTTGTGCAATGAACATCAATGGAGGCAACACTCTAGCTTGCACCCGAAGGATTGACACCAACC TCAATAAGGTCTCAAAAATCTACCCTCTTCCACACATGTATGTGATAAAGGATCTTGTTCCCGA TTTGAGCAACTTCTATGCACAGTACAAATCCATTGAGCCTTATTTGAAGAAGAAGGATGAATCT CAGGAAGGCAAGCAGCAGTATCTGCAGTCCATAGAAGAGCGTGAGAAACTGGACGGGCTCTACG AGTGCATTCTCTGTGCCTGCTGTAGCACCAGCTGCCCCAGCTACTGGTGGAACGGAGACAAATA TCTGGGGCCTGCAGTTCTTATGCAGGCCTATCGCTGGATGATTGACTCCAGAGATGACTTCACA GAGGAGCGCCTGGCCAAGCTGCAGGACCCATTCTCTCTATACCGCTGCCACACCATCATGAACT GCACAAGGACCTGTCCTAAGGGTCTGAATCCAGGGAAAGCTATTGCAGAGATCAAGAAAATGAT GGCAACCTATAAGGAGAAGAAAGCTTCAGTTTAACTGTTTCCATGCTAAACATGATTTATAACC AGCTCAGAGCTGAACATAATTTATATCTAATTTGAGTTCCTTTAAAGATCTTGGTTTTCCATGA ATACAGCATGTATAATAAAAATTTTAAGAAATAAATGTTATTCTACTTTATTAACAAAAAAAAA AAAAAAAAA Download Select all
Length	1161

CDS Information

Location	join(152..223,9283..9410,21026..21111,25435..25571, 26306..26422,30097..30198,31441..31563,35213..35290)
CDS Sequence	>lcl\|NM_003000.2_cds_NP_002991.2_1 [gene=SDHB] [protein=succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor] [protein_id=NP_002991.2] [location=152..994] ATGGCGGCGGTGGTCGCCCTCTCCTTGAGGCGCCGGTTGCCGGCCACAACCCTTGGCGGAGCCTGCCTGC AGGCCTCCCGAGGAGCCCAGACAGCTGCAGCCACAGCTCCCCGTATCAAGAAATTTGCCATCTATCGATG GGACCCAGACAAGGCTGGAGACAAACCTCATATGCAGACTTATGAAGTTGACCTTAATAAATGTGGCCCC ATGGTATTGGATGCTTTAATCAAGATTAAGAATGAAGTTGACTCTACTTTGACCTTCCGAAGATCATGCA GAGAAGGCATCTGTGGCTCTTGTGCAATGAACATCAATGGAGGCAACACTCTAGCTTGCACCCGAAGGAT TGACACCAACCTCAATAAGGTCTCAAAAATCTACCCTCTTCCACACATGTATGTGATAAAGGATCTTGTT CCCGATTTGAGCAACTTCTATGCACAGTACAAATCCATTGAGCCTTATTTGAAGAAGAAGGATGAATCTC AGGAAGGCAAGCAGCAGTATCTGCAGTCCATAGAAGAGCGTGAGAAACTGGACGGGCTCTACGAGTGCAT TCTCTGTGCCTGCTGTAGCACCAGCTGCCCCAGCTACTGGTGGAACGGAGACAAATATCTGGGGCCTGCA GTTCTTATGCAGGCCTATCGCTGGATGATTGACTCCAGAGATGACTTCACAGAGGAGCGCCTGGCCAAGC TGCAGGACCCATTCTCTCTATACCGCTGCCACACCATCATGAACTGCACAAGGACCTGTCCTAAGGGTCT GAATCCAGGGAAAGCTATTGCAGAGATCAAGAAAATGATGGCAACCTATAAGGAGAAGAAAGCTTCAGTT TAA Download Select all
CCDS ID	CCDS176.1

Protein Information

Protein ID	NP_002991.2
Protein Name	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Molecular Wt. (Da)	2840
Protein Sequence	>6390 MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQTYEVD LNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLNKVSKIY PLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACC STSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTRTCPKG LNPGKAIAEIKKMMATYKEKKASV Download Select all
Length	280
Uniprot ID	P41134
Ensembl Protein ID	ENSP00000365273

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
T	Phosphorylation	119

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

No matching records from HPRD source could be found.

Pathway Information

Pathway Name	Pathway ID
Alzheimer's disease	hsa05010
Carbon metabolism	hsa01200
Citrate cycle (TCA cycle)	hsa00020
Huntington's disease	hsa05016
Metabolic pathways	hsa01100
Non-alcoholic fatty liver disease (NAFLD)	hsa04932
Oxidative phosphorylation	hsa00190
Parkinson's disease	hsa05012

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd00207	56-109	fer2
cl00159	56-109	fer2 superfamily
pfam13085	41-147	Fer2_3
pfam13534	185-258	Fer4_17
cl19102	185-258	HCP_like superfamily
pfam13183	183-257	Fer4_8
PLN00129	5-271	PLN00129
PRK05950	41-272	sdhB
COG0479	38-277	FrdB
TIGR00384	44-267	dhsB
PRK12575	44-271	PRK12575
PRK12576	41-276	PRK12576
PRK12577	42-279	PRK12577
PRK12385	38-267	PRK12385
PRK06259	44-277	PRK06259
PRK13552	38-272	frdB
PRK12386	41-257	PRK12386
PRK08640	35-266	sdhB
COG0247	177-271	GlpC
PRK07570	47-146	PRK07570

Ontology Information

HPRD ID	8995
Molecular Class	Enzyme: Dehydrogenase
Molecular Function	Transcription regulator activity (GO:0030528)
Biological Process	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)

SNP Information

View SNP Geneview Report

Drug Information

Uniprot ID DrugBank ID Name Type
P21912 DB00139 Succinic acid SmallMoleculeDrug

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO